PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33330513-8 2020 In addition, C-peptide potentiated the inhibitory effects of both insulin and palmitic acid in an AKT- and autophagy-independent manner, respectively. Palmitic Acid 78-91 AKT serine/threonine kinase 1 Homo sapiens 98-101 33686181-5 2021 Using human SH-SY5Yneuroblastoma cell line we show that palmitic acid treatment impaired insulin-dependent Akt and Erk phosphorylation whereas DHA preserved insulin action. Palmitic Acid 56-69 AKT serine/threonine kinase 1 Homo sapiens 107-110 33562475-4 2021 The incubation with palmitic acid (PA), which inhibits insulin-mediated Akt Ser473 phosphorylation, resulted in the increased RGS2 expression in human umbilical vein endothelial-CS (HUVEC-CS) cells. Palmitic Acid 20-33 AKT serine/threonine kinase 1 Homo sapiens 72-75 33562475-4 2021 The incubation with palmitic acid (PA), which inhibits insulin-mediated Akt Ser473 phosphorylation, resulted in the increased RGS2 expression in human umbilical vein endothelial-CS (HUVEC-CS) cells. Palmitic Acid 35-37 AKT serine/threonine kinase 1 Homo sapiens 72-75 31518729-8 2020 PA affected cellular proliferation, apoptosis and endoplasmic reticulum stress markers along with reducing the phosphor-AKT/AKT levels and increasing the expression levels of caspase-3 and CHOP in GCs. Palmitic Acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 120-123 31518729-8 2020 PA affected cellular proliferation, apoptosis and endoplasmic reticulum stress markers along with reducing the phosphor-AKT/AKT levels and increasing the expression levels of caspase-3 and CHOP in GCs. Palmitic Acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 124-127 31332162-9 2019 Further mechanistic studies showed that inhibition of PI3K/Akt signaling, or its upstream mediator STAT5 can prevent PA-induced SLAMF3 upregulation on T cells. Palmitic Acid 117-119 AKT serine/threonine kinase 1 Homo sapiens 59-62 31828133-0 2019 Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 101-104 31828133-4 2019 Compared with controls, PA significantly decreased glucose uptake, increased insulin receptor substrate-2 (IRS-2) and miR-221 expression, and decreased phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and glucose transporter type 4 (GLUT4) mRNA expression. Palmitic Acid 24-26 AKT serine/threonine kinase 1 Homo sapiens 204-207 31839747-7 2019 LPS+PA treatment group significantly decreases the relative expression level of IRS-1, PI3K, AKT, phosphorylation of AKT, TLR-4, MyD88, phosphorylation of IKKalpha, NF-kappaB, Bcl-2 and increases the relative expression level of Bax, cleaved caspase 3 and cleaved caspase 8, compared with the cells treated with NAFLD model. Palmitic Acid 4-6 AKT serine/threonine kinase 1 Homo sapiens 93-96 31839747-7 2019 LPS+PA treatment group significantly decreases the relative expression level of IRS-1, PI3K, AKT, phosphorylation of AKT, TLR-4, MyD88, phosphorylation of IKKalpha, NF-kappaB, Bcl-2 and increases the relative expression level of Bax, cleaved caspase 3 and cleaved caspase 8, compared with the cells treated with NAFLD model. Palmitic Acid 4-6 AKT serine/threonine kinase 1 Homo sapiens 117-120 31332162-0 2019 Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. Palmitic Acid 54-67 AKT serine/threonine kinase 1 Homo sapiens 91-94 31332162-8 2019 RNA sequencing revealed strong activation of the PI3K/Akt signaling pathway in T cells that were primed with PA. Palmitic Acid 109-111 AKT serine/threonine kinase 1 Homo sapiens 54-57 31828133-7 2019 PA decreased glucose uptake in HepG2 cells by inducing the expression of miR-221, which bound to PI3K mRNA and suppressed PI3K/AKT signaling. Palmitic Acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 127-130 30913535-6 2019 Besides, insulin-induced phosphorylation of Akt was reduced by PA in a dose and time-dependent manner. Palmitic Acid 63-65 AKT