PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15240680-3 2004 In this study, we show that adenosine suppressed IL-2-dependent proliferation of CTLL-2 T cells by inhibiting STAT5a/b tyrosine phosphorylation that is associated with IL-2R signaling without affecting IL-2-induced phosphorylation of Jak1 or Jak3. Tyrosine 119-127 interleukin 2 Mus musculus 49-53 19586919-4 2009 CD2 and CD244 both contribute positively to the immune response as mutation of proline-rich motifs or tyrosine motifs in the tails of CD2 and CD244, respectively, result in a decrease in antigen-specific interleukin-2 production. Tyrosine 102-110 interleukin 2 Mus musculus 204-217 19185518-2 2009 Here, we show that expression of IL-2Rbeta chains that lack tyrosine residues important for the association of the adaptor Shc and the transcription factor STAT5 in IL-2Rbeta-deficient mice resulted in production of a normal proportion of natural Treg cells that suppressed severe autoimmunity related with deficiency in IL-2 or IL-2R. Tyrosine 60-68 interleukin 2 Mus musculus 33-37 17234744-4 2007 Accordingly, methylprednisolone inhibited Tyr phosphorylation of STAT1, STAT3, and STAT5 in IL-2-cultured NK cells but only marginally in IL-15-cultured NK cells, whereas JAK3 was inhibited under both conditions. Tyrosine 42-45 interleukin 2 Mus musculus 92-96 15240680-0 2004 Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: role of cyclic adenosine 3",5"-monophosphate and phosphatases. Tyrosine 60-68 interleukin 2 Mus musculus 47-51 15240680-4 2004 The inhibitory effect of adenosine on IL-2-induced STAT5a/b tyrosine phosphorylation was reversed by the protein tyrosine phosphatase inhibitors sodium orthovanadate and bpV(phen). Tyrosine 60-68 interleukin 2 Mus musculus 38-42 15240680-6 2004 The inhibitory effect of adenosine on IL-2-induced STAT5a/b tyrosine phosphorylation was reproduced by A(2) receptor agonists and was blocked by selective A(2a) and A(2b) receptor antagonists, indicating that adenosine was mediating its effect through A(2) receptors. Tyrosine 60-68 interleukin 2 Mus musculus 38-42 11909529-8 2002 TCPTP-deficient lymphocytes treated with IL-2 had increased levels of tyrosine-phosphorylated STAT5, and thymocytes treated with interferon (IFN)-alpha or IFN-gamma had increased tyrosine-phosphorylated STAT1. Tyrosine 70-78 interleukin 2 Mus musculus 41-45 11815609-4 2002 In addition, Tyr-103, Cys-161, Cys-210, and Cys-211, previously identified to contribute to binding IL-2 and IL-7, were also found to be involved in binding IL-4 and IL-15. Tyrosine 13-16 interleukin 2 Mus musculus 100-104 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 184-192 interleukin 2 Mus musculus 124-128 12637316-5 2003 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells, we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5, while IL-12 plus IL-4 treatment resulted in a more substantial increase in tyrosine-phosphorylated Stat4. Tyrosine 294-302 interleukin 2 Mus musculus 124-128 11278301-0 2001 Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. Tyrosine 53-61 interleukin 2 Mus musculus 31-44 11278301-4 2001 Exposure of the murine T cell line CTLL to IL-2 caused tyrosine phosphorylation of STAT5 that was remarkably reduced when cells were exposed to UV. Tyrosine 55-63 interleukin 2 Mus musculus 43-47 11278301-6 2001 In contrast, IL-2-induced tyrosine phosphorylation of the kinases Jak1 and Jak3 located upstream of STAT5 was not affected by UV. Tyrosine 26-34 interleukin 2 Mus musculus 13-17 10861847-4 2000 Stimulation of CTLL-2 cells with IL-2 induced phosphorylation on extracellular signal-regulated kinases more intensively than on c-Jun NH2-terminal kinases (JNKs), and provoked tyrosine phosphorylation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). Tyrosine 177-185 interleukin 2 Mus musculus 33-37 9079703-1 1997 Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation. Tyrosine 44-52 interleukin 2 Mus musculus 69-73 9578412-12 1997 IL-2 induces a rapid tyrosine phoshorylation in MILG cells, which is followed by a prolonged induction