PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28011403-6 2017 We observed that these effects were exerted by changes on the phosphorylation of IRS-1 on specific serine and tyrosine residues modulated by PA through the modulation of JNK and IKK activity. Tyrosine 110-118 mitogen-activated protein kinase 8 Homo sapiens 170-173 29052270-2 2018 It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein kinases ERK2, JNK1 and p38-alpha. Tyrosine 30-38 mitogen-activated protein kinase 8 Homo sapiens 129-133 26705936-7 2017 MCF-7 cells cocultured with M2 TAM showed activated JAK1/STAT3 and Raf/MEK/JNK pathways contributing to tyrosine and serine phophorylation of STAT3, respectively. Tyrosine 104-112 mitogen-activated protein kinase 8 Homo sapiens 75-78 22833523-8 2013 The MUC1-CT/p120ctn interaction was highly dependent on EGFR/Src/Jnk-mediated tyrosine phosphorylation (TyrP) of MUC1-CT. Tyrosine 78-86 mitogen-activated protein kinase 8 Homo sapiens 65-68 25708150-2 2015 The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine residues, Tyr-397 in FAK and Tyr-402 in PYK2, and then association with different signalling proteins which mediate activation of downstream targets such as ERK and JNK mitogen-activated kinase cascades. Tyrosine 82-90 mitogen-activated protein kinase 8 Homo sapiens 256-259 25708150-2 2015 The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine residues, Tyr-397 in FAK and Tyr-402 in PYK2, and then association with different signalling proteins which mediate activation of downstream targets such as ERK and JNK mitogen-activated kinase cascades. Tyrosine 101-104 mitogen-activated protein kinase 8 Homo sapiens 256-259 25708150-2 2015 The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine residues, Tyr-397 in FAK and Tyr-402 in PYK2, and then association with different signalling proteins which mediate activation of downstream targets such as ERK and JNK mitogen-activated kinase cascades. Tyrosine 120-123 mitogen-activated protein kinase 8 Homo sapiens 256-259 26429914-4 2015 Here we report on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 with JNK, on the regulation of JNK downstream signaling by GSTP1, and on tumor cell survival. Tyrosine 58-66 mitogen-activated protein kinase 8 Homo sapiens 116-119 26429914-4 2015 Here we report on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 with JNK, on the regulation of JNK downstream signaling by GSTP1, and on tumor cell survival. Tyrosine 58-66 mitogen-activated protein kinase 8 Homo sapiens 142-145 26429914-5 2015 Using in vitro and in vivo growing human brain tumors, we show that tyrosine phosphorylation shifts the GSTP1 dimer-monomer equilibrium to the monomeric state and facilitates the formation of the GSTP1-JNK complex, in which JNK is functionally inhibited. Tyrosine 68-76 mitogen-activated protein kinase 8 Homo sapiens 202-205 26429914-5 2015 Using in vitro and in vivo growing human brain tumors, we show that tyrosine phosphorylation shifts the GSTP1 dimer-monomer equilibrium to the monomeric state and facilitates the formation of the GSTP1-JNK complex, in which JNK is functionally inhibited. Tyrosine 68-76 mitogen-activated protein kinase 8 Homo sapiens 224-227 26429914-6 2015 Targeted mutagenesis and functional analysis demonstrated that the increased GSTP1 binding to JNK results from phosphorylation of the GSTP1 C-terminal Tyr-198 by EGFR and is associated with a >2.5-fold decrease in JNK downstream signaling and a significant suppression of both spontaneous and drug-induced apoptosis in the tumor cells. Tyrosine 151-154 mitogen-activated protein kinase 8 Homo sapiens 94-97 26429914-6 2015 Targeted mutagenesis and functional analysis demonstrated that the increased GSTP1 binding to JNK results from phosphorylation of the GSTP1 C-terminal Tyr-198 by EGFR and is associated with a >2.5-fold