serine/threonine kinase 1 Homo sapiens 44-47 31223033-5 2019 PTS reversed PA-mediated activation of c-Jun N-terminal kinase (JNK), which in turn altered insulin signalling pathway by phosphorylating IRS-1 at Ser 307, leading to inhibition of phosphorylation of Akt and GSK-3beta. Palmitic Acid 13-15 AKT serine/threonine kinase 1 Homo sapiens 200-203 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 13-15 AKT serine/threonine kinase 1 Homo sapiens 97-100 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 129-131 AKT serine/threonine kinase 1 Homo sapiens 97-100 30764838-5 2019 Phosphorylation of Akt and eNOS, as well as NO production were attenuated and accompanied by an increased expression of caspase 3 when HUVECs were subjected to sodium palmitate, and all these changes were restored by pretreatment with U50,488H, the effects of U50,488H were abolished by nor-BNI, and specific inhibitors to PI3K, Akt, eNOS, respectively. Palmitic Acid 160-176 AKT serine/threonine kinase 1 Homo sapiens 329-332 30799086-5 2019 Coinciding with these results, interference of NPM using small interfering RNA (siRNA) oligos ameliorated PA-induced insulin resistance, as revealed by increased phosphorylation of AKT and GSK3beta following insulin treatment. Palmitic Acid 106-108 AKT serine/threonine kinase 1 Homo sapiens 181-184 29307883-0 2018 Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of Nitric Oxide (NO). Palmitic Acid 46-59 AKT serine/threonine kinase 1 Homo sapiens 120-123 30678035-0 2019 Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway. Palmitic Acid 42-55 AKT serine/threonine kinase 1 Homo sapiens 204-207 30678035-9 2019 Interestingly, PA promoted cell apoptosis and autophagy through stimulation of phosphorylation of mitogen-activated protein kinases (MAPKs), AMP-activated protein kinase (AMPK), and inhibition of phosphorylation of Akt and mammalian target of rapamycin (mTOR), which was reversed by GLP. Palmitic Acid 15-17 AKT serine/threonine kinase 1 Homo sapiens 215-218 29607540-5 2018 In HepG2 cells treated with 300 mumol/L of palmitic acid, phosphorylated AKT expression decreased, and FETUA expression increased, but this effect was inhibited by treatment with 10 mumol/L of melatonin. Palmitic Acid 43-56 AKT serine/threonine kinase 1 Homo sapiens 73-76 30764838-5 2019 Phosphorylation of Akt and eNOS, as well as NO production were attenuated and accompanied by an increased expression of caspase 3 when HUVECs were subjected to sodium palmitate, and all these changes were restored by pretreatment with U50,488H, the effects of U50,488H were abolished by nor-BNI, and specific inhibitors to PI3K, Akt, eNOS, respectively. Palmitic Acid 160-176 AKT serine/threonine kinase 1 Homo sapiens 19-22 29720254-7 2018 Further, the decreased levels of acetyl CoA and dependency of acetyl CoA acetyl transferase protein on AKT1 kinase activity was also found to perturb the synthesis rate of palmitic acid which is a representative of fatty acid. Palmitic Acid 172-185 AKT serine/threonine kinase 1 Homo sapiens 103-107 29307883-0 2018 Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of Nitric Oxide (NO). Palmitic Acid 61-63 AKT serine/threonine kinase 1 Homo sapiens 120-123 28827061-4 2017 Palmitic acid (PA) repressed insulin-stimulated Akt phosphorylation in HepG2 cells within 12h. