PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29886733-0	2018	Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway.	Palmitic Acid	59-72	sirtuin 1	Homo sapiens	120-125	
28899784-6	2017	And palmitic acid (PA) treatment increased the miR-181b expression while decreased SIRT1 expression in HepG2 cells.	Palmitic Acid	4-17	sirtuin 1	Homo sapiens	83-88	
29535452-7	2018	In vitro incubation of the ALDH2 activator Alda-1 rescued against palmitic acid-induced changes in cardiomyocyte function, the effect of which was nullified by the Sirt-1 inhibitor nicotinamide and the CaM kinase II inhibitor KN-93 (p < 0.0001).	Palmitic Acid	66-79	sirtuin 1	Homo sapiens	164-170	
28899784-6	2017	And palmitic acid (PA) treatment increased the miR-181b expression while decreased SIRT1 expression in HepG2 cells.	Palmitic Acid	19-21	sirtuin 1	Homo sapiens	83-88	
31139863-14	2019	Palmitic acid-induced muscle cell dysfunction occurs, at least in part, through activation of the miR-34a/SIRT1:AMPK pathway.	Palmitic Acid	0-13	sirtuin 1	Homo sapiens	106-111	
22363635-9	2012	Exendin-4 enhanced protein expression of Sirt1 and phospho-AMPKalpha in HepG2 cells treated with 0.4 mM palmitic acid.	Palmitic Acid	104-117	sirtuin 1	Homo sapiens	41-46	
32158242-10	2020	Inhibition of Sirt1 by sirtinol partially reversed the beneficial effects of DHA on PA-treated cells.	Palmitic Acid	84-86	sirtuin 1	Homo sapiens	14-19	
24446069-10	2014	In conclusion, increased SIRT1 by exendin-4 attenuates PA-induced ER stress and mitochondrial dysfunction in hepatocytes.	Palmitic Acid	55-57	sirtuin 1	Homo sapiens	25-30	
33750217-0	2021	Inhibitory Effect of Paeonol on Apoptosis, Oxidative Stress, and Inflammatory Response in Human Umbilical Vein Endothelial Cells Induced by High Glucose and Palmitic Acid Induced Through Regulating SIRT1/FOXO3a/NF-kappaB Pathway.	Palmitic Acid	157-170	sirtuin 1	Homo sapiens	198-203	
32343969-0	2020	Paeonol prevents lipid metabolism dysfunction in palmitic acid-induced HepG2 injury through promoting SIRT1-FoxO1-ATG14-dependent autophagy.	Palmitic Acid	49-62	sirtuin 1	Homo sapiens	102-107	
32343969-11	2020	Most importantly, autophagy inhibitor, as well as SIRT1 inhibitor blocked the effects of Pae on PA-induced cell injury and metabolism dysfunction, respectively.	Palmitic Acid	96-98	sirtuin 1	Homo sapiens	50-55	
31811908-7	2020	In HCC cells, hepatitis B virus X protein (HBx) and palmitic acid (PA) increased the level of acetylated AFP by disrupting SIRT1-mediated deacetylation.	Palmitic Acid	52-65	sirtuin 1	Homo sapiens	123-128	
31811908-7	2020	In HCC cells, hepatitis B virus X protein (HBx) and palmitic acid (PA) increased the level of acetylated AFP by disrupting SIRT1-mediated deacetylation.	Palmitic Acid	67-69	sirtuin 1	Homo sapiens	123-128	
31073968-0	2019	Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons.	Palmitic Acid	0-13	sirtuin 1	Homo sapiens	80-85	
31073968-4	2019	A possible molecular mechanism involved in the effects of PA may be through dysfunction of the NAD+ sensor enzyme, SIRT1.	Palmitic Acid	58-60	sirtuin 1	Homo sapiens	115-120	
31073968-5	2019	Therefore, the aim of the present study was to analyze the relationship between the effects of PA metabolism on the function of SIRT1 and the upregulation of BACE1 in cultured hippocampal neurons.	Palmitic Acid	95-97	sirtuin 1	Homo sapiens	128-133	
31073968-6	2019	PA reduced the total amount of NAD+ in neurons that caused an increase in p65 K310 acetylation due to inhibition of SIRT1 activity and low protein content.	Palmitic Acid	0-2	sirtuin 1	Homo sapiens	116-121