PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26069676-10 2013 Oleic acid and palmitic acid inhibited MMP1 gene expression in chondrocytes stimulated with TNFalpha. Palmitic Acid 15-28 tumor necrosis factor Homo sapiens 92-100 25242580-5 2014 The purpose of the present study was to observe the effect of palmitic acid on the expression of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in VSMCs. Palmitic Acid 62-75 tumor necrosis factor Homo sapiens 123-150 25242580-5 2014 The purpose of the present study was to observe the effect of palmitic acid on the expression of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in VSMCs. Palmitic Acid 62-75 tumor necrosis factor Homo sapiens 152-161 25242580-8 2014 The results showed that palmitic acid significantly stimulated mRNA and protein expression of CRP, TNF-alpha and iNOS in VSMCs in time- and concentration-dependent manners, and therefore, palmitic acid is able to exert a pro-inflammatory effect on VSMCs via stimulating CRP, TNF-alpha and iNOS expression. Palmitic Acid 24-37 tumor necrosis factor Homo sapiens 99-108 25242580-8 2014 The results showed that palmitic acid significantly stimulated mRNA and protein expression of CRP, TNF-alpha and iNOS in VSMCs in time- and concentration-dependent manners, and therefore, palmitic acid is able to exert a pro-inflammatory effect on VSMCs via stimulating CRP, TNF-alpha and iNOS expression. Palmitic Acid 24-37 tumor necrosis factor Homo sapiens 275-284 25242580-8 2014 The results showed that palmitic acid significantly stimulated mRNA and protein expression of CRP, TNF-alpha and iNOS in VSMCs in time- and concentration-dependent manners, and therefore, palmitic acid is able to exert a pro-inflammatory effect on VSMCs via stimulating CRP, TNF-alpha and iNOS expression. Palmitic Acid 188-201 tumor necrosis factor Homo sapiens 99-108 25242580-8 2014 The results showed that palmitic acid significantly stimulated mRNA and protein expression of CRP, TNF-alpha and iNOS in VSMCs in time- and concentration-dependent manners, and therefore, palmitic acid is able to exert a pro-inflammatory effect on VSMCs via stimulating CRP, TNF-alpha and iNOS expression. Palmitic Acid 188-201 tumor necrosis factor Homo sapiens 275-284 23632636-5 2013 Microarray analysis revealed increased expression of genes regulating inflammation, stress response, and immediate early response in cytotrophoblasts in response to palmitic acid (PA), TNFalpha, or a combination of both (PA + TNFalpha). Palmitic Acid 165-178 tumor necrosis factor Homo sapiens 226-234 23632636-5 2013 Microarray analysis revealed increased expression of genes regulating inflammation, stress response, and immediate early response in cytotrophoblasts in response to palmitic acid (PA), TNFalpha, or a combination of both (PA + TNFalpha). Palmitic Acid 180-182 tumor necrosis factor Homo sapiens 226-234 22683933-7 2012 Moreover, PA inhibited the TNF-alpha-induced phosphorylation of AKT, but not c-Jun N-terminal kinase, indicating that inhibition of survival signaling pathways activated by TNF-alpha may explain the effects of PA on TNF-alpha-induced cytotoxicity. Palmitic Acid 210-212 tumor necrosis factor Homo sapiens 27-36 22683933-0 2012 Effects of palmitic acid on TNF-alpha-induced cytotoxicity in SK-Hep-1 cells. Palmitic Acid 11-24 tumor necrosis factor Homo sapiens 28-37 24078775-0 2013 Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha via a NF-kappaB-dependent mechanism in HaCaT keratinocytes. Palmitic Acid 0-13 tumor necrosis factor Homo sapiens 100-127 24078775-4 2013 Our results showed that palmitic acid induced an upregulation of IL-6, TNF- alpha , IL-1 beta secretions, accompanied by NF- kappa B nuclear translocation and activation. Palmitic Acid 24-37 tumor necrosis factor Homo sapiens 71-81 24078775-6 2013 Palmitic acid-induced IL-6, TNF- alpha , IL-1 beta productions were attenuated by NF- kappa B inhibitor PDTC. Palmitic Acid 0-13 tumor necrosis factor Homo sapiens 28-38 24078775-8 2013 These data demonstrate for the first time that palmitic acid can stimulate IL-6, TNF- alpha , IL-1 beta productions