decrease in JNK downstream signaling and a significant suppression of both spontaneous and drug-induced apoptosis in the tumor cells. Tyrosine 151-154 mitogen-activated protein kinase 8 Homo sapiens 217-220 24002526-8 2013 Furthermore, an increased tyrosine phosphorylated c-Jun N-terminal kinase (JNK) was seen in the PTPRK knockdown cells. Tyrosine 26-34 mitogen-activated protein kinase 8 Homo sapiens 50-73 24002526-8 2013 Furthermore, an increased tyrosine phosphorylated c-Jun N-terminal kinase (JNK) was seen in the PTPRK knockdown cells. Tyrosine 26-34 mitogen-activated protein kinase 8 Homo sapiens 75-78 21737448-10 2011 Osmotic stress induced a robust increase in tyrosine phosphorylation of occludin, which was attenuated by BAPTA, SP600125 (JNK inhibitor), or PP2. Tyrosine 44-52 mitogen-activated protein kinase 8 Homo sapiens 123-126 21660049-1 2012 c-Jun N-terminal kinase (JNK) is activated by dual phosphorylation of both threonine and tyrosine residues in the phosphorylation loop of the protein in response to several stress factors. Tyrosine 89-97 mitogen-activated protein kinase 8 Homo sapiens 0-23 21660049-1 2012 c-Jun N-terminal kinase (JNK) is activated by dual phosphorylation of both threonine and tyrosine residues in the phosphorylation loop of the protein in response to several stress factors. Tyrosine 89-97 mitogen-activated protein kinase 8 Homo sapiens 25-28 23185569-11 2012 PTPRM coordinated cell migration and invasion through the regulation of tyrosine phosphorylation of ERK and JNK. Tyrosine 72-80 mitogen-activated protein kinase 8 Homo sapiens 108-111 22433870-0 2012 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). Tyrosine 0-8 mitogen-activated protein kinase 8 Homo sapiens 122-145 22433870-0 2012 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). Tyrosine 0-8 mitogen-activated protein kinase 8 Homo sapiens 147-150 22433870-0 2012 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). Tyrosine 0-3 mitogen-activated protein kinase 8 Homo sapiens 122-145 22433870-0 2012 Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). Tyrosine 0-3 mitogen-activated protein kinase 8 Homo sapiens 147-150 22006247-10 2012 Indeed, tunicamycin induced a robust activation of the inositol-requiring enzyme 1 (IRE-1)/c-JUN NH2-terminal kinase (JNK) pathway, leading to serine phosphorylation of insulin receptor substrate 1 (IRS-1) and a decrease in IRS-1 tyrosine phosphorylation. Tyrosine 230-238 mitogen-activated protein kinase 8 Homo sapiens 118-121 18713649-0 2008 JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Tyrosine 50-58 mitogen-activated protein kinase 8 Homo sapiens 0-3 22161830-10 2011 While integrin activation occurred, tyrosine-phosphorylation of paxillin, Fak and Src was significantly damped by JNK inhibition. Tyrosine 36-44 mitogen-activated protein kinase 8 Homo sapiens 114-117 20156194-2 2010 JNK activation is regulated by phosphorylation of specific tyrosine and threonine residues sequentially catalysed by MKK4 and MKK7, which are both dual-specificity MAPKKs (MAPK kinases). Tyrosine 59-67 mitogen-activated protein kinase 8 Homo sapiens 0-3 20156194-3 2010 Previously, we reported that tyrosine-phosphorylation of JNK by MKK4 precedes threonine-phosphorylation by MKK7, and that both are required for synergistic JNK activation. Tyrosine 29-37 mitogen-activated protein kinase 8 Homo sapiens 57-60 20156194-3 2010 Previously, we reported that tyrosine-phosphorylation of JNK by MKK4 precedes threonine-phosphorylation by MKK7, and that both are required for synergistic JNK activation. Tyrosine 29-37 mitogen-activated protein kinase 8 Homo sapiens 156-159 20649571-10 2010 PPTMB stimulated JNK phosphorylation at Thr(183)/Tyr(185). Tyrosine 49-52 mitogen-activated protein kinase 8 Homo sapiens 17-20 18713649-9 2008 Taken together, these results suggest that