PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18544567-12	2008	Mesalazine-mediated increased caspase-3 activity, the expression of PTEN, cleavage of PARP and caspase-8 as well as reduced levels of survivin and Xiap were completely abolished in the PPARgamma mutant cell lines.	Mesalamine	0-10	phosphatase and tensin homolog	Homo sapiens	68-72	
23867870-3	2013	We now hypothesize that 5-ASA mediates changes in intestinal epithelial cell (IEC) reactive oxygen species during colitis to affect phosphatase and tensin homolog (PTEN), PI3K, and beta-catenin signaling.	Mesalamine	24-29	phosphatase and tensin homolog	Homo sapiens	164-168	
23867870-9	2013	Data showed 5-ASA-induced peroxisome proliferator-activated receptor gamma DNA binding to the PTEN promoter (chromatin immunoprecipitation) and reduced both phosphorylated and oxidized (inactive) PTEN protein levels.	Mesalamine	12-17	phosphatase and tensin homolog	Homo sapiens	94-98	
23867870-9	2013	Data showed 5-ASA-induced peroxisome proliferator-activated receptor gamma DNA binding to the PTEN promoter (chromatin immunoprecipitation) and reduced both phosphorylated and oxidized (inactive) PTEN protein levels.	Mesalamine	12-17	phosphatase and tensin homolog	Homo sapiens	196-200	
23867870-11	2013	Reduced PI3K/Akt signaling and expression of beta-catenin target genes in 5-ASA-treated CUC patients additionally suggests enhanced PTEN activity as well.	Mesalamine	74-79	phosphatase and tensin homolog	Homo sapiens	132-136	
23867870-12	2013	CONCLUSIONS: Therefore, 5-ASA reduces CUC-induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity, thus attenuating PI3K/Akt signaling.	Mesalamine	24-29	phosphatase and tensin homolog	Homo sapiens	115-119