PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31244108-2 2019 A proline-centered pentapeptide isoconformational to arachidonic acid, which exhibited appreciable selectivity for COX-2, overcoming acetic acid- and formalin-induced pain in rats to almost 80%, was treated as a substrate by the enzyme. Arachidonic Acid 53-69 cytochrome c oxidase II, mitochondrial Rattus norvegicus 115-120 33618245-2 2021 However, when administered to unanesthetized rats at clinically relevant doses, they modulate neurotransmission involving arachidonic acid and brain activity of COX-2, which oxidizes arachidonic acid within the arachidonic acid metabolic cascade. Arachidonic Acid 183-199 cytochrome c oxidase II, mitochondrial Rattus norvegicus 161-166 33618245-2 2021 However, when administered to unanesthetized rats at clinically relevant doses, they modulate neurotransmission involving arachidonic acid and brain activity of COX-2, which oxidizes arachidonic acid within the arachidonic acid metabolic cascade. Arachidonic Acid 183-199 cytochrome c oxidase II, mitochondrial Rattus norvegicus 161-166 33868179-8 2021 Verification by experimental showed that compared with the control rats, the expression of the COX-1, COX-2, PTGFR, and TBXA2R genes associated with the arachidonic acid metabolism pathway has significantly increased the uterus and serum of RSA rats (P < 0.05). Arachidonic Acid 153-169 cytochrome c oxidase II, mitochondrial Rattus norvegicus 102-107 32410351-4 2020 The difluorinated analogue simultaneously inhibits two key enzymes of the arachidonic acid cascade, namely mPGES-1 and COX-2, where the mPGES-1 inhibition represents the principal mechanism of action. Arachidonic Acid 74-90 cytochrome c oxidase II, mitochondrial Rattus norvegicus 119-124 31378306-4 2019 Cox2 is one of two Cox isoenzymes that is responsible for the formation of prostanoids from arachidonic acid. Arachidonic Acid 92-108 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-4 31244108-4 2019 The kinetic parameter Kcat/Km for COX-2-mediated metabolism of the peptide (6.3 x 105 M-1 s-1) was quite similar to 9.5 x 105 M-1 s-1 for arachidonic acid. Arachidonic Acid 138-154 cytochrome c oxidase II, mitochondrial Rattus norvegicus 34-39 28451639-2 2017 They are synthesized from arachidonic acid by cyclooxygenase 1 (COX1) and COX2. Arachidonic Acid 26-42 cytochrome c oxidase II, mitochondrial Rattus norvegicus 74-78 21328464-7 2011 These data suggest that the delay of PGE(2) release after COX-2 upregulation triggered by PAR1 is due to the poor supply of free arachidonic acid at the early stage in RGM1 cells, and that plural isozymes of PLA(2) including sPLA(2)-IIA may complementarily contribute to the liberation of free arachidonic acid. Arachidonic Acid 129-145 cytochrome c oxidase II, mitochondrial Rattus norvegicus 58-63 23551902-2 2013 COX-2-10aa-PGIS is a newly engineered protein with COX-2 and prostacyclin synthase activities that converts arachidonic acid directly to prostacyclin (prostaglandin I2 [PGI2]). Arachidonic Acid 108-124 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-5 23551902-2 2013 COX-2-10aa-PGIS is a newly engineered protein with COX-2 and prostacyclin synthase activities that converts arachidonic acid directly to prostacyclin (prostaglandin I2 [PGI2]). Arachidonic Acid 108-124 cytochrome c oxidase II, mitochondrial Rattus norvegicus 51-56 24854565-3 2014 Cyclooxygenase (COX)-2 is the inducible isoform of an intracellular enzyme that converts arachidonic acid into prostaglandins. Arachidonic Acid 89-105 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-22 22476691-7 2012 COX-2 protein and prostaglandin F2alpha and E2 production were stimulated by 20:3n-6, ARA, 18:3n-3 and 20:5 n-3. Arachidonic Acid 86-89 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-5 21239635-1 2011 Cyclooxygenase (COX)-2 expression is increased in the kidney of rats made diabetic with streptozotocin and associated with enhanced release of prostaglandins stimulated by arachidonic acid (AA). Arachidonic Acid 172-188 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-22 20043943-2 2010 COX-1 and COX-2 converts arachidonic acid into prostaglandins. Arachidonic Acid 25-41 cytochrome c oxidase II, mitochondrial Rattus norvegicus 10-15 21070866-1 2011 BACKGROUND: Dietary n-3 polyunsaturated fatty acid (PUFA) deprivation increases expression of arachidonic acid (AA 20:4n-6)-selective cytosolic phospholipase A(2) (cPLA(2)) IVA and cyclooxygenase (COX)-2 in rat brain, while decreasing expression of docosahexaenoic acid (DHA 22:6n-3)-selective calcium-independent iPLA(2) VIA. Arachidonic Acid 94-110 cytochrome c oxidase