PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24263105-8 2013 Thus, p38 MAPK promotes ABT-737-induced apoptosis by inhibiting the cPLA2/arachidonate pathway. Arachidonic Acid 74-86 mitogen-activated protein kinase 14 Homo sapiens 6-9 24219282-1 2013 Arachidonic acid stimulates cell adhesion by activating alpha2beta1 integrins in a process that depends on protein kinases, including p38 mitogen activated protein kinase. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 134-137 24219282-5 2013 Confocal microscopy of arachidonic acid-treated cells showed that vinculin and phospho-p38 both appeared enriched in pseudopodia and at the tips of actin filaments, and fluorescence ratio imaging indicated the increase was specific for the phospho-(active) form of p38. Arachidonic Acid 23-39 mitogen-activated protein kinase 14 Homo sapiens 87-90 24219282-5 2013 Confocal microscopy of arachidonic acid-treated cells showed that vinculin and phospho-p38 both appeared enriched in pseudopodia and at the tips of actin filaments, and fluorescence ratio imaging indicated the increase was specific for the phospho-(active) form of p38. Arachidonic Acid 23-39 mitogen-activated protein kinase 14 Homo sapiens 265-268 24219282-6 2013 Immunoprecipitates of phospho-p38 from extracts of arachidonic acid-treated cells contained vinculin, and GST-vinculin fusion proteins carrying the central region of vinculin bound phospho-p38, whereas fusion proteins expressing the terminal portions of vinculin did not. Arachidonic Acid 51-67 mitogen-activated protein kinase 14 Homo sapiens 30-33 24219282-6 2013 Immunoprecipitates of phospho-p38 from extracts of arachidonic acid-treated cells contained vinculin, and GST-vinculin fusion proteins carrying the central region of vinculin bound phospho-p38, whereas fusion proteins expressing the terminal portions of vinculin did not. Arachidonic Acid 51-67 mitogen-activated protein kinase 14 Homo sapiens 189-192 24802256-0 2015 Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 62-65 24263105-10 2013 Our data support the hypothesis that the p38 MAPK-triggered arachidonate pathway serves as a defense mechanism against apoptosis under physiological conditions. Arachidonic Acid 60-72 mitogen-activated protein kinase 14 Homo sapiens 41-44 22949356-0 2012 Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes. Arachidonic Acid 42-58 mitogen-activated protein kinase 14 Homo sapiens 27-30 21281639-1 2011 Arachidonic acid (AA) stimulates cell adhesion through a p38 mitogen activated protein kinase-mediated RhoA signaling pathway. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 57-60 21847583-8 2011 LDL from metabolic syndrome and type 2 diabetic patients were equally potent in activating the platelet arachidonic acid signalling cascade through increased phosphorylation of p38 mitogen-activated protein kinase and cytosolic phospholipase A(2), and through increased thromboxane B(2) formation. Arachidonic Acid 104-120 mitogen-activated protein kinase 14 Homo sapiens 177-180 19595442-2 2010 The role(s) of MAP kinases (ERKs and p38(MAPK)) are unclear, although at high, but not low, collagen concentrations p38(MAPK) is involved in cPLA(2)-mediated arachidonic acid release, prior to thromboxane generation. Arachidonic Acid 158-174 mitogen-activated protein kinase 14 Homo sapiens 116-119 19720122-0 2009 Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 153-156 19506078-0 2009 Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 58-61 19540902-0 2009 Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 165-173 19720122-1 2009 Arachidonic acid (AA)-induced apoptotic death of human leukemia U937 cells was characteristic of increase in intracellular Ca(2+) concentration ([Ca(2+)]i), ROS generation, ERK inactivation, p38 MPAK activation, degradation of procaspase-8 and production of truncated Bid (tBid). Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 191-194 16210322-10 2005 Western analysis demonstrated increased phosphorylation of p38 mitogen-activated protein kinase (MAPK) in arachidonic acid-treated cells, whereas extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity was not changed. Arachidonic Acid 106-122 mitogen-activated protein kinase 14 Homo sapiens 59-95 17999933-8 2008 In addition, we also show via biophysical methods that arachidonic acid and its derivatives bind p38 alpha in vitro. Arachidonic Acid 55-71 mitogen-activated protein kinase 14 Homo sapiens 97-106 17341567-4 2007 The activation of platelet p38 MAPK, the stress kinase responsible for the activation of cytosolic phospholipase A(2), and the concentration of thromboxane B(2), the stable catabolite of the proaggregatory arachidonic acid metabolite thromboxane A(2), were assessed. Arachidonic Acid 206-222 mitogen-activated protein kinase 14 Homo sapiens 27-30 17065898-8 2006 Activation of p38 MAPK preceded activation of arachidonic acid pathways. Arachidonic Acid 46-62 mitogen-activated protein kinase 14 Homo sapiens 14-17 16210322-11 2005 Incubating the hepatocytes with the p38 MAPK inhibitor, SB203580, blocked the arachidonic acid inhibition of G6PD mRNA accumulation. Arachidonic Acid 78-94 mitogen-activated protein kinase 14 Homo sapiens 36-39 16210322-13 2005 Thus, arachidonic acid inhibits the insulin stimulation of G6PD mRNA accumulation by stimulating the p38 MAPK pathway, thereby inhibiting insulin signal transduction. Arachidonic Acid 6-22 mitogen-activated protein kinase 14 Homo sapiens 101-104 12957656-1 2003 Exogenous arachidonic acid (AA) has been shown to induce the antioxidant manganese superoxide dismutase gene by reactive oxygen species (ROS) derived from AA metabolism and the participation of the p38 mitogen-activated protein kinase (MAPK) pathway in human HepG2 hepatoma cells. Arachidonic Acid 10-26 mitogen-activated protein kinase 14 Homo sapiens 198-234 16210322-0 2005 Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase. Arachidonic Acid 0-16 mitogen-activated protein kinase 14 Homo sapiens 89-92 16000313-0 2005 15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. Arachidonic Acid 28-44 mitogen-activated protein kinase 14 Homo sapiens 139-142 16000313-3 2005 Activation of p38 mitogen-activated protein kinase (p38 MAPK) is required for increased cell adhesion to type IV collagen, and this activation is sensitive to inhibitors of lipoxygenases, suggesting a requirement for arachidonic acid metabolism. Arachidonic Acid 217-233 mitogen-activated protein kinase 14 Homo sapiens 14-50 16000313-3 2005 Activation of p38 mitogen-activated protein kinase (p38 MAPK) is required for increased cell adhesion to type IV collagen, and this activation is sensitive to inhibitors of lipoxygenases, suggesting a requirement for arachidonic acid metabolism. Arachidonic Acid 217-233 mitogen-activated protein kinase 14 Homo sapiens 52-60 16000313-4 2005 The goals of the current study were to identify the one or more key metabolites of arachidonic acid that are responsible for activation of p38 MAPK and to elucidate the upstream kinases that lead to p38 MAPK activation. Arachidonic Acid 83-99 mitogen-activated protein kinase 14 Homo sapiens 139-147 16000313-4 2005 The goals of the current study were to identify the one or more key metabolites of arachidonic acid that are responsible for activation of p38 MAPK and to elucidate the upstream kinases that lead to p38 MAPK activation. Arachidonic Acid 83-99 mitogen-activated protein kinase 14 Homo sapiens 139-142 16000313-7 2005 A LOX inhibitor, nordihydroguaiaretic acid, attenuated production of 15(S)-HETE and inhibited the phosphorylation of p38 MAPK following exposure to arachidonic acid. Arachidonic Acid 148-164 mitogen-activated protein kinase 14 Homo sapiens 117-125 16000313-8 2005 In contrast, overexpression of LOX-2 sensitized the cells to the addition of arachidonic acid, leading to increased activation of p38 MAPK. Arachidonic Acid 77-93 mitogen-activated protein kinase 14 Homo sapiens 130-138 16000313-10 2005 Transfection of these cells with a dominant negative form of TAK1 blocked arachidonic acid-stimulated p38 MAPK phosphorylation. Arachidonic Acid 74-90 mitogen-activated protein kinase 14 Homo sapiens 102-105 14514662-11 2004 Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most probably COX-2 up-regulation, since exogenous arachidonate did