phosphorylation of paxillin on Ser 178 by JNK is required for the association of paxillin with FAK, and subsequent tyrosine phosphorylation of paxillin. Tyrosine 158-166 mitogen-activated protein kinase 8 Homo sapiens 85-88 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 177-185 mitogen-activated protein kinase 8 Homo sapiens 23-26 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 177-185 mitogen-activated protein kinase 8 Homo sapiens 101-104 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 217-220 mitogen-activated protein kinase 8 Homo sapiens 23-26 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 217-220 mitogen-activated protein kinase 8 Homo sapiens 101-104 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 228-231 mitogen-activated protein kinase 8 Homo sapiens 23-26 18713649-5 2008 Specific inhibition of JNK activation by inhibitor SP600125 or overexpression of a dominant-negative JNK mutant not only blocked EGF-induced cell migration, but also eliminated tyrosine phosphorylation of paxillin on Tyr 31 and Tyr 118. Tyrosine 228-231 mitogen-activated protein kinase 8 Homo sapiens 101-104 17848570-12 2007 Ethanol-induced oxidative stress enhanced the tyrosine phosphorylation of PKCdelta, which in turn caused the proteasomal degradation of MKP-1, leading to sustained JNK activation and increased apoptosis in VL-17A cells. Tyrosine 46-54 mitogen-activated protein kinase 8 Homo sapiens 164-167 17654528-1 2008 In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. Tyrosine 36-44 mitogen-activated protein kinase 8 Homo sapiens 171-174 18460189-8 2008 CONCLUSION: Exposure to DE (PM10, 300 mug/m3) caused enhanced EGFR expression and phosphorylation of the tyrosine residue (Tyr 1173) which is in accordance with the previously demonstrated activation of the JNK, AP-1, p38 MAPK and NFkB pathways and associated downstream signalling and cytokine production. Tyrosine 123-126 mitogen-activated protein kinase 8 Homo sapiens 207-210 17827708-6 2007 In the obesity-induced insulin resistant condition, JNK and p70S6K are activated and phosphorylate IRS-proteins, which diminishes the insulin-induced tyrosine phosphorylation of IRS-proteins and thereby impairs the PI 3-kinase/AKT activations. Tyrosine 150-158 mitogen-activated protein kinase 8 Homo sapiens 52-55 17637928-10 2007 Mutation of tyrosine to serine at the 21st amino acid of the Bcl-2 protein BH4 domain resulted in a loss both of suppression of JNK1/2 phosphorylation and its anti-apoptotic function. Tyrosine 12-20 mitogen-activated protein kinase 8 Homo sapiens 128-132 17488712-4 2007 A sensor for large neutral AA (e.g. Tyr, Gln) inhibits JNK activation and SNAT2 up-regulation. Tyrosine 36-39 mitogen-activated protein kinase 8 Homo sapiens 55-58 17392283-3 2007 Mutations of tyrosine residues Y674A and Y680A within the TIR domains of CD4-TLR4 impaired its ability to elicit phosphorylation of p38 and JNK mitogen-activated protein kinases, IkappaB-alpha degradation, and activation of NF-kappaB and RANTES reporters. Tyrosine 13-21 mitogen-activated protein kinase 8 Homo sapiens 140-143 17875416-8 2007 JNK then provides a signal for CD95/EGFR association and subsequent CD95 tyrosine phosphorylation, which is mediated by the EGFR tyrosine kinase activity. Tyrosine 73-81 mitogen-activated protein kinase 8 Homo sapiens 0-3 17242197-4 2007 We find that Src family kinases directly bind and tyrosine phosphorylate JIP1 under basal conditions in several naturally occurring systems and, by doing so, appear to provide a regulated signal that increases the affinity of JIP1 for DLK and maintains the JIP-JNK module in a catalytically inactive state. Tyrosine 50-58 mitogen-activated protein kinase 8 Homo sapiens 261-264 17239858-4 2007 However, the activation of JNK1/2 could be decreased by the elevation of Akt activation via increasing