PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31443089-9 2019 The effect of treatment with liposomal suspensions of 5-ASA and CGA was evaluated macroscopically and by measuring myeloperoxidase (MPO) activity. Mesalamine 54-59 myeloperoxidase Mus musculus 115-130 33138176-8 2020 Intrarectal treatment of colitis with 30 mg/kg chitosan alone and with 30 mg/kg 5-ASA for 3 days led to a significant decrease in MPO, ALP, TNF-alpha, IL-6, IL-1beta and NF-kappaB in colitis mice compared to untreated mice. Mesalamine 80-85 myeloperoxidase Mus musculus 130-133 31443089-9 2019 The effect of treatment with liposomal suspensions of 5-ASA and CGA was evaluated macroscopically and by measuring myeloperoxidase (MPO) activity. Mesalamine 54-59 myeloperoxidase Mus musculus 132-135 29407223-8 2018 Therefore, these data demonstrated that an HSA NP formulation has the potential to specifically deliver 5-ASA to an inflamed site where MPO is highly expressed. Mesalamine 104-109 myeloperoxidase Mus musculus 136-139 29407223-1 2018 To develop a new strategy for inflamed site-specific drug delivery in the colon for the treatment of ulcerative colitis (UC), we leveraged on the interaction between myeloperoxidase (MPO) and human serum albumin (HSA) and prepared nanoparticles (HSA NPs) conjugated with 5-aminosalicylic acid (5-ASA). Mesalamine 271-292 myeloperoxidase Mus musculus 166-181 29407223-1 2018 To develop a new strategy for inflamed site-specific drug delivery in the colon for the treatment of ulcerative colitis (UC), we leveraged on the interaction between myeloperoxidase (MPO) and human serum albumin (HSA) and prepared nanoparticles (HSA NPs) conjugated with 5-aminosalicylic acid (5-ASA). Mesalamine 271-292 myeloperoxidase Mus musculus 183-186 29407223-1 2018 To develop a new strategy for inflamed site-specific drug delivery in the colon for the treatment of ulcerative colitis (UC), we leveraged on the interaction between myeloperoxidase (MPO) and human serum albumin (HSA) and prepared nanoparticles (HSA NPs) conjugated with 5-aminosalicylic acid (5-ASA). Mesalamine 294-299 myeloperoxidase Mus musculus 166-181 29407223-1 2018 To develop a new strategy for inflamed site-specific drug delivery in the colon for the treatment of ulcerative colitis (UC), we leveraged on the interaction between myeloperoxidase (MPO) and human serum albumin (HSA) and prepared nanoparticles (HSA NPs) conjugated with 5-aminosalicylic acid (5-ASA). Mesalamine 294-299 myeloperoxidase Mus musculus 183-186 29407223-4 2018 The specific interaction between the 5-ASA-HSA NPs and MPO was observed using quartz crystal microbalance analysis in vitro. Mesalamine 37-42 myeloperoxidase Mus musculus 55-58 27416043-10 2016 In the setting of colitis, 5-ASA significantly restored colon length and decreased myeloperoxidase activity in NAT knockout but not in WT mice. Mesalamine 27-32 myeloperoxidase Mus musculus 83-98 28138699-5 2017 The therapeutic effect of 5-ASA-SiO2 NPs was assessed based on their disease activity index (DAI), colon histopathology, myeloperoxidase (MPO) and levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Mesalamine 26-31 myeloperoxidase Mus musculus 121-136 25101553-6 2014 Oral administration of 65, 130 and 195 mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-alpha, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Mesalamine 45-50 myeloperoxidase Mus musculus 176-179 34059563-4 2021 Intrarectal treatment of moderate and severe colitis with 5-ASA alone or HA alone at a dose of 30 mg/kg led to a significant decrease in clinical activity and histology scores, myeloperoxidase activity (MPO), TNF-alpha, IL-6 and IL-1beta in colitis mice compared to untreated animals. Mesalamine 58-63 myeloperoxidase Mus musculus 177-192 34059563-4 2021 Intrarectal treatment of moderate and severe colitis with 5-ASA alone or HA alone at a dose of 30 mg/kg led to a significant decrease in clinical activity and histology scores, myeloperoxidase activity (MPO), TNF-alpha, IL-6 and IL-1beta in colitis mice compared to untreated animals. Mesalamine 58-63 myeloperoxidase Mus musculus 203-206 34059563-5 2021 The combination of HA (30 mg/kg) and 5-ASA in severe colitis led to a significant improvement of colitis compared to 5-ASA alone (MPO, moderate, 5-ASA: 1,776 +- 315, 5-ASA+HA: 1,157 +- 561; severe, 5-ASA: 5,742 +- 611, 5-ASA+HA: 2,953 +- 2,611 U/g tissue). Mesalamine 37-42 myeloperoxidase Mus musculus 130-133