PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10188594-2 1999 The fatty acid composition was also modified by high alpha-linolenate oil; arachidonic acid (AA) level in alkylacyl-GPC, a platelet-activating factor (PAF) precursor, decreased by 30% along with concomitant increases in the n-3 fatty acid levels. Arachidonic Acid 75-91 PCNA clamp associated factor Rattus norvegicus 123-149 12529272-10 2003 Thus PAF can activate both an arachidonate pathway-mediated suppression of proximal tubule sodium transport and a nitric oxide pathway-mediated dilatory action on renal hemodynamics that likely contributes to the natriuresis and diuresis observed in vivo. Arachidonic Acid 30-42 PCNA clamp associated factor Rattus norvegicus 5-8 10188594-2 1999 The fatty acid composition was also modified by high alpha-linolenate oil; arachidonic acid (AA) level in alkylacyl-GPC, a platelet-activating factor (PAF) precursor, decreased by 30% along with concomitant increases in the n-3 fatty acid levels. Arachidonic Acid 75-91 PCNA clamp associated factor Rattus norvegicus 151-154 9101420-7 1997 PAF synthesis and counter-regulatory prostaglandins may be derived from the same arachidonate precursor. Arachidonic Acid 81-93 PCNA clamp associated factor Rattus norvegicus 0-3 9101420-12 1997 The sustained hyperinsulinemia stimulated plasma membrane CoA-independent transacylase activity, which is responsible for the mobilization of arachidonates into lyso-PAF, to form l-alkylarchidonoyl-glycerophosphocholine. Arachidonic Acid 142-155 PCNA clamp associated factor Rattus norvegicus 166-169 8615681-12 1996 The protein tyrosine kinase inhibitor genistein abolished the release of free arachidonic acid, suggesting a crucial role for tyrosine phosphorylation in PAF-induced phospholipase A2 activation in rat hepatocytes. Arachidonic Acid 78-94 PCNA clamp associated factor Rattus norvegicus 154-157 8996188-3 1997 It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 microM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. Arachidonic Acid 211-227 PCNA clamp associated factor Rattus norvegicus 32-35 8642404-7 1996 PAF-activated microglia released arachidonic acid in a Ca(2+)-dependent manner and without conversion to its derivatives. Arachidonic Acid 33-49 PCNA clamp associated factor Rattus norvegicus 0-3 8642404-8 1996 We propose that microglia as well as neurons contribute to PAF-related events in the CNS by releasing arachidonic acid. Arachidonic Acid 102-118 PCNA clamp associated factor Rattus norvegicus 59-62 8667229-6 1996 Exogenous arachidonic acid also inhibited TPA-induced PAF production in parallel with increase in PGE2 levels. Arachidonic Acid 10-26 PCNA clamp associated factor Rattus norvegicus 54-57 8667229-7 1996 Inhibition of PAF production by exogenous arachidonic acid was abolished by indomethacin. Arachidonic Acid 42-58 PCNA clamp associated factor Rattus norvegicus 14-17 8615681-13 1996 Taken together, our data indicate that the interaction of PAF with rat hepatocytes is dependent upon its metabolism, involves protein tyrosine phosphorylation/dephosphorylation and arachidonic acid release, and does not involve the heteromeric G-protein-coupled PAF receptor which has been characterized in Kupffer cells. Arachidonic Acid 181-197 PCNA clamp associated factor Rattus norvegicus 58-61 8543583-9 1995 Thus the activation of cytosolic phospholipase A2 and the acylation of lyso-PAF by such as arachidonic acid could be regulating factors for PAF production in stimulated rat neutrophils. Arachidonic Acid 91-107 PCNA clamp associated factor Rattus norvegicus 76-79 8543583-9 1995 Thus the activation of cytosolic phospholipase A2 and the acylation of lyso-PAF by such as arachidonic acid could be regulating factors for PAF production in stimulated rat neutrophils. Arachidonic Acid 91-107 PCNA clamp associated factor Rattus norvegicus 140-143 7766433-2 1995 Phospholipases A2 (PLA2) can release arachidonic acid and lysophosphatidylcholine (lysoPC), precursors for leukotriene and PAF synthesis, respectively, from membrane phospholipids. Arachidonic Acid 37-53 PCNA clamp associated factor Rattus norvegicus 123-126 1941608-1 1991 In many isolated tissues, including glomerular mesangial cells and endothelial cells, the synthesis of platelet activating factor (PAF) occurs by remodeling the phospholipids so that the production of PAF results in the release of arachidonic acid with subsequent production of cyclooxygenase or lipoxygenase products. Arachidonic Acid 231-247 PCNA clamp associated factor Rattus norvegicus 103-129 7784472-6 1995 These results suggest that PAF-induced increase of vascular permeability in rat bronchi is mediated by cyclooxygenase and lipoxygenase products of