PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28473247-0	2017	Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid.	Mesalamine	9-30	heme oxygenase 1	Homo sapiens	46-50	
28473247-0	2017	Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid.	Mesalamine	135-156	heme oxygenase 1	Homo sapiens	46-50	
28473247-9	2017	In parallel, rectal administration of 5-ASA increased the level of HO-1 and nuclear Nrf2 in the inflamed colonic tissues, but not in normal colonic tissues.	Mesalamine	38-43	heme oxygenase 1	Homo sapiens	67-71	
28473247-10	2017	Moreover, oral gavage of sulfasalazine, a colon-specific prodrug of 5-ASA currently used clinically, activated the Nrf2-HO-1 pathway in the colonic tissues where inflammation was in progress, which was not observed when inflammation subsided.	Mesalamine	68-73	heme oxygenase 1	Homo sapiens	120-124	
28473247-11	2017	Collectively, our data suggest that Nrf2-HO-1 pathway is involved in the anti-inflammatory pharmacology of 5-ASA, which was likely being exerted exclusively in the inflammatory state.	Mesalamine	107-112	heme oxygenase 1	Homo sapiens	41-45	
20631420-2	2010	Recent in vivo and in vitro studies have demonstrated that 5-aminosalicylic acid (5-ASA), regarded as the active moiety in aminosalicylate preparations such as sulfasalazine, can induce the heat shock protein, heme oxygenase-1 (HO-1) and up-regulate HO enzyme activity in the colon.	Mesalamine	59-80	heme oxygenase 1	Homo sapiens	210-226	
20631420-2	2010	Recent in vivo and in vitro studies have demonstrated that 5-aminosalicylic acid (5-ASA), regarded as the active moiety in aminosalicylate preparations such as sulfasalazine, can induce the heat shock protein, heme oxygenase-1 (HO-1) and up-regulate HO enzyme activity in the colon.	Mesalamine	59-80	heme oxygenase 1	Homo sapiens	228-232	
20631420-2	2010	Recent in vivo and in vitro studies have demonstrated that 5-aminosalicylic acid (5-ASA), regarded as the active moiety in aminosalicylate preparations such as sulfasalazine, can induce the heat shock protein, heme oxygenase-1 (HO-1) and up-regulate HO enzyme activity in the colon.	Mesalamine	82-87	heme oxygenase 1	Homo sapiens	210-226	
20631420-2	2010	Recent in vivo and in vitro studies have demonstrated that 5-aminosalicylic acid (5-ASA), regarded as the active moiety in aminosalicylate preparations such as sulfasalazine, can induce the heat shock protein, heme oxygenase-1 (HO-1) and up-regulate HO enzyme activity in the colon.	Mesalamine	82-87	heme oxygenase 1	Homo sapiens	228-232