of c-fos and c-jun genes. Tyrosine 21-29 interleukin 2 Mus musculus 0-4 9200434-5 1997 This second mechanism for inhibiting proliferation is probably inhibition of protein tyrosine kinases, since these higher concentrations of A77 1726 inhibit IL-2-induced tyrosine phosphorylation of Jak1 and Jak3, the protein tyrosine kinases initiating signaling by the IL-2R. Tyrosine 85-93 interleukin 2 Mus musculus 157-161 9200434-6 1997 Tyrosine phosphorylation of the beta-chain of the IL-2R, which is required for IL-2-driven proliferation, is also inhibited by A77 1726. Tyrosine 0-8 interleukin 2 Mus musculus 50-54 10898499-5 2000 We show that in A1.1 cells co-stimulation of IL-2 production is independent of CD28 cytoplasmic tyrosine residues, since a mutant lacking all four cytoplasmic tyrosines is still able to induce a full co-stimulatory response. Tyrosine 159-168 interleukin 2 Mus musculus 45-49 10499915-4 1999 Upon T cell activation by cross-linking with anti-CD3 and anti-CD28 antibodies, CTLA-4 engagement inhibited both proliferation and interleukin 2 production in tyrosine mutants as well as in wild-type CTLA-4 transfectants. Tyrosine 159-167 interleukin 2 Mus musculus 131-144 9079703-4 1997 We investigated the signaling pathways mediating IL-2-induced IL-2Ralpha mRNA expression using 32D myeloid progenitor cells stably transfected with either wild type IL-2Rbeta or mutants of IL-2Rbeta containing tyrosine to phenylalanine substitutions. Tyrosine 210-218 interleukin 2 Mus musculus 49-53 9079703-5 1997 Of the six cytoplasmic tyrosines in IL-2Rbeta, we have found that only the two tyrosines that mediate Stat5 activation (Tyr-392 and Tyr-510) contribute to IL-2-induced IL-2Ralpha gene expression and that either tyrosine alone is sufficient for this process. Tyrosine 23-32 interleukin 2 Mus musculus 36-40 9079703-5 1997 Of the six cytoplasmic tyrosines in IL-2Rbeta, we have found that only the two tyrosines that mediate Stat5 activation (Tyr-392 and Tyr-510) contribute to IL-2-induced IL-2Ralpha gene expression and that either tyrosine alone is sufficient for this process. Tyrosine 23-31 interleukin 2 Mus musculus 36-40 9079703-10 1997 These data suggest that Tyr-392 and Tyr-510 couple to an additional signaling pathway beyond STAT protein activation in IL-2-mediated induction of the IL-2Ralpha gene. Tyrosine 24-27 interleukin 2 Mus musculus 120-124 9079703-10 1997 These data suggest that Tyr-392 and Tyr-510 couple to an additional signaling pathway beyond STAT protein activation in IL-2-mediated induction of the IL-2Ralpha gene. Tyrosine 36-39 interleukin 2 Mus musculus 120-124 9384701-5 1996 Western blotting following stimulation of T cells with parental or genetically engineered IL-2-secreting, B7+ tumor cells revealed increased protein tyrosine phosphorylation in lysates derived from ITB compared with PTB T cells, demonstrating that tumor-derived IL-2 could influence signaling. Tyrosine 149-157 interleukin 2 Mus musculus 90-94 8977326-9 1996 Collectively, these results demonstrate that regulation of tyrosine phosphorylation plays a pivotal role in CTLA-4 function, and that the inhibition of the transition from G0/G1 to the S phase of the cell cycle and the inhibition of IL-2 secretion require distinct signaling pathways. Tyrosine 59-67 interleukin 2 Mus musculus 233-237 9384701-5 1996 Western blotting following stimulation of T cells with parental or genetically engineered IL-2-secreting, B7+ tumor cells revealed increased protein tyrosine phosphorylation in lysates derived from ITB compared with PTB T cells, demonstrating that tumor-derived IL-2 could influence signaling. Tyrosine 149-157 interleukin 2 Mus musculus 262-266 8671684-4 1996 Tyrosine phosphorylation of IL-2Rbeta was induced by stimulation of T88-Mbeta1 with not only IL-2 but also IL-5. Tyrosine 0-8 interleukin 2 Mus musculus 28-32 8643566-1 1996 Stimulation via the T-cell growth factor interleukin 2 (IL-2) leads to tyrosine phosphorylation of Shc, the interaction of Shc with Grb2, and the Ras GTP/GDP exchange factor, mSOS. Tyrosine 71-79 interleukin 2 Mus