PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20116378-5 2010 We found that palmitic acid inhibited TM expression through the JNK and p38 pathways. Palmitic Acid 14-27 mitogen-activated protein kinase 8 Homo sapiens 64-67 20226460-0 2010 Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Palmitic Acid 0-13 mitogen-activated protein kinase 8 Homo sapiens 74-77 20226460-6 2010 RESULTS: PA increased EPCs apoptosis in a dose- and time-dependent manner, upregulated phosphorylated-p38 and -JNK, caspase-3 expression of EPCs while ERK expression was not affected. Palmitic Acid 9-11 mitogen-activated protein kinase 8 Homo sapiens 111-114 20226460-7 2010 PA-induced EPCs apoptosis could be partly ameliorated by p38 inhibitor SB203580 and JNK inhibitor SP600125, but not by ERK1/2 inhibitor PD98059. Palmitic Acid 0-2 mitogen-activated protein kinase 8 Homo sapiens 84-87 20226460-8 2010 CONCLUSION: These findings suggested that PA promoted EPCs apoptosis via p38 and JNK MAPKs pathways. Palmitic Acid 42-44 mitogen-activated protein kinase 8 Homo sapiens 81-84 32199904-6 2020 Furthermore, palmitic acid and chloroquine exposure significantly increased reactive oxygen species (ROS) and activated p38 and c-Jun N-terminal kinase (JNK). Palmitic Acid 13-26 mitogen-activated protein kinase 8 Homo sapiens 128-151 19336660-7 2009 Coculture of differentiated human myotubes with macrophages in the presence of palmitic acid, to mimic an obese environment, revealed that macrophages in the presence of palmitic acid synergistically augment cytokine and chemokine expression in myotubes, decrease IkappaB-alpha protein expression, increase phosphorylated JNK, decrease phosphorylated Akt, and increase markers of muscle atrophy. Palmitic Acid 170-183 mitogen-activated protein kinase 8 Homo sapiens 322-325 34923420-9 2022 However, PA pretreatment significantly suppressed the phosphorylation level and nuclear translocation of NF-kappaB, and the phosphorylation level of ERK1/2, whereas increased the phosphorylation levels of p38 and JNK. Palmitic Acid 9-11 mitogen-activated protein kinase 8 Homo sapiens 213-216 33749115-8 2021 Besides, we found that PA could promote the up-regulation of matrix metalloproteinase (MMP)-9 expression and activate the c-Jun N-terminal kinase (JNK) pathway induced by Pb. Palmitic Acid 23-25 mitogen-activated protein kinase 8 Homo sapiens 122-145 33749115-8 2021 Besides, we found that PA could promote the up-regulation of matrix metalloproteinase (MMP)-9 expression and activate the c-Jun N-terminal kinase (JNK) pathway induced by Pb. Palmitic Acid 23-25 mitogen-activated protein kinase 8 Homo sapiens 147-150 33749115-12 2021 This may be because PA promotes the activation of JNK pathway and then up-regulated the expression of MMP-9 after Pb-exposure. Palmitic Acid 20-22 mitogen-activated protein kinase 8 Homo sapiens 50-53 34923420-10 2022 The activation of IKK which was upstream of NF-kappaB and ERK1/2 was attenuated, while the activation of TAK1 which was upstream of JNK and p38 was augmented by PA pretreatment. Palmitic Acid 161-163 mitogen-activated protein kinase 8 Homo sapiens 132-135 32199904-6 2020 Furthermore, palmitic acid and chloroquine exposure significantly increased reactive oxygen species (ROS) and activated p38 and c-Jun N-terminal kinase (JNK). Palmitic Acid 13-26 mitogen-activated protein kinase 8 Homo sapiens 153-156 31223033-5 2019 PTS reversed PA-mediated activation of c-Jun N-terminal kinase (JNK), which in turn altered insulin signalling pathway by phosphorylating IRS-1 at Ser 307, leading to inhibition of phosphorylation of Akt and GSK-3beta. Palmitic Acid 13-15 mitogen-activated protein kinase 8 