PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16527271-4 2006 Inducible expression of kinase-active Lyn, which biosynthetically reaches the Golgi apparatus, triggers tyrosine phosphorylation of proteins including annexin II. Tyrosine 104-112 annexin A2 Homo sapiens 151-161 16527271-6 2006 Furthermore, stimulation of cells with H2O2 induces tyrosine phosphorylation of annexin II on the Golgi apparatus in a manner that is dependent on the kinase activity of Src kinases, leading to the translocation of annexin II from the Golgi apparatus to the endoplasmic reticulum. Tyrosine 52-60 annexin A2 Homo sapiens 80-90 16527271-6 2006 Furthermore, stimulation of cells with H2O2 induces tyrosine phosphorylation of annexin II on the Golgi apparatus in a manner that is dependent on the kinase activity of Src kinases, leading to the translocation of annexin II from the Golgi apparatus to the endoplasmic reticulum. Tyrosine 52-60 annexin A2 Homo sapiens 215-225 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 112-120 annexin A2 Homo sapiens 27-36 15601262-0 2005 Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. Tyrosine 27-35 annexin A2 Homo sapiens 86-96 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 112-120 annexin A2 Homo sapiens 140-149 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 112-120 annexin A2 Homo sapiens 140-149 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 238-246 annexin A2 Homo sapiens 27-36 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 238-246 annexin A2 Homo sapiens 140-149 15302870-12 2004 Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23. Tyrosine 238-246 annexin A2 Homo sapiens 140-149 8551221-0 1996 CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells. Tyrosine 63-71 annexin A2 Homo sapiens 59-62 10544962-3 1999 Targeted disruption of the annexin II gene affects calcium signaling, tyrosine phosphorylation and apoptosis, indicating the important physiological role of this protein. Tyrosine 70-78 annexin A2 Homo sapiens 27-37 9013554-0 1997 Tyrosine phosphorylation of annexin II tetramer is stimulated by membrane binding. Tyrosine 0-8 annexin A2 Homo sapiens 28-38 9013554-1 1997 In the present article we have examined if the interaction of the Ca2+-binding protein, annexin II tetramer (AIIt) with the plasma membrane phospholipids or with the submembranous cytoskeleton, effects the accessibility of the tyrosine phosphorylation site of AIIt. Tyrosine 227-235 annexin A2 Homo sapiens 88-98 8550552-3 1996 However, mutation of Tyr-1136 only slightly affects the kinase activity but dramatically reduces the transforming ability and overall substrate phosphorylation, in particular, annexin II, which is strongly phosphorylated by the gag-IGFR but not by the Phe-1136 mutant. Tyrosine 21-24 annexin A2 Homo sapiens 176-186 7527029-4 1994 This association is dependent on the tyrosine phosphorylation of p36 and involves its interaction with the SH2 domain of p50csk.p36 can be phosphorylated in vitro by p50csk or by a full-length GST-Csk fusion protein expressed in Escherichia coli. Tyrosine 37-45 annexin A2 Homo sapiens 65-68 7520466-9 1994 The data show that antibodies against TCR or CD28 induce tyrosine phosphorylation of both Vav and p36. Tyrosine 57-65 annexin A2 Homo sapiens 98-101 7520466-13 1994 These studies show that for CD28 signaling, the activation of p21ras correlates more closely with p36 tyrosine phosphorylation than with Vav tyrosine phosphorylation. Tyrosine 102-110 annexin A2 Homo sapiens 98-101 7578058-0 1995 Modulation of annexin II tetramer by tyrosine phosphorylation. Tyrosine 37-45 annexin A2 Homo sapiens 14-24 7527029-4 1994 This association is dependent on the tyrosine phosphorylation of p36 and involves its interaction with the SH2 domain of p50csk.p36 can be phosphorylated in vitro by p50csk or by a full-length GST-Csk fusion protein expressed in Escherichia coli. Tyrosine 37-45 annexin A2 Homo sapiens 128-131 7527029-5 1994 Tyrosine-phosphorylated p36 is found exclusively in the particulate membrane fraction of the cell. Tyrosine 0-8 annexin A2 Homo sapiens 24-27 1387329-7 1992 These results suggest that the tyrosine phosphorylation of p36, which was probably identical to lipocortin, inhibits thrombin-induced platelet aggregation through anti-phospholipase A2 (anti-PLA2) activity. Tyrosine 31-39 annexin A2 Homo sapiens 59-62 2463166-8 1988 In contrast, protein kinase C (PKC)-dependent serine and tyrosine phosphorylations were stimulated maximally by low level occupancy of PDGF binding sites, and phosphorylation of p36 required high occupancy. Tyrosine 57-65 annexin A2 Homo sapiens 178-181 1654883-1 1991 Stimulation in vivo of Swiss 3T3 fibroblasts with platelet-derived growth factor (PDGF) in the presence of orthovanadate induces the tyrosine