PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31372222-10 2018 These results suggest that NO donors such as SNAP and SNP induce fibrinogen conformational changes by potentially nitrosating fibrinogen tyrosine residues. Tyrosine 137-145 fibrinogen beta chain Homo sapiens 65-75 31112078-1 2019 In the current study, we have developed predictive quantitative structure-activity relationship (QSAR) models for cellular response (foetal rate lung fibroblast proliferation) and protein adsorption (fibrinogen adsorption (FA)) on the surface of tyrosine-derived biodegradable polymers designed for tissue engineering purpose using a dataset of 66 and 40 biodegradable polymers, respectively, employing two-dimensional molecular descriptors. Tyrosine 246-254 fibrinogen beta chain Homo sapiens 200-210 31372222-10 2018 These results suggest that NO donors such as SNAP and SNP induce fibrinogen conformational changes by potentially nitrosating fibrinogen tyrosine residues. Tyrosine 137-145 fibrinogen beta chain Homo sapiens 126-136 20507587-9 2010 Pyk2 was tyrosine phosphorylated upon adhesion of dHL60 cells to plated fibrinogen in the presence of fMLP. Tyrosine 9-17 fibrinogen beta chain Homo sapiens 72-82 21301788-1 2011 A novel dysfibrinogenaemia with a replacement of Tyr by Asn at Bbeta41 has been discovered (fibrinogen Caracas VIII). Tyrosine 49-52 fibrinogen beta chain Homo sapiens 11-21 26461400-0 2014 Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease. Tyrosine 14-22 fibrinogen beta chain Homo sapiens 40-50 26461400-4 2014 The aim of this study was to map tyrosine nitration in fibrinogen under oxidative conditions and identify susceptible residues. Tyrosine 33-41 fibrinogen beta chain Homo sapiens 55-65 17467041-2 2007 Using fluorescence and spectrophotometric methods, we estimated that about 0.5, 2 and 8 tyrosine residues per molecule were nitrated following the reaction of Fg at concentration 5.88 muM with 10, 100 and 1000 muM PN, respectively. Tyrosine 88-96 fibrinogen beta chain Homo sapiens 159-161 19588915-6 2009 The likely cause of enhanced clot turbidity and delay in fibrinolysis was revealed by a crystal structure of the D-dimer from human fibrinogen cocrystallized with GHRPYam, the packing of which showed the direct involvement of the ligand tyrosines in antiparallel betaC-betaC interactions. Tyrosine 237-246 fibrinogen beta chain Homo sapiens 132-142 17291015-10 2007 Some of the tyrosine-derived polycarbonates were identified as useful materials for the design of blood-contacting implants on the basis of their substantially lower levels of fibrinogen adsorption relative to the commonly used controls. Tyrosine 12-20 fibrinogen beta chain Homo sapiens 176-186 19631267-2 2009 Recent small studies report that fibrinogen oxidative modifications, specifically tyrosine residue nitration, can occur in inflammatory states and may modify fibrinogen function. Tyrosine 82-90 fibrinogen beta chain Homo sapiens 33-43 19631267-2 2009 Recent small studies report that fibrinogen oxidative modifications, specifically tyrosine residue nitration, can occur in inflammatory states and may modify fibrinogen function. Tyrosine 82-90 fibrinogen beta chain Homo sapiens 158-168 18818200-0 2008 Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. Tyrosine 22-30 fibrinogen beta chain Homo sapiens 0-10 18818200-2 2008 We hypothesized that a potential mechanism for an increased prothrombotic state is the post-translational modification of fibrinogen by tyrosine nitration. Tyrosine 136-144 fibrinogen beta chain Homo sapiens 122-132 18818200-3 2008 Mass spectrometry identified tyrosine residues 292 and 422 at the carboxyl terminus of the beta-chain as the principal sites of fibrinogen nitration in vivo. Tyrosine 29-37 fibrinogen beta chain Homo sapiens 128-138 18818200-6 2008 The rate of fibrin clot formation and clot architecture was restored upon depletion of the tyrosine-nitrated fibrinogen molecules. Tyrosine 91-99 fibrinogen beta chain Homo sapiens 109-119 17539777-2 2007 GPVI is co-associated with Fc receptor gamma-chain (FcRgamma), which contains a cytoplasmic immunoreceptor tyrosine-based activation motif domain, involved in activation of Syk, and a signalling cascade leading to (i) activation of alpha(IIb)beta(3), which binds VWF and fibrinogen and mediates platelet aggregation, and (ii) metalloproteinase-mediated shedding of the GPVI ectodomain (blocked by Syk inhibitors), a