PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15027896-5 2004 Arachidonic acid (AA) mimics the action of Ang II on ERK1/ERK2 and phospholipase A2 inhibitors blocked Ang II-induced ERK1/ERK2 activation. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 43-49 15027896-5 2004 Arachidonic acid (AA) mimics the action of Ang II on ERK1/ERK2 and phospholipase A2 inhibitors blocked Ang II-induced ERK1/ERK2 activation. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 103-109 12704649-7 2003 Thus, production of reactive oxygen species, aspirin (asp)-sensitive enzymes of the arachidonate metabolism, and NIK are common transducers of AII- and TNF-dependent pathways to NFkappaB. Arachidonic Acid 84-96 angiotensinogen Homo sapiens 143-146 15044681-8 2004 Activation of protein kinase C by diacylglycerol (DAG) inhibits aldosterone production, whereas the arachidonate released from DAG in ANG II-stimulated cells is converted by lipoxygenase to 12-hydroxyeicosatetraenoic acid, which may also induce Ca(2+) signaling. Arachidonic Acid 100-112 angiotensinogen Homo sapiens 134-140 11228745-0 1999 Arachidonic acid metabolites mediate angiotensin II-induced NADH/NADPH oxidase activity and hypertrophy in vascular smooth muscle cells. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 37-51 12185963-1 2002 Arachidonic acid metabolism-derived products are key mediators of angiotensin II-mediated vascular effects. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 66-80 12439866-4 2002 It was observed that cell proliferation induced by angiotensin II, or fetal bovine serum, required the activation of a Ca(2+)-dependent cytosolic phospholipase A(2) and the subsequent release of unesterified arachidonic acid. Arachidonic Acid 208-224 angiotensinogen Homo sapiens 51-65 12450322-2 2002 We have previously shown that the 12-lipoxygenase (12-LO) pathway of arachidonic acid metabolism is a mediator of ANG II-induced aldosterone synthesis in adrenal glomerulosa cells. Arachidonic Acid 69-85 angiotensinogen Homo sapiens 114-120 11532971-0 2001 Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase. Arachidonic Acid 52-68 angiotensinogen Homo sapiens 0-14 10946074-1 2000 OBJECTIVE: This study investigated, in isolated human internal mammary artery, the involvement of the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism in the contraction induced by angiotensin II. Arachidonic Acid 150-166 angiotensinogen Homo sapiens 208-222 10946074-7 2000 However, indomethacin increased (P<0.05) angiotensin II-mediated contractile response and cysteinyl leukotriene production, suggesting a redirection of arachidonic acid metabolism from the cyclooxygenase pathway to the lipoxygenase pathway. Arachidonic Acid 155-171 angiotensinogen Homo sapiens 44-58 11228745-3 1999 Angiotensin II stimulates phospholipase A2, releasing arachidonic acid, which stimulates oxidase activity in vitro. Arachidonic Acid 54-70 angiotensinogen Homo sapiens 0-14 11228745-7 1999 Attenuation of oxidase activation by inhibiting arachidonic acid metabolism with ETYA, NDGA, baicalein, or SKF-525A also inhibits angiotensin II-stimulated protein synthesis (74 +/- 2% and 34 +/- 1%, respectively). Arachidonic Acid 48-64 angiotensinogen Homo sapiens 130-144 11228745-8 1999 Thus, endogenous noncyclooxygenase arachidonic acid metabolites mediate angiotensin II-stimulated protein synthesis in cultured VSMC by activating the NADH/NADPH oxidase, providing mechanistic evidence for redox control of VSMC hypertrophy. Arachidonic Acid 35-51 angiotensinogen Homo sapiens 72-86 9636164-0 1998 Arachidonic acid mediates angiotensin II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathway. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 26-40 9653146-2 1998 The current studies were designed to test the hypothesis that membrane-associated PLA2-induced release of arachidonic acid (AA) and/or its metabolites may serve as an upstream mediator of Ang II-induced mitogen-activated protein kinase (MAPK) activation. Arachidonic Acid 106-122 angiotensinogen Homo sapiens 188-194 9636164-3 1998 The aim of this study was to determine whether arachidonic acid mediates Ang II"s effect on p21ras and if so, to ascertain the signaling mechanism(s). Arachidonic Acid 47-63 angiotensinogen Homo sapiens 73-79 9636164-7 1998 Arachidonic acid and linoleic acid mimicked Ang II-induced tyrosine phosphorylation of Shc and activation of p21ras. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 44-50 9575888-0 1998 Arachidonic acid potentiates the feedback response of mesangial BKCa channels to angiotensin II. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 81-95 8275971-1 1994 The 12-lipoxygenase (LO) pathway of arachidonic acid plays an important role in angiotensin II (AII)-mediated aldosterone synthesis. Arachidonic Acid 36-52 angiotensinogen Homo sapiens 80-94 8166641-4 1994 AngII treatment of intact cells also activated a cPLA2, as measured in cell-free extracts by the release of radiolabelled arachidonic acid from exogenously added 1-stearoyl-2-[1-14C]arachidonoyl phosphatidylcholine. Arachidonic Acid 122-138 angiotensinogen Homo sapiens 0-5 8166641-8 1994 Together, these results suggest strongly that (1) AngII phosphorylates and activates cPLA2 in a PKC-dependent manner, and that (2) cPLA2 mediates the AngII-induced [3H]arachidonic acid release in vascular smooth-muscle cells. Arachidonic Acid 168-184 angiotensinogen Homo sapiens 50-55 8166641-8 1994 Together, these results suggest strongly that (1) AngII phosphorylates and activates cPLA2 in a PKC-dependent manner, and that (2) cPLA2 mediates the AngII-induced [3H]arachidonic acid release in vascular smooth-muscle cells. Arachidonic Acid 168-184 angiotensinogen Homo sapiens 150-155 8275971-1 1994 The 12-lipoxygenase (LO) pathway of arachidonic acid plays an important role in angiotensin II (AII)-mediated aldosterone synthesis. Arachidonic Acid 36-52 angiotensinogen Homo sapiens 96-99 8498970-7 1993 In some vessels, arachidonic acid released by Ang II may also be converted to vasoconstrictor eicosanoids, i.e. thromboxane A2, PGF2 alpha and 12-HETE. Arachidonic Acid 17-33 angiotensinogen Homo sapiens 46-52 8506339-1 1993 The lipoxygenase (LO) pathway of arachidonate metabolism has been suggested to play a key role in atherosclerosis and in mediating several actions of angiotensin II (AII). Arachidonic Acid 33-45 angiotensinogen Homo sapiens 150-164 8506339-1 1993 The lipoxygenase (LO) pathway of arachidonate metabolism has been suggested to play a key role in atherosclerosis and in mediating several actions of angiotensin II (AII). Arachidonic Acid 33-45 angiotensinogen Homo sapiens 166-169 1312960-5 1992 We have previously reported that the 12-lipoxygenase (LO) pathway of arachidonic acid plays a key role in AII-induced aldosterone synthesis. Arachidonic Acid 69-85 angiotensinogen Homo sapiens 106-109 1312960-11 1992 We observed that both AII and PDGF stimulated [3H]arachidonic acid-labeled DG formation. Arachidonic Acid 50-66 angiotensinogen Homo sapiens 22-25 2845821-9 1988 These results suggest that ANG II-induced relaxation of fowl aortas involves 1) an endothelium-dependent mechanism and 2) cGMP but not arachidonic acid metabolites. Arachidonic Acid 135-151 angiotensinogen Homo sapiens 27-33 2115225-0 1990 The action of angiotensin II on the arachidonate cascade of brain microvessels. Arachidonic Acid 36-48 angiotensinogen Homo sapiens 14-28 2115237-0 1990 The effect of angiotensin I and III on the arachidonate cascade of brain microvessels. Arachidonic Acid 43-55 angiotensinogen Homo sapiens 14-35 2295137-4 1990 Arachidonic acid superfusion reduced SS-induced shortening of sinus cycle length (SCL), atrio-His interval (AH), and effective refractory period (ERP) of the right and left ventricular myocardium and prevented intra-aortic angiotensin II (30 ng/kg/min) from augmenting SS effects on these variables. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 223-237 2295137-5 1990 Pericardial arachidonic acid plus indomethacin (1 microgram/ml) eliminated the prostaglandin increase and restored the responses of SCL, AH, and ERP to SS and to angiotensin II infusion. Arachidonic Acid 12-28 angiotensinogen Homo sapiens 162-176 2555138-4 1989 Since we have previously shown that AII action is mediated by activation of the 12-lipoxygenase (12LO) pathway of arachidonic acid, we also evaluated the effects of these cytokines on the 12LO product 12-hydroxyeicosatetraenoic acid (12HETE) using a validated RIA technique. Arachidonic Acid 114-130 angiotensinogen Homo sapiens 36-39 2847716-0 1988 Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis. Arachidonic Acid 24-40 angiotensinogen Homo sapiens 80-94 2842363-1 1988 We studied the role of the lipoxygenase pathway of arachidonic acid metabolism in angiotensin II (AII)-stimulated aldosterone secretion in normal and adenomatous human adrenal glomerulosa tissue. Arachidonic Acid 51-67 angiotensinogen Homo sapiens 82-96 34038243-4 2021 This outwardly-rectifying current was activated by arachidonic acid and inhibited by angiotensin II (AngII), adrenocorticotrophic hormone (ACTH), and forskolin. Arachidonic Acid 51-67 angiotensinogen Homo sapiens 101-106 3135214-0 1988 Angiotensin II increases pituitary cell prolactin release and arachidonate liberation. Arachidonic Acid 62-74 angiotensinogen Homo sapiens 0-14 3135214-4 1988 The diacylglycerol lipase inhibitor RHC80267 decreased AII-stimulated prolactin release and arachidonate liberation. Arachidonic Acid 92-104 angiotensinogen Homo sapiens 55-58 3135214-5 1988 Further evidence that AII-induced release of arachidonate is mediated by a diacylglycerol lipase is suggested by the finding that AII increased [14C]stearate liberation from cells prelabeled with the fatty acid. Arachidonic Acid 45-57 angiotensinogen Homo sapiens 22-25 3135214-5 1988 Further evidence that AII-induced release of arachidonate is mediated by a diacylglycerol lipase is suggested by the finding that AII increased [14C]stearate liberation from cells prelabeled with the fatty acid. Arachidonic Acid 45-57 angiotensinogen Homo sapiens 130-133 2880482-1 1986 The arachidonate cascade of human or rat platelets were found to be modified by peptides (bradykinin, angiotensin I, angiotensin II, Asp1-Val5-angiotensin II-amide, somatostatin) and proteases (trypsin, kallikrein). Arachidonic Acid 4-16 angiotensinogen Homo sapiens 102-115 6238962-2 1984 In the present study, it was shown that AII induces the rapid (10 s) hydrolysis of phosphatidylinositol 4-phosphate and -4,5-bisphosphate, leading to the sustained production of inositol bis- and trisphosphate (Ins-P3), and diacylglycerol rich in arachidonic acid. Arachidonic Acid 247-263 angiotensinogen Homo sapiens 40-43 7036731-2 1982 Synthesis of these unsaturated fatty acids from arachidonate precursors is closely regulated by intrarenal factors, and circulating angiotensin II, catecholamines, arginine vasopressin and bradykinin. Arachidonic Acid 48-60 angiotensinogen Homo sapiens 132-146 21525790-8 2011 Moreover, PLC or diacylglycerol lipase inhibition prevents the Angiotensin II effect on L-type calcium channels, while PKC inhibition with chelerythrine does not, suggesting a role of arachidonic acid in this process. Arachidonic Acid 184-200 angiotensinogen Homo sapiens 63-77 28374982-0 2017 Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes. Arachidonic Acid 89-105 angiotensinogen Homo sapiens 0-14 22475809-3 2012 Here, we determined differential effects of eicosapentaenoic acid (EPA, n-3 PUFA) vs. arachidonic acid (AA, n-6 PUFA) on expression and secretion of angiotensinogen (Agt), interleukin 6 (IL-6) and monocyte chemotactic protein (MCP-1) in 3T3-L1 adipocytes. Arachidonic Acid 86-102 angiotensinogen Homo sapiens 149-164 22475809-3 2012 Here, we determined differential effects of eicosapentaenoic acid (EPA, n-3 PUFA) vs. arachidonic acid (AA, n-6 PUFA) on expression and secretion of angiotensinogen (Agt), interleukin 6 (IL-6) and monocyte chemotactic protein (MCP-1) in 3T3-L1 adipocytes. Arachidonic Acid 86-102 angiotensinogen Homo sapiens 166-169 22796714-8 2012 In cultured cardiac fibroblasts, L-carnitine attenuated the angiotensin