PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2544450-4	1989	These observations indicate that (i) activation of PK-C and (ii) diacylglycerol formation, arachidonic acid and/or lysophosphatidylcholine release are important steps in the mechanism of action of IFN.	Arachidonic Acid	91-107	interferon alpha 1	Homo sapiens	197-200	
10421661-8	1999	Our data indicate that blockade of arachidonic acid (AA) metabolism by indomethacin activates a signaling pathway that converges on STAT1 activation to potentiate IFN-alpha-dependent gene activation.	Arachidonic Acid	35-51	interferon alpha 1	Homo sapiens	163-172	
7740291-8	1995	Arachidonic acid (AA) activation from membrane phospholipid pools is common to many receptors and can be followed by metabolization of AA by cyclooxygenase to prostanoids, thromboxanes and eicosanoids and by lipoxygenase to leukotrienes; inhibition of these AA oxidation pathways by addition of inhibitors of these enzymes (e.g. indomethacin) resulted in marked amplification of the IFN signal, possibly by using the epoxygenase enzyme family as an alternative pathway.	Arachidonic Acid	0-16	interferon alpha 1	Homo sapiens	383-386	
32281329-6	2020	Arachidonic acid(AA) metabolic pathway is principally used to synthesize inflammatory cytokines, such as monocyte chemotactic protein 1(MCP-1), tumor necrosis factor(TNF), IL, IFN, etc., which is closely related to the occurrence, development and regression of inflammation.	Arachidonic Acid	0-16	interferon alpha 1	Homo sapiens	176-179	
2073400-5	1990	It was found that both IFN alpha and IFN alpha 2 markedly increased the content of arachidonic acid.	Arachidonic Acid	83-99	interferon alpha 1	Homo sapiens	23-32	
2073400-6	1990	We suggest that exposure of BAEC to IFN enhances the activity of the cell membrane PLA2 concomitantly with enrichment of the cell membrane lipids with arachidonic acid.	Arachidonic Acid	151-167	interferon alpha 1	Homo sapiens	36-39	
6361069-1	1984	The effects of interferon (IFN) on the arachidonate metabolism and physiological functions of cultured endothelial cells and blood platelets have been examined.	Arachidonic Acid	39-51	interferon alpha 1	Homo sapiens	15-31	
2439242-6	1987	Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation.	Arachidonic Acid	135-151	interferon alpha 1	Homo sapiens	75-84	
2839422-1	1988	Arachidonic acid release and lipoxygenation activated by alpha-class interferon in human neutrophils.	Arachidonic Acid	0-16	interferon alpha 1	Homo sapiens	69-79	
2839422-6	1988	Possible effects of alpha, beta, and gamma classes of IFN on endogenous arachidonic acid (AA) release and metabolism in human neutrophils was investigated in a substudy.	Arachidonic Acid	72-88	interferon alpha 1	Homo sapiens	54-57	
2439242-8	1987	These results demonstrate the autocoid profile released by stimulated human monocytes and illustrate the effects of IFN treatment on the production of lipoxygenase metabolites of arachidonic acid as well as cyclooxygenase products.	Arachidonic Acid	179-195	interferon alpha 1	Homo sapiens	116-119	
6361069-3	1984	Several observations indicate that IFN stimulates PGI2 synthesis at the level of the enzymes phospholipase A2 and cyclooxygenase: (a) PGI2 production was dependent upon the supply of exogenous arachidonic acid or the liberation of endogenous cellular arachidonate by ionophore A23187, but was not observed when IFN-treated cells were exposed to the endoperoxide prostaglandin H2.	Arachidonic Acid	251-263	interferon alpha 1	Homo sapiens	35-38	
6361069-3	1984	Several observations indicate that IFN stimulates PGI2 synthesis at the level of the enzymes phospholipase A2 and cyclooxygenase: (a) PGI2 production was dependent upon the supply of exogenous arachidonic acid or the liberation of endogenous cellular arachidonate by ionophore A23187, but was not observed when IFN-treated cells were exposed to the endoperoxide prostaglandin H2.	Arachidonic Acid	193-209	interferon alpha 1	Homo sapiens	35-38	
6178505-3	1982	In the presence of exogenous arachidonic acid (1 microgram/ml), IFN-pretreated cells produced 5-fold more PGE compared to the cell cultures in the absence of arachidonic acid.	Arachidonic Acid	29-45	interferon alpha 1	Homo sapiens	64-67	
6178505-3	1982	In the presence of exogenous arachidonic acid (1 microgram/ml), IFN-pretreated cells produced 5-fold more PGE compared to the cell cultures in the absence of arachidonic acid.	Arachidonic Acid	158-174	interferon alpha 1	Homo sapiens	64-67	
6178505-7	1982	These data suggest that IFN stimulates prostaglandin synthesis by promoting the release of arachidonic acid from phospholipids.	Arachidonic Acid	91-107	interferon alpha 1	Homo sapiens	24-27