PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20399649-1	2010	A series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one were synthesized to modulate CYP3A4 inhibition and improve aqueous solubility of our prototypical compound BMS-536924 (1), while maintaining potent IGF-1R inhibitory activity.	3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1h-benzimidazol-2-yl]-1h-pyridine-2-one	12-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132