PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18322880-1	2008	BACKGROUND: 5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1).	Mesalamine	12-34	N-acetyltransferase 1	Homo sapiens	79-100	
25834322-9	2015	NAT1 genotypes corresponding to fast enzymatic activity were associated with reduced TGN concentration (P value linear mixed effects model 0.033), putatively because of increased 5-ASA inactivation and consequent reduced inhibition of thiopurine metabolism.	Mesalamine	179-184	N-acetyltransferase 1	Homo sapiens	0-4	
18852012-17	2008	Studies on the eukaryotic enzymes by NMR and crystallography have facilitated understanding substrate specificities of human NAT1 (5-aminosalicylate and p-aminobenzoic acid) and human NAT2 (sulphamethazine).	Mesalamine	131-148	N-acetyltransferase 1	Homo sapiens	125-129	
18322880-1	2008	BACKGROUND: 5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1).	Mesalamine	12-34	N-acetyltransferase 1	Homo sapiens	102-106	
18322880-1	2008	BACKGROUND: 5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1).	Mesalamine	36-41	N-acetyltransferase 1	Homo sapiens	79-100	
18322880-1	2008	BACKGROUND: 5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1).	Mesalamine	36-41	N-acetyltransferase 1	Homo sapiens	102-106	
18322880-8	2008	Clinical response to 5-ASA was determined by medical record review and associated with NAT1 genotypes.	Mesalamine	21-26	N-acetyltransferase 1	Homo sapiens	87-91	
12135032-1	2002	OBJECTIVES: 5-Aminosalicylate is metabolized in colonic mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2).	Mesalamine	12-29	N-acetyltransferase 1	Homo sapiens	66-87	
12135032-1	2002	OBJECTIVES: 5-Aminosalicylate is metabolized in colonic mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2).	Mesalamine	12-29	N-acetyltransferase 1	Homo sapiens	89-93	
9577349-2	1998	Other substrates include the sulphonamide 5-aminosalicylic acid (5-ASA), which is an NAT1 specific substrate; N-acetylation of 5-ASA is a major route of metabolism.	Mesalamine	65-70	N-acetyltransferase 1	Homo sapiens	85-89	
9577349-15	1998	CONCLUSIONS: The interindividual variation in NAT1 and NAT2 in the colon could affect how individuals respond to exposure to specific NAT substrates including carcinogens and 5-ASA.	Mesalamine	175-180	N-acetyltransferase 1	Homo sapiens	46-50