PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6409396-1	1983	There are two major R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) activation pathways to 5-fluorouracil, one that is mediated by microsomal cytochrome P-450 oxidation at C-5" of the tetrahydrofuran moiety and one that is mediated by soluble enzymes.	Tegafur	65-73	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	149-165	
25505563-0	2013	Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.	Tegafur	66-73	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41	
25505563-1	2013	Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes.	Tegafur	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-154	
25505563-1	2013	Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes.	Tegafur	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	156-159	
25505563-1	2013	Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes.	Tegafur	9-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-154	
25505563-1	2013	Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes.	Tegafur	9-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	156-159	
6438379-0	1984	Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil to 5-fluorouracil.	Tegafur	49-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16	
6438379-1	1984	Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)).	Tegafur	49-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16	
6438379-1	1984	Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)).	Tegafur	49-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	181-197	
6438379-1	1984	Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)).	Tegafur	90-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16	
6438379-1	1984	Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)).	Tegafur	90-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	181-197	
6797104-1	1981	Phenobarbital stimulates the induction of liver microsomal drug-metabolizing enzyme, namely, cytochrome P-450, which enhances the rate of conversion of FT-207 to 5-FU, the active substance.	Tegafur	152-158	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109