PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29233968-6 2017 Here, we show that eIF2alpha expression was increased and HRD1 expression decreased when apoptosis was induced in HKC-8 cells by palmitic acid (PA) or high glucose (HG). Palmitic Acid 129-142 synoviolin 1 Homo sapiens 58-62 29233968-6 2017 Here, we show that eIF2alpha expression was increased and HRD1 expression decreased when apoptosis was induced in HKC-8 cells by palmitic acid (PA) or high glucose (HG). Palmitic Acid 144-146 synoviolin 1 Homo sapiens 58-62 29233968-10 2017 Moreover, the HRD1 protection of PA-treated HKC-8 cells was blunted by transfection with Myc-eIF2alpha. Palmitic Acid 33-35 synoviolin 1 Homo sapiens 14-18 29233968-11 2017 Thus, eIF2alpha ubiquitylation by HRD1 protects tubular epithelial cells from apoptosis caused by HG and PA, indicating a novel upstream target for therapeutic prevention of renal tubulointerstitial injury. Palmitic Acid 105-107 synoviolin 1 Homo sapiens 34-38