PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31097402-0 2019 Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1). Oximes 30-35 solute carrier family 6 member 1 Homo sapiens 167-204 31097402-0 2019 Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1). Oximes 30-35 solute carrier family 6 member 1 Homo sapiens 206-210 31097402-1 2019 In the present study, the concept of oxime library screening by MS Binding Assays was successfully extended to N-substituted lipophilic pyrrolidine-3-carboxylic acid derivatives in the pursuit of varying the amino acid motif in order to identify new inhibitors for GAT1 and to broaden structure-activity-relationships for this target, the most abundant GABA transporter in the central nervous system. Oximes 37-42 solute carrier family 6 member 1 Homo sapiens 265-269 32896797-0 2020 Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1. Oximes 154-159 solute carrier family 6 member 1 Homo sapiens 192-210 25369775-0 2015 Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1. Oximes 28-33 solute carrier family 6 member 1 Homo sapiens 85-89 32896797-2 2020 After reaction of a nipecotic acid derivative possessing a hydroxylamine functionality with aldehydes, the resulting oxime library was screened accordingly toward the GABA transporter subtype 1 (GAT1), a drug target for several neurological disorders. Oximes 117-122 solute carrier family 6 member 1 Homo sapiens 167-193 32896797-2 2020 After reaction of a nipecotic acid derivative possessing a hydroxylamine functionality with aldehydes, the resulting oxime library was screened accordingly toward the GABA transporter subtype 1 (GAT1), a drug target for several neurological disorders. Oximes 117-122 solute carrier family 6 member 1 Homo sapiens 195-199