PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23840832-0 2013 Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-kappaB, novel targets of eicosapentaenoic acid. Palmitic Acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 101-110 23840832-9 2013 Notably, PA induced activation of NF-kappaB, and NF-kappaB inhibitor prevented PA-induction of osteoblastic gene expression and calcium deposition. Palmitic Acid 9-11 nuclear factor kappa B subunit 1 Homo sapiens 34-43 23840832-9 2013 Notably, PA induced activation of NF-kappaB, and NF-kappaB inhibitor prevented PA-induction of osteoblastic gene expression and calcium deposition. Palmitic Acid 79-81 nuclear factor kappa B subunit 1 Homo sapiens 34-43 24078775-4 2013 Our results showed that palmitic acid induced an upregulation of IL-6, TNF- alpha , IL-1 beta secretions, accompanied by NF- kappa B nuclear translocation and activation. Palmitic Acid 24-37 nuclear factor kappa B subunit 1 Homo sapiens 121-132 23840832-9 2013 Notably, PA induced activation of NF-kappaB, and NF-kappaB inhibitor prevented PA-induction of osteoblastic gene expression and calcium deposition. Palmitic Acid 79-81 nuclear factor kappa B subunit 1 Homo sapiens 49-58 23840832-11 2013 These results identify ACSL3 and NF-kappaB as mediators of PA-induced osteoblastic differentiation and calcium deposition in VSMC and suggest that EPA prevents vascular calcification by inhibiting such a new molecular pathway elicited by PA. Palmitic Acid 59-61 nuclear factor kappa B subunit 1 Homo sapiens 33-42 24078775-6 2013 Palmitic acid-induced IL-6, TNF- alpha , IL-1 beta productions were attenuated by NF- kappa B inhibitor PDTC. Palmitic Acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 82-93 22750100-3 2012 In this study, we investigated the role of adipokines, oleic acid (OA), palmitic acid (PA), and the combinations on activation of NF-kappaB target genes in human vascular smooth muscle cells (SMC) to assess the hypothesis of synergistic interactions between these molecules. Palmitic Acid 87-89 nuclear factor kappa B subunit 1 Homo sapiens 130-139 34373714-0 2021 Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-kappaB. Palmitic Acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 121-130 23251812-6 2012 Compared to the THP-1 macrophages without palmitic acid, the level of TLR4 mRNA protein and NF-kappaB p65 phosphorylation and the expression of TNF-alpha and IL-1beta increased after treatment by palmitic acid in a dose-dependent fashion (P < 0.05). Palmitic Acid 196-209 nuclear factor kappa B subunit 1 Homo sapiens 92-101 34923420-9 2022 However, PA pretreatment significantly suppressed the phosphorylation level and nuclear translocation of NF-kappaB, and the phosphorylation level of ERK1/2, whereas increased the phosphorylation levels of p38 and JNK. Palmitic Acid 9-11 nuclear factor kappa B subunit 1 Homo sapiens 105-114 34923420-10 2022 The activation of IKK which was upstream of NF-kappaB and ERK1/2 was attenuated, while the activation of TAK1 which was upstream of JNK and p38 was augmented by PA pretreatment. Palmitic Acid 161-163 nuclear factor kappa B subunit 1 Homo sapiens 44-53 23251812-0 2012 Octanoylated Ghrelin Inhibits the Activation of the Palmitic Acid-Induced TLR4/NF-kappaB Signaling Pathway in THP-1 Macrophages. Palmitic Acid 52-65 nuclear factor kappa B subunit 1 Homo sapiens 79-88 23251812-1 2012 To investigate the effect of acylated ghrelin on the activation of TLR4/NF-kappaB signaling pathway induced by palmitic acid in human monocyte-derived (THP-1) macrophages, THP-1 macrophages were cultured for 12 h by palmitic acid with various concentrations. Palmitic Acid 111-124 nuclear factor kappa B subunit 1 Homo sapiens 72-81 34373714-12 2021 In conclusion, PA promoted the TLR4/phosphorylated-NF-kappaB signaling pathway by inhibiting KLF4, promoted the upregulation of Gal-3 expression and improved the insulin resistance of macrophages. Palmitic