the tyrosine phosphorylation of PTEN by bpv(pic), a potent PTPases inhibitor for PTEN, or by intracerebroventricular infusion of PTEN antisense oligodeoxynucleotides (AS-ODNs). Tyrosine 107-115 mitogen-activated protein kinase 8 Homo sapiens 27-33 16442502-2 2006 MKK7 activates JNK via phosphorylation of a threonine and tyrosine residue in a Thr-Pro-Tyr motif within kinase subdomain VIII. Tyrosine 58-66 mitogen-activated protein kinase 8 Homo sapiens 15-18 16734756-5 2006 This complex process with a NADPH oxidase-derived reactive oxygen species signal as an important upstream event, allows via Yes, JNK and epidermal growth factor-receptor activation for CD95 tyrosine phosphorylation as a prerequisite for CD95 targeting to the plasma membrane and formation of the death inducing signalling complex. Tyrosine 190-198 mitogen-activated protein kinase 8 Homo sapiens 129-132 16442502-2 2006 MKK7 activates JNK via phosphorylation of a threonine and tyrosine residue in a Thr-Pro-Tyr motif within kinase subdomain VIII. Tyrosine 88-91 mitogen-activated protein kinase 8 Homo sapiens 15-18 15935618-2 2006 Interestingly, activation of p38 and JNK originates from tyrosine residue 861 in the OSMR; the same tyrosine residue which we identified before to be involved in the activation of the mitogen-activated kinases Erk1/2 [Hermanns, H. M., Radtke, S., Schaper, F., Heinrich, P. C., and Behrmann, I. Tyrosine 57-65 mitogen-activated protein kinase 8 Homo sapiens 37-40 15935618-2 2006 Interestingly, activation of p38 and JNK originates from tyrosine residue 861 in the OSMR; the same tyrosine residue which we identified before to be involved in the activation of the mitogen-activated kinases Erk1/2 [Hermanns, H. M., Radtke, S., Schaper, F., Heinrich, P. C., and Behrmann, I. Tyrosine 100-108 mitogen-activated protein kinase 8 Homo sapiens 37-40 16186332-9 2005 Treatment with mitomycin-C also increased the phosphotransferase activity and tyrosine phosphorylation of JNK1, whose inhibitor significantly suppressed the cytotoxicity of mitomycin-C. Tyrosine 78-86 mitogen-activated protein kinase 8 Homo sapiens 106-110 16099885-6 2005 Despite the similarity in these responses, the P387 variant induced more robust tyrosine phosphorylation of the stress-related mitogen-activated protein kinases (MAPKs): p38MAPK and c-Jun NH2-terminal kinase (JNK), as well as signal transducer and activator of transcription-1 (STAT1) and heat shock protein 27 (HSP27) than the A387 variant. Tyrosine 80-88 mitogen-activated protein kinase 8 Homo sapiens 182-207 16099885-6 2005 Despite the similarity in these responses, the P387 variant induced more robust tyrosine phosphorylation of the stress-related mitogen-activated protein kinases (MAPKs): p38MAPK and c-Jun NH2-terminal kinase (JNK), as well as signal transducer and activator of transcription-1 (STAT1) and heat shock protein 27 (HSP27) than the A387 variant. Tyrosine 80-88 mitogen-activated protein kinase 8 Homo sapiens 209-212 16150868-7 2006 Tyrosine phosphorylation of IRS-1 was recovered only by the IKK inhibitor or JNK inhibitor, suggesting specific involvement of these two kinases. Tyrosine 0-8 mitogen-activated protein kinase 8 Homo sapiens 77-80 14607833-2 2004 It is rapidly tyrosine-phosphorylated in response to receptor tyrosine activation and interacts with ras GTPase-activating protein and Nck, leading to inhibition of ras signaling pathway activation and the c-Jun N-terminal kinase (JNK) and c-Jun activation, respectively. Tyrosine 14-22 mitogen-activated protein kinase 8 Homo sapiens 206-229 16123438-10 2005 However, adding Tyr treatment stimulated the JNK1/2 and p38 pathways and modified the target transgene expression. Tyrosine 16-19 mitogen-activated protein kinase 8 Homo sapiens 45-51 16153436-10 2005 Furthermore, tyrosine residues in DOK1, the p85 subunit of