PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16289966-3 2006 We successively identified p95 as the nucleolin and the first signal transduction pathway specifically triggered by CD21 activation, i.e.: pp60Src activation, tyrosine phosphorylation of p95 nucleolin, its interaction with SH2 domains of p85 subunit and PI 3-kinase activation, followed by AKT-GSK-3 activations. Tyrosine 159-167 nucleolin Homo sapiens 38-47 25092868-3 2014 Syk binds robustly to nucleolin and phosphorylates it on tyrosine, enhancing its ability to bind the Bcl-x(L) mRNA. Tyrosine 57-65 nucleolin Homo sapiens 22-31 23161541-3 2013 Interestingly, cell surface NCL localization was detected only in cells expressing alpha(v)beta(3) and depended on the phosphorylation of beta(3) at Tyr(773) through receptor protein-tyrosine phosphatase beta/zeta (RPTPbeta/zeta) and c-Src activation. Tyrosine 149-152 nucleolin Homo sapiens 28-31 23161541-6 2013 Collectively, these data suggest that both expression and beta(3) integrin phosphorylation at Tyr(773) determine the cell surface localization of NCL downstream of the RPTPbeta/zeta/c-Src signaling cascade and can be used as a biomarker for the use of cell surface NCL antagonists as anticancer agents. Tyrosine 94-97 nucleolin Homo sapiens 146-149 18504038-5 2008 We have also found P-selectin binding to Colo-320 cells induces tyrosine phosphorylation specifically of cell-surface nucleolin and formation of a signaling complex containing cell-surface nucleolin, PI3-K and p38 MAPK. Tyrosine 64-72 nucleolin Homo sapiens 118-127 16289966-3 2006 We successively identified p95 as the nucleolin and the first signal transduction pathway specifically triggered by CD21 activation, i.e.: pp60Src activation, tyrosine phosphorylation of p95 nucleolin, its interaction with SH2 domains of p85 subunit and PI 3-kinase activation, followed by AKT-GSK-3 activations. Tyrosine 159-167 nucleolin Homo sapiens 191-200 12938232-1 2003 We previously demonstrated that CR2 activation on human B lymphocyte surface specifically triggered tyrosine phosphorylation of the 95-kDa nucleolin, this leading to its binding on SH2 domains of p85 sub-unit of PI 3-kinase and to activation of this enzyme. Tyrosine 100-108 nucleolin Homo sapiens 139-148 12938232-4 2003 Upstream, we demonstrated that pp60src, a tyrosine kinase of the src family, was involved in tyrosine phosphorylation of nucleolin, while syk tyrosine kinase was not. Tyrosine 42-50 nucleolin Homo sapiens 121-130 11207269-0 2001 Activation of the EBV/C3d receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with phosphatidylinositol 3 kinase. Tyrosine 86-94 nucleolin Homo sapiens 125-134 11207269-4 2001 Then, the isolated 95-kDa tyrosine phosphorylated band was submitted to amino acid analysis by mass spectrometry; the two different isolated peptides were characterized by amino acid sequences 100% identical with two different domains of nucleolin, localized between aa 411--420 and 611--624. Tyrosine 26-34 nucleolin Homo sapiens 238-247 11207269-6 2001 Functional studies demonstrated that CR2 activation induced, within a brief span of 2 min, tyrosine phosphorylation of nucleolin and its interaction with Src homology 2 domains of the p85 subunit of PI 3 kinase and of 3BP2 and Grb2, but not with Src homology 2 domains of Fyn and Gap. Tyrosine 91-99 nucleolin Homo sapiens 119-128 11207269-8 2001 Furthermore, tyrosine phosphorylation of nucleolin was also induced in normal B lymphocytes by CR2 activation but neither by CD19 nor BCR activation. Tyrosine 13-21 nucleolin Homo sapiens 41-50 11207269-9 2001 These data support that tyrosine phosphorylation of nucleolin and its interaction with PI 3 kinase p85 subunit constitute one of the earlier steps in the specific intracellular signaling pathway of CR2. Tyrosine 24-32 nucleolin Homo sapiens 52-61