PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27101103-0 2016 Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. Tyrosine 0-8 caspase 8 Homo sapiens 28-37 27109099-0 2016 Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex. Tyrosine 10-18 caspase 8 Homo sapiens 0-9 27109099-2 2016 However, the observation that caspase-8 is upregulated in many common tumour types led to the discovery of alternative non-apoptotic, pro-survival functions, many of which are contingent on phosphorylation of a tyrosine residue (Y380) found in the linker region between the two catalytic domains of the enzyme. Tyrosine 211-219 caspase 8 Homo sapiens 30-39 34367939-3 2021 Initially, caspase-8 phosphorylated at tyrosine 380 by c-Src predominantly enhancing c-Src activation to facilitate metastasis through attaining epithelial-mesenchymal transition (EMT) phenotype in lung adenocarcinoma. Tyrosine 39-47 caspase 8 Homo sapiens 11-20 27101103-9 2016 Finally, we demonstrate that caspase-8 activity prevents its own tyrosine phosphorylation by Src. Tyrosine 65-73 caspase 8 Homo sapiens 29-38 27101103-11 2016 Specifically, tyrosine phosphorylation by Src renders caspase-8 uncleavable and thereby inactive, and at the same time converts it to a Src activator. Tyrosine 14-22 caspase 8 Homo sapiens 54-63 24100030-4 2013 Specifically, we show that TRAIL treatment activates the tyrosine kinase Src, which subsequently phosphorylates caspase-8 at tyrosine 380, leading to the inhibition of caspase-8 activation. Tyrosine 57-65 caspase 8 Homo sapiens 112-121 24249517-9 2015 Transfection studies with wild-type and mutant focal adhesion kinases (FAK) and Western blot analyses suggest that OPN suppression of caspase-8 activation is mediated through phosphorylation of FAK at Tyr(861). Tyrosine 201-204 caspase 8 Homo sapiens 134-143 25537896-3 2014 The expression of phosphorylated caspase-8 at 380 tyrosine by Src was detected using Western blotting. Tyrosine 50-58 caspase 8 Homo sapiens 33-42 24589337-0 2014 Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8. Tyrosine 81-89 caspase 8 Homo sapiens 111-120 24589337-4 2014 Caspase-8 was constitutively tyrosine phosphorylated in a panel of resting epithelial cells, but underwent SHP-1-dependent dephosphorylation in response to hydrogen peroxide, activated neutrophils, or inhibition of Src kinases. Tyrosine 29-37 caspase 8 Homo sapiens 0-9 24100030-5 2013 We also show that upon TRAIL treatment, Src, caspase-8, and PP2A/C (a catalytic subunit of the PP2A phosphatase) are redistributed into lipid rafts, a microdomain of the plasma membrane enriched with cholesterol, where PP2A dephosphorylates Src at tyrosine 418 and in turn inhibits caspase-8 phosphorylation. Tyrosine 248-256 caspase 8 Homo sapiens 45-54 24100030-4 2013 Specifically, we show that TRAIL treatment activates the tyrosine kinase Src, which subsequently phosphorylates caspase-8 at tyrosine 380, leading to the inhibition of caspase-8 activation. Tyrosine 57-65 caspase 8 Homo sapiens 168-177 18089778-5 2007 Stimulation of motility with epidermal growth factor induced the phosphorylation of caspase-8 on tyrosine-380 and the interaction of caspase-8 with the p85 alpha subunit of phosphatidylinositol 3-kinase. Tyrosine 97-105 caspase 8 Homo sapiens 84-93 22508042-5 2012 Additionally, we detect that Src-mediated caspase-8 phosphorylation stimulates Src phosphorylation at Tyr-416 via the linkage of Src SH2 domain with phosph-Tyr-380 site of caspase-8. Tyrosine 102-105 caspase 8 Homo sapiens 42-51 22508042-5 2012 Additionally, we detect that Src-mediated caspase-8 phosphorylation stimulates Src phosphorylation at Tyr-416 via the linkage of Src SH2 domain with phosph-Tyr-380 site of caspase-8. Tyrosine 102-105 caspase 8 Homo sapiens 172-181 22508042-5 2012 Additionally, we detect that Src-mediated caspase-8 phosphorylation stimulates Src phosphorylation at Tyr-416 via the linkage of Src SH2 domain with phosph-Tyr-380 site of caspase-8. Tyrosine 156-159 caspase 8 Homo sapiens 42-51 22508042-5 2012 Additionally, we detect that Src-mediated caspase-8 phosphorylation stimulates Src phosphorylation at Tyr-416 via the linkage of Src SH2 domain with phosph-Tyr-380 site of caspase-8. Tyrosine 156-159 caspase 8 Homo sapiens 172-181 22508042-8 2012 Together, a simple model is that the peripherization of caspase-8 is well-poised to facilitate Src-mediated caspase-8 phosphrylation at Tyr-380, then binding of phospho-Tyr380 of caspase-8 to Src SH2 domain may maintain Src in an active conformation to induce EMT phenotype, a key step