phosphatidylinositol 3" kinase, JNK 1 and 2, P-38, and phospholipase-gamma were directly phosphorylated by RET. Tyrosine 13-21 mitogen-activated protein kinase 8 Homo sapiens 91-102 16153436-11 2005 CONCLUSIONS: RET directly phosphorylates tyrosine residues on FAK, ERK 1/2, DOK1, the p85 subunit of of phosphatidylinositol 3" kinase, JNK 1 and 2, P-38, and phospholipase-gamma. Tyrosine 41-49 mitogen-activated protein kinase 8 Homo sapiens 136-147 15271995-7 2004 Of these mutated residues, Leu-131 and Tyr-320 were located on a common face of the JNK protein close to other residues implicated previously in the interactions of MAPKs with substrates, phosphatases, and scaffolds. Tyrosine 39-42 mitogen-activated protein kinase 8 Homo sapiens 84-87 15001544-6 2004 RIN beta-cells exposed to high glucose exhibited increased c-Jun N-terminal kinase (JNK) and ERK1/2 activity, which was associated with increased IRS-1 phosphorylation at serine (Ser)(307) and Ser(612), respectively, that inhibits coupling of IRS-1 to the insulin receptor and is upstream of the inhibition of IRS-1 tyrosine phosphorylation. Tyrosine 316-324 mitogen-activated protein kinase 8 Homo sapiens 59-82 14607833-2 2004 It is rapidly tyrosine-phosphorylated in response to receptor tyrosine activation and interacts with ras GTPase-activating protein and Nck, leading to inhibition of ras signaling pathway activation and the c-Jun N-terminal kinase (JNK) and c-Jun activation, respectively. Tyrosine 14-22 mitogen-activated protein kinase 8 Homo sapiens 231-234 14607833-2 2004 It is rapidly tyrosine-phosphorylated in response to receptor tyrosine activation and interacts with ras GTPase-activating protein and Nck, leading to inhibition of ras signaling pathway activation and the c-Jun N-terminal kinase (JNK) and c-Jun activation, respectively. Tyrosine 62-70 mitogen-activated protein kinase 8 Homo sapiens 206-229 14607833-2 2004 It is rapidly tyrosine-phosphorylated in response to receptor tyrosine activation and interacts with ras GTPase-activating protein and Nck, leading to inhibition of ras signaling pathway activation and the c-Jun N-terminal kinase (JNK) and c-Jun activation, respectively. Tyrosine 62-70 mitogen-activated protein kinase 8 Homo sapiens 231-234 12758252-2 2003 JNK and p38 are activated by dual phosphorylation on threonine and tyrosine residues. Tyrosine 67-75 mitogen-activated protein kinase 8 Homo sapiens 0-3 12755958-4 2003 Interestingly, this single tyrosine residue represents a binding site for several signalling molecules including SHC, Enigma, SNT/FRS2, DOK and IRS1 and is responsible for activation of the RAS/ERK, PI3-K/AKT, JNK, p38MAPK and ERK5 signalling pathways. Tyrosine 27-35 mitogen-activated protein kinase 8 Homo sapiens 210-213 12624093-2 2003 SAPK/JNK activation requires the phosphorylation of both Thr and Tyr residues in its Thr-Pro-Tyr motif, and SEK1 and MKK7 have been identified as the dual specificity kinases. Tyrosine 65-68 mitogen-activated protein kinase 8 Homo sapiens 5-8 12624093-2 2003 SAPK/JNK activation requires the phosphorylation of both Thr and Tyr residues in its Thr-Pro-Tyr motif, and SEK1 and MKK7 have been identified as the dual specificity kinases. Tyrosine 93-96 mitogen-activated protein kinase 8 Homo sapiens 5-8 12624093-9 2003 These results indicate that the Tyr and Thr residues of SAPK/JNK are sequentially phosphorylated by SEK1 and MKK7, respectively, in the stress-stimulated ES cells. Tyrosine 32-35 mitogen-activated protein kinase 8 Homo sapiens 61-64 12624093-6 2003 On the other hand, Thr phosphorylation of JNK in sek1(-/-) cells was also attenuated in addition to a decreased level of its Tyr phosphorylation. Tyrosine 125-128 mitogen-activated protein kinase 8 Homo sapiens 42-45 12624093-7 2003 Analysis in human embryonic kidney 293T cells transfected with a kinase-dead