PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34681909-4 2021 We found that palmitic acid (a potent inducer of lipotoxicity), induced a rapid (~24 h) and significant increase in IL-6 in RAW264.7 cells. Palmitic Acid 14-27 interleukin 6 Mus musculus 116-120 33034881-4 2020 The results showed that PA (750 muM) evoked lipotoxicity as a reduction in cell viability, increased IL-6 and TNF-alpha expression, and enhanced reactive oxygen species (ROS). Palmitic Acid 24-26 interleukin 6 Mus musculus 101-105 33034881-5 2020 However, SFN pretreatment attenuated the levels of, IL-6 and TNF-alpha in C2C12 myotubes exposure to PA. Palmitic Acid 101-103 interleukin 6 Mus musculus 52-56 33105887-9 2020 Thus, immunohistochemical analysis of VAT showed an increase in MCP-1 and IL-6 staining in HF + PA-fed mice but not in HF + LA-fed mice compared to CD controls. Palmitic Acid 96-98 interleukin 6 Mus musculus 74-78 29486473-11 2018 JNK inhibitor SP600125 prevented PA-mediated increase of Nox4, IL-8, IL-6 and iTG. Palmitic Acid 33-35 interleukin 6 Mus musculus 69-73 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Palmitic Acid 100-113 interleukin 6 Mus musculus 50-54 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Palmitic Acid 100-113 interleukin 6 Mus musculus 189-193 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Palmitic Acid 115-117 interleukin 6 Mus musculus 50-54 29989851-6 2018 To understand how SFA and LPS interact to promote IL-6 expression, our in vitro studies showed that palmitic acid (PA), a major SFA, and LPS exerted synergistic effect on the expression of IL-6 in hepatocytes. Palmitic Acid 115-117 interleukin 6 Mus musculus 189-193 29989851-7 2018 Furthermore, coculture of hepatocytes with macrophages resulted in a greater IL-6 expression than culture of hepatocytes without macrophages in response to the combination of PA and LPS. Palmitic Acid 175-177 interleukin 6 Mus musculus 77-81 29374854-9 2018 RESULTS: PA elevated not only phosphorylation of JNK, IRS1 serines, and IKKalpha/beta, but also the expression of IL-6, TNFalpha and IL-1beta in C2C12-GLUT4myc cells. Palmitic Acid 9-11 interleukin 6 Mus musculus 114-118 29486473-13 2018 An IkappaB degradation inhibitor, BAY11-7082, prevented PA-induced increase of IL-8 and IL-6 as well as iTG, whereas it only decreased ROS levels slightly and showed no influence on cellular apoptosis. Palmitic Acid 56-58 interleukin 6 Mus musculus 88-92 30032721-8 2020 L-cycloserine, OA and EPA all counteracted PA-induced intracellular ceramide accumulation leading to a downregulation of IL-6 and TNFalpha. Palmitic Acid 23-25 interleukin 6 Mus musculus 121-125 30032721-10 2020 In conclusion, PA induced the expression of IL-6 and TNFalpha in N42 neuronal cells independently of TLR4 but, partially, via ceramide synthesis with OA and EPA being anti-inflammatory by decreasing PA-induced intracellular ceramide build-up. Palmitic Acid 15-17 interleukin 6 Mus musculus 44-48 26436985-3 2016 The mRNA expression of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha in PA-treated myotubes was suppressed by these three test long-chain PUFAs. Palmitic Acid 103-105 interleukin 6 Mus musculus 54-99 27493246-10 2016 IL6(-/-) osteoblasts displayed higher alkaline phosphatase (ALP) activity and higher mRNA levels of Runx2 and Colla1 than those in WT osteoblasts both in the control and PA treatment group (P < 0.05). Palmitic Acid 170-172 interleukin 6 Mus musculus 0-3 25687616-4 2015 Our data demonstrated that these three test 18-carbon PUFAs can inhibit PA-induced interleukin-6 and tumor necrosis factor-alpha messenger RNA (mRNA) expression and IR as evidenced by increases in phosphorylated AKT and the 160-kD AKT substrate, mRNA and plasma membrane protein expression of glucose transporter 4, and glucose uptake. Palmitic Acid 72-74 interleukin 6 Mus musculus 83-128 26306651-9 2015 Pro-inflammatory markers IL-6, TNF-alpha, and inducible nitric oxide synthase in microglial cells are increased following PA exposure, but are reduced by pretreatment with OXA. Palmitic Acid 122-124 interleukin 6 Mus musculus 25-29 23237655-4 2013 RESULTS: Under the proliferation conditions, insulin plus palmitic acid promoted a significant increase in the release of interleukin-6, keratinocyte-derived chemokine (KC)/chemokine ligand-1 (CXCL-1), monocyte chemotactic protein-1 (MCP-1), and regulated and normal T cells expressed and presumably secreted (RANTES) by 3T3-L1 preadipocytes. Palmitic Acid 58-71 interleukin 6 Mus musculus 122-135 25016520-8 2014 RESULTS: In a dose-dependent fashion, palmitic acid rapidly reduced mouse locomotor activity by a mechanism that did not rely on TLR4, MyD88, IL-1, IL-6 or TNFalpha but was dependent on fatty acid chain length. Palmitic Acid 38-51 interleukin 6 Mus musculus 148-152 21474329-8 2011 BEX significantly ameliorated PA-induced upregulation of IL-6 mRNA, which correlated with a reduction in nuclear translocation of p50, p65, and c-fos proteins with the presence of BEX, indicating inhibition of NF-kappaB and AP-1 activation. Palmitic Acid 30-32 interleukin 6 Mus musculus 57-61 19509460-10 2008 EGT has a protective role on PA-induced cell death, possibly via 2. reduced activity of MAPKs cascade having also 3. an anti-inflammatory action exerted on the IL-6 modulation. Palmitic Acid 29-31 interleukin 6 Mus musculus 160-164