PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25825493-1 2015 Cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin G2. Arachidonic Acid 68-84 cytochrome c oxidase I, mitochondrial Mus musculus 24-29 28819782-7 2018 The COX-1 and COX-2 activities were evaluated by ELISA in J774 cell line induced by LPS and arachidonic acid (AA). Arachidonic Acid 92-108 cytochrome c oxidase I, mitochondrial Mus musculus 4-9 31487817-1 2019 Cyclooxygenases (COXs), including COX-1 and -2, are enzymes essential for lipid mediator (LMs) syntheses from arachidonic acid (AA), such as prostaglandins (PGs). Arachidonic Acid 110-126 cytochrome c oxidase I, mitochondrial Mus musculus 34-46 31243090-1 2019 Cyclooxygenase (COX)-1, one of the critical enzymes required for the conversion of arachidonic acid to PGs, has been demonstrated to play an important role not only in the cardiovascular system but also in the immune system. Arachidonic Acid 83-99 cytochrome c oxidase I, mitochondrial Mus musculus 0-22 27875294-2 2016 Two cyclooxygenases, COX-1 and COX-2, catalyze the initial step in the metabolism of arachidonic acid to prostaglandins. Arachidonic Acid 85-101 cytochrome c oxidase I, mitochondrial Mus musculus 21-26 23784669-6 2013 Finally, platelet activation by PARs was shown to be differentially dependent on COX-1 and 12-LOX with PAR1 relying on COX-1 oxidation of arachidonic acid while PAR4 being more dependent on 12-LOX for normal platelet function. Arachidonic Acid 138-154 cytochrome c oxidase I, mitochondrial Mus musculus 119-124 24878773-8 2014 However, the contraction to arachidonic acid, but not that to PGI2, was abolished in vessels from COX-1(-/-) mice. Arachidonic Acid 28-44 cytochrome c oxidase I, mitochondrial Mus musculus 98-103 24015204-4 2013 METHODOLOGY/PRINCIPAL FINDINGS: The analogue of arachidonic acid (AA), 2-hydroxy-arachidonic acid (2OAA), was designed to inhibit the activities of COX1 and COX2 and it was predicted to have similar binding energies as AA for the catalytic sites of COX1 and COX2. Arachidonic Acid 48-64 cytochrome c oxidase I, mitochondrial Mus musculus 148-152 24015204-4 2013 METHODOLOGY/PRINCIPAL FINDINGS: The analogue of arachidonic acid (AA), 2-hydroxy-arachidonic acid (2OAA), was designed to inhibit the activities of COX1 and COX2 and it was predicted to have similar binding energies as AA for the catalytic sites of COX1 and COX2. Arachidonic Acid 48-64 cytochrome c oxidase I, mitochondrial Mus musculus 249-253 22637474-1 2012 The cyclooxygenases (COX-1 and COX-2) generate prostaglandin H(2) from arachidonic acid (AA). Arachidonic Acid 71-87 cytochrome c oxidase I, mitochondrial Mus musculus 21-26 22412193-2 2012 This lipid mediator can induce the cardinal signs of inflammation, and the beneficial actions of nonsteroidal anti-inflammatory drugs are attributed to inhibition of cyclooxygenase (COX)-1 and COX-2, enzymes essential in the biosynthesis of PGE(2) from arachidonic acid. Arachidonic Acid 253-269 cytochrome c oxidase I, mitochondrial Mus musculus 166-188 21489986-1 2011 The cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) in the committed step of prostaglandin biogenesis. Arachidonic Acid 48-64 cytochrome c oxidase I, mitochondrial Mus musculus 21-26 21843643-1 2011 The cyclooxygenases (COX-1 and COX-2) are membrane-associated, heme-containing homodimers that generate prostaglandin H(2) from arachidonic acid (AA) in the committed step of prostaglandin biogenesis and are the targets for nonsteroidal anti-inflammatory drugs (NSAIDs). Arachidonic Acid 128-144 cytochrome c oxidase I, mitochondrial Mus musculus 21-26 22149144-7 2012 There was apparent shunting of arachidonic acid to 12-/15-LOX in the COX-1 null animals. Arachidonic Acid 31-47 cytochrome c oxidase I, mitochondrial Mus musculus 69-74 20463020-1 2010 The cyclooxygenases (COX-1 and COX-2) are membrane-associated heme-containing homodimers that generate prostaglandin H(2) from arachidonic acid (AA). Arachidonic Acid 127-143 cytochrome c oxidase I, mitochondrial Mus musculus 21-26 20546888-2 2010 It is produced from arachidonic acid (AA) by a cascade of enzymatic reactions involving cyclooxygenases (COX-1 and -2) and prostaglandin E synthases (cPGES, mPGES-1 and -2). Arachidonic Acid 20-36 cytochrome c oxidase I, mitochondrial Mus musculus 105-117 19710084-7 2010 Arachidonic acid elicited an endothelium- and COX-1-dependent relaxation in pulmonary arteries from normoxic mice. Arachidonic Acid 0-16 cytochrome c oxidase I, mitochondrial Mus musculus 46-51 19996299-1 2010 Prostaglandin D(2) (PGD(2)) is