PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27990118-7	2016	A 444A > C SNP polymorphism in the LTC4S gene, encoding an enzyme required for the formation of a glutathione adduct at the C-6 position of the arachidonic acid backbone, is associated with severe asthma and altered response to the CYSLTR1 receptor antagonist zafirlukast.	Arachidonic Acid	147-163	leukotriene C4 synthase	Homo sapiens	38-43	
27477678-2	2016	They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) that is subsequently conjugated with glutathione (GSH) by LTC4 synthase (LTC4S).	Arachidonic Acid	47-63	leukotriene C4 synthase	Homo sapiens	171-184	
27477678-2	2016	They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) that is subsequently conjugated with glutathione (GSH) by LTC4 synthase (LTC4S).	Arachidonic Acid	47-63	leukotriene C4 synthase	Homo sapiens	186-191	
24991451-1	2014	Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway.	Arachidonic Acid	83-99	leukotriene C4 synthase	Homo sapiens	127-150	
21454538-2	2011	LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubility; that amphipathic LTA(4) as a derivative of arachidonic acid and a water-soluble glutathione (GSH).	Arachidonic Acid	232-248	leukotriene C4 synthase	Homo sapiens	0-15	
17924829-2	2007	This study evaluated associations between the clinical requirement for LTRA and genetic polymorphisms of the ALOX5, LTC4S, COX-2, CysLTR1 and TBXA2R genes in the arachidonic acid cascade in the long-term management of 89 AIA patients from a Korean population.	Arachidonic Acid	162-178	leukotriene C4 synthase	Homo sapiens	116-121	
17632548-5	2007	LTC4S conjugates glutathione to LTA4, the endogenous substrate derived from arachidonic acid through the 5-lipoxygenase pathway.	Arachidonic Acid	76-92	leukotriene C4 synthase	Homo sapiens	0-5	
17110605-6	2007	CONCLUSIONS: LTC4S plays a key role in the process of inflammation as the rate limiting enzyme in the conversion of arachidonic acid to cysteinyl-leukotrienes, important mediators of inflammatory responses.	Arachidonic Acid	116-132	leukotriene C4 synthase	Homo sapiens	13-18	
16579869-3	2006	With regard to the metabolism of arachidonic acid (AA) in NSAID-intolerant asthmatic patients, the following changes have been observed: 1) A low production of prostaglandin E2, seemingly due to deficient Cox-2 regulation; 2) an increased expression of leukotriene-C4 synthase; and 3) a reduced production of metabolites (lipoxins) released through the transcellular metabolism of AA.	Arachidonic Acid	33-49	leukotriene C4 synthase	Homo sapiens	253-276	
12569976-4	2002	METHODS: The effect of arachidonic acid or platelet agonists on LTC4 synthase activity was investigated in platelets obtained from healthy volunteers, aspirin-intolerant asthmatics or aspirin-tolerant asthmatics after in vivo treatment or in vitro pre-incubation with aspirin.	Arachidonic Acid	23-39	leukotriene C4 synthase	Homo sapiens	64-77	
12569976-5	2002	RESULTS: Incubation of normal platelets with arachidonic acid or collagen provoked approximately 50% reduction of platelet LTC4 synthase activity, as determined by the conversion of LTA4 to LTC4.	Arachidonic Acid	45-61	leukotriene C4 synthase	Homo sapiens	123-136	
12569976-7	2002	Arachidonic acid-induced inhibition of LTC4 synthase activity was totally abolished in platelets collected from peripheral blood already 30 min after aspirin ingestion but was fully restored in platelets collected 3 to 7 days after the administration of aspirin.	Arachidonic Acid	0-16	leukotriene C4 synthase	Homo sapiens	39-52	
12569976-10	2002	Similarly, LTC4 synthase activity in platelets from AIA and aspirin-tolerant asthmatics (ATA) was reduced by approximately 50% after pre-treatment with arachidonic acid in vitro.	Arachidonic Acid	152-168	leukotriene C4 synthase	Homo sapiens	11-24	
10497182-9	1999	Finally, in the presence of platelets (which contain LTC(4) synthase), the LTA(4) synthesized from exogenous deuterium-labeled arachidonate was converted to cys-LTs to a greater degree than that from endogenous sources.	Arachidonic Acid	127-139	leukotriene C4 synthase	Homo sapiens	53-68	
9431445-10	1997	These results implicate that compounds that bind competitively to arachidonic acid binding sites on FLAP and 5-LO recognize motifs that are also weakly conserved on the binding site of LTC4 synthase.	Arachidonic Acid	66-82	leukotriene C4 synthase	Homo sapiens	185-198	
9004830-1	1996	Leukotrienes (LT) are synthesized from arachidonic acid by several enzymes such as phospholipase A2, 5-lipoxygenase, LTC4 synthase, as a consequence of a wide range of inflammatory stimuli.	Arachidonic Acid	39-55	leukotriene C4 synthase	Homo sapiens	117-130