phosphorylation of a 39 kDa protein, identified as the phosphorylated slow-migrating form of calpactin I (annexin II) heavy chain, p36. Tyrosine 133-141 annexin A2 Homo sapiens 273-276 34684255-7 2021 Furthermore, ectopic expression of phosphodefective and phosphomimic mutants replacing tyrosine (Y) 23 of ANXA2 in ANXA2-knock out BMECs results in different binding force to reOmpB in response to the activation of EPAC1. Tyrosine 87-95 annexin A2 Homo sapiens 106-111 34684255-7 2021 Furthermore, ectopic expression of phosphodefective and phosphomimic mutants replacing tyrosine (Y) 23 of ANXA2 in ANXA2-knock out BMECs results in different binding force to reOmpB in response to the activation of EPAC1. Tyrosine 87-95 annexin A2 Homo sapiens 115-120 26716413-3 2016 In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23. Tyrosine 149-157 annexin A2 Homo sapiens 94-104 33374917-7 2020 Our analyses on breast cancer cell lines demonstrated that secretion of AnxA2 is associated with its tyrosine 23 (Tyr23) phosphorylation in cells. Tyrosine 101-109 annexin A2 Homo sapiens 72-77 2946941-2 1986 These have been used to examine the sites and extent of serine and tyrosine phosphorylation of p36 in human cells treated with epidermal growth factor and platelet-derived growth factor and in human cells transformed with viruses whose oncogenes encode protein-tyrosine kinases. Tyrosine 67-75 annexin A2 Homo sapiens 95-98 2981869-6 1985 Physicochemical properties of protein I and its isolated subunits reveal a Ca2+-dependent conformational change in the 36-kDa subunit which involves the exposure of 1 or more tyrosine residues to a more aqueous environment. Tyrosine 175-183 annexin A2 Homo sapiens 30-39 32866522-8 2020 Interestingly, we identified that blocking of ANXA2 significantly inhibited tyrosine phosphorylation (Tyr-P) of ANXA2 implying its involvement in tyrosine signaling pathway and suggesting it may regulate angiogenesis. Tyrosine 76-84 annexin A2 Homo sapiens 46-51 32866522-8 2020 Interestingly, we identified that blocking of ANXA2 significantly inhibited tyrosine phosphorylation (Tyr-P) of ANXA2 implying its involvement in tyrosine signaling pathway and suggesting it may regulate angiogenesis. Tyrosine 76-84 annexin A2 Homo sapiens 112-117 32866522-8 2020 Interestingly, we identified that blocking of ANXA2 significantly inhibited tyrosine phosphorylation (Tyr-P) of ANXA2 implying its involvement in tyrosine signaling pathway and suggesting it may regulate angiogenesis. Tyrosine 146-154 annexin A2 Homo sapiens 46-51 32866522-8 2020 Interestingly, we identified that blocking of ANXA2 significantly inhibited tyrosine phosphorylation (Tyr-P) of ANXA2 implying its involvement in tyrosine signaling pathway and suggesting it may regulate angiogenesis. Tyrosine 146-154 annexin A2 Homo sapiens 112-117 28867585-7 2017 By contrast, Tyr phosphorylation of AnxA2 regulates its role in actin dynamics and increases its association with endosomal compartments. Tyrosine 13-16 annexin A2 Homo sapiens 36-41 26716413-3 2016 In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23. Tyrosine 149-157 annexin A2 Homo sapiens 119-129 23691485-0 2012 Tyrosine 23 Phosphorylation of Annexin A2 Promotes Proliferation, Invasion, and Stat3 Phosphorylation in the Nucleus of Human Breast Cancer SK-BR-3 Cells. Tyrosine 0-8 annexin A2 Homo sapiens 31-41 24239898-10 2014 Taken together, our results indicate that P-gp may promote the invasion of MDR breast cancer cells by modulating the tyrosine phosphorylation of Anxa2. Tyrosine 117-125 annexin A2 Homo sapiens 145-150 23555942-9 2013 These results suggest that extracellular AnxA2, most likely in its Tyr phosphorylated form, plays a pivotal role in angiogenesis. Tyrosine 67-70 annexin A2 Homo sapiens 41-46 27274723-2 2016 Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). Tyrosine 153-161 annexin A2 Homo sapiens 31-37 27274723-2 2016 Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). Tyrosine 179-187 annexin A2 Homo sapiens 31-37 27274723-3 2016 And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. Tyrosine 66-74 annexin A2 Homo sapiens 20-26 25321192-7 2014 Blocking AnxA2 function at the cell surface by anti-AnxA2 antibody suppressed the EGF-induced EGFR tyrosine phosphorylation and internalisation by blocking its homodimerisation. Tyrosine 99-107 annexin A2 Homo sapiens 9-14 25321192-7 2014 Blocking AnxA2 function at the cell surface by anti-AnxA2 antibody suppressed the EGF-induced EGFR tyrosine phosphorylation and internalisation by blocking its homodimerisation. Tyrosine 99-107 annexin A2 Homo sapiens 52-57 24742684-6 2014 Glutamate-induced translocation of AnxA2 is dependent on the phosphorylation of tyrosine 23 at the N terminus, and mutation of tyrosine 23 to a non-phosphomimetic variant