PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29098062-4 2017 We found that both the SMUG1 protein and the TDG protein exhibit DNA glycosylase activity against thymine mispaired with 8BrG and that the MUTYH protein exhibits DNA glycosylase activity against adenine mispaired with 8BrG. Adenine 195-202 thymine DNA glycosylase Homo sapiens 45-48 25375110-2 2014 TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU) paired with adenine or guanine. Adenine 140-147 thymine DNA glycosylase Homo sapiens 0-3 16984202-3 2006 Human thymine DNA glycosylase (hTDG) cleaves thymine from mutagenic G.T mispairs, recognizes many additional lesions, and has a strong preference for nucleobases paired with guanine rather than adenine. Adenine 194-201 thymine DNA glycosylase Homo sapiens 6-29 24692658-4 2014 Here we demonstrate that TDG initiates aberrant repair by excising T when it is paired with a damaged adenine residue in DNA duplex. Adenine 102-109 thymine DNA glycosylase Homo sapiens 25-28 18789404-3 2008 This work investigates the DNA repair activity of Spo TDG on all four deaminated bases: xanthine (X) and oxanine (O) from guanine, hypoxanthine (I) from adenine, and uracil from cytosine. Adenine 153-160 thymine DNA glycosylase Homo sapiens 54-57 16984202-3 2006 Human thymine DNA glycosylase (hTDG) cleaves thymine from mutagenic G.T mispairs, recognizes many additional lesions, and has a strong preference for nucleobases paired with guanine rather than adenine. Adenine 194-201 thymine DNA glycosylase Homo sapiens 31-35 27890638-7 2017 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. Adenine 140-147 thymine DNA glycosylase Homo sapiens 65-68 27890638-7 2017 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. Adenine 140-147 thymine DNA glycosylase Homo sapiens 128-131 27890638-7 2017 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. Adenine 210-217 thymine DNA glycosylase Homo sapiens 65-68 27890638-7 2017 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. Adenine 210-217 thymine DNA glycosylase Homo sapiens 128-131 12124995-3 2002 DNA is cross-hybridized to form mismatches at the positions of point mutations, de-phosphorylated to eliminate any pre-existing phosphorylated DNA ends, and then exposed to enzymatic treatment to remove mismatched thymidine (TDG) or adenine (MutY). Adenine 233-240 thymine DNA glycosylase Homo sapiens 225-228 27890638-6 2017 Mismatch-specific adenine- and thymine-DNA glycosylases (MutY/MUTYH and TDG/MBD4, respectively) initiated BER and mismatch repair (MMR) pathways can recognize and remove normal DNA bases in mismatched DNA duplexes. Adenine 18-25 thymine DNA glycosylase Homo sapiens 72-75