PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22798672-0 2012 Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene. Tyrosine 0-8 interleukin 4 Mus musculus 61-65 25151041-2 2014 We have now developed a novel HIV vaccine that co-expresses a C-terminal deletion mutant of the mouse IL-4, deleted for the essential tyrosine (Y119) required for signalling. Tyrosine 134-142 interleukin 4 Mus musculus 102-106 27330190-1 2016 Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway. Tyrosine 71-79 interleukin 4 Mus musculus 124-137 27330190-1 2016 Insulin receptor substrate 2 (IRS2) is an adaptor protein that becomes tyrosine-phosphorylated in response to the cytokines interleukin-4 (IL-4) and IL-13, which results in activation of the phosphoinositide 3-kinase (PI3K)-Akt pathway. Tyrosine 71-79 interleukin 4 Mus musculus 139-143 22798672-4 2012 In this study, to our knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th cells and that the level of its tyrosine phosphorylation positively correlates with IL-4 expression by peripheral Th cells, but is negatively associated with the severity of disease in NOD mice. Tyrosine 88-96 interleukin 4 Mus musculus 203-207 22798672-4 2012 In this study, to our knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th cells and that the level of its tyrosine phosphorylation positively correlates with IL-4 expression by peripheral Th cells, but is negatively associated with the severity of disease in NOD mice. Tyrosine 151-159 interleukin 4 Mus musculus 203-207 22798672-6 2012 Furthermore, tyrosine phosphorylation at these three residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells. Tyrosine 13-21 interleukin 4 Mus musculus 106-110 22798672-6 2012 Furthermore, tyrosine phosphorylation at these three residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells. Tyrosine 13-21 interleukin 4 Mus musculus 124-128 22761864-8 2012 In addition, mouse eosinophils responded to IL-4 with the robust tyrosine phosphorylation of STAT6 and IRS-2, while IL-13-induced responses were considerably weaker. Tyrosine 65-73 interleukin 4 Mus musculus 44-48 19592641-5 2009 After IL-4 removal, tyrosine-phosphorylated STAT6 rapidly decayed in cells expressing I50 or P503R576 murine IL-4Ralpha. Tyrosine 20-28 interleukin 4 Mus musculus 6-10 20371618-7 2010 Moreover, increased levels of IL-4 improved spatial learning, promoted phosphorylation of N-methyl-D-aspartate receptor subunit 2B at Tyr 1472, and enhanced its cell surface retention both in vivo and in vitro. Tyrosine 134-137 interleukin 4 Mus musculus 30-34 19799897-6 2009 Priming fibroblasts with OSM for 6 h markedly enhanced subsequent IL-13 and IL-4-induced eotaxin-1 responses and STAT6 tyrosine-641 phosphorylation. Tyrosine 119-127 interleukin 4 Mus musculus 76-80 19592641-4 2009 Each form of the murine IL-4R(alpha) mediated tyrosine phosphorylation of STAT6 in response to murine IL-4 treatment similar to the induction of tyrosine phosphorylation by human IL-4 signaling through the endogenous human IL-4R(alpha). Tyrosine 46-54 interleukin 4 Mus musculus 24-28 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 184-192 interleukin 4 Mus musculus 85-89 19592641-4 2009 Each form of the murine IL-4R(alpha) mediated tyrosine phosphorylation of STAT6 in response to murine IL-4 treatment similar to the induction of tyrosine phosphorylation by human IL-4 signaling through the endogenous human IL-4R(alpha). Tyrosine 145-153 interleukin 4 Mus musculus 24-28 17827176-5 2007 Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling; however, only the activation of Stat6, not the IRS-2-dependent phosphorylation of Akt, was perturbed in Dok-1-deficient cells stimulated with IL-4. Tyrosine 0-8 interleukin 4 Mus musculus 89-93 17513737-7 2007 Examination of IL-4 signaling in db/db macrophages revealed that IL-4-dependent IRS-2/PI3K complex formation and IRS-2 tyrosine phosphorylation was reduced compared with db/+ macrophages. Tyrosine 119-127 interleukin 4 Mus musculus 15-19 15526032-6 2004 Stat6 tyrosine phosphorylation and Jak1 activation were ablated in the liver of ConA-injected PKCzeta-/- mice and in IL-4-stimulated PKCzeta-/- fibroblasts. Tyrosine 6-14 interleukin 4 Mus musculus 117-121 15128777-6 2004 IL-4-mediated DAK activity depends on the KARAP/DAP12-triggering receptor expressed on myeloid cell 2 signaling pathway because: 1) gene targeting of the adaptor molecule KARAP/DAP12, a transmembrane polypeptide with an intracytoplasmic immunoreceptor tyrosine-based activation motif, suppresses the DC(GM/IL-4) capacity to activate NK cells, and 2) IL-4-mediated DAK activity