PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19592641-4	2009	Each form of the murine IL-4R(alpha) mediated tyrosine phosphorylation of STAT6 in response to murine IL-4 treatment similar to the induction of tyrosine phosphorylation by human IL-4 signaling through the endogenous human IL-4R(alpha).	Tyrosine	46-54	interleukin 4	Mus musculus	24-28	
19592641-4	2009	Each form of the murine IL-4R(alpha) mediated tyrosine phosphorylation of STAT6 in response to murine IL-4 treatment similar to the induction of tyrosine phosphorylation by human IL-4 signaling through the endogenous human IL-4R(alpha).	Tyrosine	145-153	interleukin 4	Mus musculus	24-28	
19592641-5	2009	After IL-4 removal, tyrosine-phosphorylated STAT6 rapidly decayed in cells expressing I50 or P503R576 murine IL-4Ralpha.	Tyrosine	20-28	interleukin 4	Mus musculus	6-10	
17827176-5	2007	Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling; however, only the activation of Stat6, not the IRS-2-dependent phosphorylation of Akt, was perturbed in Dok-1-deficient cells stimulated with IL-4.	Tyrosine	0-8	interleukin 4	Mus musculus	89-93	
17513737-7	2007	Examination of IL-4 signaling in db/db macrophages revealed that IL-4-dependent IRS-2/PI3K complex formation and IRS-2 tyrosine phosphorylation was reduced compared with db/+ macrophages.	Tyrosine	119-127	interleukin 4	Mus musculus	15-19	
15526032-6	2004	Stat6 tyrosine phosphorylation and Jak1 activation were ablated in the liver of ConA-injected PKCzeta-/- mice and in IL-4-stimulated PKCzeta-/- fibroblasts.	Tyrosine	6-14	interleukin 4	Mus musculus	117-121	
12426308-3	2003	IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes.	Tyrosine	13-21	interleukin 4	Mus musculus	0-4	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	184-192	interleukin 4	Mus musculus	85-89	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	184-192	interleukin 4	Mus musculus	134-138	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	184-192	interleukin 4	Mus musculus	134-138	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	294-302	interleukin 4	Mus musculus	85-89	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	294-302	interleukin 4	Mus musculus	134-138	
12637316-5	2003	In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4.	Tyrosine	294-302	interleukin 4	Mus musculus	134-138	
15128777-6	2004	IL-4-mediated DAK activity depends on the KARAP/DAP12-triggering receptor expressed on myeloid cell 2 signaling pathway because: 1) gene targeting of the adaptor molecule KARAP/DAP12, a transmembrane polypeptide with an intracytoplasmic immunoreceptor tyrosine-based activation motif, suppresses the DC(GM/IL-4) capacity to activate NK cells, and 2) IL-4-mediated DAK activity is significantly blocked by soluble triggering receptor expressed on myeloid cell 2 Fc molecules.	Tyrosine	252-260	interleukin 4	Mus musculus	0-4	
12426308-3	2003	IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes.	Tyrosine	13-21	interleukin 4	Mus musculus	88-92	
12426308-7	2003	In contrast, IL-4-induced tyrosine phosphorylation of Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling.	Tyrosine	26-34	interleukin 4	Mus musculus	13-17	
12429573-14	2002	Moreover, IL-4, IL-10, GM-CSF and M-CSF elicited tyrosine phosphorylation of STAT3, STAT5 and/or STAT6 in macrophages were diminished by the presence of ATA.	Tyrosine	49-57	interleukin 4	Mus musculus	10-14	
12370375-3	2002	Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6.	Tyrosine	106-114	interleukin 4	Mus musculus	11-15	
11305324-2	2001	IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts.	Tyrosine	17-25	interleukin 4	Mus musculus	0-4	
11815609-4	2002	In addition, Tyr-103, Cys-161, Cys-210, and Cys-211, previously identified to contribute to binding IL-2 and IL-7, were also found to be involved in binding IL-4 and IL-15.	Tyrosine	13-16	interleukin 4	Mus musculus	157-161	
11788580-3	2002	IRS proteins are tyrosine-phosphorylated following IL-9 and IL-4 stimulation, a process in part mediated by JAK tyrosine kinases (Yin, T. G., Keller, S. R., Quelle, F. W., Witthuhn, B.	Tyrosine	17-25	interleukin 4	Mus musculus	60-64	
10421786-3	1999	However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.	Tyrosine	155-163	interleukin 4	Mus musculus	115-119	
