PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18459146-2 2008 Here we show that the restriction of tyrosine (Tyr) and phenylalanine (Phe), methionine (Met) or glutamine (Gln) modulates the activity of G proteins and affects the balance between two actin-binding proteins, cofilin and profilin, in these two cell lines. Tyrosine 37-45 cofilin 1 Homo sapiens 210-217 22105349-5 2011 Furthermore, cortactin tyrosine phosphorylation mediates the recruitment of NHE1 to the invadopodium compartment, where it locally increases the pH to cause the release of cofilin from cortactin. Tyrosine 23-31 cofilin 1 Homo sapiens 172-179 19802004-0 2010 Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway. Tyrosine 0-8 cofilin 1 Homo sapiens 28-35 19802004-4 2010 Here, we show direct tyrosine phosphorylation of cofilin by v-Src and identify Y68 as the major phosphorylation site. Tyrosine 21-29 cofilin 1 Homo sapiens 49-56 19802004-8 2010 Together, these results suggest a novel mechanism by which cofilin is regulated by v-Src through tyrosine phosphorylation at Y68 that triggers the degradation of cofilin through ubiquitination-proteosome pathway and consequently inhibits cofilin activity in reducing cellular F-actin contents and cell spreading. Tyrosine 97-105 cofilin 1 Homo sapiens 59-66 19802004-8 2010 Together, these results suggest a novel mechanism by which cofilin is regulated by v-Src through tyrosine phosphorylation at Y68 that triggers the degradation of cofilin through ubiquitination-proteosome pathway and consequently inhibits cofilin activity in reducing cellular F-actin contents and cell spreading. Tyrosine 97-105 cofilin 1 Homo sapiens 162-169 19802004-8 2010 Together, these results suggest a novel mechanism by which cofilin is regulated by v-Src through tyrosine phosphorylation at Y68 that triggers the degradation of cofilin through ubiquitination-proteosome pathway and consequently inhibits cofilin activity in reducing cellular F-actin contents and cell spreading. Tyrosine 97-105 cofilin 1 Homo sapiens 162-169 30550596-8 2018 Interestingly, this 2D gel based proteomic study identified new phosphorylation sites on cofilin, such as threonine 63, tyrosine 82 and serine 108. Tyrosine 120-128 cofilin 1 Homo sapiens 89-96 21798346-7 2011 This suppression was accompanied by an increase in the phosphorylation of Src at Tyr-416, which led to a loss of actin stress fibers and focal contacts and a decrease in the phosphorylation level of cofilin. Tyrosine 81-84 cofilin 1 Homo sapiens 199-206 18459146-2 2008 Here we show that the restriction of tyrosine (Tyr) and phenylalanine (Phe), methionine (Met) or glutamine (Gln) modulates the activity of G proteins and affects the balance between two actin-binding proteins, cofilin and profilin, in these two cell lines. Tyrosine 47-50 cofilin 1 Homo sapiens 210-217