not restore PGE2 synthesis. Arachidonic Acid 77-89 mitogen-activated protein kinase 14 Homo sapiens 32-35 14514662-11 2004 Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most probably COX-2 up-regulation, since exogenous arachidonate did not restore PGE2 synthesis. Arachidonic Acid 150-162 mitogen-activated protein kinase 14 Homo sapiens 32-35 16214108-5 2005 Hence, targeted inhibition of p38alpha MAPK could be therapeutically beneficial to PDT, since it would prevent COX-2 expression, the inducible release of growth and angiogenic factors by the cancer cells, and cause an increase in the levels of free arachidonic acid, which promotes apoptosis. Arachidonic Acid 249-265 mitogen-activated protein kinase 14 Homo sapiens 30-38 15583748-8 2004 It has been postulated that a potential role of p38 MAPK is to activate phospholipase A(2) (cPLA(2)) which catalyses formation of arachidonic acid leading to production of thromboxane. Arachidonic Acid 130-146 mitogen-activated protein kinase 14 Homo sapiens 48-51 15556273-1 2004 We showed that the metabolism of arachidonic acid (AA) in HepG2 cells generates reactive oxygen species (ROS), which activate the p38 mitogen-activated protein kinase (MAPK) pathway and the redox-sensitive transcription factors AP-1 and NF-kappaB, leading to the induction of the antioxidant manganese superoxide dismutase gene. Arachidonic Acid 33-49 mitogen-activated protein kinase 14 Homo sapiens 130-166 14691575-10 2004 Moreover, release of arachidonic acid induced by VWF was strongly impaired by inhibition of p38MAPK. Arachidonic Acid 21-37 mitogen-activated protein kinase 14 Homo sapiens 92-99 14691575-12 2004 These results demon-strate that p38MAPK is a key element in the FCgammaRIIA-independent pathway for VWF-induced platelet activation, and is involved in the stimulation of phospholipase A(2) and arachidonic acid release. Arachidonic Acid 194-210 mitogen-activated protein kinase 14 Homo sapiens 32-39 12928445-8 2003 Inhibition of p38 MAPK activity by SB203580 and SB202190 resulted in decreased iPLA2 activity, arachidonic acid release, and DNA synthesis induced by thrombin in VSMC. Arachidonic Acid 95-111 mitogen-activated protein kinase 14 Homo sapiens 14-17 12031898-0 2002 Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells. Arachidonic Acid 27-43 mitogen-activated protein kinase 14 Homo sapiens 87-90 12388177-9 2003 Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most likely COX-2 upregulation, because exogenous arachidonate did not restore PGE(2) synthesis. Arachidonic Acid 77-89 mitogen-activated protein kinase 14 Homo sapiens 32-35 12388177-9 2003 Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most likely COX-2 upregulation, because exogenous arachidonate did not restore PGE(2) synthesis. Arachidonic Acid 149-161 mitogen-activated protein kinase 14 Homo sapiens 32-35 12525578-2 2003 We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused prominent 5-LO product formation that coincided with the activity of extracellular signal-regulated kinases (ERKs) and p38 mitogen-activated protein kinase. Arachidonic Acid 129-145 mitogen-activated protein kinase 14 Homo sapiens 277-280 12917365-5 2003 Short-term depression and the release of arachidonate are blocked by the specific p38 kinase inhibitor SB 203580. Arachidonic Acid 41-53 mitogen-activated protein kinase 14 Homo sapiens 82-85 11078353-2 2000 We found that in these cells both PKC and p38 MAP kinases play a critical role in ET-1-induced cPLA, phosphorylation and arachidonic acid (AA) release. Arachidonic Acid 121-137 mitogen-activated protein kinase 14 Homo sapiens 42-45 12051955-5 2002 These effects were investigated in relationship to the activation of p38 mitogen activated protein kinase (p38 MAPK) and c-jun amino-terminal kinase (JNK) by arachidonic acid in these cell lines. Arachidonic Acid 158-174 mitogen-activated protein kinase 14 Homo sapiens 69-105 12051955-5 2002 These effects were investigated in relationship to the activation of p38 mitogen activated protein kinase (p38 MAPK) and c-jun amino-terminal kinase (JNK) by arachidonic acid in these cell lines. Arachidonic Acid 158-174 mitogen-activated