11164892-1	2000	The binding of IL-4 to its receptor results in rapid tyrosine phosphorylation of STAT6 by IL-4R-associated Jak kinases.	Tyrosine	53-61	interleukin 4	Mus musculus	15-19	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Tyrosine	24-32	interleukin 4	Mus musculus	89-93	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Tyrosine	24-32	interleukin 4	Mus musculus	178-182	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Tyrosine	195-203	interleukin 4	Mus musculus	89-93	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Tyrosine	195-203	interleukin 4	Mus musculus	178-182	
10207105-8	1999	IL-4 stimulation of the IGF-IR transfectants resulted in enhanced tyrosine phosphorylation of SHC, Erk2, and signal transducer and activator of transcription 6 (STAT6) proteins.	Tyrosine	66-74	interleukin 4	Mus musculus	0-4	
9916733-6	1999	The stimulation with CD40L and/or IL-4 resulted in tyrosine phosphorylation of Janus kinase 3 (JAK3) in B cells, which was more strongly inducible in NC/Nga mice than in BALB/c mice.	Tyrosine	51-59	interleukin 4	Mus musculus	34-38	
10202031-2	1999	IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K).	Tyrosine	34-42	interleukin 4	Mus musculus	0-4	
10202031-4	1999	TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6.	Tyrosine	36-44	interleukin 4	Mus musculus	23-27	
10202031-6	1999	These results suggested that IL-4-induced activation of PDE3 and PDE4 was downstream of IRS-2/PI3-K, not STAT6, and that inhibition of tyrosine phosphorylation of IRS molecules might be one mechnism whereby TNF-alpha could selectively regulate activities of cytokines that utilized IRS proteins as signal transducers.	Tyrosine	135-143	interleukin 4	Mus musculus	29-33	
9670964-2	1998	We have analyzed the role that tyrosine-containing domains within the cytoplasmic tail of IL-4R alpha play in IL-4-mediated protection from apoptosis.	Tyrosine	31-39	interleukin 4	Mus musculus	90-94	
8602263-2	1996	IL-4 activates two distinct signalling pathways through tyrosine phosphorylation of Stat6, a signal transducer and activator of transcription, and of a 170K protein called 4PS.	Tyrosine	56-64	interleukin 4	Mus musculus	0-4	
9013772-6	1997	In 32D cells, IRS-1 and IRS-2 undergo differential tyrosine phosphorylation during insulin or IL-4 stimulation, as assessed indirectly by interaction with various recombinant SH2 domains.	Tyrosine	51-59	interleukin 4	Mus musculus	94-98	
8995447-1	1997	Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin.	Tyrosine	100-108	interleukin 4	Mus musculus	143-156	
8995447-1	1997	Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin.	Tyrosine	100-108	interleukin 4	Mus musculus	158-162	
8995447-3	1997	T and B lymphocytes and macrophages from primary cultures expressed only IRS-2, which became phosphorylated on tyrosine following stimulation with both IL-4 and insulin.	Tyrosine	111-119	interleukin 4	Mus musculus	152-156	
8916957-1	1996	We have previously demonstrated that interleukin-4 (IL-4) induces tyrosine phosphorylation of a protein closely related or identical to the c-fes proto-oncogene product (FES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha).	Tyrosine	66-74	interleukin 4	Mus musculus	37-50	
8916957-1	1996	We have previously demonstrated that interleukin-4 (IL-4) induces tyrosine phosphorylation of a protein closely related or identical to the c-fes proto-oncogene product (FES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha).	Tyrosine	66-74	interleukin 4	Mus musculus	52-56	
8703030-11	1996	Strikingly, the concurrent addition of IL-4 enhanced PDGF BB-induced Iepsilon binding activity, Jak1 tyrosine phosphorylation, and [3H]thymidine incorporation.	Tyrosine	101-109	interleukin 4	Mus musculus	39-43	
9045682-5	1997	IL-4-mediated tyrosine phosphorylation of Stat6 was pronounced in 1D4 cells, while no IL-4-induced Stat6 phosphorylation was detected in E1C3 cells.	Tyrosine	14-22	interleukin 4	Mus musculus	0-4	
8999817-5	1997	QY also inhibited the IL-4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL-4-stimulated BA/F3 cells.	Tyrosine	141-149	interleukin 4	Mus musculus	22-26	
8954948-1	1996	We have recently demonstrated that c-fes protooncogene product (FES), or a FES-related protein, associates with the interleukin-4 receptor alpha chain (IL-4R alpha) and phosphatidylinositol-3 (PI3) kinase in mouse T cell lines; however, others have demonstrated that PI3 kinase associates with IL-4R alpha through tyrosine phosphorylated insulin receptor substrate (IRS)-2 in other cell types.	Tyrosine	314-322	interleukin 4	Mus musculus	116-129	
8954948-3	1996	In both cell lines, IL-4 induced tyrosine phosphorylation of IRS-2, association of PI3 kinase with IRS-2, and FES or a FES-related protein.	Tyrosine	33-41	interleukin 4	Mus musculus	20-24	