musculus 41-54 8671684-7 1996 On the other hand, the detection of JAK1 and the other common set of phosphotyrosine-containing proteins after stimulation with either IL-5 or IL-2 suggests the existence of the same tyrosine phosphorylation pathways. Tyrosine 76-84 interleukin 2 Mus musculus 143-147 8643566-1 1996 Stimulation via the T-cell growth factor interleukin 2 (IL-2) leads to tyrosine phosphorylation of Shc, the interaction of Shc with Grb2, and the Ras GTP/GDP exchange factor, mSOS. Tyrosine 71-79 interleukin 2 Mus musculus 56-60 7499411-8 1995 This study thus defines the critical domain within the IL-2R beta chain required to mediate Shc binding and Shc tyrosine phosphorylation and further shows that Shc binding and phosphorylation are not required for IL-2-dependent mitogenesis. Tyrosine 112-120 interleukin 2 Mus musculus 55-59 7593241-0 1995 Regulation of apoptosis of interleukin 2-dependent mouse T-cell line by protein tyrosine phosphorylation and polyamines. Tyrosine 80-88 interleukin 2 Mus musculus 27-40 7543676-5 1995 The IL-2R beta chain appeared critical for IL-2-induced activation of STAT-5, since a mutant beta chain lacking all cytoplasmic tyrosine residues was incapable of inducing this DNA binding. Tyrosine 128-136 interleukin 2 Mus musculus 4-8 7489734-2 1995 The heterotrimeric complex of the mouse exogenous alpha and beta chains and the endogenous gamma chain on mouse lymphoid BW5147 cells showed the ability to bind IL-2 with high affinity, resulting in IL-2-induced tyrosine phosphorylation of a cytosolic tyrosine kinase, JAK3, which is involved in IL-2-dependent signals. Tyrosine 212-220 interleukin 2 Mus musculus 161-165 7489734-2 1995 The heterotrimeric complex of the mouse exogenous alpha and beta chains and the endogenous gamma chain on mouse lymphoid BW5147 cells showed the ability to bind IL-2 with high affinity, resulting in IL-2-induced tyrosine phosphorylation of a cytosolic tyrosine kinase, JAK3, which is involved in IL-2-dependent signals. Tyrosine 212-220 interleukin 2 Mus musculus 199-203 7489734-2 1995 The heterotrimeric complex of the mouse exogenous alpha and beta chains and the endogenous gamma chain on mouse lymphoid BW5147 cells showed the ability to bind IL-2 with high affinity, resulting in IL-2-induced tyrosine phosphorylation of a cytosolic tyrosine kinase, JAK3, which is involved in IL-2-dependent signals. Tyrosine 212-220 interleukin 2 Mus musculus 199-203 7759480-12 1995 Finally, tyrosine phosphorylation in CTLL-4 cells stimulated by IL-2 was also inhibited by leflunomide. Tyrosine 9-17 interleukin 2 Mus musculus 64-68 7781605-3 1995 Here we demonstrate that interleukin 2 (IL-2) as well as erythropoietin (EPO) stimulate STAT5 and induce tyrosine phosphorylation of STAT5. Tyrosine 105-113 interleukin 2 Mus musculus 25-38 7781605-3 1995 Here we demonstrate that interleukin 2 (IL-2) as well as erythropoietin (EPO) stimulate STAT5 and induce tyrosine phosphorylation of STAT5. Tyrosine 105-113 interleukin 2 Mus musculus 40-44 7686931-7 1993 These results suggest that specific defects in tyrosine phosphorylation pathways required for the induction of IL-2 synthesis may help to explain nonresponsiveness to Ag in tolerant T cells. Tyrosine 47-55 interleukin 2 Mus musculus 111-115 7744803-10 1995 Immunoblot analyses confirmed that cytoplasmic STAT3 was heavily phosphorylated on tyrosine in IL-2-stimulated cells, and that phosphorylated STAT3 appeared in the nuclei of these cells. Tyrosine 83-91 interleukin 2 Mus musculus 95-99 8207200-5 1994 We observed that the high affinity IL-2R in NIH 3T3 fibroblasts can mediate the IL-2-stimulated tyrosine phosphorylation of p42/p44 (mitogen-activated protein kinase) and the induction of the c-fos, c-jun and c-myc genes. Tyrosine 96-104 interleukin 2 Mus musculus 35-39 8294403-1 1994 Binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) stimulates Src family kinases, tyrosine phosphorylation of several proteins, conversion of Ras to its active GTP-bound form, and eventually c-fos, c-jun, and c-myc induction. Tyrosine 92-100 interleukin 2 Mus