PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6797104-1 1981 Phenobarbital stimulates the induction of liver microsomal drug-metabolizing enzyme, namely, cytochrome P-450, which enhances the rate of conversion of FT-207 to 5-FU, the active substance. Tegafur 152-158 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-109 6438379-0 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil to 5-fluorouracil. Tegafur 49-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6438379-1 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)). Tegafur 49-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6438379-1 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)). Tegafur 49-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 181-197 6438379-1 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)). Tegafur 90-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 6438379-1 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)). Tegafur 90-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 181-197 6409396-1 1983 There are two major R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) activation pathways to 5-fluorouracil, one that is mediated by microsomal cytochrome P-450 oxidation at C-5" of the tetrahydrofuran moiety and one that is mediated by soluble enzymes. Tegafur 65-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 149-165 25505563-0 2013 Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes. Tegafur 66-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 25505563-1 2013 Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. Tegafur 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-154 25505563-1 2013 Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. Tegafur 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 156-159 25505563-1 2013 Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. Tegafur 9-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-154 25505563-1 2013 Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. Tegafur 9-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 156-159