PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15659814-5 2004 BACE1 expression is upregulated in AD brain, and we have recently shown in human brain and in vitro that BACE product CTFs, when phosphorylated in tyrosine residues, interact with the adaptor proteins ShcA and Grb2, which usually are involved in signal transduction pathways. Tyrosine 147-155 beta-secretase 1 Homo sapiens 0-5 15659814-5 2004 BACE1 expression is upregulated in AD brain, and we have recently shown in human brain and in vitro that BACE product CTFs, when phosphorylated in tyrosine residues, interact with the adaptor proteins ShcA and Grb2, which usually are involved in signal transduction pathways. Tyrosine 147-155 beta-secretase 1 Homo sapiens 0-4 10574939-8 1999 Alanine-scanning mutagenesis identified several charged and aromatic residues (Asp-2, Tyr-3, Tyr-10, Asp-11, and Glu-18) that played an important role in both chemokine and Env high affinity binding. Tyrosine 93-96 beta-secretase 1 Homo sapiens 79-84 21590744-0 2011 The role of tyrosine 71 in modulating the flap conformations of BACE1. Tyrosine 12-20 beta-secretase 1 Homo sapiens 64-69 21500352-2 2011 BACE1 is also known to cleave APP at a much less well-characterized beta"-cleavage site (Tyr(681) -Glu(682) ). Tyrosine 89-92 beta-secretase 1 Homo sapiens 0-5 30264484-7 2019 This work indicates that Tyr 71 stabilizes catalytic water in the aspartyl dyad active site, enabling BACE-1 activity. Tyrosine 25-28 beta-secretase 1 Homo sapiens 102-108