key mechanism for regulating GPVI surface expression. Tyrosine 107-115 fibrinogen beta chain Homo sapiens 271-281 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 28-30 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 163-165 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 163-165 15457437-4 2004 When FBG was prepared by the 2KBr method and pressure was increased up to 400 kg/cm(2), peaks at 1625 (intermolecular beta-sheet) and 1611 (beta-sheet aggregates structure and/or the side-chain absorption of the tyrosine residues) cm(-1) were enhanced. Tyrosine 212-220 fibrinogen beta chain Homo sapiens 5-8 15711748-0 2005 CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen. Tyrosine 29-37 fibrinogen beta chain Homo sapiens 82-92 14566784-9 2003 Platelets markedly amplified the anti-phosphotyrosine staining on both fibrinogen- and IgG-coated surfaces whereas the low level of tyrosine phosphorylation in neutrophils on albumin-coated surfaces was not further elevated by platelets. Tyrosine 45-53 fibrinogen beta chain Homo sapiens 71-81 15229106-5 2004 Fibrinogen enhanced fMLP-induced tyrosine phosphorylation in human neutrophils and markedly enhanced the phosphorylation of mitogen-activated protein kinases (MAPK) caused by fMLP. Tyrosine 33-41 fibrinogen beta chain Homo sapiens 0-10 15613026-6 2004 This novel His-->Tyr substitution was not detected when plasma fibrinogen was analyzed by electrospray ionization mass spectrometry. Tyrosine 17-20 fibrinogen beta chain Homo sapiens 63-73 14762929-5 2004 The screening assay was used to measure the adsorption of human fibrinogen on 46 test polymers (44 polyarylates selected from a combinatorial library of tyrosine-derived polyarylates, and two lactide-based polymers). Tyrosine 153-161 fibrinogen beta chain Homo sapiens 64-74 11901150-3 2002 Thrombin recognizes fibrinogen with an extended binding surface, key elements of which are Tyr(76) in exosite I, located about 20 A away from the active site, and the aryl binding site located in close proximity to the catalytic triad. Tyrosine 91-94 fibrinogen beta chain Homo sapiens 20-30 12189015-5 2002 The different susceptibility in tyrosine nitration of fibrinogen subunits was also observed. Tyrosine 32-40 fibrinogen beta chain Homo sapiens 54-64 12049640-4 2002 In sharp contrast, although fibrinogen binding to platelets stimulates alphaIIbbeta3-dependent activation of Syk and tyrosine phosphorylation of SLP-76 and PLCgamma2, it does not utilize GEMs to promote these responses or to support platelet aggregation. Tyrosine 117-125 fibrinogen beta chain Homo sapiens 28-38 11311131-5 2001 Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tyrosine 31-39 fibrinogen beta chain Homo sapiens 112-122 11460503-1 2001 Platelet adhesion to low-density coated fibrinogen induces greater protein tyrosine phosphorylation of SYK and FAK than adhesion to high-density coated fibrinogen, and leads to activation of integrin alpha IIb beta 3 on the luminal side of adherent platelets. Tyrosine 75-83 fibrinogen beta chain Homo sapiens 40-50 11311131-4 2001 In addition, direct activation of protein kinase C with PMA resulted in tyrosine phosphorylation of Hic-5 only when platelets were fully aggregated with the exogenous addition of fibrinogen. Tyrosine 72-80 fibrinogen beta chain Homo sapiens 179-189 10749687-6 2000 In contrast, direct activation of PKC with the active phorbol ester PMA induced the tyrosine phosphorylation of Pyk2 and FAK but only when platelets were fully aggregated with the exogenous addition of fibrinogen (the ligand for alphaIIbbeta3 integrin). Tyrosine 84-92 fibrinogen beta chain Homo sapiens 202-212 11050236-4 2000 Interaction of soluble or immobilized fibrinogen with normal human or murine platelets triggers rapid tyrosine phosphorylation of SLP-76. Tyrosine 102-110 fibrinogen beta chain Homo sapiens 38-48 11050236-5 2000 Moreover, platelet adhesion to fibrinogen stimulates actin rearrangements, filopodial and lamellipodial extension, and localization of tyrosine phosphorylated proteins to the cell periphery. Tyrosine 135-143 fibrinogen beta chain Homo sapiens 31-41 10864922-2 2000 In our studies, the ligation of Fg to ICAM-1 on tumor necrosis factor-alpha-stimulated endothelial cells resulted in the tyrosine phosphorylation of Src homology domain 2 (SH2)-containing phosphatase-2 (SHP-2). Tyrosine 121-129 fibrinogen beta chain Homo sapiens 32-34 10961871-6 2000 Cell