Acid 15-17 nuclear factor kappa B subunit 1 Homo sapiens 51-60 34072916-7 2021 In particular, the upregulation of NADPH oxidase (NOX) 4 and the translocation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) induced by PA and LPS were suppressed by auranofin. Palmitic Acid 172-174 nuclear factor kappa B subunit 1 Homo sapiens 150-159 35078487-3 2022 METHODS: Using a mouse model of high-fat diet (HFD) feeding and a cellular model of HepG2 cells challenged by lipopolysaccharide (LPS) and palmitic acid (PA), the possible molecular mechanisms were exploited in the aspects of NF-kappaB/NLRP3 inflammasome and mTORC1-SREBPs signaling pathways by examining the relevant gene/protein expressions. Palmitic Acid 139-152 nuclear factor kappa B subunit 1 Homo sapiens 226-235 33021853-4 2020 RESULTS: Caco-2 exposed to palmitic acid (PA) in the serosal (basolateral) side showed a combined state of epithelial inflammation, inducing NF-kappaB pathway and downstream cytokines, that was reverted by C3G apical pre-treatment. Palmitic Acid 27-40 nuclear factor kappa B subunit 1 Homo sapiens 141-150 33021853-4 2020 RESULTS: Caco-2 exposed to palmitic acid (PA) in the serosal (basolateral) side showed a combined state of epithelial inflammation, inducing NF-kappaB pathway and downstream cytokines, that was reverted by C3G apical pre-treatment. Palmitic Acid 42-44 nuclear factor kappa B subunit 1 Homo sapiens 141-150 32222879-6 2020 Furthermore, Cer and PA attenuated expression levels of IL-10 in colorectal cancer cells co-cultured with M2 macrophages and downregulated STAT3 and NF-kappaB expression. Palmitic Acid 21-23 nuclear factor kappa B subunit 1 Homo sapiens 149-158 32400338-11 2020 The PA-induced phosphorylation of the inflammatory pathway mediators IKK and NF-kappaB, as well as the elevated expression and secretion of proinflammatory cytokines (IL-6, TNF-alpha), were reduced in cells pre-exposed to HEL. Palmitic Acid 4-6 nuclear factor kappa B subunit 1 Homo sapiens 77-86 30799086-7 2019 Finally, we showed that NPM plays an indispensible role in PA-induced activation of NF-kappaB pathway. Palmitic Acid 59-61 nuclear factor kappa B subunit 1 Homo sapiens 84-93 31839747-7 2019 LPS+PA treatment group significantly decreases the relative expression level of IRS-1, PI3K, AKT, phosphorylation of AKT, TLR-4, MyD88, phosphorylation of IKKalpha, NF-kappaB, Bcl-2 and increases the relative expression level of Bax, cleaved caspase 3 and cleaved caspase 8, compared with the cells treated with NAFLD model. Palmitic Acid 4-6 nuclear factor kappa B subunit 1 Homo sapiens 165-174 30957183-5 2019 Furthermore, nuclear factor (NF)-kappaB signaling in endothelial cells was significantly increased when treated with PA-induced PVAT-derived exosomes, whereas exosomes from the supernatant of PVAT stimulated with mangiferin reduced p65 and p50 phosphorylation levels in the cells, and inhibited p65 transportation to the nucleus. Palmitic Acid 117-119 nuclear factor kappa B subunit 1 Homo sapiens 13-39 30957183-5 2019 Furthermore, nuclear factor (NF)-kappaB signaling in endothelial cells was significantly increased when treated with PA-induced PVAT-derived exosomes, whereas exosomes from the supernatant of PVAT stimulated with mangiferin reduced p65 and p50 phosphorylation levels in the cells, and inhibited p65 transportation to the nucleus. Palmitic Acid 117-119 nuclear factor kappa B subunit 1 Homo sapiens 240-243 31467529-0 2019 Ginsenoside Rg1 Ameliorates Palmitic Acid-Induced Hepatic Steatosis and Inflammation in HepG2 Cells via the AMPK/NF-kappaB Pathway. Palmitic Acid 28-41 nuclear factor kappa B subunit 1 Homo sapiens 113-122 31155812-6 2019 In addition, PA induces inflammation with activation of NF-kappaB pathway, whereas ACN extract pretreatment dose-dependently inhibited this pathway. Palmitic Acid 13-15 nuclear factor kappa B subunit 1 Homo sapiens 56-65 29736947-8 2018 In addition, incubating placental explants with