PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8494501-11 1993 Combination of pyridostigmine pretreatment and oxime treatment enhanced the recovery of the tracheal contraction response and the ChE activity in the trachea compared to treatment with oximes alone. Oximes 47-52 butyrylcholinesterase Rattus norvegicus 130-133 8603667-1 1996 The oxime HI-6 dichloride [1-(2 hydroxyiminomethyl -1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate] has shown to be a potent reactivator of cholinesterase activity and may have efficacy for the treatment of organophosphate intoxication [SIPRI, 1976; Schenk et al. Oximes 4-9 butyrylcholinesterase Rattus norvegicus 168-182 8311691-1 1993 The ability of three oximes, HI-6, MMB-4 and ICD-467, to reactivate cholinesterase (ChE) inhibited by the organophosphorus compound soman was compared in blood (plasma and erythrocytes), brain regions (including spinal cord) and peripheral tissues of rats. Oximes 21-27 butyrylcholinesterase Rattus norvegicus 84-87 17304644-2 2007 The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using methyl-paraoxon [dimethyl p-nitrophenyl phosphate; (methyl-POX)] as a cholinesterase inhibitor. Oximes 63-68 butyrylcholinesterase Rattus norvegicus 167-181 6628257-5 1983 The effectiveness of these oximes in restoration of VX-inactivated ChE in vivo offers an explanation as to why conventional atropine/oxime therapy is so effective against VX intoxication. Oximes 27-33 butyrylcholinesterase Rattus norvegicus 67-70 1664202-1 1991 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. Oximes 84-89 butyrylcholinesterase Rattus norvegicus 100-114 1664202-1 1991 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. Oximes 84-89 butyrylcholinesterase Rattus norvegicus 116-119 1664202-3 1991 Atropinized rats were artificially ventilated after injection with 3 x LD50 soman for 3 h and then treated with HI-6, i.e. at a time when oxime reactivation of soman inhibited ChE is no longer possible. Oximes 138-143 butyrylcholinesterase Rattus norvegicus 176-179 6628257-5 1983 The effectiveness of these oximes in restoration of VX-inactivated ChE in vivo offers an explanation as to why conventional atropine/oxime therapy is so effective against VX intoxication. Oximes 27-32 butyrylcholinesterase Rattus norvegicus 67-70 5315345-2 1971 From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes. Oximes 90-96 butyrylcholinesterase Rattus norvegicus 62-76 799866-2 1976 Described is an activating affect (observed for the first time in vivo) on ChE preduced by low and very low concentrations of reactivators of the group of oximes. Oximes 155-161 butyrylcholinesterase Rattus norvegicus 75-78 799866-4 1976 The low concentrations of the specific oxime ractivators of ChE, followed up by ChDT, can be used as sensitive quantitative indicators of the activity of ChE. Oximes 39-44 butyrylcholinesterase Rattus norvegicus 60-63 799866-4 1976 The low concentrations of the specific oxime ractivators of ChE, followed up by ChDT, can be used as sensitive quantitative indicators of the activity of ChE. Oximes 39-44 butyrylcholinesterase Rattus norvegicus 154-157 5315345-2 1971 From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes. Oximes 257-263 butyrylcholinesterase Rattus norvegicus 62-76 26705700-5 2016 Brain cholinesterase inhibition was slightly less in novel oxime treated rats compared to 2-PAM in the 24h survivors. Oximes 59-64 butyrylcholinesterase Rattus norvegicus 6-20 31516541-2 2019 In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. Oximes 52-57 butyrylcholinesterase Rattus norvegicus 267-281 31516541-2 2019 In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. Oximes 52-57 butyrylcholinesterase Rattus norvegicus 283-286 31516541-2 2019 In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. Oximes 104-109 butyrylcholinesterase Rattus norvegicus 267-281 31516541-2 2019 In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats. Oximes 104-109 butyrylcholinesterase Rattus norvegicus 283-286 27387540-5 2016 A number of these novel oximes have shown the ability to decrease the level of ChE inhibition in the brains of rats treated with a high sublethal dosage of either a sarin surrogate (nitrophenyl isopropyl methylphosphonate, NIMP) or the VX surrogate NEMP. Oximes 24-30 butyrylcholinesterase Rattus norvegicus 79-82 27387540-8 2016 Therefore these novel oximes have demonstrated an ability to reactivate inhibited ChE in brain preparations from two species and in vivo data support their ability to enter the brain and provide a therapeutic action. Oximes 22-28 butyrylcholinesterase Rattus norvegicus 82-85 27153507-0 2016 Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Oximes 24-30 butyrylcholinesterase Rattus norvegicus 51-65 27153507-1 2016 Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo. Oximes 8-13 butyrylcholinesterase Rattus norvegicus 57-71 27153507-1 2016 Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo. Oximes 8-13 butyrylcholinesterase Rattus norvegicus 73-76 24295433-1 2014 The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. Oximes 35-41 butyrylcholinesterase Rattus norvegicus 88-102 24295433-1 2014 The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. Oximes 35-40 butyrylcholinesterase Rattus norvegicus 88-102 24295433-3 2014 In the brain, the potency of both newly developed oximes to reactivate tabun-inhibited cholinesterase was negligible. Oximes 50-56 butyrylcholinesterase Rattus norvegicus 87-101 23220589-6 2013 The aim of the present study was to evaluate the efficacy of some ChE reactivators against OPC intoxication (tabun, paraoxon and dichlorvos) in in vitro experiments and to compare their activity to that known for some currently used oximes (obidoxime, HI-6, 2-PAM). Oximes 233-239 butyrylcholinesterase Rattus norvegicus 66-69