arachidonic acid metabolism. Arachidonic Acid 147-163 PCNA clamp associated factor Rattus norvegicus 27-30 8111595-11 1994 In separate experiments, infusion of this "priming" dose of PAF into isolated perfused lungs induced LTC4 synthesis and augmented lung thromboxane A2 synthesis after arachidonic acid infusion. Arachidonic Acid 166-182 PCNA clamp associated factor Rattus norvegicus 60-63 8111595-12 1994 We conclude that both cyclooxygenase and lipoxygenase products of arachidonic acid metabolism are involved in PAF-induced potentiation of protamine lung edema. Arachidonic Acid 66-82 PCNA clamp associated factor Rattus norvegicus 110-113 1790592-8 1991 Our results suggest that in astroglial cells, PAF, a compound which is produced in several tissues including brain, mobilizes a selected arachidonic acid pool, possibly associated with diacylglycerol production, from phospholipids, thus activating the conversion of the released fatty acid via the cyclo and the 12-lipoxygenase pathways. Arachidonic Acid 137-153 PCNA clamp associated factor Rattus norvegicus 46-49 1331121-8 1992 We suggest that arachidonate released specifically from PtdCho via phospholipase A2 is a source of this PAF-elevated PGE2. Arachidonic Acid 16-28 PCNA clamp associated factor Rattus norvegicus 104-107 1941608-1 1991 In many isolated tissues, including glomerular mesangial cells and endothelial cells, the synthesis of platelet activating factor (PAF) occurs by remodeling the phospholipids so that the production of PAF results in the release of arachidonic acid with subsequent production of cyclooxygenase or lipoxygenase products. Arachidonic Acid 231-247 PCNA clamp associated factor Rattus norvegicus 131-134 1941608-1 1991 In many isolated tissues, including glomerular mesangial cells and endothelial cells, the synthesis of platelet activating factor (PAF) occurs by remodeling the phospholipids so that the production of PAF results in the release of arachidonic acid with subsequent production of cyclooxygenase or lipoxygenase products. Arachidonic Acid 231-247 PCNA clamp associated factor Rattus norvegicus 201-204 1941608-2 1991 In some tissues, including the renal medulla, another pathway for PAF biosynthesis (the de novo pathway) has been found in which the production of PAF is not linked to the production of arachidonic acid products. Arachidonic Acid 186-202 PCNA clamp associated factor Rattus norvegicus 66-69 2546734-10 1989 The inhibitors of arachidonic acid metabolism, indomethacin, eicosatetraynoic acid, and the calcium channel blocker verapamil, inhibited PAF-stimulated CRH secretion, suggesting mediation by Ca2+ influx and phospholipase-A2 activation. Arachidonic Acid 18-34 PCNA clamp associated factor Rattus norvegicus 137-140 1769369-8 1991 In similar experiments, 0.2 microM PAF enhanced the depletion of jejunal mucosal free arachidonic acid as measured by gas chromatography. Arachidonic Acid 86-102 PCNA clamp associated factor Rattus norvegicus 35-38 1910120-0 1991 Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism. Arachidonic Acid 134-146 PCNA clamp associated factor Rattus norvegicus 100-103 1910120-12 1991 Changes in the mucosal level of cyclooxygenase products, especially thromboxanes, by drugs modifying the arachidonate metabolism would be closely associated with their prevention or aggravation of gastric damage induced by PAF. Arachidonic Acid 105-117 PCNA clamp associated factor Rattus norvegicus 223-226 2261677-16 1990 The action of PAF requires the participation of cells such as platelets, macrophages, neutrophils, and monocytes and involvement of arachidonic acid metabolites. Arachidonic Acid 132-148 PCNA clamp associated factor Rattus norvegicus 14-17 2322287-9 1990 This therefore, suggests that the release of PAF may be involved in the hypotensive action of this epoxide of arachidonic acid. Arachidonic Acid 110-126 PCNA clamp associated factor Rattus norvegicus 45-48 2170386-1 1990 Treatment of cultured Kupffer cells with the beta-adrenergic agonist isoproterenol (10 microM) for a short period of time (30 min) attenuated the subsequent platelet-activating factor (PAF)-induced arachidonic acid release and cyclooxygenase-derived eicosanoid (e.g. thromboxane B2 and prostaglandin E2) production. Arachidonic Acid 198-214 PCNA clamp associated factor Rattus norvegicus 157-183 2170386-1 1990 Treatment of cultured Kupffer cells with the beta-adrenergic agonist isoproterenol (10 microM) for a short period of time (30 min) attenuated the subsequent platelet-activating factor (PAF)-induced arachidonic acid release and cyclooxygenase-derived eicosanoid (e.g. thromboxane B2 and prostaglandin E2) production. Arachidonic Acid 198-214 PCNA clamp associated factor