in HaCaT keratinocytes and cell proliferation, thereby potentially contributing to acne inflammation and pilosebaceous duct hyperkeratinization. Palmitic Acid 47-60 tumor necrosis factor Homo sapiens 81-91 22683933-5 2012 PA augmented TNF-alpha-induced cytotoxicity, while the unsaturated fatty acids attenuated TNF-alpha-induced cytotoxicity. Palmitic Acid 0-2 tumor necrosis factor Homo sapiens 13-22 22683933-7 2012 Moreover, PA inhibited the TNF-alpha-induced phosphorylation of AKT, but not c-Jun N-terminal kinase, indicating that inhibition of survival signaling pathways activated by TNF-alpha may explain the effects of PA on TNF-alpha-induced cytotoxicity. Palmitic Acid 210-212 tumor necrosis factor Homo sapiens 173-182 22683933-6 2012 In a mechanistic study, PA enhanced TNF-alpha-mediated apoptosis in the absence of oxidative stress, as determined by measuring the cellular glutathione and malondialdehyde levels. Palmitic Acid 24-26 tumor necrosis factor Homo sapiens 36-45 22683933-7 2012 Moreover, PA inhibited the TNF-alpha-induced phosphorylation of AKT, but not c-Jun N-terminal kinase, indicating that inhibition of survival signaling pathways activated by TNF-alpha may explain the effects of PA on TNF-alpha-induced cytotoxicity. Palmitic Acid 10-12 tumor necrosis factor Homo sapiens 27-36 22683933-7 2012 Moreover, PA inhibited the TNF-alpha-induced phosphorylation of AKT, but not c-Jun N-terminal kinase, indicating that inhibition of survival signaling pathways activated by TNF-alpha may explain the effects of PA on TNF-alpha-induced cytotoxicity. Palmitic Acid 210-212 tumor necrosis factor Homo sapiens 173-182 22661989-6 2012 RESULTS: Our findings indicated that palmitic acid up-regulates the expression of ICAM-1 and VCAM-1 in HBMECs when these cells are induced with TNF-alpha or LPS. Palmitic Acid 37-50 tumor necrosis factor Homo sapiens 144-153 21801123-11 2012 Tumor necrosis factor-alpha levels were inversely proportional to the palmitic acid percentage (p = 0.0275) and positively associated with the percentages of stearic (18:0) (p = 0.0132) and oleic (p = 0.0290) acids. Palmitic Acid 70-83 tumor necrosis factor Homo sapiens 0-27 22791168-4 2012 Pre-treatment of homoplantaginin on human umbilical vein endothelial cells (HUVECs) significantly inhibited PA induced tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) mRNA expression, and inhibitory kappaB kinase beta (IKKbeta) and nuclear factor-kappaB (NF-kappaB) p65 phosphorylation. Palmitic Acid 108-110 tumor necrosis factor Homo sapiens 149-158 23251812-6 2012 Compared to the THP-1 macrophages without palmitic acid, the level of TLR4 mRNA protein and NF-kappaB p65 phosphorylation and the expression of TNF-alpha and IL-1beta increased after treatment by palmitic acid in a dose-dependent fashion (P < 0.05). Palmitic Acid 196-209 tumor necrosis factor Homo sapiens 144-153 11434916-2 2001 The cDNA encoding pro-TNF was expressed in both COS-1 cells and Sf9 cells and metabolic labeling with [(3)H]myristic or [(3)H]palmitic acid was attempted. Palmitic Acid 126-139 tumor necrosis factor Homo sapiens 18-25 7929601-6 1994 Palmitic acid enhanced the release of IFN-gamma at concentrations that diminished TNF-alpha production. Palmitic Acid 0-13 tumor necrosis factor Homo sapiens 82-91 34923420-6 2022 Compared with control, PA pretreatment significantly increased LPS-induced TNF-alpha production and secretion in macrophages. Palmitic Acid 23-25 tumor necrosis factor Homo sapiens 75-84 34923420-12 2022 The differential regulation of LPS-induced TNF-alpha and IL-1beta production by PA was associated with cellular metabolism of PA, because inhibiting metabolism of PA with etomoxir or pretreatment with Br-PA which cannot be metabolized reversed these effects. Palmitic Acid 80-82 tumor necrosis factor Homo sapiens 43-52 34332276-7 2021 In addition, SP significantly increased TNF-alpha, IL-1beta, IL-6, ICAM-1, VCAM-1, P-selectin, and E-selectin levels (P < 0.01), decreased IL-10 levels (P < 0.01), and increased the adhesion rates of monocytes and neutrophils (P < 0.01). Palmitic Acid 13-15 tumor