Homo sapiens 39-62 31793207-14 2020 Human PNPLA3 was shown to be a target of NF-kB, and PNPLA3 I148M mediated the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells, most likely via the IRE-1alpha/JNK/c-Jun ER stress pathway. Palmitic Acid 124-126 mitogen-activated protein kinase 8 Homo sapiens 179-182 31675670-0 2019 Ginsenoside Rg1 ameliorates palmitic acid-induced insulin resistance in HepG2 cells in association with modulating Akt and JNK activity. Palmitic Acid 28-41 mitogen-activated protein kinase 8 Homo sapiens 123-126 31675670-9 2019 GRg1 increased Akt activation but inhibited JNK activation in PA-challenged HepG2 cells. Palmitic Acid 62-64 mitogen-activated protein kinase 8 Homo sapiens 44-47 31223033-5 2019 PTS reversed PA-mediated activation of c-Jun N-terminal kinase (JNK), which in turn altered insulin signalling pathway by phosphorylating IRS-1 at Ser 307, leading to inhibition of phosphorylation of Akt and GSK-3beta. Palmitic Acid 13-15 mitogen-activated protein kinase 8 Homo sapiens 64-67 24132507-8 2014 On a molecular level, inhibition of GSK-3beta expression or activity suppressed sodium palmitate-induced c-Jun-N-terminal kinase (JNK) phosphorylation and Bax upregulation, whereas GSK-3beta inhibition did not affect endoplasmic reticulum stress-induced activation of unfolded protein response. Palmitic Acid 80-96 mitogen-activated protein kinase 8 Homo sapiens 105-128 30478982-6 2019 High glucose, insulin, and palmitic acid also increased the expressions of c-Jun N-terminal kinase-1 (JNK1) and signal transducer and activator of transcription 3 (Stat3), individual knockdown of which upregulated the treatment-increased expression of 14-3-3sigma and promoted the centrosome amplification. Palmitic Acid 27-40 mitogen-activated protein kinase 8 Homo sapiens 75-100 30478982-6 2019 High glucose, insulin, and palmitic acid also increased the expressions of c-Jun N-terminal kinase-1 (JNK1) and signal transducer and activator of transcription 3 (Stat3), individual knockdown of which upregulated the treatment-increased expression of 14-3-3sigma and promoted the centrosome amplification. Palmitic Acid 27-40 mitogen-activated protein kinase 8 Homo sapiens 102-106 31357761-13 2019 Glucagon-like peptide-1 analogue, liraglutide may improve lipotoxicity of palmitic acid by mediating p38 MAPK and JNK pathways. Palmitic Acid 74-87 mitogen-activated protein kinase 8 Homo sapiens 114-117 27457805-7 2016 RESULTS: PA elevated not only phosphorylation of JNK and IKKalpha/beta, but also the expression of IL-6 in HUVECs. Palmitic Acid 9-11 mitogen-activated protein kinase 8 Homo sapiens 49-52 26475209-6 2016 The mechanism by which palmitic acid impairs insulin signaling may involve endoplasmic reticulum stress, because this fatty acid induced activation of both PERK, an ER stress marker, and JNK, a kinase associated with insulin resistance. Palmitic Acid 23-36 mitogen-activated protein kinase 8 Homo sapiens 187-190 31357761-7 2019 Results: Palmitic acid increased the phosphorylation of p38 MAPK and JNK in HepG2 cells (P< 0.05). Palmitic Acid 9-22 mitogen-activated protein kinase 8 Homo sapiens 69-72 30913535-0 2019 Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. Palmitic Acid 0-13 mitogen-activated protein kinase 8 Homo sapiens 77-80 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 13-15 mitogen-activated protein kinase 8 Homo sapiens 45-48 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 13-15 mitogen-activated protein kinase 8 Homo sapiens 53-56 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 129-131 mitogen-activated protein kinase 8 Homo sapiens 45-48 30913535-7 2019 Furthermore, PA increased