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 48-51 29768267-12 2018 Results from further analyses showed that AKT-ROS-dependent upregulations of expression, binding and centrosome translocation of ROCK1 and 14-3-3sigma was the molecular pathway underlying the centrosome amplification in vitro triggered by high glucose, insulin and palmitic acid. Palmitic Acid 265-278 AKT serine/threonine kinase 1 Homo sapiens 42-45 28919254-0 2017 Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 69-72 28919254-4 2017 Here, we used cultured rat cortical neurons and differentiated human neuroblastoma cells to demonstrate that PA blocks insulin-induced metabolic activation, inhibits the activation of the insulin/PI3K/Akt pathway and activates mTOR kinase downstream of Akt. Palmitic Acid 109-111 AKT serine/threonine kinase 1 Homo sapiens 201-204 28919254-4 2017 Here, we used cultured rat cortical neurons and differentiated human neuroblastoma cells to demonstrate that PA blocks insulin-induced metabolic activation, inhibits the activation of the insulin/PI3K/Akt pathway and activates mTOR kinase downstream of Akt. Palmitic Acid 109-111 AKT serine/threonine kinase 1 Homo sapiens 253-256 28827061-4 2017 Palmitic acid (PA) repressed insulin-stimulated Akt phosphorylation in HepG2 cells within 12h. Palmitic Acid 15-17 AKT serine/threonine kinase 1 Homo sapiens 48-51 28827061-8 2017 Forced expression of mitofusin-2, a critical component of the MAM, partially restored MAM contact area and ameliorated the PA-elicited suppression of insulin sensitivity with Ser473 phosphorylation of Akt selectively improved. Palmitic Acid 123-125 AKT serine/threonine kinase 1 Homo sapiens 201-204 28827061-9 2017 These results suggest that loss of proximity between ER and mitochondria, but not perturbation of homeostasis in the two organelles individually, plays crucial roles in PA-evoked Akt inactivation in hepatic insulin resistance. Palmitic Acid 169-171 AKT serine/threonine kinase 1 Homo sapiens 179-182 28659580-0 2017 Palmitic Acid-BSA enhances Amyloid-beta production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1alpha and Akt/NF-kappaB pathways. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 126-129 28656239-0 2017 Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3beta signaling pathway, and inhibits the inflammatory response in HepG2 cells. Palmitic Acid 27-29 AKT serine/threonine kinase 1 Homo sapiens 73-76 28659580-0 2017 Palmitic Acid-BSA enhances Amyloid-beta production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1alpha and Akt/NF-kappaB pathways. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 150-153 28659580-7 2017 In conclusion, these results show that extra-cellular PA coupled with GPR40 induces the expression of APP and BACE1 to facilitate Abeta production via the Akt-mTOR-HIF-1alpha and Akt-NF-kappaB pathways in SK-N-MC cells. Palmitic Acid 54-56 AKT serine/threonine kinase 1 Homo sapiens 155-158 28659580-7 2017 In conclusion, these results show that extra-cellular PA coupled with GPR40 induces the expression of APP and BACE1 to facilitate Abeta production via the Akt-mTOR-HIF-1alpha and Akt-NF-kappaB pathways in SK-N-MC cells. Palmitic Acid 54-56 AKT serine/threonine kinase 1 Homo sapiens 179-182 26475209-2 2016 At the molecular level, palmitic acid reduces insulin stimulated Akt Ser473 phosphorylation. Palmitic Acid 24-37 AKT serine/threonine kinase 1 Homo sapiens 65-68 26899878-9 2016 Finally, Cox-2 selective inhibitor, celecoxib protected cells from PA-reduced insulin signaling Akt phosphorylation. Palmitic Acid 67-69 AKT serine/threonine kinase 1 Homo sapiens 96-99 28011403-5 2017 Our results indicate that C3G pretreatment effectively reverses the effects of PA on PI3K/Akt axis, and restores eNOS expression and NO release, altered by PA. Palmitic Acid 79-81 AKT serine/threonine kinase 1 Homo sapiens 90-93 27665476-14 2016 CONCLUSIONS: Ghrelin pretreatment attenuated LPS- or PA-induced hepatocyte apoptosis, which may least partly via inhibition of mitogen-activated protein kinases (MAPKs)/iNOS and restoration of Akt/eNOS pathways. Palmitic Acid 53-55 AKT serine/threonine kinase 1 Homo sapiens 193-196 26748475-11 2016 Finally, we showed that PGC-1beta overexpression in PA treated macrophages improved adipocytes PI3K-Akt insulin signaling in a paracrine fashion. Palmitic Acid 52-54 AKT serine/threonine kinase 1 Homo sapiens 100-103 26643367-4 2015 Here, we report that EPO administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells and in the liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing of the erythropoietin receptor (EPOR) blocked EPO-induced AKT signalling in HepG2 cells. Palmitic Acid 112-125 AKT serine/threonine kinase 1 Homo sapiens 86-89 26643367-4 2015 Here, we report that EPO administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells and in the liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing of the erythropoietin receptor (EPOR) blocked EPO-induced AKT signalling in HepG2 cells. Palmitic Acid 127-129 AKT serine/threonine kinase 1 Homo sapiens 86-89 25737480-5 2015 Knockdown of Egr-1 increased PA-induced caspase-3 activation and ER stress markers and decreased PA-induced Akt phosphorylation and insulin secretion and signaling. Palmitic Acid 97-99 AKT serine/threonine kinase 1 Homo sapiens 108-111 25737480-6 2015 Akt replenishment and insulin supplementation rescued PA-induced apoptosis in Egr-1 knockdown cells. Palmitic Acid 54-56 AKT serine/threonine kinase 1 Homo sapiens 0-3 25737480-14 2015 Egr-1 maintains Akt survival pathway to protect beta-cells from PA-induced apoptosis. Palmitic Acid 64-66 AKT serine/threonine kinase 1 Homo sapiens 16-19 25891779-7 2015 In the PA-treated L6 cells, metformin treatment enhanced AMPK phosphorylation, reduced SREBP-1c expression and increased IRS-1 and Akt protein expression, whereas treatment with compound C blocked the effects of metformin on SREBP-1c expression and the IRS-1 and Akt levels. Palmitic Acid 7-9 AKT serine/threonine kinase 1 Homo sapiens 131-134 25891779-7 2015 In the PA-treated L6 cells, metformin treatment enhanced AMPK phosphorylation, reduced SREBP-1c expression and increased IRS-1 and Akt protein expression, whereas treatment with compound C blocked the effects of metformin on SREBP-1c expression and the IRS-1 and Akt levels. Palmitic Acid 7-9 AKT serine/threonine kinase 1 Homo sapiens 263-266 25938832-6 2015 In addition, the palmitate sodium treatment also activated the PI3K/Akt pathway,induced expression of CHOP and Bax of the UPR and non-UPR signaling pathways respectively. Palmitic Acid 17-33 AKT serine/threonine kinase 1 Homo sapiens 68-71 26064210-0 2015 SHIP2 on pI3K/Akt pathway in palmitic acid stimulated islet beta cell. Palmitic Acid 29-42 AKT serine/threonine kinase 1 Homo sapiens 14-17 25938832-7 2015 Moreover, Pretreatment with LY294002 inhibited the palmitate sodium induced-phosphorylation of PI3K and Akt, and promoted upregulation of CHOP and Bax induced by palmitate sodium. Palmitic Acid 51-67 AKT serine/threonine kinase 1 Homo sapiens 104-107 20079751-8 2010 Incubation of microvascular endothelial cells with 200 microM palmitic acid significantly inhibited Ang1-dependent Akt phosphorylation without affecting phosphorylation of the Tie-2 receptor or of ERK1/2. Palmitic Acid 62-75 AKT serine/threonine kinase 1 Homo sapiens 115-118 25079440-6 2014 In addition, both PI3K/AKT and MEK/ERK showed decreased expression in PA (800 muM)-treated beta-cells. Palmitic Acid 70-72 AKT serine/threonine kinase 1 Homo sapiens 23-26 25079440-7 2014 Overexpression of TCF2 could effectively restore the inhibitory effect of PA on the activation of PI3K/AKT and MEK/ERK as well as beta-cell viability, simultaneously, inhibited PA-induced reactive oxygen species (ROS) generation. Palmitic Acid 74-76 AKT serine/threonine kinase 1 Homo sapiens 103-106 25079440-7 2014 Overexpression of TCF2 could effectively restore the inhibitory effect of PA on the activation of PI3K/AKT and MEK/ERK as well as beta-cell viability, simultaneously, inhibited PA-induced reactive oxygen species (ROS) generation. Palmitic Acid 177-179 AKT serine/threonine kinase 1 Homo sapiens 103-106 24918290-7 2014 Using AMPK siRNA and the specific inhibitor compound C, we found that EPA restored the PA-mediated inhibitions of eNOS and AKT activities via activation of