SEK1 or a Thr-Pro-Phe mutant of JNK1 revealed that SEK1-induced Tyr phosphorylation of JNK1 was followed by additional Thr phosphorylation by MKK7. Tyrosine 141-144 mitogen-activated protein kinase 8 Homo sapiens 109-113 12624093-7 2003 Analysis in human embryonic kidney 293T cells transfected with a kinase-dead SEK1 or a Thr-Pro-Phe mutant of JNK1 revealed that SEK1-induced Tyr phosphorylation of JNK1 was followed by additional Thr phosphorylation by MKK7. Tyrosine 141-144 mitogen-activated protein kinase 8 Homo sapiens 164-168 12554784-5 2003 Finally, the MKK7 mutant, which activates JNK, reduced tyrosine phosphorylation of IRS-1 and IRS-2 and IRS-associated PI3K activity without affecting expression of the IR, IRS-1, or IRS-2. Tyrosine 55-63 mitogen-activated protein kinase 8 Homo sapiens 42-45 12514174-10 2003 Alteration of Tyr(33) to Arg(33) in WOX1 abrogated its binding interaction with JNK1 and its activity in mediating cell death, indicating that Tyr(33) phosphorylation is needed to activate WOX1. Tyrosine 14-17 mitogen-activated protein kinase 8 Homo sapiens 80-84 12119061-7 2002 RESULTS: We found that a tyrosine phosphorylated Cas substrate domain acts as a dominant negative mutant by blocking Cas-mediated signaling events, including JNK activation by the oncogene v-crk in transient and stable lines and v-crk transformation. Tyrosine 25-33 mitogen-activated protein kinase 8 Homo sapiens 158-161 12087092-7 2002 This suggested that the association of Nck to tyrosine 361 in Dok1 is necessary for the JNK and c-Jun activation by glial cell line-derived neurotrophic factor or RET-MEN2B. Tyrosine 46-54 mitogen-activated protein kinase 8 Homo sapiens 88-91 10849438-0 2000 Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription. Tyrosine 0-8 mitogen-activated protein kinase 8 Homo sapiens 108-111 11971192-4 2002 Here, we demonstrate that the tyrosine-specific and constitutively-expressed phosphatase VHR (for VH1-Related) down-regulates the JNK signaling pathway at the level of JNK dephosphorylation. Tyrosine 30-38 mitogen-activated protein kinase 8 Homo sapiens 130-133 11971192-4 2002 Here, we demonstrate that the tyrosine-specific and constitutively-expressed phosphatase VHR (for VH1-Related) down-regulates the JNK signaling pathway at the level of JNK dephosphorylation. Tyrosine 30-38 mitogen-activated protein kinase 8 Homo sapiens 168-171 11278622-8 2001 MEKK2 also synergized with anti-CD3 antibody to activate JNK in T cells, and stimulation of T cells led to induction of MEKK2 tyrosine phosphorylation. Tyrosine 126-134 mitogen-activated protein kinase 8 Homo sapiens 57-60 11418587-5 2001 Analysis in HeLa cells co-transfected with the two MAPK kinases revealed that the Thr and Tyr of SAPK/JNK were independently phosphorylated in response to heat shock by MKK7gamma1 and SEK1, respectively. Tyrosine 90-93 mitogen-activated protein kinase 8 Homo sapiens 102-105 11418587-9 2001 These data provide the first evidence that synergistic activation of SAPK/JNK requires both phosphorylation at the Thr and Tyr residues in living cells and that the preference for the Thr and Tyr phosphorylation was different among the members of MAPK kinases. Tyrosine 123-126 mitogen-activated protein kinase 8 Homo sapiens 74-77 11418587-9 2001 These data provide the first evidence that synergistic activation of SAPK/JNK requires both phosphorylation at the Thr and Tyr residues in living cells and that the preference for the Thr and Tyr phosphorylation was different among the members of MAPK kinases. Tyrosine 192-195 mitogen-activated protein kinase 8 Homo sapiens 74-77 10602026-4 2000 These events are associated with a signaling pathway involving tyrosine phosphorylation of Vav and SLP-76, activation and capping of Rac-1, a protein previously linked with cytoskeletal reorganization, and activation of