PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16344854-7 2006 In vitro investigations demonstrated a dose-dependent inhibitory effect of mirtazapine on the activity of the microsomal 3alpha-HSD in the oxidative direction (conversion of 3alpha,5alpha-tetrahydroprogesterone to 5alpha-dihydroprogesterone). 5-alpha-Dihydroprogesterone 214-240 aldo-keto reductase family 1 member C3 Homo sapiens 121-131 10557352-6 1999 Our results indicate that the SSRIs fluoxetine, sertraline, and paroxetine decrease the K(m) of the conversion of 5alpha-dihydroprogesterone to allopregnanolone by human 3alpha-HSD type III 10- to 30-fold. 5-alpha-Dihydroprogesterone 114-140 aldo-keto reductase family 1 member C3 Homo sapiens 170-180