attachment to fibrinogen caused the enhanced tyrosine phosphorylation of Pyk2 and the initial tyrosine phosphorylation of Syk, which was also inhibited by pretreatment with anti-beta2 integrin antibody. Tyrosine 99-107 fibrinogen beta chain Homo sapiens 19-29 10961871-6 2000 Cell attachment to fibrinogen caused the enhanced tyrosine phosphorylation of Pyk2 and the initial tyrosine phosphorylation of Syk, which was also inhibited by pretreatment with anti-beta2 integrin antibody. Tyrosine 50-58 fibrinogen beta chain Homo sapiens 19-29 10749687-7 2000 Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tyrosine 40-48 fibrinogen beta chain Homo sapiens 121-131 10865942-0 2000 Interaction of fibrinogen with saphenous vein endothelial cells stimulates tyrosine phosphorylation of cortactin. Tyrosine 75-83 fibrinogen beta chain Homo sapiens 15-25 10865942-2 2000 We have investigated the effect of fibrinogen on the tyrosine phosphorylation of cortactin, a cytoskeletal protein in human saphenous vein endothelial cells (HSVECs). Tyrosine 53-61 fibrinogen beta chain Homo sapiens 35-45 10865942-3 2000 Incubation of HSVECs with fibrinogen (0-4 microM) caused a concentration-dependent increase in the tyrosine phosphorylation of cortactin. Tyrosine 99-107 fibrinogen beta chain Homo sapiens 26-36 10865942-4 2000 Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. Tyrosine 96-104 fibrinogen beta chain Homo sapiens 0-10 10865942-4 2000 Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. Tyrosine 96-104 fibrinogen beta chain Homo sapiens 26-36 10865942-6 2000 At physiological concentrations fibrinogen binds to receptors (probably including ICAM-1) on HSVECs, to increase tyrosine phosphorylation of cortactin. Tyrosine 113-121 fibrinogen beta chain Homo sapiens 32-42 10543983-7 1999 Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen. Tyrosine 106-109 fibrinogen beta chain Homo sapiens 143-153 10207014-4 1999 Incubation of Raji with Fg resulted in the increased tyrosine phosphorylation of the receptor-associated tyrosine kinase, pp60(Src) and extracellular signal-regulated kinase-1 (ERK). Tyrosine 53-61 fibrinogen beta chain Homo sapiens 24-26 10521087-4 1999 The addition of inhibitors 5 minutes after adenosine diphosphate-induced fibrinogen binding also resulted in decreased tyrosine phosphorylation and dissociation of approximately 50% of bound fibrinogen within 60 minutes but failed to cause dissociation of irreversibly bound fibrinogen. Tyrosine 119-127 fibrinogen beta chain Homo sapiens 73-83 10207014-6 1999 100 microM amounts of Fg peptide gamma-(117-133) caused an increase in tyrosine phosphorylation of ERK-1. Tyrosine 71-79 fibrinogen beta chain Homo sapiens 22-24 9753458-0 1998 Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. Tyrosine 16-24 fibrinogen beta chain Homo sapiens 130-140 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Tyrosine 14-17 fibrinogen beta chain Homo sapiens 65-75 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Tyrosine 14-17 fibrinogen beta chain Homo sapiens 120-130 10213272-5 1999 Our results demonstrated that, in neutrophils adherent to fibrinogen, PP1 inhibited TNFalpha-stimulated superoxide production and protein tyrosine phosphorylation in a dose-dependent manner. Tyrosine 138-146 fibrinogen beta chain Homo sapiens 58-68 9753458-2 1998 We have examined the requirement for Phe at this position by constructing a variant recombinant fibrinogen with a conservative substitution of tyrosine for phenylalanine, Aalpha F8Y fibrinogen. Tyrosine 143-151 fibrinogen beta chain Homo sapiens 96-106 8547637-0 1996 Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen. Tyrosine 27-35 fibrinogen beta chain Homo sapiens 89-99 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 153-161 fibrinogen beta chain Homo sapiens 32-42 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 153-161 fibrinogen beta chain Homo sapiens 126-136 9694716-8 1998 In addition, the binding of soluble fibrinogen to the cells adherent to fibrinogen-coated plate resulted in tyrosine phosphorylation of integrin beta3 and a complex formation of integrin beta3 with Syk. Tyrosine 108-116 fibrinogen beta chain Homo sapiens 36-46 9694716-8 1998 In addition, the binding of soluble fibrinogen to the cells adherent to fibrinogen-coated plate resulted in tyrosine phosphorylation of integrin beta3 and a complex formation of integrin beta3 with Syk. Tyrosine 108-116 fibrinogen beta