PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26893664-8	2016	Naringenin and ABT-737 also decreased Akt activation and increased p53 expression, suggesting the involvement of these pathways in the inhibition of gastric cell growth.	naringenin	0-10	tumor protein p53	Homo sapiens	67-70	
26496980-8	2015	Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin.	naringenin	206-216	tumor protein p53	Homo sapiens	29-32	
26496980-9	2015	These results indicated that naringenin may enhance curcumin-induced apoptosis through inhibiting the Akt and ERK pathways, and promoting the JNK and p53 pathways.	naringenin	29-39	tumor protein p53	Homo sapiens	150-153	
18086244-2	2008	In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells.	naringenin	51-61	tumor protein p53	Homo sapiens	220-223	
25667616-10	2015	Furthermore, in the naringenin-treated K562 cells, the labeling index of proliferating cell nuclear antigen was observed to be increased by immunochemical staining, the mRNA and protein expression levels of p21/WAF1 were strongly upregulated in reverse transcription-polymerase chain reaction and western blot analyses, whereas p53 gene expression was not significantly changed.	naringenin	20-30	tumor protein p53	Homo sapiens	328-331	
25667616-16	2015	Cell cycle arrest and apoptosis-inducing effects, achieved through p53-independent p21/WAF1 upregulation, are likely to be the mechanism of the antileukemic effects of naringenin, and the protective effect against ADM chemotherapy-induced damage in PMNs may be due to the antioxidant capability of this agent at low concentrations.	naringenin	168-178	tumor protein p53	Homo sapiens	67-70	
23661153-7	2013	Naringenin induced a rapid accumulation of p53, which might account for the naringenin-induced G0/G1 and G2/M phase arrests in Hep G2 cells.	naringenin	0-10	tumor protein p53	Homo sapiens	43-46	
18086244-2	2008	In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells.	naringenin	63-65	tumor protein p53	Homo sapiens	220-223	
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	naringenin	139-149	tumor protein p53	Homo sapiens	202-206	
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	naringenin	45-55	tumor protein p53	Homo sapiens	131-135	
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	naringenin	45-55	tumor protein p53	Homo sapiens	165-168	
33603536-11	2021	The mRNA of tumor suppressors P53 and ERalpha were downregulated in the mammosphere, but were significantly upregulated upon naringenin treatment.	naringenin	125-135	tumor protein p53	Homo sapiens	30-33	
33603536-12	2021	By modulating the P53 and ERalpha mRNA, naringenin has the potential of inhibiting BCSCs.	naringenin	40-50	tumor protein p53	Homo sapiens	18-21	
29684853-0	2018	Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner.	naringenin	0-10	tumor protein p53	Homo sapiens	106-109	
27606834-7	2017	In a dose-dependent manner, naringenin decreased phosphorylation of ERK1/2, P70S6K, S6, and P38 in PC3 cells, and reduced phosphorylation of ERK1/2, P53, P38, and JNK proteins in LNCaP cells.	naringenin	28-38	tumor protein p53	Homo sapiens	149-152