7544011-1	1995	The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS).	Tyrosine	67-75	interleukin 4	Mus musculus	4-17	
7544789-6	1995	Lastly, we demonstrate that IL-9 induces the tyrosine phosphorylation of Stat3 and in this regard differs from IL-4, which triggers tyrosine phosphorylation of Stat6.	Tyrosine	132-140	interleukin 4	Mus musculus	111-115	
7544789-7	1995	Taken together, these results strongly suggest that IL-9 and IL-4 utilize common and unique signaling pathways via inducing the similar and distinct tyrosine-phosphorylated proteins.	Tyrosine	149-157	interleukin 4	Mus musculus	61-65	
7492780-6	1995	IL-13 and IL-4 stimulation of murine L cell fibroblasts, which endogenously express the IL-4 receptor (IL-4R alpha) and lack expression of the IL-2 receptor gamma subunit (IL-2R gamma), resulted in tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)/4PS.	Tyrosine	198-206	interleukin 4	Mus musculus	10-14	
7544888-9	1995	Activation of NFIL-4 requires tyrosine phosphorylation, occurs within 2 min and persists as long as IL-4 is present.	Tyrosine	30-38	interleukin 4	Mus musculus	16-20	
7544011-1	1995	The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS).	Tyrosine	67-75	interleukin 4	Mus musculus	19-23	
7544011-1	1995	The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS).	Tyrosine	67-75	interleukin 4	Mus musculus	154-157	
7544011-1	1995	The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS).	Tyrosine	67-75	interleukin 4	Mus musculus	167-171	
8124718-1	1994	Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1.	Tyrosine	110-118	interleukin 4	Mus musculus	0-13	
7744881-8	1995	Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1.	Tyrosine	42-50	interleukin 4	Mus musculus	15-19	
7744881-12	1995	However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4.	Tyrosine	37-45	interleukin 4	Mus musculus	24-28	
7744881-12	1995	However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4.	Tyrosine	37-45	interleukin 4	Mus musculus	69-73	
7744881-12	1995	However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4.	Tyrosine	37-45	interleukin 4	Mus musculus	69-73	
7961833-1	1994	Insulin Receptor Substrate-1 (IRS-1) is an endogenous cellular protein that is tyrosine phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4).	Tyrosine	79-87	interleukin 4	Mus musculus	156-169	
7961833-1	1994	Insulin Receptor Substrate-1 (IRS-1) is an endogenous cellular protein that is tyrosine phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4).	Tyrosine	79-87	interleukin 4	Mus musculus	171-175	
8124718-1	1994	Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1.	Tyrosine	110-118	interleukin 4	Mus musculus	15-19	
8124718-7	1994	Thus, the central tyrosine of the I4R motif has a major role in IL-4-mediated signal transduction in 32D cells.	Tyrosine	18-26	interleukin 4	Mus musculus	64-68	
7683417-3	1993	The principal tyrosine-phosphorylated substrate observed in FDC cells stimulated with IL-4, previously designated 4PS, was of the same size (170 kDa) as the major substrate phosphorylated in response to insulin or IGF-I.	Tyrosine	14-22	interleukin 4	Mus musculus	86-90	
8390454-0	1993	Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.	Tyrosine	37-45	interleukin 4	Mus musculus	0-13	
8390454-0	1993	Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.	Tyrosine	37-45	interleukin 4	Mus musculus	15-19	
8390454-1	1993	To study the signal transduction mechanism of interleukin-4 (IL-4), we have examined the effects of IL-4 on protein tyrosine phosphorylation in a mouse IL-2-dependent T cell line, HT2.	Tyrosine	116-124	interleukin 4	Mus musculus	100-104	
8390454-3	1993	Western blotting analyses using anti-phosphotyrosine antibody showed that IL-4 induces tyrosine phosphorylation of four proteins (140, 110, 100, and 92 kDa) in a dose-dependent manner.	Tyrosine	44-52	interleukin 4	Mus musculus	74-78	
8390454-4	1993	Protein tyrosine phosphorylation was detected within 1 min and reached a plateau approximately at 10 min after IL-4 stimulation.	Tyrosine	8-16	interleukin 4	Mus musculus	111-115	
7683417-7	1993	Nevertheless, IL-4, insulin, and IGF-I were capable of stimulating tyrosine phosphorylation of IRS-1 in FDC cells that expressed this substrate as a result of transfection.	Tyrosine	67-75	interleukin 4	Mus musculus	14-18	
7683417-8	1993	These findings indicate that (i) IL-4, insulin, and IGF-I use signal transduction pathways in FDC lines that have at least one major feature in common, the rapid tyrosine phosphorylation of 4PS, and (ii) insulin and IGF-I stimulation of hematopoietic cell lines leads to the phosphorylation of a substrate that may be related to but is not identical to IRS-1.	Tyrosine	162-170	interleukin 4	Mus musculus	33-37	