is significantly blocked by soluble triggering receptor expressed on myeloid cell 2 Fc molecules. Tyrosine 252-260 interleukin 4 Mus musculus 0-4 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 184-192 interleukin 4 Mus musculus 134-138 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 184-192 interleukin 4 Mus musculus 134-138 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 294-302 interleukin 4 Mus musculus 85-89 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 294-302 interleukin 4 Mus musculus 134-138 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 294-302 interleukin 4 Mus musculus 134-138 12426308-3 2003 IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes. Tyrosine 13-21 interleukin 4 Mus musculus 0-4 12426308-3 2003 IL-4 induces tyrosine phosphorylation of STAT6, which in turn leads to transcription of IL-4-specific genes. Tyrosine 13-21 interleukin 4 Mus musculus 88-92 12426308-7 2003 In contrast, IL-4-induced tyrosine phosphorylation of Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling. Tyrosine 26-34 interleukin 4 Mus musculus 13-17 12370375-3 2002 Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6. Tyrosine 106-114 interleukin 4 Mus musculus 11-15 12429573-14 2002 Moreover, IL-4, IL-10, GM-CSF and M-CSF elicited tyrosine phosphorylation of STAT3, STAT5 and/or STAT6 in macrophages were diminished by the presence of ATA. Tyrosine 49-57 interleukin 4 Mus musculus 10-14 11788580-3 2002 IRS proteins are tyrosine-phosphorylated following IL-9 and IL-4 stimulation, a process in part mediated by JAK tyrosine kinases (Yin, T. G., Keller, S. R., Quelle, F. W., Witthuhn, B. Tyrosine 17-25 interleukin 4 Mus musculus 60-64 11815609-4 2002 In addition, Tyr-103, Cys-161, Cys-210, and Cys-211, previously identified to contribute to binding IL-2 and IL-7, were also found to be involved in binding IL-4 and IL-15. Tyrosine 13-16 interleukin 4 Mus musculus 157-161 10421786-3 1999 However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation. Tyrosine 155-163 interleukin 4 Mus musculus 115-119 10731717-8 2000 We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3. Tyrosine 24-32 interleukin 4 Mus musculus 89-93 10731717-8 2000 We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3. Tyrosine 24-32 interleukin 4 Mus musculus 178-182 10731717-8 2000 We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3. Tyrosine 195-203 interleukin 4 Mus musculus 89-93 10731717-8 2000 We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3. Tyrosine 195-203 interleukin 4 Mus musculus 178-182 11305324-2 2001 IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Tyrosine 17-25 interleukin 4 Mus musculus 0-4 11164892-1 2000 The binding of IL-4 to its receptor results in rapid tyrosine phosphorylation of STAT6 by IL-4R-associated Jak kinases. Tyrosine 53-61 interleukin 4 Mus musculus 15-19 9916733-6 1999 The stimulation with CD40L and/or IL-4 resulted in tyrosine phosphorylation of Janus kinase 3 (JAK3) in B cells, which was more strongly inducible in NC/Nga mice than in BALB/c mice. Tyrosine 51-59 interleukin 4 Mus musculus 34-38 10202031-2 1999 IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K). Tyrosine 34-42 interleukin 4 Mus musculus 0-4 10202031-4 1999 TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6. Tyrosine 36-44 interleukin 4 Mus musculus 23-27 10207105-8 1999 IL-4 stimulation of the IGF-IR transfectants resulted in enhanced tyrosine phosphorylation of SHC, Erk2, and signal transducer and activator of transcription 6 (STAT6) proteins. Tyrosine 66-74 interleukin 4 Mus musculus 0-4 10202031-6 1999 These results suggested that IL-4-induced activation of PDE3 and PDE4 was downstream of IRS-2/PI3-K, not STAT6, and that inhibition of tyrosine phosphorylation of IRS molecules might be one mechnism whereby TNF-alpha could selectively regulate activities of cytokines that utilized IRS proteins as signal transducers. Tyrosine 135-143 interleukin 4 Mus musculus 29-33 8954948-1 1996 We have recently demonstrated that c-fes protooncogene product (FES), or a FES-related protein, associates with the interleukin-4 receptor alpha chain (IL-4R alpha) and phosphatidylinositol-3 (PI3) kinase in mouse T cell lines; however, others have demonstrated that PI3 kinase associates with IL-4R alpha through tyrosine phosphorylated insulin receptor substrate (IRS)-2 in other cell types. Tyrosine 314-322 interleukin 4 Mus musculus 116-129 9045682-5 1997 IL-4-mediated tyrosine phosphorylation of Stat6 was pronounced in 1D4 cells, while no IL-4-induced Stat6 phosphorylation was detected in E1C3 cells. Tyrosine 14-22 interleukin 4 