PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21600273-3	2011	An explanation for limited penetration might be that oximes are substrates for the active P-glycoprotein (Pgp) efflux transporter located in the BBB.	Oximes	53-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	90-104	
21600273-3	2011	An explanation for limited penetration might be that oximes are substrates for the active P-glycoprotein (Pgp) efflux transporter located in the BBB.	Oximes	53-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-109	
29722548-4	2019	To determine if P-gp affinity screening could be used to reduce animal use, we measured in vitro oxime-stimulated ATPase activity to see if the in vivo reactivation efficacies related to the oximes" functions as P-gp substrates.	Oximes	191-197	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	16-20	
29722548-4	2019	To determine if P-gp affinity screening could be used to reduce animal use, we measured in vitro oxime-stimulated ATPase activity to see if the in vivo reactivation efficacies related to the oximes" functions as P-gp substrates.	Oximes	191-197	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	212-216	
29722548-5	2019	High efficacy oximes were expected to be poor P-gp substrates, thus remaining in the brain longer.	Oximes	14-20	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	46-50	
29722548-6	2019	The high efficacy oximes (24-35% brain AChE reactivation) were worse P-gp substrates than the low efficacy oximes (0-7% brain AChE reactivation).	Oximes	18-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	69-73	
29722548-7	2019	However, the oxime group with medium in vivo reactivation of 10-17% were even worse P-gp substrates than the high efficacy group so their reactivation ability was not reflected by P-gp export.	Oximes	13-18	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-88	
29722548-8	2019	The results suggest that in vitro P-gp ATPase activity can remove the low efficacy oximes from in vivo testing, but is not sufficient to differentiate between the top two tiers.	Oximes	83-89	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	34-38