II-induced collagen production with increased FADS1/2 expression and enhanced production of arachidonic acid and prostacyclin. Arachidonic Acid 164-180 angiotensinogen Homo sapiens 60-74 22549224-1 2012 Although the role of arachidonic acid (AA) in angiotensin II (ANG II)- and potassium-stimulated steroid production in zona glomerulosa cells is well documented, the mechanism responsible for AA release is not fully described. Arachidonic Acid 21-37 angiotensinogen Homo sapiens 62-68 22549224-0 2012 Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line. Arachidonic Acid 27-43 angiotensinogen Homo sapiens 73-87 22549224-1 2012 Although the role of arachidonic acid (AA) in angiotensin II (ANG II)- and potassium-stimulated steroid production in zona glomerulosa cells is well documented, the mechanism responsible for AA release is not fully described. Arachidonic Acid 21-37 angiotensinogen Homo sapiens 46-60 21274755-6 2011 This review focuses on signaling processes of vasoconstriction and highlights some new mechanisms regulating the contractile machinery in controlling vasomotor tone by Ang II, including RhoA/Rho kinase, transient receptor potential (TRP) channels, reactive oxygen species, and arachidonic acid metabolites. Arachidonic Acid 277-293 angiotensinogen Homo sapiens 168-174 16915013-8 2006 Moreover, angiotensin II triggers the release of aldosterone, endothelin 1, thromboxane A2 and other derivatives of the arachidonic acid metabolism, all of which can further and independently aggravate cardiovascular damage. Arachidonic Acid 120-136 angiotensinogen Homo sapiens 10-24 20388488-0 2010 Angiotensin II-dependent growth of vascular smooth muscle cells requires transactivation of the epidermal growth factor receptor via a cytosolic phospholipase A(2)-mediated release of arachidonic acid. Arachidonic Acid 184-200 angiotensinogen Homo sapiens 0-14 16987006-0 2006 Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB. Arachidonic Acid 0-16 angiotensinogen Homo sapiens 84-98 16987006-1 2006 Angiotensin II (Ang II) induces protein synthesis and hypertrophy through arachidonic acid (AA)- and redoxdependent activation of the serine-threonine kinase Akt/PKB in mesangial cells (MCs). Arachidonic Acid 74-90 angiotensinogen Homo sapiens 0-22 16814101-1 2006 Previous studies from this laboratory have demonstrated a critical role of cytosolic phospholipase A2 (cPLA2) and arachidonic acid in angiotensin II (Ang II) AT2 receptor-mediated signal transduction in renal epithelium. Arachidonic Acid 114-130 angiotensinogen Homo sapiens 134-148 16814101-1 2006 Previous studies from this laboratory have demonstrated a critical role of cytosolic phospholipase A2 (cPLA2) and arachidonic acid in angiotensin II (Ang II) AT2 receptor-mediated signal transduction in renal epithelium. Arachidonic Acid 114-130 angiotensinogen Homo sapiens 150-156 16461001-0 2006 Regulation of Akt by arachidonic acid and phosphoinositide 3-kinase in angiotensin II-stimulated vascular smooth muscle cells. Arachidonic Acid 21-37 angiotensinogen Homo sapiens 71-85 15803435-0 2004 Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. Arachidonic Acid 26-42 angiotensinogen Homo sapiens 0-14 15803435-2 2004 Support of haematopoiesis by bone marrow stromal cells (MSC) is dependent on factors that include arachidonic acid and macrophage colony stimulating factor (MCSF), both of which are increased by Ang II stimulation in other tissues. Arachidonic Acid 98-114 angiotensinogen Homo sapiens 195-201 15803435-3 2004 To further elucidate the mechanisms of Ang II-regulated haematopoiesis, we determined whether Ang II-stimulation alters arachidonic acid release and MCSF secretion from MSC. Arachidonic Acid 120-136 angiotensinogen Homo sapiens 94-100 15803435-4 2004 METHODS: Cynomolgus monkey MSC isolated from bone marrow aspirates and the human HS-5 stromal cell line were studied for Ang II-mediated arachidonic acid (AA) release, while secretion of MCSF in response to Ang II was studied in HS-5 cells. Arachidonic Acid 137-153 angiotensinogen Homo sapiens 121-127