PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28593185-7	2017	RESULTS: Treatment of wild-type mice with mesalamine increased the accumulation of Tregs in the colon and up-regulated the AhR target gene Cyp1A1, but this effect was not observed in AhR-/- or BM-AhR-/- mice.	Mesalamine	42-52	aryl-hydrocarbon receptor	Mus musculus	123-126	
34915497-0	2022	5-Aminosalicylic Acid, A Weak Agonist for Aryl Hydrocarbon Receptor That Induces Splenic Regulatory T Cells.	Mesalamine	0-21	aryl-hydrocarbon receptor	Mus musculus	42-67	
34915497-2	2022	It has been recently reported that 5-ASA induces CD4 + Foxp3 + regulatory T cells (Tregs) in the colon via the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that regulates inflammation.	Mesalamine	35-40	aryl-hydrocarbon receptor	Mus musculus	111-136	
34915497-2	2022	It has been recently reported that 5-ASA induces CD4 + Foxp3 + regulatory T cells (Tregs) in the colon via the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that regulates inflammation.	Mesalamine	35-40	aryl-hydrocarbon receptor	Mus musculus	138-141	
34915497-3	2022	However, the role of 5-ASA as an AhR agonist that induces Tregs in the spleen remains unknown.	Mesalamine	21-26	aryl-hydrocarbon receptor	Mus musculus	33-36	
34915497-6	2022	RESULTS: The DR-EcoScreen cell-based transactivation assay revealed that 5-ASA acted as a weak AhR agonist at concentrations of >=300 muM (1.31-1.45-fold), and that a typical AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), activated AhR at a concentration of 0.1 nM (22.8-fold).	Mesalamine	73-78	aryl-hydrocarbon receptor	Mus musculus	95-98	
34915497-6	2022	RESULTS: The DR-EcoScreen cell-based transactivation assay revealed that 5-ASA acted as a weak AhR agonist at concentrations of >=300 muM (1.31-1.45-fold), and that a typical AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), activated AhR at a concentration of 0.1 nM (22.8-fold).	Mesalamine	73-78	aryl-hydrocarbon receptor	Mus musculus	242-245	
34915497-9	2022	DISCUSSION: These results suggest that 5-ASA is a weak agonist of AhR and thereby induces Tregs in spleen cells.	Mesalamine	39-44	aryl-hydrocarbon receptor	Mus musculus	66-69	
28593185-0	2017	Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor.	Mesalamine	43-53	aryl-hydrocarbon receptor	Mus musculus	72-97	
28593185-7	2017	RESULTS: Treatment of wild-type mice with mesalamine increased the accumulation of Tregs in the colon and up-regulated the AhR target gene Cyp1A1, but this effect was not observed in AhR-/- or BM-AhR-/- mice.	Mesalamine	42-52	aryl-hydrocarbon receptor	Mus musculus	183-186	
28593185-7	2017	RESULTS: Treatment of wild-type mice with mesalamine increased the accumulation of Tregs in the colon and up-regulated the AhR target gene Cyp1A1, but this effect was not observed in AhR-/- or BM-AhR-/- mice.	Mesalamine	42-52	aryl-hydrocarbon receptor	Mus musculus	183-186	
28593185-8	2017	In addition, mesalamine promoted in vitro differentiation of naive T cells to Tregs, concomitant with AhR activation.	Mesalamine	13-23	aryl-hydrocarbon receptor	Mus musculus	102-105	
28593185-9	2017	Mice treated with mesalamine exhibited increased levels of the active form of TGF-beta in the colon in an AhR-dependent manner and blockade of TGF-beta signaling suppressed induction of Tregs by mesalamine in the colon.	Mesalamine	18-28	aryl-hydrocarbon receptor	Mus musculus	106-109	
28593185-11	2017	CONCLUSIONS: We propose a novel anti-inflammatory mechanism of mesalamine for colitis: induction of Tregs in the colon via the AhR pathway, followed by TGF-beta activation.	Mesalamine	63-73	aryl-hydrocarbon receptor	Mus musculus	127-130