one of a family of biologically active lipids derived from arachidonic acid via the action of COX-1 and COX-2. Arachidonic Acid 90-106 cytochrome c oxidase I, mitochondrial Mus musculus 125-130 19710084-8 2010 In contrast, arachidonic acid induced an endothelium-independent contraction in pulmonary arteries from hypoxic mice that was partially reduced by catalase, COX-1, COX-2, or TXA2-synthase inhibitors and was totally abolished by blockade of the thromboxane (TP) receptor. Arachidonic Acid 13-29 cytochrome c oxidase I, mitochondrial Mus musculus 157-162 17199550-1 2007 BACKGROUND: Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. Arachidonic Acid 155-171 cytochrome c oxidase I, mitochondrial Mus musculus 192-214 18597804-1 2008 Prostaglandins belong to a class of cyclic lipid-derived mediators synthesized from arachidonic acid via COX-1, COX-2 and various prostaglandin synthases. Arachidonic Acid 84-100 cytochrome c oxidase I, mitochondrial Mus musculus 105-110 17266762-1 2007 BACKGROUND: Cyclooxygenase (COX)-1 and COX-2 produce prostanoids from arachidonic acid and are thought to have important yet distinct roles in normal brain function. Arachidonic Acid 70-86 cytochrome c oxidase I, mitochondrial Mus musculus 12-34 16762422-1 2006 Prostaglandins (PGs) are potent proinflammatory mediators generated through arachidonic acid metabolism by cyclooxygenase-1 and -2 (COX-1 and COX-2) in response to different stimuli and play an important role in modulating the inflammatory responses in a number of conditions, including allergic airway inflammation. Arachidonic Acid 76-92 cytochrome c oxidase I, mitochondrial Mus musculus 132-137 16510568-1 2006 Cyclooxygenases-1 and -2 (Cox-1 and Cox-2) are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. Arachidonic Acid 101-117 cytochrome c oxidase I, mitochondrial Mus musculus 26-31 16198098-2 2005 The aim of the study was to determine whether arachidonic acid (AA), E2, and PTH increase prostaglandin E(2) (PGE(2)) synthesis in MG-63 and MC3T3-E1 osteoblastic cells and the level of mediation by COX-1 and COX-2. Arachidonic Acid 46-62 cytochrome c oxidase I, mitochondrial Mus musculus 199-204 16204198-1 2005 The mammary gland, like most tissues, produces measurable amounts of prostaglandin E2 (PGE2), a metabolite of arachidonic acid produced by sequential actions of two cyclooxygenases (COX-1 and COX-2) and three terminal PGE synthases: microsomal prostaglandin E2 synthase-1 (mPGES1), mPGES2, and cytosolic prostaglandin E2 synthase (cPGES). Arachidonic Acid 110-126 cytochrome c oxidase I, mitochondrial Mus musculus 182-187 15584915-4 2004 However, when we supplied exogenous arachidonic acid (AA) to brain homogenates, COX activity was increased in the COX-2(-/-) mice, suggesting a compensatory activation of COX-1 and an intracellular compartmentalization of the COX isozymes. Arachidonic Acid 36-52 cytochrome c oxidase I, mitochondrial Mus musculus 171-176 15863457-0 2005 Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse. Arachidonic Acid 42-58 cytochrome c oxidase I, mitochondrial Mus musculus 62-67 15863457-1 2005 Generation of vasoactive prostanoids from arachidonic acid by cyclooxygenase (COX)-1 and COX-2 was investigated in anesthetized mice. Arachidonic Acid 42-58 cytochrome c oxidase I, mitochondrial Mus musculus 62-84 16128405-2 2005 Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandin synthesis from arachidonic acid and exists in two isoforms: COX-1 and COX-2. Arachidonic Acid 79-95 cytochrome c oxidase I, mitochondrial Mus musculus 124-129 12923227-6 2003 Treatment with arachidonic acid led to sustained expression of COX-1 and COX-2. Arachidonic Acid 15-31 cytochrome c oxidase I, mitochondrial Mus musculus 63-68 15187418-3 2004 This study also found that this compound inhibited COX-1 and 2-dependent conversion of the exogenous arachidonic acid to PGD(2) in a dose-dependent manner with an IC(50) values of 0.01 microM and 12.1 microM, respectively using a COX enzyme assay kit. Arachidonic Acid 101-117 cytochrome c oxidase I, mitochondrial Mus musculus 51-62 12923227-8 2003 Unexpectedly, we observed that selective COX-1 or COX-2 inhibitors rescued adipocyte differentiation in the presence of arachidonic acid as effectively as did the nonselective COX-inhibitor indomethacin. Arachidonic Acid 120-136 cytochrome c oxidase I, mitochondrial Mus musculus 41-46 10692466-3 2000 Acetylated COX-2 is essentially a lipoxygenase, making 15-(R)-hydroxyeicosatetraenoic acid (15-HETE) and 11-(R)-hydroxyeicosatetraenoic acid (11-HETE), whereas