II, mitochondrial Rattus norvegicus 181-203 19801156-8 2010 Increase in perfusion pressure with arachidonic acid in both male MS and Ovx MS was related to cyclooxygenase (COX)-1 and COX-2 overexpression in kidney. Arachidonic Acid 36-52 cytochrome c oxidase II, mitochondrial Rattus norvegicus 122-127 19801156-10 2010 The results suggest that the alteration in arachidonic acid metabolism associated with changes in the expression of COX-1 and COX-2 induced by sucrose intake, and influenced by sex hormones, may contribute to renal damage. Arachidonic Acid 43-59 cytochrome c oxidase II, mitochondrial Rattus norvegicus 126-131 16753143-5 2006 Treatment of diabetic rats with L-NAME reduced arachidonic acid-stimulated release of prostaglandins and the expression of COX-2. Arachidonic Acid 47-63 cytochrome c oxidase II, mitochondrial Rattus norvegicus 123-128 20082610-0 2010 Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats. Arachidonic Acid 8-24 cytochrome c oxidase II, mitochondrial Rattus norvegicus 50-55 17651056-4 2007 Results showed that the generation of RS from arachidonic acid through the COX-2 and XOD pathways was effectively suppressed by DHA and EPA, while GSH levels and antioxidative enzyme activities were significantly enhanced by DHA and EPA. Arachidonic Acid 46-62 cytochrome c oxidase II, mitochondrial Rattus norvegicus 75-80 12438520-3 2002 In anesthetized rats treated with bacterial lipopolysaccharide (LPS) to induce the expression of COX-2, the marked increase in PGE2 production that followed bolus intravenous injection of arachidonic acid (3 mg x kg(-1)) was strongly inhibited by diclofenac but largely unaffected by the COX-2-selective inhibitor DFP (5,5- dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone). Arachidonic Acid 188-204 cytochrome c oxidase II, mitochondrial Rattus norvegicus 97-102 16281994-0 2005 Arachidonic Acid-Induced COX-1 and COX-2-Mediated Vasodilation in Rat Gingival Arterioles In Vivo. Arachidonic Acid 0-16 cytochrome c oxidase II, mitochondrial Rattus norvegicus 35-40 15935072-2 2005 The formation of the two metabolites--produced through cyclo-oxygenase (COX) enzymatic activity and free radical-mediated peroxidation of arachidonic acid (AA), respectively,--was prevented by the specific NMDA antagonist MK-801, and was largely dependent on COX-2 activity. Arachidonic Acid 138-154 cytochrome c oxidase II, mitochondrial Rattus norvegicus 259-264 12900435-0 2003 Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney. Arachidonic Acid 56-72 cytochrome c oxidase II, mitochondrial Rattus norvegicus 8-13 12900348-8 2003 CONCLUSIONS: The results of these experiments suggest that arachidonic acid is converted into vasoactive prostanoids by the COX-2 and COX-1 pathway in the pulmonary and peripheral vascular beds in the rat and that TXA2 is a major prostanoid formed in the normal rat lung. Arachidonic Acid 59-75 cytochrome c oxidase II, mitochondrial Rattus norvegicus 124-129 15808647-2 2005 Cyclooxygenase (COX)-1 and COX-2 catalyze the initial key enzymatic steps in the metabolism of arachidonic acid. Arachidonic Acid 95-111 cytochrome c oxidase II, mitochondrial Rattus norvegicus 27-32 12438520-3 2002 In anesthetized rats treated with bacterial lipopolysaccharide (LPS) to induce the expression of COX-2, the marked increase in PGE2 production that followed bolus intravenous injection of arachidonic acid (3 mg x kg(-1)) was strongly inhibited by diclofenac but largely unaffected by the COX-2-selective inhibitor DFP (5,5- dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone). Arachidonic Acid 188-204 cytochrome c oxidase II, mitochondrial Rattus norvegicus 288-293 11795877-1 2002 COX-2 is rapidly expressed by various stimuli and plays a key role in conversion of free arachidonic acid to prostaglandins (PGs). Arachidonic Acid 89-105 cytochrome c oxidase II, mitochondrial Rattus norvegicus 0-5 11923588-2 2002 Oxidative stress may up-regulate extracellular signal regulated kinases (ERK1/2) and, subsequently, the arachidonic acid cascade mediated by phospholipase A2 (PLA2) and cyclooxygenase (COX-2). Arachidonic Acid 104-120 cytochrome c oxidase II, mitochondrial Rattus norvegicus 185-190 10922363-7 2000 cPGES/p23 was functionally linked with COX-1 in marked preference to COX-2 to produce PGE(2) from exogenous and endogenous arachidonic acid, the latter being supplied by cytosolic phospholipase A(2) in the immediate response. Arachidonic Acid 123-139 cytochrome c oxidase II, mitochondrial Rattus norvegicus 69-74 11487305-1 2001 The selective cyclooxygenase-2 (COX) inhibitor, celecoxib, and the non-selective COX-1 and COX-2 inhibitor, indomethacin, at