musculus 11-24 8294403-1 1994 Binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) stimulates Src family kinases, tyrosine phosphorylation of several proteins, conversion of Ras to its active GTP-bound form, and eventually c-fos, c-jun, and c-myc induction. Tyrosine 92-100 interleukin 2 Mus musculus 26-30 8294403-4 1994 The beta chain itself is tyrosine-phosphorylated upon IL-2 stimulation. Tyrosine 25-33 interleukin 2 Mus musculus 54-58 8294403-6 1994 Shc was found to be tyrosine-phosphorylated upon IL-2 stimulation in CTLL-20 cells. Tyrosine 20-28 interleukin 2 Mus musculus 49-53 8103063-4 1993 We have previously demonstrated alterations in TCR-mediated early protein tyrosine phosphorylation events in Th1 clones anergic for IL-2 production. Tyrosine 74-82 interleukin 2 Mus musculus 132-136 8103063-11 1993 Altered tyrosine phosphorylation is therefore closely associated with defective IL-2 production in these three anergic T cell types, and may play a role in the maintenance of anergy. Tyrosine 8-16 interleukin 2 Mus musculus 80-84 8088325-6 1994 Shc tyrosine phosphorylation as a result of IL-2 stimulation was consistently found in CTLL-2 cells and human T lymphoblasts. Tyrosine 4-12 interleukin 2 Mus musculus 44-48 7515100-5 1994 In this report, we demonstrate that IL-2 stimulation triggers tyrosine phosphorylation of the p85 subunit of PI3-kinase in the murine T cell line, CTLL-2. Tyrosine 62-70 interleukin 2 Mus musculus 36-40 7515100-6 1994 Lysates prepared from growth factor-deprived and IL-2-stimulated T cells reconstituted both the binding of CTLL-2 cell-derived Fyn to and the IL-2-inducible tyrosine phosphorylation of exogenously added recombinant p85. Tyrosine 157-165 interleukin 2 Mus musculus 49-53 7515100-6 1994 Lysates prepared from growth factor-deprived and IL-2-stimulated T cells reconstituted both the binding of CTLL-2 cell-derived Fyn to and the IL-2-inducible tyrosine phosphorylation of exogenously added recombinant p85. Tyrosine 157-165 interleukin 2 Mus musculus 142-146 1467516-8 1992 In CTLL-2-EPO-R cells, a T-lymphocyte line stably transfected with the EPO-R, the 97-Kd substrate was tyrosine-phosphorylated in response to IL-2 or EPO. Tyrosine 102-110 interleukin 2 Mus musculus 141-145 7685905-0 1993 Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line. Tyrosine 56-64 interleukin 2 Mus musculus 0-13 7685905-1 1993 Previously we found that interleukin 2 (IL-2) induces tyrosine phosphorylation and activation of the serine/threonine-specific kinase encoded by the raf-1 protooncogene in a T-cell line, CTLL-2. Tyrosine 54-62 interleukin 2 Mus musculus 25-38 7685905-1 1993 Previously we found that interleukin 2 (IL-2) induces tyrosine phosphorylation and activation of the serine/threonine-specific kinase encoded by the raf-1 protooncogene in a T-cell line, CTLL-2. Tyrosine 54-62 interleukin 2 Mus musculus 40-44 7685905-2 1993 Here we extended these findings by exploring the effects of selective removal of phosphate from tyrosines in p72-74-Raf-1 kinase that had been immunoprecipitated from IL-2-stimulated CTLL-2 cells. Tyrosine 96-105 interleukin 2 Mus musculus 167-171 7685905-8 1993 These findings provide evidence that the IL-2-stimulated phosphorylation of Raf-1 on tyrosines plays an important role in upregulating the activity of this serine/threonine-specific kinase in CTLL-2 cells and, as such, provides a model system for studying the transfer of growth factor-initiated signals from protein tyrosine kinases to serine/threonine-specific kinases. Tyrosine 85-94 interleukin 2 Mus musculus 41-45 8483935-1 1993 The binding of interleukin 2 (IL-2) to the IL-2 receptor (IL-2R) induces a rapid increase in tyrosine phosphorylation of cellular proteins. Tyrosine 93-101 interleukin 2 Mus musculus 15-28 8483935-1 1993 The binding of interleukin 2 (IL-2) to the IL-2 receptor (IL-2R) induces a rapid increase in tyrosine phosphorylation of cellular proteins. Tyrosine 93-101 interleukin 2 Mus musculus 30-34 7682694-0 1993 Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein. Tyrosine 130-138 interleukin 