necrosis factor Homo sapiens 40-49 34923420-12 2022 The differential regulation of LPS-induced TNF-alpha and IL-1beta production by PA was associated with cellular metabolism of PA, because inhibiting metabolism of PA with etomoxir or pretreatment with Br-PA which cannot be metabolized reversed these effects. Palmitic Acid 126-128 tumor necrosis factor Homo sapiens 43-52 34923420-15 2022 PA differentially affected LPS-induced production of TNF-alpha and IL-1beta in macrophages through differentially modulating these pathways. Palmitic Acid 0-2 tumor necrosis factor Homo sapiens 53-62 34643021-4 2021 Moreover, we demonstrated, for the first time in human adipocytes, that cells exposure to PA induced gene expression of proinflammatory cytokines TNF-alpha, IL-6, IL-8, and MCP-1. Palmitic Acid 90-92 tumor necrosis factor Homo sapiens 146-155 34151811-4 2021 METHODS: 200 and 400muM PA-conjugated BSA were applied to SH-SY5Y and HMC3 cells for 24 h. For FcgammaR blockage experiment, both cells were exposed to FcgammaR blocker before receiving of 200 and 400muM of PA-conjugated BSA for 24 h. RESULTS: PA significantly increased AD-related proteins, including Abeta and BACE1, as well as increasing TNFalpha, IL-1beta, and IL-6 in SH-SY5Y and HMC3 cells. Palmitic Acid 244-246 tumor necrosis factor Homo sapiens 341-349 34072916-5 2021 However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS. Palmitic Acid 246-248 tumor necrosis factor Homo sapiens 161-188 33604948-0 2021 Increased oxidative stress and mitochondrial impairments associated with increased expression of TNF-alpha and caspase-3 in palmitic acid-induced lipotoxicity in myoblasts. Palmitic Acid 124-137 tumor necrosis factor Homo sapiens 97-106 35182670-8 2022 In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05). Palmitic Acid 61-63 tumor necrosis factor Homo sapiens 125-152 35182670-8 2022 In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05). Palmitic Acid 192-194 tumor necrosis factor Homo sapiens 125-152 33958662-6 2021 Both epoxygenated fatty acids significantly decreased IL-8 expression in IL-1beta-induced MC and TNFalpha in PA-induced MC. Palmitic Acid 109-111 tumor necrosis factor Homo sapiens 97-105 33604948-3 2021 In the present study, the exposure of myoblasts to excess palmitic acid caused an elevation of tumor necrosis factor-alpha expression and an increase in reactive oxygen species levels consistent with the enhanced inflammation and oxidative stress. Palmitic Acid 58-71 tumor necrosis factor Homo sapiens 95-122 33135616-6 2021 RESULTS: B. animalis R101-8 inhibited LPS- and palmitic acid-induced protein expression of inflammatory cytokines IL-1beta, IL-6, TNF-alpha concomitant with decreases in chemerin, MCP-1, PEDF, and cellular triglycerides, and blocked NF-kB and AP-1 activation pathway through inhibition of p-IkappaBalpha, pc-Jun, and pc-Fos phosphorylation. Palmitic Acid 47-60 tumor necrosis factor Homo sapiens 130-139 33686181-6 2021 Palmitic acid up-regulated TLR4 as well as pro-inflammatory cytokines IL6 and TNFalpha contrasting with DHA effect. Palmitic Acid 0-13 tumor necrosis factor Homo sapiens 78-86 31919912-8 2020 In bone marrow-derived DCs, Ppard deficiency reduced palmitic acid-induced upregulation of co-stimulatory molecules and pro-inflammatory cytokine IL12 and TNFalpha. Palmitic Acid 53-66 tumor necrosis factor Homo sapiens 155-163 32916992-8 2020 The overexpression of LRRK2 reduced the concentration of a pro-inflammatory cytokine, tumor necrosis factor alpha (TNFalpha), induced by PA. Palmitic Acid 137-139 tumor necrosis factor Homo sapiens 86-113 32916992-8 2020 The overexpression of LRRK2 reduced the concentration of a pro-inflammatory cytokine, tumor necrosis factor alpha (TNFalpha), induced by PA. Palmitic Acid 137-139 tumor necrosis factor Homo sapiens 115-123 32557749-10 2020 Here, we found that the expression and secretion of TNF-alpha and IL-6 were enhanced by PA treatment. Palmitic Acid 88-90 tumor necrosis factor Homo sapiens 52-61 31793207-11 2020 The silencing of PNPLA3 blocked the overexpression of NF-kB or PA-induced TNF-alpha up-regulation. Palmitic