PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25569743-11	2015	In colorectal cancer cell lines, PAK1, and beta-catenin expression correlated and inhibition of PAK1 and addition of 5-ASA elicited similar molecular affects by reducing ERK and AKT activation.	Mesalamine	117-122	AKT serine/threonine kinase 1	Homo sapiens	178-181	
19879273-2	2010	The present study addressed the possibility that mesalamine reduces beta-catenin-associated progenitor cell activation, Akt-phosphorylated beta-catenin(Ser552) (P-beta-catenin), and colitis-induced dysplasia (CID).	Mesalamine	49-59	AKT serine/threonine kinase 1	Homo sapiens	120-123	
23867870-10	2013	Analysis of patient samples revealed 5-ASA that also reduced levels of active phosphorylated Akt in inflamed colitis tissue.	Mesalamine	37-42	AKT serine/threonine kinase 1	Homo sapiens	93-96	
23867870-11	2013	Reduced PI3K/Akt signaling and expression of beta-catenin target genes in 5-ASA-treated CUC patients additionally suggests enhanced PTEN activity as well.	Mesalamine	74-79	AKT serine/threonine kinase 1	Homo sapiens	13-16	
23867870-12	2013	CONCLUSIONS: Therefore, 5-ASA reduces CUC-induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity, thus attenuating PI3K/Akt signaling.	Mesalamine	24-29	AKT serine/threonine kinase 1	Homo sapiens	152-155