2 Mus musculus 45-58 7682694-1 1993 The addition of recombinant interleukin 2 (rIL-2) to anti-CD3-activated murine G0 phase T cells results in an increased level of tyrosine phosphorylation of a single 97-kDa protein. Tyrosine 129-137 interleukin 2 Mus musculus 28-41 7682694-8 1993 Irrespective of the signal-transducing structures involved, the IL-2-induced proliferative response closely correlates with an increase in p56lck kinase activity along with the tyrosine phosphorylation of a 97-kDa protein. Tyrosine 177-185 interleukin 2 Mus musculus 64-68 1850360-9 1991 Although IL2 induced rapid and potent tyrosine phosphorylation in CTLL-2.4 cells, all of the basal and cytokine-activated phosphorylation of CD45 occurred on serine residues. Tyrosine 38-46 interleukin 2 Mus musculus 9-12 1384486-0 1992 Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor beta chain cDNA. Tyrosine 59-67 interleukin 2 Mus musculus 0-13 1384486-0 1992 Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor beta chain cDNA. Tyrosine 59-67 interleukin 2 Mus musculus 15-19 1652056-1 1991 Stimulation of activated T lymphocytes with interleukin 2 (IL-2) results in rapid increases in intracellular protein tyrosine phosphorylation. Tyrosine 117-125 interleukin 2 Mus musculus 44-57 1652056-1 1991 Stimulation of activated T lymphocytes with interleukin 2 (IL-2) results in rapid increases in intracellular protein tyrosine phosphorylation. Tyrosine 117-125 interleukin 2 Mus musculus 59-63 1713578-6 1991 Within a minute following stimulation of these cells with IL-2, PI 3-kinase activity could be detected in antiphosphotyrosine (anti-P-Tyr) antibody immunoprecipitates. Tyrosine 134-137 interleukin 2 Mus musculus 58-62 1850360-1 1991 Ligation of interleukin 2 (IL2) is known to regulate both protein tyrosine and serine/threonine phosphorylation. Tyrosine 66-74 interleukin 2 Mus musculus 12-25 1850360-1 1991 Ligation of interleukin 2 (IL2) is known to regulate both protein tyrosine and serine/threonine phosphorylation. Tyrosine 66-74 interleukin 2 Mus musculus 27-30 1357030-5 1992 Because protein tyrosine phosphorylation is known to be important for the normal induction of IL-2 synthesis, these results suggest that T cell anergy may be maintained, at least in part, by alterations in tyrosine phosphorylation signaling events. Tyrosine 16-24 interleukin 2 Mus musculus 94-98 1655887-0 1991 IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. Tyrosine 25-33 interleukin 2 Mus musculus 0-4 1655887-4 1991 Incubation of cells with genistein, a selective tyrosine kinase inhibitor, blocked IL-2-dependent activation of receptor-associated tyrosine kinase and phosphatidylinositol-3-kinase activities, suggesting that tyrosine phosphorylation-dependent activation of phosphatidylinositol-3-kinase is a component of the IL-2R signal transduction process. Tyrosine 48-56 interleukin 2 Mus musculus 83-87 1690713-0 1990 Protein tyrosine phosphorylation associated with activation of the interleukin 2 receptor. Tyrosine 8-16 interleukin 2 Mus musculus 67-80 1697878-0 1990 Tyrosine phosphorylation is an obligatory event in IL-2 secretion. Tyrosine 0-8 interleukin 2 Mus musculus 51-55 1697878-15 1990 Therefore, tyrosine phosphorylation appears to represent an obligatory event in the transmembrane signaling processes that lead to IL-2 secretion. Tyrosine 11-19 interleukin 2 Mus musculus 131-135 1996324-0 1991 Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. Tyrosine 22-30 interleukin 2 Mus musculus 0-13 1996324-7 1991 Furthermore, much of the IL-2-stimulated phosphorylation of p72-74 Raf-1 occurred on tyrosines. Tyrosine 85-94 interleukin 2 Mus musculus 25-29 2007186-5 1991 In IL-2-dependent mouse T cell lines, a 100,000-Da protein was phosphorylated on tyrosine in response to IL-2 and is proposed to be the mouse IL-2 receptor beta chain. Tyrosine 81-89 interleukin 2 Mus musculus 3-7 2007186-5 1991 In IL-2-dependent mouse T cell lines, a 100,000-Da protein was phosphorylated on tyrosine in response to IL-2 and is proposed to be the mouse IL-2 receptor beta chain. Tyrosine 