protein kinase 14 Homo sapiens 107-115 11369000-5 2001 We have found that agonists that release arachidonic acid, including histamine, thrombin, AlF(4)(-), and pervanadate, all activate the MAP kinases ERK, p38 and JNK and cause phosphorylation of cPLA(2). Arachidonic Acid 41-57 mitogen-activated protein kinase 14 Homo sapiens 152-155 11369000-7 2001 Treatment with PD98059 (inhibitor of ERK-activation) or SB203580 (inhibitor of p38) caused partial decrease in arachidonic acid release and cPLA(2) activity. Arachidonic Acid 111-127 mitogen-activated protein kinase 14 Homo sapiens 79-82 9668117-0 1998 Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Arachidonic Acid 51-67 mitogen-activated protein kinase 14 Homo sapiens 15-18 10800946-0 2000 Inflammatory cytokines enhance muscarinic-mediated arachidonic acid release through p38 mitogen-activated protein kinase in A2058 cells. Arachidonic Acid 51-67 mitogen-activated protein kinase 14 Homo sapiens 84-87 10800946-4 2000 Cytokine-induced enhancement of muscarinic-mediated arachidonic acid release peaks near 1 h. Western analysis suggests that both cytokines are capable of activating the nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) pathways. Arachidonic Acid 52-68 mitogen-activated protein kinase 14 Homo sapiens 207-243 10874134-6 2000 The findings of the present study demonstrated that: (i) the release of arachidonic acid metabolites is mediated by the ERK pathway; (ii) GM-CSF production may be driven by both the ERK and JNK pathways; and (iii) the p38 MAPK pathway negatively regulates the JNK pathway. Arachidonic Acid 72-88 mitogen-activated protein kinase 14 Homo sapiens 218-226 10903976-11 2000 We therefore speculate that the MEK1/ERK and p38 kinase cascades play a role in the functional coupling of arachidonate release to COX-2. Arachidonic Acid 107-119 mitogen-activated protein kinase 14 Homo sapiens 45-48 10667354-0 1999 Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils. Arachidonic Acid 59-75 mitogen-activated protein kinase 14 Homo sapiens 33-36 9668117-3 1998 We now report that arachidonic acid stimulated the appearance of dual-phosphorylated (active) p38 mitogen-activated protein kinase as detected by Western blotting in HeLa cells, HL60 cells, human neutrophils, and human umbilical vein endothelial cells but not Jurkat cells. Arachidonic Acid 19-35 mitogen-activated protein kinase 14 Homo sapiens 94-97 9668117-4 1998 An increase in p38 kinase activity caused by arachidonic acid was also observed. Arachidonic Acid 45-61 mitogen-activated protein kinase 14 Homo sapiens 15-18 9668117-5 1998 Further studies with neutrophils show that the stimulation of p38 dual phosphorylation by arachidonic acid was transient, peaking at 5 min, and was concentration-dependent. Arachidonic Acid 90-106 mitogen-activated protein kinase 14 Homo sapiens 62-65 34246631-5 2021 Such sustained p38 MAPK activation increases the activity of cytosolic phospholipase A2 (cPLA2), which catalyzes the release of arachidonic acid, the initial substrate for PGE2 biosynthesis. Arachidonic Acid 128-144 mitogen-activated protein kinase 14 Homo sapiens 15-23 34246631-6 2021 Sustained p38 MAPK activation also induces NF-kappaB-mediated increase in expression of cyclooxygenase-2 (COX-2) that is involved in the conversion of arachidonic acid to prostanoids resulting in enhanced biosynthesis and release of PGE2 from neurons. Arachidonic Acid 151-167 mitogen-activated protein kinase 14 Homo sapiens 10-18 31014201-0 2019 Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK. Arachidonic Acid 9-25 mitogen-activated protein kinase 14 Homo sapiens 74-77 2971676-1 1988 We have examined the ability of a highly purified 38-kD phospholipase-inhibitory protein (p38) isolated from human placental membranes that is also a preferred substrate for the epidermal growth factor-urogastrone (EGF-URO) receptor/kinase, to block the release of arachidonate from zymosan-stimulated murine peritoneal macrophages in vitro and to exhibit antiinflammatory activity in a carrageenin rat paw edema test in vivo. Arachidonic Acid 265-277 mitogen-activated protein kinase 14 Homo sapiens 90-93