PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21457203-0 2011 Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. Arachidonic Acid 113-129 stearoyl-CoA desaturase Homo sapiens 14-44 24962583-3 2014 Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) and certain genetic variants within the cluster are highly associated with ARA levels. Arachidonic Acid 183-186 stearoyl-CoA desaturase Homo sapiens 42-63 24962583-3 2014 Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) and certain genetic variants within the cluster are highly associated with ARA levels. Arachidonic Acid 183-186 stearoyl-CoA desaturase Homo sapiens 65-69 24823311-8 2014 We confirmed previous findings of the FADS cluster on chromosome 11 with LA and arachidonic acid, and further observed novel genome-wide significant association of this cluster with GLA, dihomo-GLA, and adrenic acid (P=2.3x10(-72), 2.6x10(-151), and 6.3x10(-140), respectively). Arachidonic Acid 80-96 stearoyl-CoA desaturase Homo sapiens 38-42 24022589-8 2013 Genetic variation in the FADS genes was strongly associated with baseline serum arachidonic acid (n-6) but serum eicosapentaenoic acid (n-3) and colonic fatty acid concentrations were not significantly associated with genotype. Arachidonic Acid 80-96 stearoyl-CoA desaturase Homo sapiens 25-29 24022589-11 2013 These results indicate that FADS genotype could modify the effects of changes in dietary fat intakes on arachidonic acid concentrations in the colon. Arachidonic Acid 104-120 stearoyl-CoA desaturase Homo sapiens 28-32 24075244-0 2013 Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. Arachidonic Acid 8-24 stearoyl-CoA desaturase Homo sapiens 88-92 24075244-1 2013 Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined. Arachidonic Acid 80-96 stearoyl-CoA desaturase Homo sapiens 47-51 24075244-1 2013 Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined. Arachidonic Acid 98-101 stearoyl-CoA desaturase Homo sapiens 47-51 27527582-4 2017 In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and alphaLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. Arachidonic Acid 137-153 stearoyl-CoA desaturase Homo sapiens 24-28 33526157-3 2021 The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and alpha-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). Arachidonic Acid 229-245 stearoyl-CoA desaturase Homo sapiens 28-32 8939925-1 1996 The effects of arachidonic acid (20:4, n-6) and other fatty acids on the expression of stearoyl-CoA desaturase gene 1 were investigated in fully differentiated 3T3-L1 adipocytes. Arachidonic Acid 15-31 stearoyl-CoA desaturase Homo sapiens 87-110 8939925-2 1996 Treatment of 3T3-L1 adipocytes with arachidonic acid resulted in a decrease in stearoyl-CoA desaturase (Scd) enzyme activity and scd1 mRNA. Arachidonic Acid 36-52 stearoyl-CoA desaturase Homo sapiens 79-102 8939925-2 1996 Treatment of 3T3-L1 adipocytes with arachidonic acid resulted in a decrease in stearoyl-CoA desaturase (Scd) enzyme activity and scd1 mRNA. Arachidonic Acid 36-52 stearoyl-CoA desaturase Homo sapiens 104-107 8939925-2 1996 Treatment of 3T3-L1 adipocytes with arachidonic acid resulted in a decrease in stearoyl-CoA desaturase (Scd) enzyme activity and scd1 mRNA. Arachidonic Acid 36-52 stearoyl-CoA desaturase Homo sapiens 129-133 8939925-3 1996 Arachidonic acid did not alter the transcription of the scd1 gene, whereas the half-life of the scd1 mRNA was reduced from 25.1 to 8.5 h. Blocking the conversion of arachidonic acid to eicosanoids by pretreatment of the cells with cyclooxygenase, lipoxygenase, or cytochrome P-450 epoxygenase inhibitors did not reverse the inhibition caused by arachidonic acid, indicating that eicosanoid synthesis is not necessary for the repression of scd1 mRNA expression. Arachidonic Acid 165-181 stearoyl-CoA desaturase Homo sapiens 96-100 8939925-3 1996 Arachidonic acid did not alter the transcription of the scd1 gene, whereas the half-life of the scd1 mRNA was reduced from 25.1 to 8.5 h. Blocking the conversion of arachidonic acid to eicosanoids by pretreatment of the cells with cyclooxygenase, lipoxygenase, or cytochrome P-450 epoxygenase inhibitors did not reverse the inhibition caused by arachidonic acid, indicating that eicosanoid synthesis is not necessary for the repression of scd1 mRNA expression. Arachidonic Acid 165-181 stearoyl-CoA desaturase Homo sapiens 96-100 8939925-3 1996 Arachidonic acid did not alter the transcription of the scd1 gene, whereas the half-life of the scd1 mRNA was reduced from 25.1 to 8.5 h. Blocking the conversion of arachidonic acid to eicosanoids by pretreatment of the cells with cyclooxygenase, lipoxygenase, or cytochrome P-450 epoxygenase inhibitors did not reverse the inhibition caused by arachidonic acid, indicating that eicosanoid synthesis is not necessary for the repression of scd1 mRNA expression. Arachidonic Acid 345-361 stearoyl-CoA desaturase Homo sapiens 96-100 8939925-3 1996 Arachidonic acid did not alter the transcription of the scd1 gene, whereas the half-life of the scd1 mRNA was reduced from 25.1 to 8.5 h. Blocking the conversion of arachidonic acid to eicosanoids by pretreatment of the cells with cyclooxygenase, lipoxygenase, or cytochrome P-450 epoxygenase inhibitors did not reverse the inhibition caused by arachidonic acid, indicating that eicosanoid synthesis is not necessary for the repression of scd1 mRNA expression. Arachidonic Acid 345-361 stearoyl-CoA desaturase Homo sapiens 96-100 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. Arachidonic Acid 121-137 stearoyl-CoA desaturase Homo sapiens 4-25 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. Arachidonic Acid 121-137 stearoyl-CoA desaturase Homo sapiens 76-80 30050886-2 2018 Due to a key role in the metabolism of unsaturated fatty acids such as arachidonic acid, one of the most important precursors of immunity mediators, fatty acid desaturase (FADS) genes could have an important impact in the development of type 2 diabetes. Arachidonic Acid 71-87 stearoyl-CoA desaturase Homo sapiens 149-170 30050886-2 2018 Due to a key role in the metabolism of unsaturated fatty acids such as arachidonic acid, one of the most important precursors of immunity mediators, fatty acid desaturase (FADS) genes could have an important impact in the development of type 2 diabetes. Arachidonic Acid 71-87 stearoyl-CoA desaturase Homo sapiens 172-176 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Arachidonic Acid 964-980 stearoyl-CoA desaturase Homo sapiens 91-112 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Arachidonic Acid 964-980 stearoyl-CoA desaturase Homo sapiens 114-118 27613800-2 2016 Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Arachidonic Acid 84-87 stearoyl-CoA desaturase Homo sapiens 28-49 27613800-2 2016 Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Arachidonic Acid 84-87 stearoyl-CoA desaturase Homo sapiens 51-55 26869086-0 2016 Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly. Arachidonic Acid 73-89 stearoyl-CoA desaturase Homo sapiens 23-44 25264165-6 2014 Polyunsaturated docosahexaenoic acid (DHA, C22:6), eicosapentaenoic acid (EPA, C20:5) and arachidonic acid (AA, C20:4) were able to reduce SREBP-1 binding to SCD1 promoter, while saturated stearic acid (SA, C18:0) did not give any effect. Arachidonic Acid 90-106 stearoyl-CoA desaturase Homo sapiens 158-162