inhibits the translocation process. Tyrosine 80-88 annexin A2 Homo sapiens 35-40 24742684-6 2014 Glutamate-induced translocation of AnxA2 is dependent on the phosphorylation of tyrosine 23 at the N terminus, and mutation of tyrosine 23 to a non-phosphomimetic variant inhibits the translocation process. Tyrosine 127-135 annexin A2 Homo sapiens 35-40 23512564-7 2014 On an average, increased glucose transporter type 4 translocation was observed, supported by a consistent increase of tyr-24 phosphorylated annexin A2. Tyrosine 118-121 annexin A2 Homo sapiens 140-150 23691485-1 2012 OBJECTIVE: To investigate the role of tyrosine 23 (Tyr23) phosphorylation of Annexin A2 (Anxa2) in regulating the proliferation and invasion of human breast cancer SK-BR-3 cells. Tyrosine 38-46 annexin A2 Homo sapiens 77-87 23691485-1 2012 OBJECTIVE: To investigate the role of tyrosine 23 (Tyr23) phosphorylation of Annexin A2 (Anxa2) in regulating the proliferation and invasion of human breast cancer SK-BR-3 cells. Tyrosine 38-46 annexin A2 Homo sapiens 89-94 19020748-10 2008 Furthermore, ANXA2 was tyrosine-phosphorylated in HCC. Tyrosine 23-31 annexin A2 Homo sapiens 13-18 21737841-3 2011 Here, we show that the association of AnxA2 with the lipid rafts is influenced not only by intracellular levels of Ca(2+) but also by N-terminal phosphorylation at tyrosine 23. Tyrosine 164-172 annexin A2 Homo sapiens 38-43 21737841-7 2011 Phosphorylation at Tyr-23 is also important for the localization of AnxA2 to the exosomal membranes. Tyrosine 19-22 annexin A2 Homo sapiens 68-73 19779650-7 2009 It was found that p36(Syk) had a higher band 3 tyrosine phosphorylating activity compared with p72(Syk). Tyrosine 47-55 annexin A2 Homo sapiens 18-21 22235123-9 2012 Down-regulation of K17 expression, in turn, results in decreased AnxA2 phosphorylation at Tyr-23. Tyrosine 90-93 annexin A2 Homo sapiens 65-70 21572519-0 2011 Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. Tyrosine 0-8 annexin A2 Homo sapiens 67-77 21572519-7 2011 Furthermore, cell-surface localization of ANXA2 is tyrosine 23 phosphorylation-dependent; and tyrosine 23 phosphorylation is required for PDA invasion. Tyrosine 51-59 annexin A2 Homo sapiens 42-47 21572519-8 2011 We demonstrated that tyrosine 23 phosphorylation resulting in surface expression of ANXA2 is required for TGFbeta-induced, Rho-mediated epithelial-mesenchymal transition (EMT), linking the cellular function of ANXA2 which was previously shown to be associated with small GTPase-regulated cytoskeletal rearrangements, to the EMT process in PDA. Tyrosine 21-29 annexin A2 Homo sapiens 84-89 21572519-8 2011 We demonstrated that tyrosine 23 phosphorylation resulting in surface expression of ANXA2 is required for TGFbeta-induced, Rho-mediated epithelial-mesenchymal transition (EMT), linking the cellular function of ANXA2 which was previously shown to be associated with small GTPase-regulated cytoskeletal rearrangements, to the EMT process in PDA. Tyrosine 21-29 annexin A2 Homo sapiens 210-215 21237296-7 2011 Immunoblotting confirmed that phosphorylation of ANXA2, on tyrosine residues, was increased in WM-115 cells treated with dasatinib. Tyrosine 59-67 annexin A2 Homo sapiens 49-54 18990701-0 2009 Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. Tyrosine 86-94 annexin A2 Homo sapiens 0-10 18990701-6 2009 We found that endosomal AnxA2 was partially tyrosine-phosphorylated and that mutation of Tyr-23 to Ala (AnxA2Y23A), but not of Ser-25 to Ala, impaired AnxA2 endosome association. Tyrosine 44-52 annexin A2 Homo sapiens 24-29 18990701-11 2009 We conclude that phosphorylation of Tyr-23 is essential for proper endosomal association and function of AnxA2, perhaps because it stabilizes membrane-associated protein via a conformational change. Tyrosine 36-39 annexin A2 Homo sapiens 105-110 19020748-11 2008 These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC. Tyrosine 43-51 annexin A2 Homo sapiens 71-76 18565825-0 2008 Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion. Tyrosine 0-8 annexin A2 Homo sapiens 28-38 18565825-2 2008 In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation. Tyrosine 31-39 annexin A2 Homo sapiens 104-114 18565825-2 2008 In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation. Tyrosine 118-126 annexin A2 Homo sapiens 104-114 18565825-4 2008 These morphological changes are inhibited by annexin A2 depletion and require Rho/ROCK signaling downstream of tyrosine-phosphorylated annexin A2. Tyrosine 111-119 annexin A2 Homo sapiens 135-145 18565825-6 2008 Thus, a tyrosine phosphorylation switch in annexin A2 is an important event in triggering Rho/ROCK-dependent and actin-mediated changes in cell morphology associated with the control of cell adhesion. Tyrosine 8-16 annexin A2 Homo sapiens 43-53