PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24511897-7 2014 Furthermore, VPA-mediated suppression of the accumulation of the intracellular triacylglycerols was prevented by the treatment with palmitic acid, a major product of FAS. Palmitic Acid 132-145 fatty acid synthase Homo sapiens 166-169 28729415-4 2017 Inhibition or knockdown of fatty acid synthase (FASN), the enzyme that catalyzes the formation of palmitic acid from malonyl-CoA, drove NF2-deficient cells into apoptosis. Palmitic Acid 98-111 fatty acid synthase Homo sapiens 27-46 28729415-4 2017 Inhibition or knockdown of fatty acid synthase (FASN), the enzyme that catalyzes the formation of palmitic acid from malonyl-CoA, drove NF2-deficient cells into apoptosis. Palmitic Acid 98-111 fatty acid synthase Homo sapiens 48-52 28236510-1 2017 The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Palmitic Acid 194-207 fatty acid synthase Homo sapiens 111-130 28236510-1 2017 The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Palmitic Acid 194-207 fatty acid synthase Homo sapiens 132-135 27579768-6 2016 Over-expression of FASN or supplementation of palmitic acid (the product of FASN action) blocked the effects of leucine deprivation on cell proliferation and apoptosis in vitro and in vivo. Palmitic Acid 46-59 fatty acid synthase Homo sapiens 76-80 18523653-5 2008 Palmitic acid, as well as stearic acid and myristic acid, compromised the induction of p21 and Bax expression in response to double stranded breaks and ssDNA, while inhibition or knockdown of FASN enhanced these cellular events. Palmitic Acid 0-13 fatty acid synthase Homo sapiens 192-196 16996019-3 2006 Malonyl CoA, the product of the ACC reaction, and acetyl CoA serve as substrates for FAS to synthesize palmitic acid. Palmitic Acid 103-116 fatty acid synthase Homo sapiens 85-88 18281512-6 2008 The FASN-mediated drug resistance appears to be due to a decrease in drug-induced apoptosis from an overproduction of palmitic acid by FASN. Palmitic Acid 118-131 fatty acid synthase Homo sapiens 4-8 15507492-1 2004 Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. Palmitic Acid 89-102 fatty acid synthase Homo sapiens 6-25 16707454-4 2006 We show that specific silencing of either the ACCalpha or the fatty acid synthase (FAS) genes in cancer cells results in a major decrease in palmitic acid synthesis. Palmitic Acid 141-154 fatty acid synthase Homo sapiens 62-81 16707454-4 2006 We show that specific silencing of either the ACCalpha or the fatty acid synthase (FAS) genes in cancer cells results in a major decrease in palmitic acid synthesis. Palmitic Acid 141-154 fatty acid synthase Homo sapiens 83-86 9815604-3 1997 Recent biochemical studies have demonstrated that FAS expression in cancer cells connotes activation of the entire fatty acid synthesis pathway leading to the production of palmitic acid. Palmitic Acid 173-186 fatty acid synthase Homo sapiens 50-53 33431991-7 2021 Pharmacologic inhibition of fatty acid synthase, the enzyme generating palmitic acid, decreased axon growth and regeneration in vitro. Palmitic Acid 71-84 fatty acid synthase Homo sapiens 28-47 34285285-7 2021 Cell growth decreased in miR-486-3p overexpressing clones and levels of the predicted target gene fatty acid synthase (FASN) and its downstream product, palmitic acid, were lowered. Palmitic Acid 153-166 fatty acid synthase Homo sapiens 98-117 34285285-7 2021 Cell growth decreased in miR-486-3p overexpressing clones and levels of the predicted target gene fatty acid synthase (FASN) and its downstream product, palmitic acid, were lowered. Palmitic Acid 153-166 fatty acid synthase Homo sapiens 119-123 35182670-9 2022 Furthermore, the GB-N and GB-F inhibited the PA-inducible lipogenic mRNA expression, such as fatty acid synthase, sterol regulatory element-binding protein 1c, and peroxisome proliferator-activated receptor-gamma (p < 0.05). Palmitic Acid 45-47 fatty acid synthase Homo sapiens 93-112 33780787-2 2021 FASN, previously known as oncogenic antigen-519 (OA-519) catalyzes seven sequential reactions to synthesize palmitic acid (C16) from substrates acetyl CoA, and malonyl CoA. Palmitic Acid 108-121 fatty acid synthase Homo sapiens 0-4 31519174-0 2019 Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells. Palmitic Acid 22-35 fatty acid synthase Homo sapiens 96-99 31164796-12 2019 Palmitic acid, the end product of FAS catalyzed reaction, rescued the ER stress and autophagy induced by alpha-mangostin. Palmitic Acid 0-13 fatty acid synthase Homo sapiens 34-37 30006154-7 2018 Furthermore, we found that knockdown of GCN2 attenuated, whereas overexpression of GCN2 exacerbated, palmitic acid-induced steatosis, oxidative & ER stress, and changes of peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS) and metallothionein (MT) expression in HepG2 cells. Palmitic Acid 101-114 fatty acid synthase Homo sapiens 238-257 30006154-7 2018 Furthermore, we found that knockdown of GCN2 attenuated, whereas overexpression of GCN2 exacerbated, palmitic acid-induced steatosis, oxidative & ER stress, and changes of peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS) and metallothionein (MT) expression in HepG2 cells. Palmitic Acid 101-114 fatty acid synthase Homo sapiens 259-262 29940201-8 2018 CONCLUSION: Our data demonstrated that EGCG improved IR, possibly through ameliorating glucose (25 mM) and PA (0.25 mM)-induced inflammation, oxidative stress, and FFAs via the GLUT2/PGC-1beta/SREBP-1c/FAS pathway in HepG2 cells. Palmitic Acid 107-109 fatty acid synthase Homo sapiens 202-205