1692720-1	1990	The role of tyrosine phosphorylation in the signal transduction of four hematopoietic colony-stimulating factors (IL-3, IL-4, G-CSF, and GM-CSF) in myeloid cells was investigated.	Tyrosine	12-20	interleukin 4	Mus musculus	120-124	
1334461-3	1992	IL-4 triggered prominent tyrosine phosphorylation of a substrate(s) migrating at 170 kDa and less striking phosphorylation of several other proteins, including the IL-4 receptor.	Tyrosine	25-33	interleukin 4	Mus musculus	0-4	
1334461-5	1992	IL-4 treatment of FDCP-2 cells caused a dramatically strong association of phosphatidylinositol 3-kinase (PI 3-kinase) both with the 170 kDa tyrosine phosphorylated substrate and with the IL-4 receptor itself.	Tyrosine	141-149	interleukin 4	Mus musculus	0-4	
2334739-0	1990	Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells.	Tyrosine	67-75	interleukin 4	Mus musculus	42-55	
2334739-6	1990	We comparatively examined the effects of IL-2 and IL-4 on protein tyrosine phosphorylation in these cells by immunoaffinity purification of phosphotyrosyl substrates with an anti-phosphotyrosine monoclonal antibody.	Tyrosine	66-74	interleukin 4	Mus musculus	50-54	
1692720-7	1990	Finally, in NFS-107 cells, IL-3 and IL-4 stimulated the tyrosine phosphorylation, within 10 min, of two different 140-kD proteins, one of which was the IL-3 receptor.	Tyrosine	56-64	interleukin 4	Mus musculus	36-40	
34769439-7	2021	In addition, IL-4 and IL-13 stimulate tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1).	Tyrosine	38-46	interleukin 4	Mus musculus	13-17	
34769439-8	2021	Prolonged treatment with these cytokines leads to increased IRS-1 abundance, which, in turn, amplifies IL-4- and IL-13-stimulated IRS-1 tyrosine phosphorylation.	Tyrosine	136-144	interleukin 4	Mus musculus	103-107	
34769439-9	2021	Through signaling crosstalk between IL-4/IL-13 and insulin, a hormone routinely included in mammary cultures, IRS-1 tyrosine phosphorylation is further enhanced.	Tyrosine	116-124	interleukin 4	Mus musculus	36-40	
22761864-8	2012	In addition, mouse eosinophils responded to IL-4 with the robust tyrosine phosphorylation of STAT6 and IRS-2, while IL-13-induced responses were considerably weaker.	Tyrosine	65-73	interleukin 4	Mus musculus	44-48	
27330190-1	2016	Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway.	Tyrosine	71-79	interleukin 4	Mus musculus	124-137	
27330190-1	2016	Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway.	Tyrosine	71-79	interleukin 4	Mus musculus	139-143	
22798672-0	2012	Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene.	Tyrosine	0-8	interleukin 4	Mus musculus	61-65	
22798672-4	2012	In this study, to our knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th cells and that the level of its tyrosine phosphorylation positively correlates with IL-4 expression by peripheral Th cells, but is negatively associated with the severity of disease in NOD mice.	Tyrosine	88-96	interleukin 4	Mus musculus	203-207	
22798672-4	2012	In this study, to our knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th cells and that the level of its tyrosine phosphorylation positively correlates with IL-4 expression by peripheral Th cells, but is negatively associated with the severity of disease in NOD mice.	Tyrosine	151-159	interleukin 4	Mus musculus	203-207	
22798672-6	2012	Furthermore, tyrosine phosphorylation at these three residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells.	Tyrosine	13-21	interleukin 4	Mus musculus	106-110	
22798672-6	2012	Furthermore, tyrosine phosphorylation at these three residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells.	Tyrosine	13-21	interleukin 4	Mus musculus	124-128	
25151041-2	2014	We have now developed a novel HIV vaccine that co-expresses a C-terminal deletion mutant of the mouse IL-4, deleted for the essential tyrosine (Y119) required for signalling.	Tyrosine	134-142	interleukin 4	Mus musculus	102-106	
20371618-7	2010	Moreover, increased levels of IL-4 improved spatial learning, promoted phosphorylation of N-methyl-D-aspartate receptor subunit 2B at Tyr 1472, and enhanced its cell surface retention both in vivo and in vitro.	Tyrosine	134-137	interleukin 4	Mus musculus	30-34	
19799897-6	2009	Priming fibroblasts with OSM for 6 h markedly enhanced subsequent IL-13 and IL-4-induced eotaxin-1 responses and STAT6 tyrosine-641 phosphorylation.	Tyrosine	119-127	interleukin 4	Mus musculus	76-80