PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27222180-8 2016 CONCLUSION: PA treatment can stimulate lipid accumulation in hepatocytes and induce oxidative stress through NOX4 and mitochondria pathway to activate inflammasomes and stimulate the secretion of IL-1beta. Palmitic Acid 12-14 interleukin 1 beta Mus musculus 196-204 30791996-6 2019 High glucose and palmitic acid treatment enhanced the expression of interleukin-1beta and interleukin-18; these enhancements were further increased after treatment with DsbA-L siRNA but alleviated by co-treatment with an AMPK activator. Palmitic Acid 17-30 interleukin 1 beta Mus musculus 68-85 29374854-9 2018 RESULTS: PA elevated not only phosphorylation of JNK, IRS1 serines, and IKKalpha/beta, but also the expression of IL-6, TNFalpha and IL-1beta in C2C12-GLUT4myc cells. Palmitic Acid 9-11 interleukin 1 beta Mus musculus 133-141 28365872-9 2017 In vitro, PA induced MCP-1 and augmented LPS-primed production of IL-1beta and TNF-alpha in macrophages. Palmitic Acid 10-12 interleukin 1 beta Mus musculus 66-74 30387829-7 2018 The results demonstrated that PA effectively activated NLRP3 inflammasome and increased the expression and secretion of interleukin (IL)-1beta and IL-18. Palmitic Acid 30-32 interleukin 1 beta Mus musculus 120-142 30387829-8 2018 Notably, the PA-induced inflammasome activation was reversed by Nob, as indicated by the decreased expression levels of NLRP3, Caspase-1, IL-1beta and IL-18. Palmitic Acid 13-15 interleukin 1 beta Mus musculus 138-146 29437575-4 2018 APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner. Palmitic Acid 55-68 interleukin 1 beta Mus musculus 96-104 29437575-4 2018 APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner. Palmitic Acid 55-68 interleukin 1 beta Mus musculus 197-205 29111234-7 2018 Further, CXCL5 potentiated the secretion of IL-1beta from macrophages and palmitic acid, a fatty acid released from subcutaneous adipocytes, further enhanced IL-1beta secretion via endoplasmic reticulum stress induction. Palmitic Acid 74-87 interleukin 1 beta Mus musculus 158-166 28730512-9 2017 We found that KCs and NLRP3 play pro-inflammatory roles in the progression of NASH, probably through secretions of IL-1beta and IL-18 by KCs induced by PA. Palmitic Acid 152-154 interleukin 1 beta Mus musculus 115-123 28730512-12 2017 Furthermore, the levels of pro-inflammatory cytokines IL-1beta and IL-18 in the SN of KCs from WT mice were all elevated with the stimulation of PA, and the increase of these cytokines in the SN was blocked by NLRP3 deletion. Palmitic Acid 145-147 interleukin 1 beta Mus musculus 54-62 28730512-13 2017 In conclusion, our novel findings demonstrate that NLRP3 plays a pivotal role in NASH development and pro-inflammatory cytokines IL-1beta and IL-18 secretion induced by PA stimulation, and NLRP3 might be an effective potential target for the treatment of liver inflammatory diseases associated with NLRP3 inflammasome activation. Palmitic Acid 169-171 interleukin 1 beta Mus musculus 129-137 28499273-2 2017 It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs). Palmitic Acid 28-41 interleukin 1 beta Mus musculus 89-106 28499273-2 2017 It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs). Palmitic Acid 28-41 interleukin 1 beta Mus musculus 108-116 28499273-2 2017 It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs). Palmitic Acid 43-45 interleukin 1 beta Mus musculus 89-106 28499273-2 2017 It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs). Palmitic Acid 43-45 interleukin 1 beta Mus musculus 108-116 21488066-9 2011 Our novel data show that the saturated fatty acid (FA) palmitic acid (PA) activates the inflammasome and induces sensitization to LPS-induced IL-1beta release in hepatocytes. Palmitic Acid 55-68 interleukin 1 beta Mus musculus 142-150 24186874-8 2014 IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells. Palmitic Acid 126-139 interleukin 1 beta Mus musculus 0-8 22987396-2 2013 Here we show that both TLR2 and palmitic acid are required for activation of the inflammasome, interleukin (IL)-1alpha, and IL-1beta, resulting in the progression of NASH. Palmitic Acid 32-45 interleukin 1 beta Mus musculus 124-132 22987396-11 2013 In the presence of TLR2 ligand, palmitic acid did induce caspase-1 activation and release of IL-1alpha and IL-1beta in Kupffer cells; however, these effects were not observed in HSCs. Palmitic Acid 32-45 interleukin 1 beta Mus musculus 107-115 21488066-9 2011 Our novel data show that the saturated fatty acid (FA) palmitic acid (PA) activates the inflammasome and induces sensitization to LPS-induced IL-1beta release in hepatocytes. Palmitic Acid 70-72 interleukin 1 beta Mus musculus 142-150