PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12646134-5 2003 The product of PtdIns(3,5)P2 hydrolysis, PtdIns5P, causes MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of MTM1, MTMR3, and MTMR6. phosphatidylinositol 5-phosphate 41-49 myotubularin related protein 3 Homo sapiens 169-174 15840652-6 2005 Consequently, generation of PtdIns5P at the plasma membrane by ectopic expression of the bacterial phosphatase IpgD leads to a translocation of MTMR3 that requires the PH-G domain. phosphatidylinositol 5-phosphate 28-36 myotubularin related protein 3 Homo sapiens 144-149 24840251-1 2014 Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. phosphatidylinositol 5-phosphate 211-219 myotubularin related protein 3 Homo sapiens 137-142 24840251-1 2014 Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. phosphatidylinositol 5-phosphate 211-219 myotubularin related protein 3 Homo sapiens 144-174 24840251-8 2014 The results suggest a model for the activation of Rac1 in cell migration where PIKfyve and MTMR3 produce PtdIns5P on cellular membranes which may then serve to recruit effectors to activate Rac1. phosphatidylinositol 5-phosphate 105-113 myotubularin related protein 3 Homo sapiens 91-96 30944173-5 2019 Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3" position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P2 and PtdIns from PtdIns3P. phosphatidylinositol 5-phosphate 222-230 myotubularin related protein 3 Homo sapiens 53-90