PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10574939-8	1999	Alanine-scanning mutagenesis identified several charged and aromatic residues (Asp-2, Tyr-3, Tyr-10, Asp-11, and Glu-18) that played an important role in both chemokine and Env high affinity binding.	Tyrosine	93-96	beta-secretase 1	Homo sapiens	79-84	
15659814-5	2004	BACE1 expression is upregulated in AD brain, and we have recently shown in human brain and in vitro that BACE product CTFs, when phosphorylated in tyrosine residues, interact with the adaptor proteins ShcA and Grb2, which usually are involved in signal transduction pathways.	Tyrosine	147-155	beta-secretase 1	Homo sapiens	0-5	
15659814-5	2004	BACE1 expression is upregulated in AD brain, and we have recently shown in human brain and in vitro that BACE product CTFs, when phosphorylated in tyrosine residues, interact with the adaptor proteins ShcA and Grb2, which usually are involved in signal transduction pathways.	Tyrosine	147-155	beta-secretase 1	Homo sapiens	0-4	
21590744-0	2011	The role of tyrosine 71 in modulating the flap conformations of BACE1.	Tyrosine	12-20	beta-secretase 1	Homo sapiens	64-69	
21500352-2	2011	BACE1 is also known to cleave APP at a much less well-characterized beta"-cleavage site (Tyr(681) -Glu(682) ).	Tyrosine	89-92	beta-secretase 1	Homo sapiens	0-5	
30264484-7	2019	This work indicates that Tyr 71 stabilizes catalytic water in the aspartyl dyad active site, enabling BACE-1 activity.	Tyrosine	25-28	beta-secretase 1	Homo sapiens	102-108