PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20703083-6 2010 Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. Tyrosine 13-16 Harvey rat sarcoma virus oncogene Mus musculus 17-21 20703083-6 2010 Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. Tyrosine 13-16 Harvey rat sarcoma virus oncogene Mus musculus 173-177 20703083-6 2010 Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. Tyrosine 169-172 Harvey rat sarcoma virus oncogene Mus musculus 17-21 20703083-7 2010 In summary, in Tyr-HRas:Cdk4(R24C/R24C) mice, we observed that activated CDK4 cooperates with the oncogenic HRAS(G12V) protein to increase the susceptibility of melanoma development in vivo. Tyrosine 15-18 Harvey rat sarcoma virus oncogene Mus musculus 19-23 20703083-7 2010 In summary, in Tyr-HRas:Cdk4(R24C/R24C) mice, we observed that activated CDK4 cooperates with the oncogenic HRAS(G12V) protein to increase the susceptibility of melanoma development in vivo. Tyrosine 15-18 Harvey rat sarcoma virus oncogene Mus musculus 108-112 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Tyrosine 48-56 Harvey rat sarcoma virus oncogene Mus musculus 163-169 12584202-10 2003 Tyrosine phosphorylation of one Sp3 form was decreased, whereas phosphorylation of two other forms of Sp3 was increased in nuclear extracts of Ha-Ras-transformed cells. Tyrosine 0-8 Harvey rat sarcoma virus oncogene Mus musculus 143-149 17987514-0 2007 Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice. Tyrosine 53-56 Harvey rat sarcoma virus oncogene Mus musculus 57-61 17987514-3 2007 Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice. Tyrosine 83-86 Harvey rat sarcoma virus oncogene Mus musculus 87-91 17987514-10 2007 Consequently, Tyr-HRAS+ Ink4a/Arf heterozygotes provide practical advantages, compared to the cataract-prone CKDN2A knockout strains, for real-time ophthalomoscopic detection and monitoring of UM while developing chemotherapeutic regimens and other research to understand the biology of UM. Tyrosine 14-17 Harvey rat sarcoma virus oncogene Mus musculus 18-22 15123632-3 2004 FAK phosphorylation at tyrosine 861 was increased in both constitutively H-Ras-transformed and H-Ras-inducible NIH3T3 cells, in parallel with cell transformation. Tyrosine 23-31 Harvey rat sarcoma virus oncogene Mus musculus 73-78 15123632-3 2004 FAK phosphorylation at tyrosine 861 was increased in both constitutively H-Ras-transformed and H-Ras-inducible NIH3T3 cells, in parallel with cell transformation. Tyrosine 23-31 Harvey rat sarcoma virus oncogene Mus musculus 95-100 15123632-7 2004 Taken together, these results strongly suggest that FAK phosphorylation at tyrosine 861 is crucial for H-Ras-induced transformation through regulation of the association of FAK with p130(CAS). Tyrosine 75-83 Harvey rat sarcoma virus oncogene Mus musculus 103-108 9013950-7 1997 Analysis of specific effector molecules revealed that tyrosine phosphorylation of Shc, but not rasGAP or Vav, correlated with the unique ability of BCR ligation to trigger p21ras activation in CD45+ cells. Tyrosine 54-62 Harvey rat sarcoma virus oncogene Mus musculus 172-178 10729330-6 2000 In the H-ras null mutant hippocampus, the tyrosine phosphorylation of NR2A (epsilon1) and NR2B (epsilon2) subunits of NMDA receptors is increased, and, correspondingly, NMDA synaptic responses are selectively enhanced. Tyrosine 42-50 Harvey rat sarcoma virus oncogene Mus musculus 7-12 9013950-9 1997 Thus, Shc tyrosine phosphorylation may be the primary CD45-dependent mechanism by which Ag receptors are coupled to the p21ras pathway in J558Lmicrom3. Tyrosine 10-18 Harvey rat sarcoma virus oncogene Mus musculus 120-126 7829473-1 1995 Insulin receptor signaling acutely stimulates GTP loading of p21ras, apparently by mobilizing complexes of Grb2 and the guanine nucleotide exchangers Son-of-sevenless (Sos) 1 and 2 to associate with tyrosine-phosphorylated proteins in the plasma membrane. Tyrosine 199-207 Harvey rat sarcoma virus oncogene Mus musculus 61-67 8681026-6 1996 As phosphorylation on tyrosine residues of Lyn, Fyn, and Blk protein tyrosine kinases occurred upon BCR stimulation, these PTKs may be candidates being involved in an induction of not only tyrosine phosphorylation of substrates but also p 21ras activation. Tyrosine 22-30 Harvey rat sarcoma virus oncogene Mus musculus 237-244 8681026-6 1996 As phosphorylation on tyrosine residues of Lyn, Fyn, and Blk protein tyrosine kinases occurred upon BCR stimulation, these PTKs may be candidates being involved in an induction of not only tyrosine phosphorylation of substrates but also p 21ras activation. Tyrosine 69-77 Harvey rat sarcoma virus oncogene Mus musculus 237-244 8977326-4 1996 Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation. Tyrosine 94-102 Harvey rat sarcoma virus oncogene Mus musculus 155-161 7969452-2 1994 Tyrosine-phosphorylated IRS-1 binds the 85K subunit of phosphatidylinositol 3-kinase which may be involved in the translocation of glucose transporters and the abundant src homology protein (ASH)/Grb2 which may be involved in activation of p21ras and MAP kinase cascade. Tyrosine 0-8 Harvey rat sarcoma virus oncogene Mus musculus 240-246 7525585-3 1994 This tyrosine phosphorylation correlated with an increased association with the GTPase-activating protein of p21ras (GAP). Tyrosine 5-13 Harvey rat sarcoma virus oncogene Mus musculus 109-115 7511643-2 1994 This event is accompanied by the tyrosine phosphorylation of the p21ras-associated GTPase-activating protein p120 ras.GAP, raising the possibility that AgR-stimulated p21ras activity is regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases) in B cells. Tyrosine 33-41 Harvey rat sarcoma virus oncogene Mus musculus 65-71 7511643-2 1994 This event is accompanied by the tyrosine phosphorylation of the p21ras-associated GTPase-activating protein p120 ras.GAP, raising the possibility that AgR-stimulated p21ras activity is regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases) in B cells. Tyrosine 33-41 Harvey rat sarcoma virus oncogene Mus musculus 167-173 7691239-5 1993 Inhibition of p210 bcr-abl-dependent tyrosine phosphorylation resulted in a reduction of active p21RAS-GTP complexes in the transformed cells, in diminished expression of the nuclear early response genes c-jun and c-fos, and in lower cellular proliferation rate. Tyrosine 37-45 Harvey rat sarcoma virus oncogene Mus musculus 96-102 7694287-4 1993 Two of the interacting tyrosine-phosphorylated proteins were identified as the p85 subunit of phosphatidylinositol 3-kinase and the GTPase-activating protein of p21ras. Tyrosine 23-31 Harvey rat sarcoma virus oncogene Mus musculus 161-167 8459217-5 1993 Activation of p21ras is deficient in quiescent and stimulated NOD T cells, and this is correlated with a significant reduction in the tyrosine phosphorylation of p42mapk, a serine/threonine kinase active downstream of p21ras. Tyrosine 134-142 Harvey rat sarcoma virus oncogene Mus musculus 14-20 1508192-0 1992 Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Tyrosine 72-80 Harvey rat sarcoma virus oncogene Mus musculus 112-119 1508192-0 1992 Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Tyrosine 72-80 Harvey rat sarcoma virus oncogene Mus musculus 161-167 3096340-1 1986 A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized. Tyrosine 67-70 Harvey rat sarcoma virus oncogene Mus musculus 92-98 3096340-5 1986 The order of charged amino acid residues in the fragment 35-44 of p21ras is "complementary" to that of the substrate sequence of tyrosine-specific protein kinases (-Arg-X-X-Glu-Asp-X-X-Tyr-). Tyrosine 185-188 Harvey rat sarcoma virus oncogene Mus musculus 66-72