PA significantly increased NF-kappaB activity. Palmitic Acid 48-50 nuclear factor kappa B subunit 1 Homo sapiens 75-84 30598636-2 2018 Methods: The mRNA and protein expression levels of KLF7 and the factors of TLR4/NF-kappaB/IL-6 inflammatory signal pathways were detected by qRT-PCR and Western blotting after cell culture with different concentrations of palmitic acid (PA). Palmitic Acid 222-235 nuclear factor kappa B subunit 1 Homo sapiens 80-89 30598636-11 2018 Conclusion: PA promotes the expression of the inflammatory cytokine IL-6 by activating the TLR4/KLF7/NF-kappaB inflammatory signaling pathway. Palmitic Acid 12-14 nuclear factor kappa B subunit 1 Homo sapiens 101-110 25588104-3 2015 In this study, we have shown that lipid loading (oleic acid and palmitic acid, OA:PA) of Huh-7 cells leads to increased expression of classical interferon-stimulated genes (ISGs) and NF-kappabeta-dependent pro-inflammatory genes. Palmitic Acid 64-77 nuclear factor kappa B subunit 1 Homo sapiens 183-195 29626212-6 2018 Using RNA sequencing, we identified a variety of DR-relevant pathways, including NFkappaB signaling and inflammation, intracellular lipid signaling, angiogenesis, and MAPK signaling, that were stimulated by palmitic acid, while elevated glucose alone did not significantly alter any diabetes-relevant pathways. Palmitic Acid 207-220 nuclear factor kappa B subunit 1 Homo sapiens 81-89 29474492-6 2018 Results showed that DHA strongly inhibited the synergistic effect of LPS and PA on proinflammatory gene expression by targeting nuclear factor kappa B (NFkappaB)-dependent gene transcription. Palmitic Acid 77-79 nuclear factor kappa B subunit 1 Homo sapiens 128-150 29474492-6 2018 Results showed that DHA strongly inhibited the synergistic effect of LPS and PA on proinflammatory gene expression by targeting nuclear factor kappa B (NFkappaB)-dependent gene transcription. Palmitic Acid 77-79 nuclear factor kappa B subunit 1 Homo sapiens 152-160 29474492-9 2018 Taken together, this study demonstrates that DHA antagonizes the boosting effect of PA on LPS signaling on proinflammatory gene expression by targeting both NFkappaB-dependent transcription and CER de novo synthesis in macrophages. Palmitic Acid 84-86 nuclear factor kappa B subunit 1 Homo sapiens 157-165 28088520-0 2017 Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-kappaB/MMP-9 signaling pathway. Palmitic Acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 88-97 26138903-4 2015 Our results showed that PA significantly accelerated the expression of PTX3 in HUVECs through the IkappaB kinase (IKK)/IkappaB/nuclear factor-kappaB (NF-kappaB) pathway, reduced cell viability, induced cell apoptosis and triggered the inflammatory response. Palmitic Acid 24-26 nuclear factor kappa B subunit 1 Homo sapiens 150-159 28659580-0 2017 Palmitic Acid-BSA enhances Amyloid-beta production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1alpha and Akt/NF-kappaB pathways. Palmitic Acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 154-163 28659580-7 2017 In conclusion, these results show that extra-cellular PA coupled with GPR40 induces the expression of APP and BACE1 to facilitate Abeta production via the Akt-mTOR-HIF-1alpha and Akt-NF-kappaB pathways in SK-N-MC cells. Palmitic Acid 54-56 nuclear factor kappa B subunit 1 Homo sapiens 183-192 26016511-6 2015 PA augmented the expression of long-chain acyl-CoA synthetase (ACSL) and the cyclin-dependent kinase inhibitor p21, and enhanced the phosphorylation of p65, a component of NF-kappaB. Palmitic Acid 0-2 nuclear factor kappa B subunit 1 Homo sapiens 172-181 26016511-10 2015 CONCLUSIONS: These results suggest that the ACSL, p21, and NF-kappaB-dependent pathway may possibly be involved in PA-induced vascular endothelial dysfunction, and that EPA ameliorates this at least in part through the regulation of ACSL3 expression. Palmitic Acid 115-117 nuclear factor kappa B subunit 1 Homo sapiens 59-68