81-89 interleukin 2 Mus musculus 105-109 2007186-6 1991 Two other cellular proteins, pp55 and pp105 in human or pp55 and pp115 in mouse cell lines, were phosphorylated on tyrosine in response to IL-2 and coimmunoprecipitated with the high-affinity IL-2 receptor after chemical crosslinking of IL-2-stimulated cells. Tyrosine 115-123 interleukin 2 Mus musculus 139-143 2007186-6 1991 Two other cellular proteins, pp55 and pp105 in human or pp55 and pp115 in mouse cell lines, were phosphorylated on tyrosine in response to IL-2 and coimmunoprecipitated with the high-affinity IL-2 receptor after chemical crosslinking of IL-2-stimulated cells. Tyrosine 115-123 interleukin 2 Mus musculus 192-196 2334739-0 1990 Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Tyrosine 67-75 interleukin 2 Mus musculus 24-37 2334739-3 1990 In this report we have used three murine T cell clones to demonstrate that IL-2 stimulates rapid tyrosine phosphorylation of several proteins. Tyrosine 97-105 interleukin 2 Mus musculus 75-79 2334739-7 1990 Stimulation with concentrations of IL-2 resulting in maximal (10-30 U/ml) or sub-maximal (1-5 U/ml) proliferation caused the rapid tyrosine phosphorylation of 97 and 57 kDa proteins in all three cell lines. Tyrosine 131-139 interleukin 2 Mus musculus 35-39 2334739-9 1990 IL-2-dependent tyrosine phosphorylation of an 86 kDa cytosolic protein was observed only in CT6 cells. Tyrosine 15-23 interleukin 2 Mus musculus 0-4 1690713-1 1990 The addition of interleukin 2 (IL2) to the IL2-dependent murine cytotoxic T cell line CTTL-2 induced increased tyrosine phosphorylation of a protein with a molecular weight of 80,000 and, to a lesser extent, proteins with molecular weights of 130,000, 100,000, and 69,000. Tyrosine 111-119 interleukin 2 Mus musculus 16-29 1690713-1 1990 The addition of interleukin 2 (IL2) to the IL2-dependent murine cytotoxic T cell line CTTL-2 induced increased tyrosine phosphorylation of a protein with a molecular weight of 80,000 and, to a lesser extent, proteins with molecular weights of 130,000, 100,000, and 69,000. Tyrosine 111-119 interleukin 2 Mus musculus 31-34 1690713-1 1990 The addition of interleukin 2 (IL2) to the IL2-dependent murine cytotoxic T cell line CTTL-2 induced increased tyrosine phosphorylation of a protein with a molecular weight of 80,000 and, to a lesser extent, proteins with molecular weights of 130,000, 100,000, and 69,000. Tyrosine 111-119 interleukin 2 Mus musculus 43-46 3259228-2 1988 Treatment of the murine IL-2-dependent cytotoxic T cell line CTLL-2 with IL-2 resulted in an increase in tyrosine phosphorylation of several proteins of molecular weights ranging from 38,000 to 120,000. Tyrosine 105-113 interleukin 2 Mus musculus 24-28 3259228-2 1988 Treatment of the murine IL-2-dependent cytotoxic T cell line CTLL-2 with IL-2 resulted in an increase in tyrosine phosphorylation of several proteins of molecular weights ranging from 38,000 to 120,000. Tyrosine 105-113 interleukin 2 Mus musculus 73-77 3259228-4 1988 The concentration of IL-2 required for inducing this phosphorylation was similar to that required for stimulating [3H]thymidine uptake, indicating that the increase in tyrosine phosphorylation correlated with the ability of IL-2 to stimulate the proliferation of the CTLL-2 cells. Tyrosine 168-176 interleukin 2 Mus musculus 21-25 3259228-4 1988 The concentration of IL-2 required for inducing this phosphorylation was similar to that required for stimulating [3H]thymidine uptake, indicating that the increase in tyrosine phosphorylation correlated with the ability of IL-2 to stimulate the proliferation of the CTLL-2 cells. Tyrosine 168-176 interleukin 2 Mus musculus 224-228 3260330-1 1988 By immunoblotting with antibodies for phosphotyrosine, we have demonstrated that the hematopoietic growth factors interleukin-2, interleukin-3, interleukin-4, and granulocyte-macrophage colony-stimulating factor stimulate the tyrosine phosphorylation of specific sets of proteins in murine hematopoietic progenitor cell lines. Tyrosine 45-53 interleukin 2 Mus musculus 114-127