PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12069594-4 2002 Similar to wild-type neuropeptide Y (NPY) and [Ala(31), Aib(32)]-NPY, the N-terminal residues Tyr(1)-Asp(16) are disordered in solution. Tyrosine 94-97 neuropeptide Y Homo sapiens 37-40 11334558-0 2001 Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90). Tyrosine 92-95 neuropeptide Y Homo sapiens 44-47 11287101-2 2001 In HUVECs, NPY is co-localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr(1)-Pro(2) from NPY(1-36) to form NPY(3-36) resulting in the formation of a non-Y1 receptor agonist, which remains angiogenic. Tyrosine 82-85 neuropeptide Y Homo sapiens 101-104 11287101-2 2001 In HUVECs, NPY is co-localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr(1)-Pro(2) from NPY(1-36) to form NPY(3-36) resulting in the formation of a non-Y1 receptor agonist, which remains angiogenic. Tyrosine 82-85 neuropeptide Y Homo sapiens 101-104 11287101-2 2001 In HUVECs, NPY is co-localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr(1)-Pro(2) from NPY(1-36) to form NPY(3-36) resulting in the formation of a non-Y1 receptor agonist, which remains angiogenic. Tyrosine 82-85 neuropeptide Y Homo sapiens 11-14 10088996-1 1999 The high concentration of the tyrosine-rich polypeptide, neuropeptide Y (NPY), and the increase in the number of its receptor subtypes that have been characterized in the brain, raise the question of a functional role for NPY in the CNS. Tyrosine 30-38 neuropeptide Y Homo sapiens 57-71 2172766-8 1990 Modifications of the tyrosine residue in position 20 led to the development of two analogues, [D-Tyr20]hNPY and [D-Trp20]hNPY, which show an apparent preference for the vas deferens NPY receptor. Tyrosine 21-29 neuropeptide Y Homo sapiens 104-107 8741767-3 1995 High levels of GAP43 mRNA were found in intra-adrenal ganglion neurons also expressing neuropeptide tyrosine (NPY) mRNA (type I ganglion neurons), and at prenatal and early postnatal stages in large medullarly clusters of NPY mRNA containing cells, probably representing type I ganglion neurons precursors. Tyrosine 100-108 neuropeptide Y Homo sapiens 110-113 7565622-4 1995 The inactive NPY carboxyl-terminal pentapeptide (Thr-Arg-Gln-Arg-Tyr-NH2; IC50 > 100 microM) was modified by replacing threonine with an aromatic amino acid and glutamine with leucine. Tyrosine 65-68 neuropeptide Y Homo sapiens 13-16 7565622-6 1995 The structure-affinity data suggest that these peptides may represent a noncontinuous epitope containing the amino-terminal tyrosine and the carboxyl-terminal residues Arg-35 and Tyr-36 of NPY. Tyrosine 124-132 neuropeptide Y Homo sapiens 189-192 7565622-6 1995 The structure-affinity data suggest that these peptides may represent a noncontinuous epitope containing the amino-terminal tyrosine and the carboxyl-terminal residues Arg-35 and Tyr-36 of NPY. Tyrosine 179-182 neuropeptide Y Homo sapiens 189-192 7907802-6 1993 Incubation of neuropeptide Y or peptide YY with immunocytochemically defined, cultivated endothelial cells from human umbilical cord also yielded Tyr-Pro. Tyrosine 146-149 neuropeptide Y Homo sapiens 14-28 8250906-2 1993 The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr > Ser > Gly > Gln > Cys > Asn > Asp > Val > Phe > Glu > Lys > Tyr > Ala = Trp > His > Arg, suggesting the importance of end capping. Tyrosine 198-201 neuropeptide Y Homo sapiens 59-62 1576993-6 1992 Large changes in the intrinsic fluorescence intensity of neuropeptide Y tyrosine residues allowed the determination of the dimer dissociation constant as 1.6 +/- 0.6 microM at pH 2-8 in aqueous buffers and also indicated the enclosure of several tyrosine residues in the hydrophobic environment of the interface region in the dimeric species. Tyrosine 72-80 neuropeptide Y Homo sapiens 57-71 1576993-6 1992 Large changes in the intrinsic fluorescence intensity of neuropeptide Y tyrosine