PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9722514-4	1998	The ability of these oligosaccharides to activate bFGF in a mitogenic assay was then correlated with their length and disaccharide composition.	Disaccharides	118-130	fibroblast growth factor 2	Homo sapiens	50-54	
24959968-0	2014	Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.	Disaccharides	75-88	fibroblast growth factor 2	Homo sapiens	92-118	
24959968-4	2014	Herein, we evaluated the affinities of the same sugars against FGF2 and determined the crystal structures of FGF2 in complex with three disaccharides carrying N-sulfonated glucosamine and 2-O-sulfonated iduronic acid as basic backbones.	Disaccharides	136-149	fibroblast growth factor 2	Homo sapiens	109-113	
24959968-7	2014	These findings suggest that the water-mediated interactions and the intermolecular interactions influence the binding affinity of different disaccharides with FGF2, correlating with their respective dissociation constants in solution.	Disaccharides	140-153	fibroblast growth factor 2	Homo sapiens	159-163	
20657775-6	2010	Correspondingly, the inhibitory potential of oligosaccharides against FGF2- and VEGF165-induced endothelial cell responses was greater in longer oligosaccharide species that were comprised of disaccharides bearing both 2-O- and N-sulfation (2SNS).	Disaccharides	192-205	fibroblast growth factor 2	Homo sapiens	70-74	
19819428-3	2009	Molecular docking calculations showed that the predicted locations of the disaccharide sulfo groups in the binding site of FGF-1 and FGF-2 are similar to the positions observed for co-crystallized heparin-derived oligosaccharides obtained from published crystal structures.	Disaccharides	74-86	fibroblast growth factor 2	Homo sapiens	133-138	
9195945-4	1997	Analytical ultracentrifugation of FGF-2 in the presence of heparin-derived saccharides shows that both an active heparin octasaccharide and an inactive heparin-like disaccharide induce fibroblast growth factor-2 self-association.	Disaccharides	165-177	fibroblast growth factor 2	Homo sapiens	34-39	
9195945-4	1997	Analytical ultracentrifugation of FGF-2 in the presence of heparin-derived saccharides shows that both an active heparin octasaccharide and an inactive heparin-like disaccharide induce fibroblast growth factor-2 self-association.	Disaccharides	165-177	fibroblast growth factor 2	Homo sapiens	185-211	
9195945-6	1997	Evidence is presented indicating that the dimer conformation induced by the heparin octasaccharide is a side by side dimer with the FGF-2 molecules cis to the heparin, while the disaccharide-induced dimer is a head to head dimer in which FGF-2 molecules are trans to the ligand.	Disaccharides	178-190	fibroblast growth factor 2	Homo sapiens	238-243	
30239102-2	2019	Disaccharide analogues of heparan sulfate had previously been identified as the shortest components out of the sugars that bind to FGF-1 and FGF-2.	Disaccharides	0-12	fibroblast growth factor 2	Homo sapiens	141-146	
8444842-4	1993	In this report, a specific hexasaccharide having high affinity for recombinant human bFGF was isolated and its structure deduced by analysis of its reduced disaccharide products after treatment with nitrous acid at pH 1.5, and by 1H NMR spectroscopy.	Disaccharides	156-168	fibroblast growth factor 2	Homo sapiens	85-89	
1587820-3	1992	bFGF-affinity chromatography of sulfated oligosaccharides released from HS by treatment with heparitinase led to the identification of an oligosaccharide component (oligo-H), seven disaccharides in length, with a similar affinity for bFGF as the parent molecule.	Disaccharides	181-194	fibroblast growth factor 2	Homo sapiens	0-4	
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Disaccharides	99-112	fibroblast growth factor 2	Homo sapiens	71-75	
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Disaccharides	99-112	fibroblast growth factor 2	Homo sapiens	204-208