JNK. Tyrosine 63-71 mitogen-activated protein kinase 8 Homo sapiens 220-223 10506143-2 1999 JNK is activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and tyrosine (Tyr) 185 residues. Tyrosine 180-188 mitogen-activated protein kinase 8 Homo sapiens 0-3 10521505-5 1999 We further demonstrate that JNK1, activated by its upstream kinase MKK7, negatively regulated the tyrosine phosphorylation and DNA binding and transcriptional activities of Stat3 stimulated by EGF. Tyrosine 98-106 mitogen-activated protein kinase 8 Homo sapiens 28-32 10506143-2 1999 JNK is activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and tyrosine (Tyr) 185 residues. Tyrosine 180-188 mitogen-activated protein kinase 8 Homo sapiens 20-23 10506143-2 1999 JNK is activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and tyrosine (Tyr) 185 residues. Tyrosine 190-193 mitogen-activated protein kinase 8 Homo sapiens 0-3 10506143-2 1999 JNK is activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and tyrosine (Tyr) 185 residues. Tyrosine 190-193 mitogen-activated protein kinase 8 Homo sapiens 20-23 10506143-7 1999 Immunoblotting analysis indicated that JNK1 was phosphorylated by JNKK2 in the fusion protein on both Thr(183) and Tyr(185) residues. Tyrosine 115-118 mitogen-activated protein kinase 8 Homo sapiens 39-43 10085098-9 1999 These findings indicate that RAFTK-dependent induction of JNK in response to MMS is sensitive to Bcl-xL, but not to CrmA and p35, by a mechanism that inhibits tyrosine phosphorylation and thereby activation of RAFTK. Tyrosine 159-167 mitogen-activated protein kinase 8 Homo sapiens 58-61 10438480-8 1999 In contrast, leukocyte MP stimulated a sustained, time-dependent increased tyrosine phosphorylation of approximately 46-kDa c-Jun NH(2)-terminal kinase (JNK1) in EC. Tyrosine 75-83 mitogen-activated protein kinase 8 Homo sapiens 153-157 9207092-1 1997 The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr. Tyrosine 128-131 mitogen-activated protein kinase 8 Homo sapiens 31-34 9627110-8 1998 The pathway leading to the activation of JNK by RET is clearly divergent from that leading to the activation of ERK: substitution of the tyrosine 1062 of Ret, the Shc binding site, for phenylalanine abrogates ERK but not JNK activation. Tyrosine 137-145 mitogen-activated protein kinase 8 Homo sapiens 41-44 9312068-2 1997 JNK is activated by JNK-activating kinase 1 (JNKK1), a dual specificity protein kinase that phosphorylates JNK on threonine 183 and tyrosine 185 residues. Tyrosine 132-140 mitogen-activated protein kinase 8 Homo sapiens 0-3 9312068-2 1997 JNK is activated by JNK-activating kinase 1 (JNKK1), a dual specificity protein kinase that phosphorylates JNK on threonine 183 and tyrosine 185 residues. Tyrosine 132-140 mitogen-activated protein kinase 8 Homo sapiens 20-23 9891090-2 1999 JNK activation is regulated by phosphorylation on both Thr and Tyr residues by a dual-specificity MAPK kinase (MAPKK). Tyrosine 63-66 mitogen-activated protein kinase 8 Homo sapiens 0-3 9603971-4 1998 High glucose treatment activated the tyrosine phosphorylation of both p38 kinase and JNK in a dose- and time-dependent fashion. Tyrosine 37-45 mitogen-activated protein kinase 8 Homo sapiens 85-88 9661668-8 1998 An in-vitro kinase assay demonstrated that JNK1 activation by hJNKK2 alpha requires phosphorylation of the theronine and tyrosine residues at positions 183 and 185 in JNK1. Tyrosine 121-129 mitogen-activated protein kinase 8 Homo sapiens 43-47 9661668-8 1998 An in-vitro kinase assay demonstrated that JNK1 activation by hJNKK2 alpha requires phosphorylation of the theronine and tyrosine residues at positions 183 and 185 in JNK1. Tyrosine 121-129 mitogen-activated protein kinase 8 Homo sapiens 167-171 9207092-1 1997 The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr. Tyrosine 128-131 mitogen-activated