PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26829444-9 2016 Eleven metabolites allowed differentiation between both diabetes types and alanine, alpha-amino-adipic acid, isoleucin, and stearic acid showed an inverse association with insulin sensitivity in both T2D and T1D combined. stearic acid 124-136 insulin Homo sapiens 172-179 32900520-13 2021 In women, the stearic-acid diet increased insulin concentrations (1.57 muU/mL; p = 0.002), while in men, C-peptide concentrations were lower (-0.15 ng/mL; p = 0.037). stearic acid 14-26 insulin Homo sapiens 42-49 32900520-17 2021 Insulin sensitivity in women and low-grade inflammation might be unfavorably affected by stearic-acid intake. stearic acid 89-101 insulin Homo sapiens 0-7 5792362-2 1969 Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid. stearic acid 96-108 insulin Homo sapiens 10-17 33879968-0 2021 Oleic acid to stearic acid ratio might be a potential marker for insulin resistance in non-obese Japanese. stearic acid 14-26 insulin Homo sapiens 65-72 33879968-6 2021 The oleic acid/stearic acid ratio exhibited a positive correlation with the logmatic transformed triglyceride/high-density lipoprotein cholesterol ratio and the fasting triglycerides-glucose index, both of which were used as markers for insulin resistance. stearic acid 15-27 insulin Homo sapiens 237-244 33879968-10 2021 In conclusion, oleic acid/stearic acid ratio might be a useful marker for insulin resistance in non-obese Japanese subjects. stearic acid 26-38 insulin Homo sapiens 74-81 27051626-1 2016 INTRODUCTION: The aim of this study was to use Eudragit( ) RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded Eudragit( ) entrapped microspheres prepared by the emulsification-coacervation technique. stearic acid 95-113 insulin Homo sapiens 208-215 22966071-0 2013 Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia. stearic acid 79-91 insulin Homo sapiens 126-133 27051626-2 2016 MATERIALS AND METHODS: Mucoadhesive insulin-loaded microspheres containing magnesium stearate and varying proportions of Eudragit( ) RL 100 were prepared by the emulsification-coacervation technique and evaluated for thermal properties, physicochemical performance, and in vitro dissolution in acidic and subsequently basic media. stearic acid 75-93 insulin Homo sapiens 36-43 26739624-4 2016 To this end, human HepaRG cells were incubated for one week with stearic acid or oleic acid, in the presence of different concentrations of insulin. stearic acid 65-77 insulin Homo sapiens 140-147 24972532-9 2014 Stearic acid can induce insulin resistance, whereas alpha-linolenic acid may protect against it. stearic acid 0-12 insulin Homo sapiens 24-31 24384240-6 2014 CONCLUSIONS: Patients with insulin resistance display a pattern of high long chain saturated FAs (PA, SA and arachidic acids). stearic acid 102-104 insulin Homo sapiens 27-34 24211519-4 2014 Apocynin, a NOX4 inhibitor, restored the SA-induced inhibition of Akt phosphorylation, suggesting the role of NOX4 in insulin resistance induced by SA. stearic acid 41-43 insulin Homo sapiens 118-125 24211519-4 2014 Apocynin, a NOX4 inhibitor, restored the SA-induced inhibition of Akt phosphorylation, suggesting the role of NOX4 in insulin resistance induced by SA. stearic acid 148-150 insulin Homo sapiens 118-125 24211519-6 2014 Although binding immunoglobulin protein, a marker of endoplasmic reticulum stress, was transiently increased in SKHep-1 cells treated with SA, 4-phenyl butyric acid, a chemical chaperone, had no effect on the insulin-mediated Akt phosphorylation inhibited by SA. stearic acid 139-141 insulin Homo sapiens 209-216 25527759-8 2015 RESULTS: At baseline, circulating palmitic acid and stearic acid were positively associated with adiposity, triglycerides, inflammation biomarkers, and insulin resistance (P-trend < 0.01 each), whereas oleic acid showed generally beneficial associations (P-trend < 0.001 each). stearic acid 52-64 insulin Homo sapiens 152-159 22966071-4 2013 The elevation of SA is due to increased insulin-stimulated de novo synthesis mediated by sterol regulatory element-binding protein-1c (SREBP-1c)/acetyl-CoA carboxylase/fatty acid synthase/elongation of long-chain fatty acid family member 6 (ELOVL6) and the elongation of palmitic acid (PA) catalyzed by ELOVL6. stearic acid 17-19 insulin Homo sapiens 40-47 22966071-7 2013 In summary, increased postprandial SA is caused by the insulin-stimulated SREBP-1c pathway and elongation of PA in HLP. stearic acid 35-37 insulin Homo sapiens 55-62 22848162-0 2012 Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. stearic acid 40-52 insulin Homo sapiens 93-100 24296476-7 2013 Stearic acid (30 muM) significantly increased insulin-induced phosphorylation of insulin receptor at Tyr1185, but insulin-induced phosphorylation of Akt was not significantly enhanced. stearic acid 0-12 insulin Homo sapiens 46-53 24296476-7 2013 Stearic acid (30 muM) significantly increased insulin-induced phosphorylation of insulin receptor at Tyr1185, but insulin-induced phosphorylation of Akt was not significantly enhanced. stearic acid 0-12 insulin Homo sapiens 81-88 19252892-5 2009 RESULTS: We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p < 0.01 for each), and inverse relationships with adipocyte size (p < 0.01, p < 0.05, respectively). stearic acid 126-138 insulin Homo sapiens 151-158