Mus musculus 0-4 8999817-5 1997 QY also inhibited the IL-4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL-4-stimulated BA/F3 cells. Tyrosine 141-149 interleukin 4 Mus musculus 22-26 8995447-1 1997 Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. Tyrosine 100-108 interleukin 4 Mus musculus 143-156 8995447-1 1997 Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. Tyrosine 100-108 interleukin 4 Mus musculus 158-162 8995447-3 1997 T and B lymphocytes and macrophages from primary cultures expressed only IRS-2, which became phosphorylated on tyrosine following stimulation with both IL-4 and insulin. Tyrosine 111-119 interleukin 4 Mus musculus 152-156 9670964-2 1998 We have analyzed the role that tyrosine-containing domains within the cytoplasmic tail of IL-4R alpha play in IL-4-mediated protection from apoptosis. Tyrosine 31-39 interleukin 4 Mus musculus 90-94 9013772-6 1997 In 32D cells, IRS-1 and IRS-2 undergo differential tyrosine phosphorylation during insulin or IL-4 stimulation, as assessed indirectly by interaction with various recombinant SH2 domains. Tyrosine 51-59 interleukin 4 Mus musculus 94-98 8954948-3 1996 In both cell lines, IL-4 induced tyrosine phosphorylation of IRS-2, association of PI3 kinase with IRS-2, and FES or a FES-related protein. Tyrosine 33-41 interleukin 4 Mus musculus 20-24 8916957-1 1996 We have previously demonstrated that interleukin-4 (IL-4) induces tyrosine phosphorylation of a protein closely related or identical to the c-fes proto-oncogene product (FES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha). Tyrosine 66-74 interleukin 4 Mus musculus 37-50 8916957-1 1996 We have previously demonstrated that interleukin-4 (IL-4) induces tyrosine phosphorylation of a protein closely related or identical to the c-fes proto-oncogene product (FES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha). Tyrosine 66-74 interleukin 4 Mus musculus 52-56 8124718-1 1994 Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1. Tyrosine 110-118 interleukin 4 Mus musculus 0-13 8703030-11 1996 Strikingly, the concurrent addition of IL-4 enhanced PDGF BB-induced Iepsilon binding activity, Jak1 tyrosine phosphorylation, and [3H]thymidine incorporation. Tyrosine 101-109 interleukin 4 Mus musculus 39-43 8602263-2 1996 IL-4 activates two distinct signalling pathways through tyrosine phosphorylation of Stat6, a signal transducer and activator of transcription, and of a 170K protein called 4PS. Tyrosine 56-64 interleukin 4 Mus musculus 0-4 7492780-6 1995 IL-13 and IL-4 stimulation of murine L cell fibroblasts, which endogenously express the IL-4 receptor (IL-4R alpha) and lack expression of the IL-2 receptor gamma subunit (IL-2R gamma), resulted in tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)/4PS. Tyrosine 198-206 interleukin 4 Mus musculus 10-14 7544888-9 1995 Activation of NFIL-4 requires tyrosine phosphorylation, occurs within 2 min and persists as long as IL-4 is present. Tyrosine 30-38 interleukin 4 Mus musculus 16-20 7961833-1 1994 Insulin Receptor Substrate-1 (IRS-1) is an endogenous cellular protein that is tyrosine phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4). Tyrosine 79-87 interleukin 4 Mus musculus 156-169 7961833-1 1994 Insulin Receptor Substrate-1 (IRS-1) is an endogenous cellular protein that is tyrosine phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4). Tyrosine 79-87 interleukin 4 Mus musculus 171-175 7544789-6 1995 Lastly, we demonstrate that IL-9 induces the tyrosine phosphorylation of Stat3 and in this regard differs from IL-4, which triggers tyrosine phosphorylation of Stat6. Tyrosine 132-140 interleukin 4 Mus musculus 111-115 7544789-7 1995 Taken together, these results strongly suggest that IL-9 and IL-4 utilize common and unique signaling pathways via inducing the similar and distinct tyrosine-phosphorylated proteins. Tyrosine 149-157 interleukin 4 Mus musculus 61-65 7544011-1 1995 The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). Tyrosine 67-75 interleukin 4 Mus musculus 4-17 7544011-1 1995 The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). Tyrosine 67-75 interleukin 4 Mus musculus 19-23 7544011-1 1995 The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). Tyrosine 67-75 interleukin 4 Mus musculus 154-157 7544011-1 1995 The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). Tyrosine 67-75 interleukin 4 Mus musculus 167-171 7744881-8 1995 Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1. Tyrosine 42-50 interleukin 4 Mus musculus 15-19 7744881-12 1995 However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4. Tyrosine 37-45 interleukin 