microM concentrations, stimulate the release of arachidonic acid from rat liver cells (the C-9 cell line). Arachidonic Acid 173-189 cytochrome c oxidase II, mitochondrial Rattus norvegicus 91-96 11133513-1 2001 The generation of PGs from arachidonic acid is mediated by cyclooxygenase (COX), which consists of a constitutive (COX-1) and an inducible (COX-2) isoform. Arachidonic Acid 27-43 cytochrome c oxidase II, mitochondrial Rattus norvegicus 140-145 10674759-1 2000 Prostaglandins, potent mediators of inflammation, are generated from arachidonic acid (AA) via the action of cyclooxygenase-1 and -2 (COX-1 and COX-2). Arachidonic Acid 69-85 cytochrome c oxidase II, mitochondrial Rattus norvegicus 144-149 9789085-1 1998 The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. Arachidonic Acid 95-111 cytochrome c oxidase II, mitochondrial Rattus norvegicus 61-66 10669114-3 1999 The present study was aimed at determining the effects of the COX-2 inhibitor NS-398 on the release of COX and 5-lipoxygenase (LOX) metabolites of arachidonic acid in isolated perfused lungs obtained from endotoxin-treated rats before and after stimulation with the leukocyte secretagogue N-formyl-methionyl-leucyl-phenylalanine (FMLP). Arachidonic Acid 147-163 cytochrome c oxidase II, mitochondrial Rattus norvegicus 62-67 9674017-5 1998 When exposed to lipopolysaccharide (LPS), the induction of COX-2 and the enhancement of PGE2 synthesis upon CaI were much lower in TGM as compared with RM the releasability of arachidonic acid upon CaI stimulation was relatively unchanged in RM but was reduced in TGM Thus, in TGM as compared with RM, a lower level of COX-1 expression and a lower level of COX-2 induction, and the reduction of arachidonate releasability by LPS exposure, are mainly responsible for lower PGE2 synthetic ability upon CaI stimulation. Arachidonic Acid 176-192 cytochrome c oxidase II, mitochondrial Rattus norvegicus 357-362 9510202-5 1998 Preferred coupling of the two inducible enzymes, COX-2 and PGE2 synthase, was further confirmed by the ability of LPS-treated cells to convert exogenous arachidonic acid to PGE2 optimally at a time when both enzymes were simultaneously induced. Arachidonic Acid 153-169 cytochrome c oxidase II, mitochondrial Rattus norvegicus 49-54 12160205-3 1997 Cyclooxygenase (COX), which acts in the synthesis of PG from arachidonic acid, has been recently revealed to have two subtypes, a constitutive type (COX-1) and an inducible one (COX-2). Arachidonic Acid 61-77 cytochrome c oxidase II, mitochondrial Rattus norvegicus 178-183 9732393-2 1998 The conversion of arachidonic acid (AA) to prostaglandin H2 is catalyzed at least by two isoforms of cyclooxygenase, named Cox-1 and Cox-2. Arachidonic Acid 18-34 cytochrome c oxidase II, mitochondrial Rattus norvegicus 133-138 9681442-3 1998 The synthesis of prostaglandins depends upon the production and conversion of arachidonic acid, steps that are catalyzed by phospholipase A2 (PLA2) and cyclooxygenase (COX), respectively. Arachidonic Acid 78-94 cytochrome c oxidase II, mitochondrial Rattus norvegicus 168-171 8274023-8 1993 However, COX-2 mRNA was expressed in vivo in the lung and kidney, but not in the heart, after systemic administration of LPS, suggesting that COX-2 but not COX-1 plays a major role in producing COX-derived products of arachidonic acid during endotoxic shock. Arachidonic Acid 218-234 cytochrome c oxidase II, mitochondrial Rattus norvegicus 9-14 8274023-8 1993 However, COX-2 mRNA was expressed in vivo in the lung and kidney, but not in the heart, after systemic administration of LPS, suggesting that COX-2 but not COX-1 plays a major role in producing COX-derived products of arachidonic acid during endotoxic shock. Arachidonic Acid 218-234 cytochrome c oxidase II, mitochondrial Rattus norvegicus 142-147 34776980-10 2021 Among them, arachidonic acid is in a pivotal position, and the expression of its rate-limiting enzyme (COX-2) involved in its cyclooxygenase metabolic pathway was significantly up-regulated in the model group, but significantly decreased after the intervention of Guizhi Fuling Capsules. Arachidonic Acid 12-28 cytochrome c oxidase II, mitochondrial Rattus norvegicus 103-108 34776980-11 2021 In conclusion, Guizhi Fuling Capsules can effectively relieve primary dysmenorrhea, and this effect may be attributed to the regulation effects of Guizhi Fuling Capsules on endogenous metabolism, such as inhibiting arachidonic acid converted to prostaglandins through downregulate the expression of COX-2, which plays an anti-inflammatory effect. Arachidonic Acid 215-231 cytochrome c oxidase II, mitochondrial Rattus norvegicus 299-304