PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16690067-1	2006	A simple and reliable HPLC method for the determination of the plasma level of K-27, an oxime type antidote of use in organophosphorus poisoning is presented.	Oximes	88-93	keratin 27	Rattus norvegicus	79-83	
17309042-1	2007	In the search for new oximes with higher reactivation potency and a broader spectrum, K-27 and K-48, have recently been synthesized.	Oximes	22-28	keratin 27	Rattus norvegicus	86-90	
16583462-5	2006	Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27).	Oximes	80-86	keratin 27	Rattus norvegicus	303-307	
16583462-5	2006	Based on our previous in vitro work the protection conferred by the various new oximes against inhibition by paraoxon as quantified by the IC(50) shift (nM increase in the IC(50) of the inhibitor per microM oxime present) is: 0.3 (PRX), 0.4 (methoxime; MMC-4), 1 (K-33), 1.2 (BI-6), 1.5 (K-48) and 3.7 (K-27).	Oximes	80-85	keratin 27	Rattus norvegicus	303-307	
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	42-48	keratin 27	Rattus norvegicus	164-168	
33802843-11	2021	Our present data, together with previous results on other OPCs, indicate that the experimental oximes K-27 and K-48 are very promising pretreatment compounds.	Oximes	95-101	keratin 27	Rattus norvegicus	102-106	
24136594-9	2014	Prophylactic administration of an oxime (such as K-27) in case of imminent OPC exposure may be a viable option.	Oximes	34-39	keratin 27	Rattus norvegicus	49-53	
19603416-4	2009	The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic.	Oximes	137-143	keratin 27	Rattus norvegicus	164-168