AMPK. Palmitic Acid 71-73 AKT serine/threonine kinase 1 Homo sapiens 123-126 21620957-0 2011 ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation. Palmitic Acid 63-76 AKT serine/threonine kinase 1 Homo sapiens 27-30 21620957-6 2011 The employment of several inhibitors and antioxidants indicates that a ROS-induced stress-sensitive p38 MAPK/ERK-Akt cascade plays a critical role in the regulation of PA on cell cycle and cell proliferation. Palmitic Acid 168-170 AKT serine/threonine kinase 1 Homo sapiens 113-116 21620957-7 2011 Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation. Palmitic Acid 10-12 AKT serine/threonine kinase 1 Homo sapiens 124-127 21620957-7 2011 Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation. Palmitic Acid 215-217 AKT serine/threonine kinase 1 Homo sapiens 124-127 21620957-8 2011 In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner. Palmitic Acid 109-111 AKT serine/threonine kinase 1 Homo sapiens 188-191 24857031-8 2014 In mTOR-dependent pathway, the PI3K-Class I, Akt, and p-mTOR proteins were decreased with PA treatment. Palmitic Acid 90-92 AKT serine/threonine kinase 1 Homo sapiens 45-48 34097902-4 2021 Insulin resistance was induced by culturing with insulin resistance induction medium supplemented with palmitic acid for 24 h. When Cr was added to the medium, the increase in glucose-6-phosphatase and phosphoenolpyruvate carboxykinase 1 mRNA expression levels and the decrease in the ratio of phosphorylated Akt to Akt protein were suppressed, and the induction of insulin resistance prevented. Palmitic Acid 103-116 AKT serine/threonine kinase 1 Homo sapiens 309-312 34953312-15 2022 PA decreased PI3K and Akt phosphorylation, whereas melatonin increased p-PI3K and p-Akt levels. Palmitic Acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 22-25 34953312-16 2022 Melatonin can reduce IR in GCs and PA-induced SVOG cells via the PI3K/Akt signaling pathway, providing more evidence for treating polycystic ovary syndrome. Palmitic Acid 35-37 AKT serine/threonine kinase 1 Homo sapiens 70-73 34332276-10 2021 CONCLUSION: Our findings suggest that kappa-OR activation inhibits SP-induced inflammation by activating the PI3K/Akt/eNOS signaling pathway. Palmitic Acid 67-69 AKT serine/threonine kinase 1 Homo sapiens 114-117 19721393-9 2009 CONCLUSIONS: Taken together, we have demonstrated that palmitic acid induces accumulation of ceramide, which appears to mediate palmitic acid"s inhibitory effects on the Akt/eNOS pathway, leading to a significant decrease in NO generation. Palmitic Acid 55-68 AKT serine/threonine kinase 1 Homo sapiens 170-173 19721393-9 2009 CONCLUSIONS: Taken together, we have demonstrated that palmitic acid induces accumulation of ceramide, which appears to mediate palmitic acid"s inhibitory effects on the Akt/eNOS pathway, leading to a significant decrease in NO generation. Palmitic Acid 128-141 AKT serine/threonine kinase 1 Homo sapiens 170-173 19336660-7 2009 Coculture of differentiated human myotubes with macrophages in the presence of palmitic acid, to mimic an obese environment, revealed that macrophages in the presence of palmitic acid synergistically augment cytokine and chemokine expression in myotubes, decrease IkappaB-alpha protein expression, increase phosphorylated JNK, decrease phosphorylated Akt, and increase markers of muscle atrophy. Palmitic Acid 170-183 AKT serine/threonine kinase 1 Homo sapiens 351-354 19494713-10 2009 In accordance with the reduced IRS-2 level, the insulin-stimulated phosphorylation of Akt was diminished in the PA-treated cells. Palmitic Acid 112-114 AKT serine/threonine kinase 1 Homo sapiens 86-89 34619135-0 2022 Chronic Exposure to Palmitic Acid Down-regulates AKT in Beta-Cells through Activation of mTOR. Palmitic Acid 20-33 AKT serine/threonine kinase 1 Homo sapiens 49-52 34619135-5 2022 Using palmitic acid (PA) in cultured beta-cells and islets, we