Rattus norvegicus 185-188 2703999-5 1989 The decidua-like reaction induced by PAF involves the generation of cyclooxygenase metabolites of arachidonic acid since it was inhibited by indomethacin. Arachidonic Acid 98-114 PCNA clamp associated factor Rattus norvegicus 37-40 2924083-14 1989 This study suggests that Paf-acether-induced pleurisy in the rat may be mediated by lipoxygenase arachidonic acid metabolites and that pleurisy induced by zymosan, but not by carrageenin, is largely dependent upon Paf-acether. Arachidonic Acid 97-113 PCNA clamp associated factor Rattus norvegicus 25-28 3337246-4 1988 PAF also rapidly increased free arachidonate, diacylglycerol, and inositol trisphosphate (IP3) levels. Arachidonic Acid 32-44 PCNA clamp associated factor Rattus norvegicus 0-3 2849046-7 1988 The effect of PAF on arachidonic acid metabolism was inhibited by prior exposure of the cells to PAF. Arachidonic Acid 21-37 PCNA clamp associated factor Rattus norvegicus 14-17 2849046-7 1988 The effect of PAF on arachidonic acid metabolism was inhibited by prior exposure of the cells to PAF. Arachidonic Acid 21-37 PCNA clamp associated factor Rattus norvegicus 97-100 3040878-1 1987 Addition of platelet-activating factor (PAF) to cells doubly labeled with [14C]glycerol plus [3H]arachidonic acid resulted in a transient decrease of [14C]glycerol-labeled phosphatidylinositol (PI) and a transient increase of [14C]glycerol-labeled lysophosphatidylinositol (LPI). Arachidonic Acid 97-113 PCNA clamp associated factor Rattus norvegicus 12-38 3040878-1 1987 Addition of platelet-activating factor (PAF) to cells doubly labeled with [14C]glycerol plus [3H]arachidonic acid resulted in a transient decrease of [14C]glycerol-labeled phosphatidylinositol (PI) and a transient increase of [14C]glycerol-labeled lysophosphatidylinositol (LPI). Arachidonic Acid 97-113 PCNA clamp associated factor Rattus norvegicus 40-43 3653044-5 1987 The stimulatory effect of PAF on mucin secretion is blocked by equimolar concentrations of nordihydroguiaretic acid (NDGA) a "mixed" inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism. Arachidonic Acid 187-203 PCNA clamp associated factor Rattus norvegicus 26-29 3034369-11 1987 These results suggest that the coronary vasoconstrictor actions of Paf are partially dependent on the release of vasoactive arachidonic acid metabolites. Arachidonic Acid 124-140 PCNA clamp associated factor Rattus norvegicus 67-70 3108322-6 1987 These findings support the hypothesis that a relationship between PAF and arachidonate metabolism exists at the intact organ level. Arachidonic Acid 74-86 PCNA clamp associated factor Rattus norvegicus 66-69 2997065-2 1985 Kadsurenone inhibits the specific binding of 3H-PAF to a receptor preparation from rabbit platelet membrane in a competitive and reversible manner, its Ki being 3.88 X 10(-8) M. It inhibits the aggregation of rabbit platelets in plasma induced by PAF with a pA2 of 6.28, but not those induced by arachidonic acid, epinephrine, ADP or A-23187. Arachidonic Acid 296-312 PCNA clamp associated factor Rattus norvegicus 48-51 3036733-7 1987 These results suggest that PAF acts, as least partly, via the release of vasoactive arachidonic acid metabolites. Arachidonic Acid 84-100 PCNA clamp associated factor Rattus norvegicus 27-30 3095850-0 1986 Platelet-activating factor-induced vasoconstriction in rat isolated, perfused hearts: contribution of cyclo-oxygenase and lipoxygenase arachidonic acid metabolites. Arachidonic Acid 135-151 PCNA clamp associated factor Rattus norvegicus 0-26 3095850-6 1986 These findings suggest a causal role for vasoconstrictor arachidonic acid metabolites in the acute cardiac effects of PAF with the quantitatively most important contribution to the vasoconstriction made by LTC4. Arachidonic Acid 57-73 PCNA clamp associated factor Rattus norvegicus 118-121 3087218-1 1986 Platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) results in contraction of isolated glomeruli and cultured mesangial cells and concomitantly causes release of arachidonic acid and prostaglandin E2 (PGE2) formation. Arachidonic Acid 191-207 PCNA clamp associated factor Rattus norvegicus 0-26 4052436-8 1985 The sequestering of arachidonic acid into the PAF precursor pool and the substantial amount of lyso-PAF secreted by macrophages into the extracellular fluid appear to be significant events in the inactivation process. Arachidonic Acid 20-36 PCNA clamp associated factor Rattus norvegicus 46-49 6423667-5 1984 In cells prelabeled with [14C]arachidonic acid both PAF and serum-treated zymosan released 14C from phospholipids and increased free [14C]arachidonate. Arachidonic Acid 30-46 PCNA clamp associated factor Rattus norvegicus 52-55