PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3942557-0 1986 Chlorpromazine inhibits arterial ACAT and reduces arterial cholesterol and cholesteryl ester accumulation in cholesterol-fed rabbits. Chlorpromazine 0-14 sterol O-acyltransferase 1 Oryctolagus cuniculus 33-37 3942557-2 1986 After 2 weeks, arterial acyl CoA: cholesterol acyltransferase (ACAT) activity tended to be reduced by chlorpromazine treatment with no affect on net arterial cholesterol. Chlorpromazine 102-116 sterol O-acyltransferase 1 Oryctolagus cuniculus 24-61 3942557-2 1986 After 2 weeks, arterial acyl CoA: cholesterol acyltransferase (ACAT) activity tended to be reduced by chlorpromazine treatment with no affect on net arterial cholesterol. Chlorpromazine 102-116 sterol O-acyltransferase 1 Oryctolagus cuniculus 63-67 6852207-1 1983 Chlorpromazine (CPZ), a major tranquilizer, was found to be a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in isolated arterial microsomes and in intact arterial tissue from the rat and cholesterol-fed rabbit in vitro. Chlorpromazine 0-14 sterol O-acyltransferase 1 Oryctolagus cuniculus 119-123 6852207-1 1983 Chlorpromazine (CPZ), a major tranquilizer, was found to be a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in isolated arterial microsomes and in intact arterial tissue from the rat and cholesterol-fed rabbit in vitro. Chlorpromazine 16-19 sterol O-acyltransferase 1 Oryctolagus cuniculus 119-123 6852207-2 1983 In isolated rabbit arterial microsomes, CPZ resulted in a concentration-dependent inhibition of ACAT with 50% inhibition of [1-14C]oleoylCoA incorporation into [14C]cholesteryl esters occurring at 0.1 mM CPZ. Chlorpromazine 40-43 sterol O-acyltransferase 1 Oryctolagus cuniculus 96-100