4 Mus musculus 24-28 7744881-12 1995 However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4. Tyrosine 37-45 interleukin 4 Mus musculus 69-73 7744881-12 1995 However, both IL-13 and IL-4 induced tyrosine phosphorylation of the IL-4-140 kDa receptor chain, suggesting that this is a component of both receptors in these cells and accounts for the similarities in signaling pathways shared by IL-13 and IL-4. Tyrosine 37-45 interleukin 4 Mus musculus 69-73 8124718-1 1994 Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1. Tyrosine 110-118 interleukin 4 Mus musculus 15-19 8124718-7 1994 Thus, the central tyrosine of the I4R motif has a major role in IL-4-mediated signal transduction in 32D cells. Tyrosine 18-26 interleukin 4 Mus musculus 64-68 1692720-1 1990 The role of tyrosine phosphorylation in the signal transduction of four hematopoietic colony-stimulating factors (IL-3, IL-4, G-CSF, and GM-CSF) in myeloid cells was investigated. Tyrosine 12-20 interleukin 4 Mus musculus 120-124 8390454-4 1993 Protein tyrosine phosphorylation was detected within 1 min and reached a plateau approximately at 10 min after IL-4 stimulation. Tyrosine 8-16 interleukin 4 Mus musculus 111-115 8390454-0 1993 Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2. Tyrosine 37-45 interleukin 4 Mus musculus 0-13 8390454-0 1993 Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2. Tyrosine 37-45 interleukin 4 Mus musculus 15-19 8390454-1 1993 To study the signal transduction mechanism of interleukin-4 (IL-4), we have examined the effects of IL-4 on protein tyrosine phosphorylation in a mouse IL-2-dependent T cell line, HT2. Tyrosine 116-124 interleukin 4 Mus musculus 100-104 8390454-3 1993 Western blotting analyses using anti-phosphotyrosine antibody showed that IL-4 induces tyrosine phosphorylation of four proteins (140, 110, 100, and 92 kDa) in a dose-dependent manner. Tyrosine 44-52 interleukin 4 Mus musculus 74-78 7683417-3 1993 The principal tyrosine-phosphorylated substrate observed in FDC cells stimulated with IL-4, previously designated 4PS, was of the same size (170 kDa) as the major substrate phosphorylated in response to insulin or IGF-I. Tyrosine 14-22 interleukin 4 Mus musculus 86-90 7683417-7 1993 Nevertheless, IL-4, insulin, and IGF-I were capable of stimulating tyrosine phosphorylation of IRS-1 in FDC cells that expressed this substrate as a result of transfection. Tyrosine 67-75 interleukin 4 Mus musculus 14-18 7683417-8 1993 These findings indicate that (i) IL-4, insulin, and IGF-I use signal transduction pathways in FDC lines that have at least one major feature in common, the rapid tyrosine phosphorylation of 4PS, and (ii) insulin and IGF-I stimulation of hematopoietic cell lines leads to the phosphorylation of a substrate that may be related to but is not identical to IRS-1. Tyrosine 162-170 interleukin 4 Mus musculus 33-37 1334461-3 1992 IL-4 triggered prominent tyrosine phosphorylation of a substrate(s) migrating at 170 kDa and less striking phosphorylation of several other proteins, including the IL-4 receptor. Tyrosine 25-33 interleukin 4 Mus musculus 0-4 1334461-5 1992 IL-4 treatment of FDCP-2 cells caused a dramatically strong association of phosphatidylinositol 3-kinase (PI 3-kinase) both with the 170 kDa tyrosine phosphorylated substrate and with the IL-4 receptor itself. Tyrosine 141-149 interleukin 4 Mus musculus 0-4 2334739-0 1990 Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Tyrosine 67-75 interleukin 4 Mus musculus 42-55 2334739-6 1990 We comparatively examined the effects of IL-2 and IL-4 on protein tyrosine phosphorylation in these cells by immunoaffinity purification of phosphotyrosyl substrates with an anti-phosphotyrosine monoclonal antibody. Tyrosine 66-74 interleukin 4 Mus musculus 50-54 1692720-7 1990 Finally, in NFS-107 cells, IL-3 and IL-4 stimulated the tyrosine phosphorylation, within 10 min, of two different 140-kD proteins, one of which was the IL-3 receptor. Tyrosine 56-64 interleukin 4 Mus musculus 36-40 34769439-7 2021 In addition, IL-4 and IL-13 stimulate tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1). Tyrosine 38-46 interleukin 4 Mus musculus 13-17 34769439-8 2021 Prolonged treatment with these cytokines leads to increased IRS-1 abundance, which, in turn, amplifies IL-4- and IL-13-stimulated IRS-1 tyrosine phosphorylation. Tyrosine 136-144 interleukin 4 Mus musculus 103-107 34769439-9 2021 Through signaling crosstalk between IL-4/IL-13 and insulin, a hormone routinely included in mammary cultures, IRS-1 tyrosine phosphorylation is further enhanced. Tyrosine 116-124 interleukin 4 Mus musculus 36-40