PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9851870-4	1998	This mitogenic activity was dependent on the lectin property of galectin-3, as it could be significantly inhibited by lactose, a disaccharide competitive for carbohydrate-binding by galectin-3.	Disaccharides	129-141	galectin 3	Homo sapiens	64-74	
15963723-2	2005	The 3-(1H-[1,2,3]-triazol-1-yl)-1-thio-galactoside collection synthesized contained inhibitors of the tumor- and inflammation-related galectin-3 with Kd values as low as 107 microM, which is as potent as the natural disaccharide inhibitors lactose and N-acetyllactosamine.	Disaccharides	216-228	galectin 3	Homo sapiens	134-144	
9851870-4	1998	This mitogenic activity was dependent on the lectin property of galectin-3, as it could be significantly inhibited by lactose, a disaccharide competitive for carbohydrate-binding by galectin-3.	Disaccharides	129-141	galectin 3	Homo sapiens	182-192	
33988358-4	2021	In our efforts to identify novel galectin-3 disaccharide mimics to improve drug-like properties, we found that one of the monosaccharide subunits can be replaced with a suitably functionalized tetrahydropyran ring.	Disaccharides	44-56	galectin 3	Homo sapiens	33-43	
3170547-3	1988	Upon hydrazine/nitrous acid fragmentation and radiolabeling with NaB3H4, all human unit B DEAE-resolved glycopeptide fractions yielded an acidic disaccharide which was characterized as Gal-3-SO4 beta 1----4-anhydromannitol.	Disaccharides	145-157	galectin 3	Homo sapiens	185-201	
30499163-0	2019	Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.	Disaccharides	57-69	galectin 3	Homo sapiens	138-143	
30499163-5	2019	Herein, synthetic methodology for the construction of well-defined bioconjugates consisting of biologically relevant disaccharide fragments grafted onto a dextran backbone is presented, and a preliminary NMR spectroscopy study of their interactions with galectin-3 as a model lectin is conducted.	Disaccharides	117-129	galectin 3	Homo sapiens	254-264	
27526114-3	2016	In this review we present an updated selection of synthetic glycoconjugates inhibitors of tumor-related galectin-3, properly addressed as monosaccharide- and disaccharide-based inhibitors, and multivalent-based inhibitors, disclosuring relevant methods for their synthesis along with their inhibitory activities towards galectin-3.	Disaccharides	158-170	galectin 3	Homo sapiens	104-114	
26129647-4	2015	The dissociation constants (Kd) for interaction of galectin-3 and the glycosylated MUC1 fragments measured by isothermal titration calorimetry decreased up to 10 times in comparison to that of the free TF disaccharide.	Disaccharides	205-217	galectin 3	Homo sapiens	51-61	
26280564-2	2015	We explore this approach by calculating the relative binding free energy of two synthetic disaccharides binding to galectin-3 at a reasonably high QM level (dispersion-corrected density functional theory with a triple-zeta basis set) and with a sufficiently large QM system to include all short-range interactions with the ligand (744-748 atoms).	Disaccharides	90-103	galectin 3	Homo sapiens	115-125	
20807768-5	2010	Galectin-3 R186S, which has selectively lost affinity for LacNAc, a disaccharide moiety commonly found on glycoprotein glycans, has lost the ability to activate neutrophil leukocytes and intracellular targeting into vesicles.	Disaccharides	68-80	galectin 3	Homo sapiens	0-10	
24567334-5	2014	Down-regulation of Gal3 protein or incubation with lactose, a galactose-containing disaccharide that competitively inhibits galectin binding to Dsg2, decreased intercellular adhesion in intestinal epithelial cells.	Disaccharides	83-95	galectin 3	Homo sapiens	19-23	
23218331-1	2013	Force spectroscopy has been used to investigate the interaction between the disaccharide beta-galactobiose and the pro-metastatic regulatory protein galectin-3 (Gal3).	Disaccharides	76-88	galectin 3	Homo sapiens	149-159	
23218331-1	2013	Force spectroscopy has been used to investigate the interaction between the disaccharide beta-galactobiose and the pro-metastatic regulatory protein galectin-3 (Gal3).	Disaccharides	76-88	galectin 3	Homo sapiens	161-165	
17385862-6	2007	The approach is validated through the observation of bound-state RDCs for the disaccharide, lactose, bound to the carbohydrate recognition domain of the mammalian lectin, galectin-3.	Disaccharides	78-90	galectin 3	Homo sapiens	171-181	
17451431-5	2007	Furthermore, cell fusion was reduced (specifically) by the disaccharide lactose, a known ligand for the carbohydrate recognition domain of galectin 3, suggesting that the association was functional.	Disaccharides	59-71	galectin 3	Homo sapiens	139-149