PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26157144-8	2015	NR4A1 overexpression in MIN6 cells reduced C/EBP homologous protein (CHOP) expression and Caspase3 activation induced by TG or PA.	Palmitic Acid	127-129	caspase 3	Mus musculus	90-98	
28805970-6	2017	In mouse, insulinoma MIN6 cells, palmitic acid induced the activity of caspase 3/7 after a 72-h exposure, while pharmacologically active concentrations of MR1704 did not.	Palmitic Acid	33-46	caspase 3	Mus musculus	71-80	
27449757-8	2016	We demonstrate that OXA attenuates PA-induced hypothalamic cell death via reduced caspase-3/7 apoptosis, stabilization of Bcl-2 gene expression, and reduced Bax/Bcl-2 gene expression ratio.	Palmitic Acid	35-37	caspase 3	Mus musculus	82-91	
26672616-5	2016	PA treatment also induced increased protein expression of inositol requiring protein 1alpha (IRE1alpha), phosphorylated eukaryotic initiation factor-alpha (eIF2alpha), and activating transcription factor 4 (ATF4) as well as activation of caspase-3.	Palmitic Acid	0-2	caspase 3	Mus musculus	238-247	
26472223-9	2015	In vitro, stable XBP1-knockdown Huh7 cells (Huh7-KD) and scramble control cells (Huh7-SCR) were generated and treated with palmitic acid (PA) for 24 h. PA-treated Huh7-KD cells had increased cytotoxicity measured by lactate dehydrogenase release, apoptotic nuclei, and caspase3/7 activity assays compared with Huh7-SCR cells.	Palmitic Acid	152-154	caspase 3	Mus musculus	269-277	
29720871-13	2018	We also observed that quercetin could inhibit palmitic acid-induced cell apoptosis via suppressing the activation of caspase-3, -9, -12; increasing the ratio of Bcl-2/BAX and reversing the impaired mitochondrial membrane potential.	Palmitic Acid	46-59	caspase 3	Mus musculus	117-130	
25841776-6	2015	Similar results were found in mouse hepatocytes in which LA attenuated PA-mediated activation of caspase 3 and reduced lipid accumulation by decreasing PA uptake and increasing fatty acid oxidation and lipophagy, thereby preventing lipoapoptosis.	Palmitic Acid	71-73	caspase 3	Mus musculus	97-106	
26113535-6	2015	We show that Foxc2 reduces the expression of Bax, caspase-9, and caspase-3 in both serum-starved and palmitic acid-induced cell apoptotic models, which confirms the anti-apoptotic role of Foxc2.	Palmitic Acid	101-114	caspase 3	Mus musculus	65-74	
31472681-10	2019	RESULTS: Exposure to 100-400 muM PA reduced cell viability, activated caspase 3, and enhanced the expression levels of the apoptosis-related protein BCL-2-associated X protein (BAX) and ER stress markers glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in MLTC-1 cells.	Palmitic Acid	33-35	caspase 3	Mus musculus	70-79	
25846498-4	2015	In human and mouse hepatocytes palmitic acid at a lipotoxic concentration triggered early activation of endoplasmic reticulum (ER) stress-related kinases, induced the apoptotic transcription factor CHOP, activated caspase 3 and increased the percentage of apoptotic cells.	Palmitic Acid	31-44	caspase 3	Mus musculus	214-223	
22542939-6	2012	After the 24h of PA exposure, cells also underwent marked apoptosis and showed increased activation of the apoptosis protease, caspase-3.	Palmitic Acid	17-19	caspase 3	Mus musculus	127-136	
22542939-9	2012	Collectively, these results demonstrated that the JNK-mediated signaling mechanism of PA-induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3.	Palmitic Acid	86-88	caspase 3	Mus musculus	178-187	
31472681-12	2019	Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78.	Palmitic Acid	43-45	caspase 3	Mus musculus	89-98	
31077207-8	2019	Our results showed that 200-800 muM PA treatment reduces cell viability, induces cell apoptosis, enhances the expression of apoptosis-related genes (Caspase 3 and B-cell lymphoma-2 (BCL-2) associated X protein (BAX)), and activates the expression of ER stress marker genes (glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP)).	Palmitic Acid	36-38	caspase 3	Mus musculus	149-158