PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22697478-2	2012	This protective effect is blunted upon mutation of residues T105, E107 and E110 in human TNF into alanine or upon pre-incubation of the cytokine with the disaccharide N,N"-diacetylchitobiose.	Disaccharides	154-166	tumor necrosis factor	Homo sapiens	89-92	
26046354-7	2015	A disaccharide fraction of enoxaparin inhibited the release of IL-4, IL-5, IL-13 and TNF-alpha by more than 57% while a tetrasaccharide fraction was found to inhibit the release of tested cytokines by more than 68%.	Disaccharides	2-14	tumor necrosis factor	Homo sapiens	85-94	
11159885-6	2001	RESULTS: Specific disaccharides suppressed spontaneous and TNF-alpha-induced mediator secretion in a dose-dependent manner.	Disaccharides	18-31	tumor necrosis factor	Homo sapiens	59-68	
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	Disaccharides	34-47	tumor necrosis factor	Homo sapiens	135-144	
17918767-1	2007	A cyclic disulfide heptadecapeptide (TIP17ox; 2) derived from the lectin-like 17-amino acid domain of human tumor necrosis factor-alpha [TNF-alpha (100-116)] was synthesised and demonstrated to bind specifically to N,N-diacetylchitobiose, a disaccharide present in many glycan structures of glycoproteins.	Disaccharides	241-253	tumor necrosis factor	Homo sapiens	108-135	
17918767-1	2007	A cyclic disulfide heptadecapeptide (TIP17ox; 2) derived from the lectin-like 17-amino acid domain of human tumor necrosis factor-alpha [TNF-alpha (100-116)] was synthesised and demonstrated to bind specifically to N,N-diacetylchitobiose, a disaccharide present in many glycan structures of glycoproteins.	Disaccharides	241-253	tumor necrosis factor	Homo sapiens	137-146	
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	28-41	tumor necrosis factor	Homo sapiens	189-216	
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	28-41	tumor necrosis factor	Homo sapiens	218-227	
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	43-45	tumor necrosis factor	Homo sapiens	189-216	
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	43-45	tumor necrosis factor	Homo sapiens	218-227	
12782582-4	2003	Here, we show that treatment of cultured human adenocarcinoma cells with micromolar concentrations of the peracetylated disaccharide, (Ac)(6)GlcNAcbeta1,3Galbeta-O-naphthalenemethanol (AcGnG-NM) reduces the expression of sLe(X) and diminishes binding in vitro to selectin-coated dishes, thrombin-activated platelets, and tumor necrosis factor alpha-activated endothelial cells.	Disaccharides	120-132	tumor necrosis factor	Homo sapiens	321-348	
10651945-1	2000	We have found previously that disaccharides (DS) enzymatically generated from heparin or heparan sulphate can modulate tumour necrosis factor-alpha (TNF-alpha) secretion from immune cells in vitro and cell-mediated immune reactions in vivo.	Disaccharides	30-43	tumor necrosis factor	Homo sapiens	149-158	
10651945-1	2000	We have found previously that disaccharides (DS) enzymatically generated from heparin or heparan sulphate can modulate tumour necrosis factor-alpha (TNF-alpha) secretion from immune cells in vitro and cell-mediated immune reactions in vivo.	Disaccharides	45-47	tumor necrosis factor	Homo sapiens	149-158	
9352356-3	1997	We now report that the cleavage of heparin by the enzyme heparinase I generates sulfated disaccharide (DS) molecules that can inhibit the production of TNF-alpha.	Disaccharides	89-101	tumor necrosis factor	Homo sapiens	152-161	
9352356-3	1997	We now report that the cleavage of heparin by the enzyme heparinase I generates sulfated disaccharide (DS) molecules that can inhibit the production of TNF-alpha.	Disaccharides	103-105	tumor necrosis factor	Homo sapiens	152-161