demonstrated that chronic exposure to lipids leads to reduced viability and inhibition of cell cycle progression concurrent with downregulation of a pro-growth/survival kinase AKT, independent of glucose. Palmitic Acid 6-19 AKT serine/threonine kinase 1 Homo sapiens 239-242 34619135-5 2022 Using palmitic acid (PA) in cultured beta-cells and islets, we demonstrated that chronic exposure to lipids leads to reduced viability and inhibition of cell cycle progression concurrent with downregulation of a pro-growth/survival kinase AKT, independent of glucose. Palmitic Acid 21-23 AKT serine/threonine kinase 1 Homo sapiens 239-242 34619135-6 2022 This AKT downregulation by PA is correlated with the induction of mTOR/S6K activity. Palmitic Acid 27-29 AKT serine/threonine kinase 1 Homo sapiens 5-8 34653428-0 2021 Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway. Palmitic Acid 0-13 AKT serine/threonine kinase 1 Homo sapiens 97-100 34653428-11 2021 Furthermore, a mechanistic study indicated that palmitic acid inhibited the key molecules of the PI3K/Akt pathway to block prostate cancer proliferation and metastasis. Palmitic Acid 48-61 AKT serine/threonine kinase 1 Homo sapiens 102-105 34653428-12 2021 SIGNIFICANCE: Our findings suggested the antitumor potential of palmitic acid for prostate cancer by targeting the PI3K/Akt pathway. Palmitic Acid 64-77 AKT serine/threonine kinase 1 Homo sapiens 120-123 34332276-6 2021 RESULTS: The SP-induced hyperlipidemic cell model demonstrated increased expression of NLRP3 and caspase-1 proteins (P < 0.05) and elevated ROS levels (P < 0.01), and decreased phosphorylated-Akt and phosphorylated-eNOS expression (P < 0.05). Palmitic Acid 13-15 AKT serine/threonine kinase 1 Homo sapiens 192-195 34097902-4 2021 Insulin resistance was induced by culturing with insulin resistance induction medium supplemented with palmitic acid for 24 h. When Cr was added to the medium, the increase in glucose-6-phosphatase and phosphoenolpyruvate carboxykinase 1 mRNA expression levels and the decrease in the ratio of phosphorylated Akt to Akt protein were suppressed, and the induction of insulin resistance prevented. Palmitic Acid 103-116 AKT serine/threonine kinase 1 Homo sapiens 316-319 34308859-8 2021 The expression of p-mTOR was significantly lower and that of p-AKT was higher in cells treated with PA+exendin-4 than in PA-treated cells. Palmitic Acid 100-103 AKT serine/threonine kinase 1 Homo sapiens 63-66 34503515-13 2021 Moreover, TRIB3 knockdown reversed declines in FSHR expression and estradiol (E2) production in KGN cells treated with PA, which also resulted in increased p-Akt levels and declines in the p-GSK3beta level. Palmitic Acid 119-121 AKT serine/threonine kinase 1 Homo sapiens 158-161 34308859-8 2021 The expression of p-mTOR was significantly lower and that of p-AKT was higher in cells treated with PA+exendin-4 than in PA-treated cells. Palmitic Acid 121-123 AKT serine/threonine kinase 1 Homo sapiens 63-66 35585811-5 2022 PZ-DHA treatment of the myotubes reversed PA-induced insulin resistance; this was indicated by increases in glucose uptake and the expression of membrane glucose transporter 4 (Glut4) and phosphorylated Akt. Palmitic Acid 42-44 AKT serine/threonine kinase 1 Homo sapiens 203-206 35405148-3 2022 The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 muM and improve glucose uptake in a concentration dependent manner. Palmitic Acid 43-56 AKT serine/threonine kinase 1 Homo sapiens 169-172 35405148-3 2022 The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 muM and improve glucose uptake in a concentration dependent manner. Palmitic Acid 43-56 AKT serine/threonine kinase 1 Homo sapiens 176-179 35405148-3 2022 The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 muM and improve glucose uptake in a concentration dependent manner. Palmitic Acid 58-60 AKT serine/threonine kinase 1 Homo sapiens 169-172