toward cancer metastasis. Tyrosine 136-139 caspase 8 Homo sapiens 56-65 22508042-8 2012 Together, a simple model is that the peripherization of caspase-8 is well-poised to facilitate Src-mediated caspase-8 phosphrylation at Tyr-380, then binding of phospho-Tyr380 of caspase-8 to Src SH2 domain may maintain Src in an active conformation to induce EMT phenotype, a key step toward cancer metastasis. Tyrosine 136-139 caspase 8 Homo sapiens 108-117 22508042-8 2012 Together, a simple model is that the peripherization of caspase-8 is well-poised to facilitate Src-mediated caspase-8 phosphrylation at Tyr-380, then binding of phospho-Tyr380 of caspase-8 to Src SH2 domain may maintain Src in an active conformation to induce EMT phenotype, a key step toward cancer metastasis. Tyrosine 136-139 caspase 8 Homo sapiens 108-117 18974049-2 2008 Previously, we identified caspase 8 as an effector of migration, promoting motility in a manner dependent upon phosphorylation on Tyr-380 by Src family kinases and its subsequent association with Src homology 2 domain-containing proteins. Tyrosine 130-133 caspase 8 Homo sapiens 26-35 18216014-0 2008 Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. Tyrosine 29-37 caspase 8 Homo sapiens 49-58 18216014-2 2008 Here, we show that tyrosine 380 in the linker loop of human caspase 8 is a critical switch determining caspase 8 function. Tyrosine 19-27 caspase 8 Homo sapiens 60-69 18216014-2 2008 Here, we show that tyrosine 380 in the linker loop of human caspase 8 is a critical switch determining caspase 8 function. Tyrosine 19-27 caspase 8 Homo sapiens 103-112 18216014-5 2008 Instead, we find that integrin-mediated adhesion promotes caspase 8 phosphorylation on tyrosine 380. Tyrosine 87-95 caspase 8 Homo sapiens 58-67 18086677-2 2008 Here we report a novel mechanism regulating neutrophil survival dynamically through the tyrosine phosphorylation or dephosphorylation of caspase-8. Tyrosine 88-96 caspase 8 Homo sapiens 137-146 18086677-3 2008 Caspase-8 is tyrosine-phosphorylated in freshly isolated neutrophils but spontaneously dephosphorylates in culture, in association with the progression of constitutive apoptosis. Tyrosine 13-21 caspase 8 Homo sapiens 0-9 18086677-4 2008 Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) and enables SHP-1 to dephosphorylate caspase-8, permitting apoptosis to proceed. Tyrosine 32-35 caspase 8 Homo sapiens 19-28 18086677-4 2008 Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) and enables SHP-1 to dephosphorylate caspase-8, permitting apoptosis to proceed. Tyrosine 32-35 caspase 8 Homo sapiens 178-187 18086677-5 2008 The non-receptor tyrosine kinase, Lyn, can phosphorylate caspase-8 on Tyr-397 and Tyr-465, rendering it resistant to activational cleavage and inhibiting apoptosis. Tyrosine 70-73 caspase 8 Homo sapiens 57-66 18089778-6 2007 Tyrosine-380 was required for the restoration of cell motility and cell adhesion in caspase-8-null cells, demonstrating the importance of the caspase-8-p85 interaction for these nonapoptotic functions. Tyrosine 0-8 caspase 8 Homo sapiens 84-93 18089778-6 2007 Tyrosine-380 was required for the restoration of cell motility and cell adhesion in caspase-8-null cells, demonstrating the importance of the caspase-8-p85 interaction for these nonapoptotic functions. Tyrosine 0-8 caspase 8 Homo sapiens 142-151 18089778-7 2007 These results suggest that caspase-8 phosphorylation converts it from a proapoptotic factor to a cell motility factor that, through tyrosine-380, interacts with p85, an established cell migration component. Tyrosine 132-140 caspase 8 Homo sapiens 27-36 16619028-7 2006 These data provide the first evidence for a direct role of tyrosine phosphorylation in the control of caspases and reveal a new mechanism through which tyrosine kinases inhibit apoptosis and participate in tumor progression. Tyrosine 59-67 caspase 8 Homo sapiens 102-110 12061801-6 2002 Western blot analysis showed that caspases 3, 7, 8, and 9 are activated by deprivation of Tyr/Phe. Tyrosine 90-93 caspase 8 Homo sapiens 34-42 12061801-11 2002 These results indicate that activation of caspases, cleavage of Bid, and mitochondrial release of cytochrome c are required for apoptosis induced by Tyr/Phe deprivation. Tyrosine 149-152 caspase 8 Homo sapiens 42-50 10447681-4 1999 Inhibition of tyrosine phosphatases delayed the cleavage and activation of caspase-8 and caspase-3 and antagonized the tyrosine dephosphorylation of the CD95 receptor-associated phosphoproteins p61 and p89/92. Tyrosine 14-22 caspase 8 Homo sapiens 75-84