PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8444842-4 1993 In this report, a specific hexasaccharide having high affinity for recombinant human bFGF was isolated and its structure deduced by analysis of its reduced disaccharide products after treatment with nitrous acid at pH 1.5, and by 1H NMR spectroscopy. Disaccharides 156-168 fibroblast growth factor 2 Homo sapiens 85-89 9195945-4 1997 Analytical ultracentrifugation of FGF-2 in the presence of heparin-derived saccharides shows that both an active heparin octasaccharide and an inactive heparin-like disaccharide induce fibroblast growth factor-2 self-association. Disaccharides 165-177 fibroblast growth factor 2 Homo sapiens 34-39 9195945-4 1997 Analytical ultracentrifugation of FGF-2 in the presence of heparin-derived saccharides shows that both an active heparin octasaccharide and an inactive heparin-like disaccharide induce fibroblast growth factor-2 self-association. Disaccharides 165-177 fibroblast growth factor 2 Homo sapiens 185-211 9195945-6 1997 Evidence is presented indicating that the dimer conformation induced by the heparin octasaccharide is a side by side dimer with the FGF-2 molecules cis to the heparin, while the disaccharide-induced dimer is a head to head dimer in which FGF-2 molecules are trans to the ligand. Disaccharides 178-190 fibroblast growth factor 2 Homo sapiens 238-243 9722514-4 1998 The ability of these oligosaccharides to activate bFGF in a mitogenic assay was then correlated with their length and disaccharide composition. Disaccharides 118-130 fibroblast growth factor 2 Homo sapiens 50-54 30239102-2 2019 Disaccharide analogues of heparan sulfate had previously been identified as the shortest components out of the sugars that bind to FGF-1 and FGF-2. Disaccharides 0-12 fibroblast growth factor 2 Homo sapiens 141-146 1587820-3 1992 bFGF-affinity chromatography of sulfated oligosaccharides released from HS by treatment with heparitinase led to the identification of an oligosaccharide component (oligo-H), seven disaccharides in length, with a similar affinity for bFGF as the parent molecule. Disaccharides 181-194 fibroblast growth factor 2 Homo sapiens 0-4 35348113-5 2022 We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Disaccharides 99-112 fibroblast growth factor 2 Homo sapiens 71-75 35348113-5 2022 We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Disaccharides 99-112 fibroblast growth factor 2 Homo sapiens 204-208 20657775-6 2010 Correspondingly, the inhibitory potential of oligosaccharides against FGF2- and VEGF165-induced endothelial cell responses was greater in longer oligosaccharide species that were comprised of disaccharides bearing both 2-O- and N-sulfation (2SNS). Disaccharides 192-205 fibroblast growth factor 2 Homo sapiens 70-74 19819428-3 2009 Molecular docking calculations showed that the predicted locations of the disaccharide sulfo groups in the binding site of FGF-1 and FGF-2 are similar to the positions observed for co-crystallized heparin-derived oligosaccharides obtained from published crystal structures. Disaccharides 74-86 fibroblast growth factor 2 Homo sapiens 133-138 24959968-0 2014 Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2. Disaccharides 75-88 fibroblast growth factor 2 Homo sapiens 92-118 24959968-4 2014 Herein, we evaluated the affinities of the same sugars against FGF2 and determined the crystal structures of FGF2 in complex with three disaccharides carrying N-sulfonated glucosamine and 2-O-sulfonated iduronic acid as basic backbones. Disaccharides 136-149 fibroblast growth factor 2 Homo sapiens 109-113 24959968-7 2014 These findings suggest that the water-mediated interactions and the intermolecular interactions influence the binding affinity of different disaccharides with FGF2, correlating with their respective dissociation constants in solution. Disaccharides 140-153 fibroblast growth factor 2 Homo sapiens 159-163