Acid 63-65 tumor necrosis factor Homo sapiens 74-83 32400338-11 2020 The PA-induced phosphorylation of the inflammatory pathway mediators IKK and NF-kappaB, as well as the elevated expression and secretion of proinflammatory cytokines (IL-6, TNF-alpha), were reduced in cells pre-exposed to HEL. Palmitic Acid 4-6 tumor necrosis factor Homo sapiens 173-182 31793207-12 2020 Moreover, mutant PNPLA3 overexpression prevented NF-kB inhibitor-induced down-regulation of TNF-alpha expression in PA-treated HepG2 cells. Palmitic Acid 116-118 tumor necrosis factor Homo sapiens 92-101 30463189-3 2018 The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha). Palmitic Acid 121-123 tumor necrosis factor Homo sapiens 239-248 30958623-5 2019 Our results showed that PA treatment caused the deposition of lipid droplets and resulted in an increased expression of tumor necrosis factor-alpha in a dose-dependent manner. Palmitic Acid 24-26 tumor necrosis factor Homo sapiens 120-147 31423543-8 2019 The results showed that the treatment with PA increased IL-18 and TNF-alpha production. Palmitic Acid 43-45 tumor necrosis factor Homo sapiens 66-75 30102465-5 2018 METHODS AND RESULTS: EAHy926 cells (EC lineage) are exposed to PA, OA, or POA, and stimulated with tumor necrosis factor (TNF)-alpha. Palmitic Acid 63-65 tumor necrosis factor Homo sapiens 99-132 30102465-7 2018 PA, but not OA, enhances the production of IL-6 and IL-8 in response to TNF-alpha. Palmitic Acid 0-2 tumor necrosis factor Homo sapiens 72-81 28304381-0 2017 TNF-alpha stimulates endothelial palmitic acid transcytosis and promotes insulin resistance. Palmitic Acid 33-46 tumor necrosis factor Homo sapiens 0-9 29569260-8 2018 Of note, the reduced level of TNF-alpha, IL-6 as well as Leptin and the production of Adiponectin by miR-375 inhibitors was significantly reversed by silencing of AdipoR2 in PA-induced HepG2 cells. Palmitic Acid 174-176 tumor necrosis factor Homo sapiens 30-39 29164820-3 2018 METHODS & RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6). Palmitic Acid 48-61 tumor necrosis factor Homo sapiens 237-245 28304381-5 2017 In the present study, we discovered that TNF-alpha might stimulate PA transcytosis across cardiac microvascular endothelial cells, which further impaired the insulin-stimulated glucose uptake by cardiomyocytes and promoted insulin resistance. Palmitic Acid 67-69 tumor necrosis factor Homo sapiens 41-50 26748475-7 2016 PGC-1beta inhibited PA induced TNFalpha, MCP-1, and IL-1beta mRNA and protein expressions. Palmitic Acid 20-22 tumor necrosis factor Homo sapiens 31-39 27639126-10 2016 ROS scavenger N-acetylcysteine (NAC) and NF-kappaB inhibitor PDTC showed similar effect on PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1. Palmitic Acid 91-93 tumor necrosis factor Homo sapiens 115-124 27639126-8 2016 PA-induced secretion of TNF-alpha, IL-6, and expression of ICAM-1 at protein and mRNA levels, which was significantly inhibited by APN. Palmitic Acid 0-2 tumor necrosis factor Homo sapiens 24-33 26324406-7 2015 Lowering the habitually high PA intake by feeding the HOA diet resulted in lower secretion of interleukin (IL)-1beta, IL-18, IL-10, and tumor necrosis factor-alpha by PBMCs, as well as lower relative mRNA expression of cJun and NLRP3 in muscle. Palmitic Acid 29-31 tumor necrosis factor Homo sapiens 136-163 26739470-10 2015 CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors. Palmitic Acid 46-48 tumor necrosis factor Homo sapiens 97-106 26254104-8 2015 Silencing p66Shc normalized PA action on VEGF-A and TNFalpha specifically, without abolishing the PA-induced oxidative stress, which suggests a deleterious role of p66Shc independently of any major modulation of the cellular oxidative status in a high NEFA levels context. Palmitic Acid 28-30 tumor necrosis factor Homo sapiens 52-60 26254104-5 2015 Resveratrol further decreased the deleterious action of PA on gene expression of vascularization factors (TNFalpha, VEGF-A, SDF1alpha, PECAM-1, VEGFR2, Tie2 and CXCR4) and improved CAC motility. Palmitic Acid 56-58 tumor necrosis factor Homo sapiens 106-114