phosphorylation of JNK and JNK blockage rescued the phosphorylation of Akt which was down-regulated by PA. Palmitic Acid 129-131 mitogen-activated protein kinase 8 Homo sapiens 53-56 28011403-6 2017 We observed that these effects were exerted by changes on the phosphorylation of IRS-1 on specific serine and tyrosine residues modulated by PA through the modulation of JNK and IKK activity. Palmitic Acid 141-143 mitogen-activated protein kinase 8 Homo sapiens 170-173 24608675-10 2014 Moreover, pretreatment with SP600125, an inhibitor of JNK, effectively abrogated PA-mediated autophagy and apoptosis. Palmitic Acid 81-83 mitogen-activated protein kinase 8 Homo sapiens 54-57 24608675-13 2014 CONCLUSION: JNK1 promotes PA-induced lipoapoptosis, whereas JNK2 activates pro-survival autophagy and inhibits PA lipotoxicity. Palmitic Acid 26-28 mitogen-activated protein kinase 8 Homo sapiens 12-16 24132507-8 2014 On a molecular level, inhibition of GSK-3beta expression or activity suppressed sodium palmitate-induced c-Jun-N-terminal kinase (JNK) phosphorylation and Bax upregulation, whereas GSK-3beta inhibition did not affect endoplasmic reticulum stress-induced activation of unfolded protein response. Palmitic Acid 80-96 mitogen-activated protein kinase 8 Homo sapiens 130-133 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 55-68 mitogen-activated protein kinase 8 Homo sapiens 14-37 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 55-68 mitogen-activated protein kinase 8 Homo sapiens 39-42 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 55-68 mitogen-activated protein kinase 8 Homo sapiens 111-114 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 176-189 mitogen-activated protein kinase 8 Homo sapiens 14-37 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 176-189 mitogen-activated protein kinase 8 Homo sapiens 39-42 22521608-10 2012 Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Palmitic Acid 176-189 mitogen-activated protein kinase 8 Homo sapiens 111-114 21078775-5 2011 PA induced ER stress, as determined by phosphorylation of PERK, eIF2alpha, and JNK, as well as induction of CHOP in macrophage-like THP-1 cells. Palmitic Acid 0-2 mitogen-activated protein kinase 8 Homo sapiens 79-82 23319068-5 2013 In parallel to this, the expression of phospho-c-Jun N-terminal kinase (p-JNK) in NSCs challenged with PA was increased significantly; however, JNK expression appeared stable. Palmitic Acid 103-105 mitogen-activated protein kinase 8 Homo sapiens 74-77 23319068-6 2013 Remarkably, JNK inhibitor effectively reduced the apoptosis of NSCs induced by PA. Palmitic Acid 79-81 mitogen-activated protein kinase 8 Homo sapiens 12-15 22766885-4 2012 Our studies herein demonstrate that sodium palmitate (C16:0) or laurate (C12:0) without BSA solubilization induced phosphorylation of inhibitor of nuclear factor-kappaB alpha, c-Jun N-terminal kinase (JNK), p44/42 mitogen-activated-kinase (ERK), and nuclear factor-kappaB subunit p65, and TLR target gene expression in THP1 monocytes or RAW264.7 macrophages, respectively, when cultured in low FBS (0.25%) medium. Palmitic Acid 36-52 mitogen-activated protein kinase 8 Homo sapiens 176-199 22766885-4 2012 Our studies herein demonstrate that sodium palmitate (C16:0) or laurate (C12:0) without BSA solubilization induced phosphorylation of inhibitor of nuclear factor-kappaB alpha, c-Jun N-terminal kinase (JNK), p44/42 mitogen-activated-kinase (ERK), and nuclear factor-kappaB subunit p65, and TLR target gene expression in THP1 monocytes or RAW264.7 macrophages, respectively, when cultured in low FBS (0.25%) medium. Palmitic Acid 36-52 mitogen-activated protein kinase 8 Homo sapiens 201-204