chain Homo sapiens 72-82 9590268-4 1998 In the present study, we observed increased tyrosine phosphorylation of both focal adhesion kinase and Syk in FMLP-activated PMNs that had been plated onto fibrinogen; an increase in Syk activity, but not focal adhesion kinase activity, was apparent. Tyrosine 44-52 fibrinogen beta chain Homo sapiens 156-166 9022036-3 1997 We demonstrate that vitronectin and fibrinogen, but not laminin or collagen, are also able to both facilitate degranulation in the presence of substimulatory anti-CD3 and stimulate tyrosine phosphorylation of these 115-125-kDa proteins, with a 115-kDa protein being the most prominently phosphorylated. Tyrosine 181-189 fibrinogen beta chain Homo sapiens 36-46 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 52-60 fibrinogen beta chain Homo sapiens 32-42 9523019-1 1997 The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. Tyrosine 79-87 fibrinogen beta chain Homo sapiens 56-66 9057641-13 1997 Our findings suggest that binding of NNKY5-5 to GPIb potentiates platelet aggregation by facilitating the interaction between fibrinogen and GPIIb/IIIa through a mechanism associated with p72syk activation and tyrosine phosphorylation of a 64-kD protein. Tyrosine 210-218 fibrinogen beta chain Homo sapiens 126-136 8547637-1 1996 Platelet adhesion to immobilized fibrinogen stimulates the induction of tyrosine phosphorylation of multiple proteins. Tyrosine 72-80 fibrinogen beta chain Homo sapiens 33-43 7519620-7 1994 Protein tyrosine phosphorylation increased in PMN plated on fibrinogen and this phosphorylation was enhanced by TNF. Tyrosine 8-16 fibrinogen beta chain Homo sapiens 60-70 7961845-7 1994 Furthermore, fibrinogen binding to alpha IIb beta 3 stimulated directly with an anti-beta 3 antibody activated pp72syk 3-fold and stimulated its tyrosine phosphorylation. Tyrosine 145-153 fibrinogen beta chain Homo sapiens 13-23 7519620-11 1994 We found that the fgr protein-tyrosine kinase (p58fgr) activity, and its extent of phosphorylation in tyrosine, in PMN adherent to fibrinogen, was enhanced by TNF. Tyrosine 30-38 fibrinogen beta chain Homo sapiens 131-141 7518445-9 1994 Binding of fibrinogen or PAC1 IgM to platelets induced tyrosine phosphorylation of a 140-kDa platelet protein, but binding of PAC1 Fab did not. Tyrosine 55-63 fibrinogen beta chain Homo sapiens 11-21 21244912-3 1993 Tyrosine phosphorylation of several platelet proteins is regulated by fibrinogen binding to its integrin receptor and subsequent platelet aggregation, suggesting specific functions for tyrosine phosphorylation in integrin-regulated intracellular processes. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 70-80 21244912-3 1993 Tyrosine phosphorylation of several platelet proteins is regulated by fibrinogen binding to its integrin receptor and subsequent platelet aggregation, suggesting specific functions for tyrosine phosphorylation in integrin-regulated intracellular processes. Tyrosine 185-193 fibrinogen beta chain Homo sapiens 70-80 34943112-3 2021 The analyses of structural modifications of human fibrinogen under oxidative stress conditions (C-ELISA, SDS-PAGE and Western blot) revealed that the extracts (at a concentration of 1-5 microg/mL) considerably reduced the nitration of tyrosine residues and formation of high-molecular-weight aggregates. Tyrosine 235-243 fibrinogen beta chain Homo sapiens 50-60 1385445-6 1992 These results indicate that tyrosine phosphorylation of pp125FAK is dependent on platelet aggregation mediated by fibrinogen binding to the integrin receptor GP IIb-IIIa. Tyrosine 28-36 fibrinogen beta chain Homo sapiens 114-124 7686553-3 1993 In this report, we examined whether fibrinogen binding, per se, triggers a process of tyrosine phosphorylation in the absence of exogenous agonists. Tyrosine 86-94 fibrinogen beta chain Homo sapiens 36-46 7686553-5 1993 Proteins of 50-68 KD and 140 kD became phosphorylated on tyrosine residues in a fibrinogen-dependent manner. Tyrosine 57-65 fibrinogen beta chain Homo sapiens 80-90 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 88-98 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 21-29 fibrinogen beta chain Homo sapiens 0-10 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 21-29 fibrinogen beta chain Homo sapiens 110-120 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 172-180 fibrinogen beta chain Homo sapiens 0-10 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 