residues allowed the determination of the dimer dissociation constant as 1.6 +/- 0.6 microM at pH 2-8 in aqueous buffers and also indicated the enclosure of several tyrosine residues in the hydrophobic environment of the interface region in the dimeric species. Tyrosine 246-254 neuropeptide Y Homo sapiens 57-71 9219539-1 1997 The three-dimensional structure of neuropeptide tyrosine (NPY) 13-36, a specific Y2 receptor agonist, has been investigated by two-dimensional 1H-NMR spectroscopy in solution. Tyrosine 48-56 neuropeptide Y Homo sapiens 58-61 8885995-0 1996 Solid-phase synthesis of caged peptides using tyrosine modified with a photocleavable protecting group: application to the synthesis of caged neuropeptide Y. Tyrosine 46-54 neuropeptide Y Homo sapiens 142-156 8036020-1 1994 In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. Tyrosine 101-109 neuropeptide Y Homo sapiens 111-114 2170253-0 1990 Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)-mediated sympathetic cotransmission. Tyrosine 47-55 neuropeptide Y Homo sapiens 57-60 2164786-9 1990 In summary, [D-Tyr-36]NPY and NPY-(18-36) are partial agonists, the relative potency of which varies between systems. Tyrosine 15-18 neuropeptide Y Homo sapiens 22-25 2342055-7 1990 A critical loss of potency of hNPY was also observed after the substitution of the Tyr-1 residue by L-Ala, thus confirming the important role played by this residue for the full expression of the biological activity of NPY. Tyrosine 83-86 neuropeptide Y Homo sapiens 30-34 2708330-7 1989 It is concluded that monoiodinated radioligands of the tyrosine-rich neuropeptide Y can be prepared and that receptors for these ligands in two apparently different subtypes are found on a series of human neuroblastoma cell lines. Tyrosine 55-63 neuropeptide Y Homo sapiens 69-83 34684394-3 2021 Various neuropeptides, including neuropeptide tyrosine (neuropeptide Y or NPY), control physiological processes in the airway including cytokine release, fluid secretion, and ciliary beating. Tyrosine 46-54 neuropeptide Y Homo sapiens 56-70 34684394-3 2021 Various neuropeptides, including neuropeptide tyrosine (neuropeptide Y or NPY), control physiological processes in the airway including cytokine release, fluid secretion, and ciliary beating. Tyrosine 46-54 neuropeptide Y Homo sapiens 74-77 6957876-2 1982 The amino acid sequence of neuropeptide Y has been found to be: Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr -Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2. Tyrosine 64-67 neuropeptide Y Homo sapiens 27-41 2665962-1 1989 Human neuropeptide Y was semisynthesized by enzymatic condensation of des-Tyr36-NH2 human neuropeptide Y and H-Tyr-NH2 using Pseudomonas aeruginosa elastase, a metalloenzyme possessing a hydrolytic specificity for the imino side of hydrophobic amino acids. Tyrosine 74-77 neuropeptide Y Homo sapiens 6-20 2665962-1 1989 Human neuropeptide Y was semisynthesized by enzymatic condensation of des-Tyr36-NH2 human neuropeptide Y and H-Tyr-NH2 using Pseudomonas aeruginosa elastase, a metalloenzyme possessing a hydrolytic specificity for the imino side of hydrophobic amino acids. Tyrosine 74-77 neuropeptide Y Homo sapiens 90-104 3522662-1 1986 The detailed distribution of neuropeptide tyrosine (neuropeptide Y; NPY) immunoreactive neurons and fibers is given for the normal human hippocampus. Tyrosine 42-50 neuropeptide Y Homo sapiens 52-66 28737807-10 2017 Collectively, these data imply that the self-association of NPY with heme potentially induces tyrosine nitration, destroys the active monomeric conformation of the peptide and thereby counteracts its bioactivity. Tyrosine 94-102 neuropeptide Y Homo sapiens 60-63 29619413-6 2018 Successive mutation of the tyrosines to more hydrophobic phenylalanines increased the thermal stability of NPY and reduced functional activity, consistent with