protein kinase 8 Homo sapiens 4-29 9099744-6 1997 In this report we demonstrate that conditioning human glomerular mesangial cells with IL-1beta results in the tyrosine phosphorylation and activation of two members of the MAP kinase family, extracellular signal-regulated protein kinase 2 (ERK2) and p54 Jun-NH2-terminal kinase (JNK). Tyrosine 110-118 mitogen-activated protein kinase 8 Homo sapiens 254-277 9153555-6 1997 Ligation of the Fas molecule on RA synoviocytes induced a rapid tyrosine phosphorylation of JNK (c-Jun amino-terminal kinase) and formation of the AP-1 transcription factor. Tyrosine 64-72 mitogen-activated protein kinase 8 Homo sapiens 92-95 9153555-6 1997 Ligation of the Fas molecule on RA synoviocytes induced a rapid tyrosine phosphorylation of JNK (c-Jun amino-terminal kinase) and formation of the AP-1 transcription factor. Tyrosine 64-72 mitogen-activated protein kinase 8 Homo sapiens 97-124 9175761-6 1997 Mutant beta c lacking all the tyr residues hardly activates JNK, thereby indicating that the tyr residue(s) is essential for the activation of JNK. Tyrosine 93-96 mitogen-activated protein kinase 8 Homo sapiens 143-146 9099744-6 1997 In this report we demonstrate that conditioning human glomerular mesangial cells with IL-1beta results in the tyrosine phosphorylation and activation of two members of the MAP kinase family, extracellular signal-regulated protein kinase 2 (ERK2) and p54 Jun-NH2-terminal kinase (JNK). Tyrosine 110-118 mitogen-activated protein kinase 8 Homo sapiens 279-282 8824287-7 1996 In addition, JNK activation by PMA plus ionophore was sensitive to inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation, which failed to inhibit the activation mediated by PDTC. Tyrosine 138-146 mitogen-activated protein kinase 8 Homo sapiens 13-16 8925912-2 1996 They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress-activated protein kinase-1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress-activated protein kinase-2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2). Tyrosine 39-47 mitogen-activated protein kinase 8 Homo sapiens 101-134 8654373-1 1996 The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Tyrosine 130-138 mitogen-activated protein kinase 8 Homo sapiens 4-7 8047888-2 1994 A mammalian protein kinase, Jnk, which is a distant relative of the mitogen-activated protein kinase group, was activated by phosphorylation on threonine and tyrosine in osmotically shocked cells. Tyrosine 158-166 mitogen-activated protein kinase 8 Homo sapiens 28-31 7565768-11 1995 In contrast, genistein, in concentrations sufficient to inhibit Ca(2+)-dependent tyrosine phosphorylation, prevented Ang II and thapsigargin-induced JNK activation. Tyrosine 81-89 mitogen-activated protein kinase 8 Homo sapiens 149-152 7565768-13 1995 The inhibition by genistein suggest that Ca(2+)-dependent tyrosine phosphorylation may modulate the JNK pathway in a cell type-specific manner, particularly in cells with a readily detectable Ca(2+)-regulated tyrosine kinase. Tyrosine 58-66 mitogen-activated protein kinase 8 Homo sapiens 100-103 17180058-8 1996 JNK1, a relative of the MAP kinase group, is activated by dual phosphorylation at Thr and Tyr during the UV response. Tyrosine 90-93 mitogen-activated protein kinase 8 Homo sapiens 0-4 8607977-18 1995 Evidence is presented here to demonstrate that Jnk is a distant relative of the MAP kinase group that is activated by dual phosphorylation at Tyr and Thr. Tyrosine 142-145 mitogen-activated protein kinase 8 Homo sapiens 47-50 7535770-1 1995 Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. Tyrosine 53-56 mitogen-activated protein kinase 8 Homo sapiens 126-129 8137421-3 1994 Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr during the UV response. Tyrosine 166-169 mitogen-activated protein kinase 8 Homo sapiens 64-68