acetylated COX-1 is unable to oxidize arachidonic acid to any products. Arachidonic Acid 198-214 cytochrome c oxidase I, mitochondrial Mus musculus 171-176 12709576-1 2003 Prostaglandins (PGs) originate from the degradation of membranar arachidonic acid by cyclooxygenases (COX-1 and COX-2). Arachidonic Acid 65-81 cytochrome c oxidase I, mitochondrial Mus musculus 102-107 10773026-4 2000 In segments of colon mounted in Ussing chambers, arachidonic acid caused a concentration-dependent increase in short-circuit current that was blocked by piroxicam, the COX-2 inhibitor NS-398, and the COX-1 inhibitor SC-560. Arachidonic Acid 49-65 cytochrome c oxidase I, mitochondrial Mus musculus 200-205 12902868-2 2003 Cyclooxygenases, COX-1 and COX-2, are two key enzymes in the conversion of arachidonic acid to PGE2. Arachidonic Acid 75-91 cytochrome c oxidase I, mitochondrial Mus musculus 17-22 12126310-2 2002 Cyclooxygenase (COX), the rate-limiting enzyme for the production of prostaglandins (PG) from arachidonic acid, exists in at least two isoforms, COX-1 and COX-2. Arachidonic Acid 94-110 cytochrome c oxidase I, mitochondrial Mus musculus 145-150 11238561-1 2001 The importance of arachidonic acid metabolites (termed eicosanoids), particularly those derived from the COX-1 and COX-2 pathways (termed prostanoids), in platelet homeostasis has long been recognized. Arachidonic Acid 18-34 cytochrome c oxidase I, mitochondrial Mus musculus 105-110 8945508-1 1996 Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. Arachidonic Acid 51-67 cytochrome c oxidase I, mitochondrial Mus musculus 102-107 10604722-2 1999 COX is a key enzyme in the conversion of arachidonic acid to prostaglandins and two isoforms of COX have been characterized, COX-1 and COX-2. Arachidonic Acid 41-57 cytochrome c oxidase I, mitochondrial Mus musculus 125-130 10370867-4 1999 Antipromotion activity was indicated by antiinflammatory effects, inhibition of production of arachidonic acid metabolites catalyzed by either COX-1 or COX-2, and chemical carcinogen-induced neoplastic transformation of mouse embryo fibroblasts. Arachidonic Acid 94-110 cytochrome c oxidase I, mitochondrial Mus musculus 143-148 9077547-3 1997 PGs are synthesized from arachidonate by either of two cyclooxygenases, cyclooxygenase-1 (Cox-1) or cyclooxygenase-2 (Cox-2), which are present in a wide variety of mamalian cells. Arachidonic Acid 25-37 cytochrome c oxidase I, mitochondrial Mus musculus 90-95 9850065-15 1998 Anti-COX-1 and -2, arachidonic acid, ASA, and NS-398 inhibited NNK bioactivation by COX-1 and -2 from 22-49%. Arachidonic Acid 19-35 cytochrome c oxidase I, mitochondrial Mus musculus 84-96 9031736-10 1997 Therefore, in subsequent studies, the effect of mercaptoalkylguanidines on COX-1 activity was studied in HUVEC stimulated with arachidonic acid for 6 h, and in J774 cells stimulated with arachidonic acid for 30 min. Arachidonic Acid 127-143 cytochrome c oxidase I, mitochondrial Mus musculus 75-80 9031736-14 1997 In experiments designed to measure COX-1 activity in HUVEC, the cells were stimulated by arachidonic acid (15 microM) for 6 h. This treatment induced a significant production of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha, the stable metabolite of prostacyclin), while nitrite production was undetectable by the Griess reaction. Arachidonic Acid 89-105 cytochrome c oxidase I, mitochondrial Mus musculus 35-40 9031736-17 1997 In experiments designed to measure COX-1 activity in J774.2 macrophages, the cells were stimulated by arachidonic acid (15 microM) for 30 min; this also induced a significant production of 6-keto-PGF1 alpha and MEG (1 microM to 3 mM), aminoguanidine (at 1 and 3 mM), but neither L-NAME nor L-NMA inhibited the production of prostaglandins. Arachidonic Acid 102-118 cytochrome c oxidase I, mitochondrial Mus musculus 35-40 8855314-6 1996 Finally, NSAIDs inhibited arachidonic acid-induced lipid body formation likewise in macrophages from wild-type and COX-1- and COX-2-deficient mice. Arachidonic Acid 26-42 cytochrome c oxidase I, mitochondrial Mus musculus 115-120 9156514-1 1996 Cyclo-oxygenase (COX) is a rate-limiting enzyme that converts arachidonic acid to prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2. Arachidonic Acid 62-78 cytochrome c oxidase I, mitochondrial Mus musculus 131-136 7688473-10 1993 Furthermore, sodium nitroprusside (0.25-1 mM) increased arachidonic acid-stimulated PGE2 production by murine recombinant COX-1 and COX-2. Arachidonic Acid 56-72 cytochrome c oxidase I, mitochondrial Mus musculus 122-127