computational studies predicting a more stable hairpin structure. Tyrosine 27-36 neuropeptide Y Homo sapiens 107-110 30079723-4 2018 Besides, copper could also catalyze protein tyrosine nitration under oxidative stress, and there are two tyrosine residues playing an important role in NPY. Tyrosine 105-113 neuropeptide Y Homo sapiens 152-155 30079723-5 2018 Therefore, it is also likely that copper has an action on NPY and potentially influences its functions through tyrosine nitration. Tyrosine 111-119 neuropeptide Y Homo sapiens 58-61 30079723-9 2018 Furthermore, liquid chromatography-mass spectrometry (LC-MS) identify that the tyrosine residues in NPY are all nitrated during the nitration process, which will cause the inactivation of NPY shown by our previous study. Tyrosine 79-87 neuropeptide Y Homo sapiens 100-103 30079723-9 2018 Furthermore, liquid chromatography-mass spectrometry (LC-MS) identify that the tyrosine residues in NPY are all nitrated during the nitration process, which will cause the inactivation of NPY shown by our previous study. Tyrosine 79-87 neuropeptide Y Homo sapiens 188-191 20042335-1 2010 We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R). Tyrosine 66-69 neuropeptide Y Homo sapiens 27-41 27736725-8 2017 The elongation of the peptide chain partially (NPY13-36 and NPY22-36) or completely (NPY3-36 and NPY) protects the Tyr residue against conversion to the radical form. Tyrosine 115-118 neuropeptide Y Homo sapiens 85-100 25313473-5 2015 Our findings demonstrated that in all of the investigated compounds, the NPY(32-36)C-terminal fragment (Thr(32)-Arg(33)-Gln(34)-Arg(35)-Tyr(36)NH2) was involved in the adsorption process onto metal substrate. Tyrosine 136-139 neuropeptide Y Homo sapiens 73-76 20042335-1 2010 We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R). Tyrosine 66-69 neuropeptide Y Homo sapiens 43-46 19319516-1 2009 The interaction of the 36 amino acid neuropeptide Y (NPY) with liposomes was studied using the intrinsic tyrosine fluorescence of NPY and an NPY fragment comprising amino acids 18-36. Tyrosine 105-113 neuropeptide Y Homo sapiens 37-51 19319516-1 2009 The interaction of the 36 amino acid neuropeptide Y (NPY) with liposomes was studied using the intrinsic tyrosine fluorescence of NPY and an NPY fragment comprising amino acids 18-36. Tyrosine 105-113 neuropeptide Y Homo sapiens 53-56 19319516-6 2009 Further, the position of NPY"s alpha-helix in the membrane was estimated from the intrinsic tyrosine fluorescence of NPY, from quenching experiments with spin-labelled phospholipids using [Trp(32)]-NPY, and from (1)H magic-angle spinning NMR relaxation measurements using spin-labelled [Ala(31), TOAC(32)]-NPY. Tyrosine 92-100 neuropeptide Y Homo sapiens 25-28 19319516-6 2009 Further, the position of NPY"s alpha-helix in the membrane was estimated from the intrinsic tyrosine fluorescence of NPY, from quenching experiments with spin-labelled phospholipids using [Trp(32)]-NPY, and from (1)H magic-angle spinning NMR relaxation measurements using spin-labelled [Ala(31), TOAC(32)]-NPY. Tyrosine 92-100 neuropeptide Y Homo sapiens 117-120 19319516-6 2009 Further, the position of NPY"s alpha-helix in the membrane was estimated from the intrinsic tyrosine fluorescence of NPY, from quenching experiments with spin-labelled phospholipids using [Trp(32)]-NPY, and from (1)H magic-angle spinning NMR relaxation measurements using spin-labelled [Ala(31), TOAC(32)]-NPY. Tyrosine 92-100 neuropeptide Y Homo sapiens 117-120 19319516-6 2009 Further, the position of NPY"s alpha-helix in the membrane was estimated from the intrinsic tyrosine fluorescence of NPY, from quenching experiments with spin-labelled phospholipids using [Trp(32)]-NPY, and from (1)H magic-angle spinning NMR relaxation measurements using spin-labelled [Ala(31), TOAC(32)]-NPY. Tyrosine 92-100 neuropeptide Y Homo sapiens 117-120