172-180 fibrinogen beta chain Homo sapiens 110-120 1421580-4 1992 Stimulation of these cells either by adhesion to fibrinogen or with antiserum directed against alpha IIb beta 3 results in induction of calcium oscillations, followed by tyrosine phosphorylation of at least one protein of molecular weight approximately 125 kDa. Tyrosine 170-178 fibrinogen beta chain Homo sapiens 49-59 1892842-6 1991 These results clarify previous findings of the sulfation of tyrosine in human fibrinogen. Tyrosine 60-68 fibrinogen beta chain Homo sapiens 78-88 34994377-2 2022 First described in human fibrinogen, tyrosine-O-sulfation has long been associated with the modulation of protein-protein interactions in several physiological processes. Tyrosine 37-45 fibrinogen beta chain Homo sapiens 25-35 2819242-7 1989 The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization. Tyrosine 80-88 fibrinogen beta chain Homo sapiens 200-210 6636042-0 1983 Comparative study of the iodination of tyrosines in the amino terminal domain of fibrinogen and in N-DSK and fibrin-N-DSK. Tyrosine 39-48 fibrinogen beta chain Homo sapiens 81-91 6636042-1 1983 Lactoperoxidase catalyzed iodination has been used to probe for differences in surface orientation of tyrosine residues in the amino-terminal disulfide knot (N-DSK) domain of fibrinogen, in N-DSK and in Fb-N-DSK prepared from fibrin. Tyrosine 102-110 fibrinogen beta chain Homo sapiens 175-185 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tyrosine 169-177 fibrinogen beta chain Homo sapiens 11-21 479159-1 1979 A study of those tyrosines in fibrinogen which are surface-oriented and which may be involved in polymerization has been investigated using as a probe iodination catalyzed by lactoperoxidase. Tyrosine 17-26 fibrinogen beta chain Homo sapiens 30-40 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tyrosine 169-177 fibrinogen beta chain Homo sapiens 88-98 291382-18 1978 Amino termini of the fibrinogen moiety of cryofibrinogen were found to consist of alanine, tyrosine, and a small quantity of aspartic acid, consistent with the NH2 terminal moiety composition of normal fibrinogen but not of soluble fibrin monomer complex. Tyrosine 91-99 fibrinogen beta chain Homo sapiens 21-31 638197-0 1978 Four states of tyrosine residues in the fibrinogen molecule. Tyrosine 15-23 fibrinogen beta chain Homo sapiens 40-50 638197-1 1978 The ionization of tyrosine residues in fibrinogen was studied by a spectrophotometric method. Tyrosine 18-26 fibrinogen beta chain Homo sapiens 39-49 638197-2 1978 The total of 100 tyrosine residues in the fibrinogen molecule was classified into four states: (1) 28 tyrosine residues with pK 10.1 (m = 1.0). Tyrosine 17-25 fibrinogen beta chain Homo sapiens 42-52 638197-2 1978 The total of 100 tyrosine residues in the fibrinogen molecule was classified into four states: (1) 28 tyrosine residues with pK 10.1 (m = 1.0). Tyrosine 102-110 fibrinogen beta chain Homo sapiens 42-52 638197-6 1978 The ionization characteristics of tyrosine residues in plasmin-digested fibrinogen were similar to those of fibrinogen, while in CNBr-treated fibrinogen they were fairly different. Tyrosine 34-42 fibrinogen beta chain Homo sapiens 72-82 6029930-1 1967 I. Helical content and the role of the tyrosine moiety in the fibrinogen molecule. Tyrosine 39-47 fibrinogen beta chain Homo sapiens 62-72 240516-4 1975 The amount of tyrosine liberated from the fibrinogen is measured and is related to activity. Tyrosine 14-22 fibrinogen beta chain Homo sapiens 42-52 33245842-5 2021 RESULT: Molecular analysis revealed a novel homozygous missense mutation in FGB exon 5, p.Cys241 Tyr, that was named "Fibrinogen Krakow V". Tyrosine 97-100 fibrinogen beta chain Homo sapiens 76-79 33245842-5 2021 RESULT: Molecular analysis revealed a novel homozygous missense mutation in FGB exon 5, p.Cys241 Tyr, that was named "Fibrinogen Krakow V". Tyrosine 97-100 fibrinogen beta chain Homo sapiens 118-128 33548450-12 2021 Different tyrosine nitration patterns were also observed in fibrinogen modified in vitro and in vivo, suggesting differences in the nitration process in these situations. Tyrosine 10-18 fibrinogen beta chain Homo sapiens 60-70 33548450-13 2021 This is the first study showing a putative association between the nitration profile of specific tyrosine residues in human fibrinogen and ischemic stroke. Tyrosine 97-105 fibrinogen beta chain Homo sapiens 124-134